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40 results on '"Jung, Min Su"'

1. Long-term clinical outcomes of image-guided percutaneous coronary intervention in acute myocardial infarction from the Korea Acute Myocardial Infarction Registry.

Author

Kwon, Youngjoon, Kim, Namkyun, Kim, Chang-Yeon, Kim, Do-Hoon, Shin, Hyewon, Jung, Min-Su, Park, Jong Sung, Park, Yoon Jung, Park, Bo Eun, Kim, Hong Nyun, Jang, Se Yong, Bae, Myung Hwan, Lee, Jang Hoon, Yang, Dong Heon, Park, Hun Sik, Cho, Yongkeun, Cha, Kwang Soo, Hur, Seung-Ho, Hwang, Jin-Yong, and Jeong, Myung Ho

Subjects
MYOCARDIAL infarction, PERCUTANEOUS coronary intervention, CORONARY vasospasm, INTRAVASCULAR ultrasonography, OPTICAL coherence tomography, PROPENSITY score matching
Abstract

Imaging modalities for percutaneous coronary intervention (PCI), such as intravascular ultrasound (IVUS) or optical coherence tomography (OCT), have increased in the current PCI era. However, their clinical benefits in acute myocardial infarction (AMI) have not been fully elucidated. This study investigated the long-term outcomes of image-guided PCI in patients with AMI using data from the Korean Acute Myocardial Infarction Registry. A total of 9,271 patients with AMI, who underwent PCI with second-generation drug-eluting stents between November 2011 and December 2015, were retrospectively examined, and target lesion failure (TLF) at 3 years (defined as the composite of cardiac death, target vessel myocardial infarction, and ischemia-driven target lesion revascularization) was evaluated. From the registry, 2,134 patients (23.0%) underwent image-guided PCI (IVUS-guided: n = 1,919 [20.6%]; OCT-guided: n = 215 patients [2.3%]). Based on propensity score matching, image-guided PCI was associated with a significant reduction in TLF (hazard ratio: 0.76; 95% confidence interval: 0.59–0.98, p = 0.035). In addition, the TLF incidence in the OCT-guided PCI group was comparable to that in the IVUS-guided PCI group (5.3% vs 4.7%, p = 0.903). Image-guided PCI, including IVUS and OCT, is associated with favorable clinical outcomes in patients with AMI at 3 years post-intervention. Additionally, OCT-guided PCI is not inferior to IVUS-guided PCI in patients with AMI. [ABSTRACT FROM AUTHOR]

Published
2024
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3. 13.2 A 32Gb 8.0Gb/s/pin DDR5 SDRAM with a Symmetric-Mosaic Architecture in a 5th-Generation 10nm DRAM Process

Author

Choi, Ikjoon, primary, Hong, Seunghwan, additional, Kim, Kihyun, additional, Hwang, Jeong-Sik, additional, Woo, Seunghan, additional, Kim, Young-Sang, additional, Cho, Cheong-Ryong, additional, Lee, Eun-Young, additional, Lee, Hun-Jae, additional, Jung, Min-Su, additional, Jung, Hee-Yun, additional, Hwang, Ju-Seong, additional, Yoon, Junsub, additional, Lim, Wonmook, additional, Yoo, Hyeong-Jin, additional, Lee, Won-Ki, additional, Oh, Jung-Kyun, additional, Lee, Dong-Su, additional, Lee, Jong-Eun, additional, Kim, Jun-Hyung, additional, Kim, Young-Kwan, additional, Park, Su-Jin, additional, Ho, Byung-Kyu, additional, Na, Byong-Wook, additional, Choi, Hye-In, additional, Lee, Chung-Ki, additional, Lee, Soo-Jung, additional, Shin, Hyunsung, additional, Lee, Young-Kyu, additional, Ryu, Jang-Woo, additional, Shin, Sangwoong, additional, Park, Sungchul, additional, Lim, Daihyun, additional, Bae, Seung-Jun, additional, Sohn, Young-Soo, additional, Oh, Tae-Young, additional, and Hwang, SangJoon, additional

Published
2024
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6. THE ASSOCIATION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND VENOUS THROMBOEMBOLIC DISEASE IN HEALTHY ADULTS: A NATIONWIDE STUDY OF KOREAN PEOPLE

Author

Kim, Namkyun, primary, Kim, Chang-Yeon, additional, Roh, Jae-Hyung, additional, Jung, Min Su, additional, Kwon, Youngjoon, additional, Park, Jong Sung, additional, Kim, Hong Nuyn, additional, Jang, Se Yong, additional, Bae, Myung Hwan, additional, Lee, Jang Hoon, additional, Yang, Dong Heon, additional, park, hun sik, additional, and Cho, Yongkeun, additional

Published
2023
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40. Silencing of MUC8 by siRNA increases P2Y₂-induced airway inflammation.

Author

Cha HJ, Jung MS, Ahn do W, Choi JK, Ock MS, Kim KS, Yoon JH, Song EJ, and Song KS

Subjects
Animals, Cell Line, Tumor, Humans, Inflammation genetics, Inflammation metabolism, Inflammation pathology, Interleukin 1 Receptor Antagonist Protein genetics, Interleukin 1 Receptor Antagonist Protein metabolism, Interleukin-1alpha genetics, Interleukin-1alpha metabolism, Interleukin-6 genetics, Interleukin-6 metabolism, Mice, Mice, Knockout, Mucins genetics, Receptors, Purinergic P2Y2 genetics, Respiratory Tract Diseases genetics, Respiratory Tract Diseases pathology, Transforming Growth Factor beta genetics, Transforming Growth Factor beta metabolism, Adenosine Triphosphate metabolism, Gene Silencing, Mucins biosynthesis, RNA, Small Interfering, Receptors, Purinergic P2Y2 metabolism, Respiratory Tract Diseases metabolism
Abstract

Mucin hypersecretion and overproduction are frequent manifestations of respiratory disease. Determining the physiological function of airway mucin is presently considered more important than identifying the relevant signaling pathways. The lack of a full-length human mucin 8 (MUC8) cDNA sequence has hindered the generation of a Muc8 knockout mouse line. Thus, the precise physiological functions of MUC8 are unclear. Herein, we investigated the function of MUC8 using a small-interfering RNA (siRNA)-mediated genetic silencing approach in human airway epithelial cells. Herein, intracellular IL-1α production was stimulated by an ATP/P2Y2 complex. While ATP/P2Y₂ increased IL-1α secretion in a time-dependent manner, treatment with P2Y₂-specific siRNA significantly decreased IL-1α secretion. Moreover, ATP increased P2Y₂-mediated upregulation of MUC8 expression; however, IL-1α significantly decreased the extent to which ATP/P2Y₂ upregulated MUC8 expression. Interestingly, treatment with MUC8-specific siRNA decreased the production of anti-inflammatory cytokines (TGF-β and IL-1 receptor antagonist) and increased the production of inflammatory cytokines (IL-1α and IL-6) in our system. In addition, siRNA-mediated knockdown of MUC8 expression dramatically increased the secretion of inflammatory chemokines and resulted in an approximately threefold decrease in cell chemotaxis. We propose that MUC8 may function as an anti-inflammatory mucin that participates in inflammatory response by attracting immune cells/cytokines to the site of inflammation. Our results provide new insight into the physiological function of MUC8 and enhance our understanding of mucin overproduction during airway inflammation., (Copyright © 2015 the American Physiological Society.)

Published
2015
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