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2. Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics

Author

Jung, Jesse J, Soh, Yu Qiang, Sha, Patricia, Yu, Sophia, Durbin, Mary K, and Hoang, Quan V

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurodegenerative, Clinical Research, Neurosciences, Adult, Astigmatism, Cross-Over Studies, Female, Fluorescein Angiography, Fovea Centralis, Healthy Volunteers, Humans, Male, Middle Aged, Prospective Studies, Retinal Vessels, Tomography, Optical Coherence, Visual Acuity, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTo analyze the effect of induced astigmatism on en-face spectral-domain optical coherence tomography angiography quantitative metrics.DesignProspective crossover study.MethodsNormal eyes without astigmatism and with 0.75, 1.75, and 2.75 diopters (D) of with-the-rule (WTR) astigmatism were imaged using a 3 × 3-mm scan pattern SD-OCTA CIRRUS 5000 HD-OCT with AngioPlex (Carl Zeiss Meditec, Dublin, CA, USA). Quantitative parameters, including foveal avascular zone metrics, parafoveal vessel length density (VD), and perfusion density (PD) were corrected for magnification secondary to axial length and analyzed. Univariate linear regressions were performed within each eye to correlate quantitative metrics to the level of an induced astigmatic cylinder.ResultsFifteen eyes from 15 patients were imaged. Every 1-D increase in induced WTR astigmatism was associated with a statistically significant decrease in VD and PD within all Early Treatment Diabetic Retinopathy Study inner ring quadrants; however, especially more so nasally (VD: 0.63; P < .001; PD: 0.0089; P = .001). For every 1-D increase in induced astigmatism, the resulting decrease in the inner ring superior quadrant was 12% greater for VD and 16% greater for PD versus that in the inferior quadrant. The resulting decrease in the inner ring nasal quadrant was 40% greater for VD and 48% greater for PD versus that in the temporal quadrant.ConclusionsIncreasing levels of induced WTR astigmatism correlated with globally diminishing VD and PD, was more symmetrical for vertical than horizontal quadrants, and was most pronounced nasally. This may be due to a high prevalence of horizontally oriented vessels nasally and the horizontal optical defocus induced by WTR astigmatism.

Published
2020

3. Cytomegalovirus Retinal Necrosis With Occlusive Vasculopathy Secondary to Steroid Immunosuppression for Giant Cell Arteritis

Author

Zeng, Anne, Strauss, Ron, Goglin, Sarah E, Gonzales, John, Pawar, Varun K, Imes, Richard K, and Jung, Jesse J

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Infectious Diseases, Eye Disease and Disorders of Vision, Eye, central retinal artery occlusion, CMV chronic retinal necrosis, cytomegalovirus, giant cell arteritis, immunosuppression, necrotizing retinitis, neovascular glaucoma, prednisone, tocilizumab, valganciclovir
Abstract

PurposeThis case report discusses an atypical case of cytomegalovirus (CMV) retinal necrosis with panretinal occlusive vasculopathy in a 77-year-old man who was immunosuppressed following treatment for giant cell arteritis (GCA).MethodsA case report is presented.ResultsClinical examination demonstrated a central retinal artery occlusion and pale disc suspicious for arteritic ischemic optic neuropathy in the right eye. Biopsy-proven GCA prompted treatment with oral prednisone. While on glucocorticoid immunosuppression, the patient suffered vision loss in the left eye from CMV-necrotizing retinitis with occlusive vasculopathy. Treatment controlled the CMV infection but tapering of his steroids resulted in worsening GCA, requiring a steroid-sparing treatment, tocilizumab.ConclusionsCorticosteroid immunosuppression for GCA may lead to immune dysfunction allowing for an atypical occlusive vasculitis with retinal necrosis from CMV. Early identification and treatment are essential to adjust the level of immunosuppression and consider alternate therapies to control the GCA and prevent worsening of this opportunistic infection.

