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1. Impact of DLL3 Expression as Prognostic Factor in Extensive Stage of Small Cell Lung Cancer Treated With First‐Line Chemotherapy.

Author

Nam, Hohyung, Jung, Soon‐Hee, Lee, Jii Bum, Kong, Jee Hyun, and Lim, Seungtaek

Subjects
*SMALL cell lung cancer, *SMALL cell carcinoma, *OVERALL survival, *SURVIVAL rate, *PROGNOSIS
Abstract

ABSTRACT Introduction Materials and Methods Results Conclusion Small cell lung cancer (SCLC) is known for its high proliferative rate and poor prognosis. Although Delta‐like ligand 3 (DLL3) is specifically expressed on the surface of SCLC, the association of DLL3 with prognosis in SCLC remains uncertain. Hence, we aimed to evaluate prognostic role of DLL3 in extensive stage of SCLC treated with first‐line chemotherapy.A total of 54 patients with extensive stage of SCLC (ES‐SCLC) who were treated with first‐line chemotherapy were included for our analysis. In addition, tissue specimen should be available for immuno‐histochemical staining for DLL3, and their clinico‐pathologic data, including progression‐free survival (PFS) and overall survival (OS), were obtained. DLL3 expression and the percentage of tumor cells with DLL3 positive among total cancer cells were analyzed microscopically and DLL3 high and DLL3 low were defined as the percentage of DLL3 positive tumor cells versus total cancer cells ≧ 75% and < 75%, respectively.DLL3 expression was not associated with any of the clinico‐pathological characteristics such as age at diagnosis, sex, response to first‐line chemotherapy, second‐line chemotherapy (Yes or No), and number of metastatic sites. However, response to first‐line chemotherapy and number of metastatic sites were correlated to PFS, while DLL3 expression and number of metastatic sites were correlated to OS.DLL3 was highly expressed in SCLC, and not associated with any clinico‐pathological characteristics. In survival outcome, DLL3 was correlated with worse OS, which suggests the prognostic role of DLL3 in ES‐SCLC. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Air Pollution and Noncommunicable Diseases A Review by the Forum of International Respiratory Societies’ Environmental Committee, Part 1: The Damaging Effects of Air Pollution

Author

Schraufnagel, Dean E, Balmes, John R, Cowl, Clayton T, De Matteis, Sara, Jung, Soon-Hee, Mortimer, Kevin, Perez-Padilla, Rogelio, Rice, Mary B, Riojas-Rodriguez, Horacio, Sood, Akshay, Thurston, George D, To, Teresa, Vanker, Anessa, and Wuebbles, Donald J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Prevention, Climate-Related Exposures and Conditions, Genetics, Cardiovascular, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Air Pollution, Humans, Noncommunicable Diseases, air pollution, mechanism of damage, noncommunicable diseases, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter < 2.5 μm) exposure is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths and > 103 million disability-adjusted life years lost according to the Global Burden of Disease Report. The World Health Organization attributes 3.8 million additional deaths to indoor air pollution. Air pollution can harm acutely, usually manifested by respiratory or cardiac symptoms, as well as chronically, potentially affecting every organ in the body. It can cause, complicate, or exacerbate many adverse health conditions. Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes. Susceptibility is partly under genetic and epigenetic regulation. Although air pollution affects people of all regions, ages, and social groups, it is likely to cause greater illness in those with heavy exposure and greater susceptibility. Persons are more vulnerable to air pollution if they have other illnesses or less social support. Harmful effects occur on a continuum of dosage and even at levels below air quality standards previously considered to be safe.

Published
2019

3. Air Pollution and Noncommunicable Diseases A Review by the Forum of International Respiratory Societies’ Environmental Committee, Part 2: Air Pollution and Organ Systems

Author

Schraufnagel, Dean E, Balmes, John R, Cowl, Clayton T, De Matteis, Sara, Jung, Soon-Hee, Mortimer, Kevin, Perez-Padilla, Rogelio, Rice, Mary B, Riojas-Rodriguez, Horacio, Sood, Akshay, Thurston, George D, To, Teresa, Vanker, Anessa, and Wuebbles, Donald J

Subjects
Climate-Related Exposures and Conditions, Pediatric, Lung, Clinical Research, Aging, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Respiratory, Good Health and Well Being, Air Pollution, Bone Diseases, Cardiovascular Diseases, Digestive System Diseases, Endocrine System Diseases, Humans, Immune System Diseases, Neoplasms, Nervous System Diseases, Noncommunicable Diseases, Respiratory Tract Diseases, Skin Diseases, air pollution, noncommunicable diseases, organ systems, Clinical Sciences, Respiratory System
Abstract

Although air pollution is well known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million COPD deaths can be attributed to air pollution, but air pollution may also account for 19% of all cardiovascular deaths and 21% of all stroke deaths. Air pollution has been linked to other malignancies, such as bladder cancer and childhood leukemia. Lung development in childhood is stymied with exposure to air pollutants, and poor lung development in children predicts lung impairment in adults. Air pollution is associated with reduced cognitive function and increased risk of dementia. Particulate matter in the air (particulate matter with an aerodynamic diameter < 2.5 μm) is associated with delayed psychomotor development and lower child intelligence. Studies link air pollution with diabetes mellitus prevalence, morbidity, and mortality. Pollution affects the immune system and is associated with allergic rhinitis, allergic sensitization, and autoimmunity. It is also associated with osteoporosis and bone fractures, conjunctivitis, dry eye disease, blepharitis, inflammatory bowel disease, increased intravascular coagulation, and decreased glomerular filtration rate. Atopic and urticarial skin disease, acne, and skin aging are linked to air pollution. Air pollution is controllable and, therefore, many of these adverse health effects can be prevented.

