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4 results on '"Jung, Seong-Yun"'

2. p34SEI-1inhibits ROS-induced cell death through suppression of ASK1

Author

Hong, Seung-Woo, primary, Shin, Jae-Sik, additional, Lee, Young-Min, additional, Kim, Dong-Gil, additional, Lee, Sok-Young, additional, Yoon, Dok Hyun, additional, Jung, Seong-Yun, additional, Hwang, Jung Jin, additional, Lee, Seung-Jin, additional, Cho, Dong-Hyung, additional, Hong, Yong-Sang, additional, Kim, Tae-Won, additional, Jin, Dong-Hoon, additional, and Lee, Won-Keun, additional

Published
2011
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3. Development of anti-gravity control model for robot gait traing system.

Author

Kang, Sung-Jae, Cho, Hyun-seok, Jung, Seong-Yun, Kim, Gyu-Seok, Ryu, Jei-Cheong, and Mun, Mu-seong

Abstract

The anti-gravity gait training system is a rehabilitation training device for patients with neurological impairments and elderly people having problems with walking. We are developing a unloading body weight device for the gait training system. Unloading device is a necessary part because the user of this system have a muscular skeletal weaknesses. We want to control the unloading forces to be steady because the physiological gait pattern can be obtained in this condition only. We have developed the simulation model of gait training system, a human dummy models, various traditional unloading devices and the controlled unloading device. Simulation model will be used for designing a novel controller and mechanism of unloading system. [ABSTRACT FROM PUBLISHER]

Published
2012

4. p34 (SEI-1) inhibits ROS-induced cell death through suppression of ASK1.

Author

Hong SW, Shin JS, Lee YM, Kim DG, Lee SY, Yoon DH, Jung SY, Hwang JJ, Lee SJ, Cho DH, Hong YS, Kim TW, Jin DH, and Lee WK

Subjects
Cell Cycle, Cell Line, Colonic Neoplasms metabolism, Humans, Hydrogen Peroxide pharmacology, Inhibitor of Apoptosis Proteins genetics, Inhibitor of Apoptosis Proteins metabolism, RNA Interference, RNA, Small Interfering, Signal Transduction, Transcription Factors, Ubiquitin, Ubiquitination, Apoptosis, MAP Kinase Kinase Kinase 5 metabolism, Nuclear Proteins metabolism, Reactive Oxygen Species metabolism, Trans-Activators metabolism
Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a key factor for controlling several cellular events including the cell cycle, senescence and apoptosis, in response to reactive oxygen species (ROS). However, the mechanisms that regulate ASK1 protein levels remain largely unexplored. In this study, we demonstrate that p34 (SEI-1) , a positive cell cycle regulator with an oncogenic potential, inhibits ROS-induced cell death by suppressing ASK1. We first found that p34 (SEI-1) -expressing cells have enhanced resistance to hydrogen peroxide (H 2O 2). Moreover, ectopic expression of p34 (SEI-1) clearly inhibited H 2O 2-induced phosphorylation of ASK1 in the colon cancer cell lines- HCT116 and SW620-in association with a decrease in ASK1 protein levels. Interestingly, p34 (SEI-1) induced ubiquitination of ASK1, however, no direct interaction was found between p34 (SEI-1) and ASK1. These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1.

Published
2011
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