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BACKGROUND: In early 2020, the coronavirus 2019 (COVID-19) pandemic necessitated changes in social behavior to prevent its spread, including holding online classes, implementing social distancing, and allowing employees to telecommute. However, these changes have had a negative impact on people's sleep patterns and mental health, particularly for college students. OBJECTIVE: This study investigated the relationship between mental health and sleep quality according to the changes in lifestyle of college students in the periods before and after COVID-19. METHODS: The study subjects were 164 college students from Korea who had both face-to-face and non-face-to-face college experiences before and after COVID-19. The experiment was conducted using a Google survey, and the participants were recruited from the college community. The general features and lifestyle habits for the individuals were assessed using the AUDIT-K, Delphi method, KGHQ (General Mental Health Scale), and PSQI-K (Pittsburg Sleep Quality Index). RESULTS: The KGHQ and PSQI scores increased with the spread of COVID-19, which means that the mental health and sleep quality of college students deteriorated. 11 categories of variables were further investigated to evaluate changes in lifestyle, and the results indicate significant changes in the number of private meetings per week, monthly drinking, outdoor activity time, electronic device usage time, weekly food delivery, weekly late-night snacks, daily snacks, and daily coffee intake and no significant changes in exercise, smoking, and fast food intake. CONCLUSION: COVID-19 caused many changes in the lifestyle of college students, which adversely affected mental health and sleep. [ABSTRACT FROM AUTHOR]