Published
2019

15. Imaging Assessment of Visceral Pleural Surface Invasion by Lung Cancer: Comparison of CT and Contrast-Enhanced Radial T1-Weighted Gradient Echo 3-Tesla MRI

Author

Zhang, Yu, primary, Kwon, Woocheol, additional, Lee, Ho Yun, additional, Ko, Sung Min, additional, Kim, Sang-Ha, additional, Lee, Won-Yeon, additional, Yong, Suk Joong, additional, Jung, Soon-Hee, additional, Byun, Chun Sung, additional, Lee, JunHyeok, additional, Yang, Honglei, additional, Han, Junhee, additional, and Ackman, Jeanne B., additional

Published
2021
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18. Renal cell carcinoma in South Korea: A multicenter study

Author

Kim, Haeryoung, Cho, Nam Hoon, Kim, Dong-Sug, Kwon, Young-Mi, Kim, Eun Kyung, Rha, Seo Hee, Park, Yong Wook, Shim, Jung Weon, Lee, Sang Sook, Lee, Shi Nae, Lee, Juhie, Lee, Jin Sook, Lee, Tae-Jin, Jung, Soo Jin, Jung, Soon-Hee, Chung, Jin Haeng, Cho, Hyun Yee, Joo, Hee Jae, Choi, Yeong-Jin, Choi, Chan, Han, Woon Sup, Hur, Bang, and Ro, Jae Y.

Published
2004
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20. Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 1: The Damaging Effects of Air Pollution

Author

Schraufnagel, Dean E., Balmes, John R., Cowl, Clayton T., De Matteis, Sara, Jung, Soon-Hee, Mortimer, Kevin, Perez-Padilla, Rogelio, Rice, Mary B., Riojas-Rodriguez, Horacio, Sood, Akshay, Thurston, George D., To, Teresa, Vanker, Anessa, and Wuebbles, Donald J.

Subjects
noncommunicable diseases, Prevention, air pollution, Clinical Sciences, Respiratory System, Special Feature, mechanism of damage, 1103 Clinical Sciences, Cardiovascular, Good Health and Well Being, Genetics, Humans, 2.2 Factors relating to the physical environment, Climate-Related Exposures and Conditions, Aetiology
Abstract

Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter< 2.5 μm) exposure is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths and > 103 million disability-adjusted life years lost according to the Global Burden of Disease Report. The World Health Organization attributes 3.8 million additional deaths to indoor air pollution. Air pollution can harm acutely, usually manifested by respiratory or cardiac symptoms, as well as chronically, potentially affecting every organ in the body. It can cause, complicate, or exacerbate many adverse health conditions. Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes. Susceptibility is partly under genetic and epigenetic regulation. Although air pollution affects people of all regions, ages, and social groups, it is likely to cause greater illness in those with heavy exposure and greater susceptibility. Persons are more vulnerable to air pollution if they have other illnesses or less social support. Harmful effects occur on a continuum of dosage and even at levels below air quality standards previously considered to be safe.

Published
2019

21. Air pollution and noncommunicable diseases: a review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: air pollution and organ systems

Author

Schraufnagel, Dean E., Balmes, John R., Cowl, Clayton T., De Matteis, Sara, Jung, Soon-Hee, Mortimer, Kevin, Perez-Padilla, Rogelio, Rice, Mary B., Riojas-Rodriguez, Horacio, Sood, Akshay, Thurston, George D., To, Teresa, Vanker, Anessa, and Wuebbles, Donald J.

Subjects
Aging, noncommunicable diseases, Digestive System Diseases, Respiratory Tract Diseases, Clinical Sciences, air pollution, Respiratory System, Endocrine System Diseases, Skin Diseases, Clinical Research, Neoplasms, Humans, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Climate-Related Exposures and Conditions, Aetiology, Lung, Pediatric, Special Feature, 1103 Clinical Sciences, organ systems, Good Health and Well Being, Immune System Diseases, Cardiovascular Diseases, Respiratory, Bone Diseases, Nervous System Diseases
Abstract

Although air pollution is well known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million COPD deaths can be attributed to air pollution, but air pollution may also account for 19%of all cardiovascular deaths and 21%of all stroke deaths. Air pollution has been linked to other malignancies, such as bladder cancer and childhood leukemia. Lung development in childhood is stymied with exposure to air pollutants, and poor lung development in children predicts lung impairment in adults. Air pollution is associated with reduced cognitive function and increased risk of dementia. Particulate matter in the air (particulate matter with an aerodynamic diameter< 2.5 μm) is associated with delayed psychomotor development and lower child intelligence. Studies link air pollution with diabetes mellitus prevalence, morbidity, and mortality. Pollution affects the immune system and is associated with allergic rhinitis, allergic sensitization, and autoimmunity. It is also associated with osteoporosis and bone fractures, conjunctivitis, dry eye disease, blepharitis, inflammatory bowel disease, increased intravascular coagulation, and decreased glomerular filtration rate. Atopic and urticarial skin disease, acne, and skin aging are linked to air pollution. Air pollution is controllable and, therefore, many of these adverse health effects can be prevented.

Published
2018

22. Air pollution in the Asia‐Pacific Region

Author

North, Crystal M., primary, Rice, Mary B., additional, Ferkol, Thomas, additional, Gozal, David, additional, Hui, Christopher, additional, Jung, Soon‐Hee, additional, Kuribayashi, Kozo, additional, McCormack, Meredith C., additional, Mishima, Michiaki, additional, Morimoto, Yasuo, additional, Song, Yuanlin, additional, Wilson, Kevin C., additional, Kim, Woo Jin, additional, and Fong, Kwun M., additional

Published
2019
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23. Air Pollution in the Asia-Pacific Region. A Joint Asian Pacific Society of Respirology/American Thoracic Society Perspective

Author

North, Crystal M., primary, Rice, Mary B., additional, Ferkol, Thomas, additional, Gozal, David, additional, Hui, Christopher, additional, Jung, Soon-Hee, additional, Kuribayashi, Kozo, additional, McCormack, Meredith C., additional, Mishima, Michiaki, additional, Morimoto, Yasuo, additional, Song, Yuanlin, additional, Wilson, Kevin C., additional, Kim, Woo Jin, additional, and Fong, Kwun M., additional

Published
2019
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31. Experience of Korean-Mongolian international joint workshops on pathology and cytopathology since 2007

Author

Choe, Gheeyoung, primary, Kang, Shin Kwang, additional, Kwon, Kun-Young, additional, Kim, Hankyeom, additional, Lee, An Hee, additional, Park, Jae-Bok, additional, Kim, Kyu-rae, additional, Hong, Sung Ran, additional, Jung, Soon-Hee, additional, Ha, Seung Yeon, additional, Ha, Changwon, additional, Noh, Mee Sook, additional, Lee, Sanghan, additional, Park, No Won, additional, Kim, Kee Hong, additional, Yong, Seok Joong, additional, Yoon, Moo Yeol, additional, Jeon, Seung Min, additional, Kang, Dae Young, additional, Kang, Chang Suk, additional, Kim, Ji Yeon, additional, Kim, Jihun, additional, Kim, Chul Hwan, additional, Kim, Han Sung, additional, Park, Yong-Koo, additional, Sohn, Kyung-Rak, additional, Sohn, Jin Hee, additional, Sung, Sun Hee, additional, Yu, Eunsil, additional, Yoo, Changyoung, additional, Lee, Kyi Beom, additional, Hyuk lee, Jae, additional, Lee, Ji Shin, additional, Cho, Kyung-Ja, additional, Jeong, Jin Sook, additional, and Hong, Eun Kyung, additional

Published
2016
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36. Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report

Author

Choi, Yeun Seoung, primary, Lim, Jung Soo, additional, Kwon, Woocheol, additional, Jung, Soon-Hee, additional, Park, Il Hwan, additional, Lee, Myoung Kyu, additional, Lee, Won Yeon, additional, Yong, Suk Joong, additional, Lee, Seok Jeong, additional, Jung, Ye-Ryung, additional, Choi, Jiwon, additional, Choi, Ji Sun, additional, Jeong, Joon Taek, additional, Yoo, Jin Sae, additional, and Kim, Sang-Ha, additional

Published
2015
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40. No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea

Author

Eom, Minseob, primary, Abdul-Ghafar, Jamshid, additional, Park, Sun-Mi, additional, Han, Joung Ho, additional, Hong, Soon Won, additional, Kwon, Kun Young, additional, Ko, Eun Suk, additional, Kim, Lucia, additional, Kim, Wan Seop, additional, Ha, Seung Yeon, additional, Lee, Kyo Young, additional, Lee, Chang Hun, additional, Yoon, Hye Kyoung, additional, Choi, Yoo Duk, additional, Chung, Myoung Ja, additional, and Jung, Soon-Hee, additional

Published
2013
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48. A Case of Dermatomyositis Presenting with Rhabdomyolysis

Author

Lee, Hyang Sun, primary, Jee, Yong Gwan, additional, Song, Sin Han, additional, Sung, Se Yong, additional, Lee, Ji Ho, additional, Yang, Jae Won, additional, Han, Byoung-Geun, additional, Jung, Soon Hee, additional, Park, Jeong Ha, additional, and Kang, Tae Young, additional

Published
2011
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