Published
2020

6. Anatomic, Visual, and Financial Outcomes for Traditional and Nontraditional Primary Pneumatic Retinopexy for Retinal Detachment

Author

Jung, Jesse J, Cheng, John, Pan, Jane Y, Brinton, Daniel A, and Hoang, Quan V

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Clinical Research, Adolescent, Adult, Aged, Aged, 80 and over, Cost-Benefit Analysis, Cryotherapy, Endotamponade, Female, Health Care Costs, Humans, Laser Therapy, Male, Middle Aged, Retinal Detachment, Retrospective Studies, Scleral Buckling, Sulfur Hexafluoride, Treatment Outcome, Visual Acuity, Vitrectomy, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PURPOSE:To determine factors predictive of anatomic, visual, and financial outcomes after traditional and nontraditional primary pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RD). DESIGN:Retrospective interventional case series and cost comparison. METHODS:Participants: Total of 178 eyes (156 patients) with PR-repaired primary RD by a single surgeon at a clinical practice from January 2001 to December 2013 and followed for ≥1 year. The cohort had 2 subgroups: traditional (TPR) and nontraditional (NTPR) PR. MAIN OUTCOME MEASURES:Characteristics associated with best-corrected visual acuity (BCVA) and anatomic outcomes. Cost analysis and potential cost savings comparing PR to scleral buckle and vitrectomy. RESULTS:One hundred thirty-one of 178 eyes (73.5%) were successfully treated at 1 year (postoperative year 1): 72.8% (75/103) in TPR and 74.6% (56/75) in NTPR. Macula-off detachment (-0.44 logMAR, P < .001) and clock hours of RD (-0.84 logMAR, P < .001) correlated with improved BCVA; pseudophakia (0.26 logMAR, P = .002) and inferior retinal tears (0.62 logMAR, P = .009) correlated with worsening BCVA. Pseudophakia (-0.15, P = .03), inferior quadrant RD (-0.27, P < .001), and proliferative vitreoretinopathy (-0.68, P < .001) correlated with anatomic failure. Total average cost for TPR and NTPR was $1248.37 ± $882.11 and $1471.91 ± $942.84, respectively (P = .10). PR had a potential cost savings of 62% and 60.8% when compared to scleral buckle and vitrectomy, respectively. CONCLUSIONS:PR results in successful anatomic and visual outcomes in both TPR and NTPR repair of primary RD. Preoperative pseudophakia is associated with worse visual outcomes and less anatomic success. The cost of primary PR and subsequent procedures to achieve final anatomic success was not significantly different between TPR and NTPR, and supports the possible cost-effectiveness of expanded indications for PR.

Published
2019

8. Focal Scleral Nodule: A New Name for Solitary Idiopathic Choroiditis and Unifocal Helioid Choroiditis

Author

Fung, Adrian T., Waldstein, Sebastian M., Gal-Or, Orly, Pellegrini, Marco, Preziosa, Chiara, Shields, Jerry A., Welch, R. Joel, Dolz-Marco, Rosa, Sarraf, David, Nagiel, Aaron, Lalane, Robert, Jung, Jesse J., Ghazi, Nicola G., Ramtohul, Prithvi, Arnold, Jennifer J., Sakurada, Yoichi, Choudhry, Netan, Balaratnasingam, Chandrakumar, Freund, K. Bailey, and Shields, Carol L.

Published
2020
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18. Haptic Erosion Following Sutureless Scleral-fixated Intraocular Lens Placement

Author

Pakravan, Parastou, primary, Patel, Veshesh, additional, Chau, Viet, additional, Rohowetz, Landon, additional, Lai, James, additional, Fan, Kenneth C., additional, Al-khersan, Hasenin, additional, Melo, Isabela M., additional, Muni, Rajeev H., additional, Tsao, Sean W., additional, Kaplan, Richard, additional, Jung, Jesse J., additional, Hoyek, Sandra, additional, Patel, Nimesh A., additional, Kuriyan, Ajay E., additional, Laura, Diana M., additional, Mantopoulos, Dimosthenis, additional, Syed, Zeba A., additional, and Yannuzzi, Nicolas A., additional

Published
2022
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23. Nodular Epiretinal Mϋller Cell Gliosis in the Fovea

Author

Jung, Jesse J., primary, Zeng, Anne, additional, Komati, Rahul, additional, Mackin, Anna G., additional, Skondra, Dimitra, additional, Yonekawa, Yoshihiro, additional, Fineman, Mitchell S., additional, Ezon, Isaac, additional, Rofagha, Soraya, additional, and Hoang, Quan V., additional

Published
2022
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25. Impact of Coronavirus Disease 2019 Restrictions on Retinal Detachment: A Multicenter Experience

Author

Jung, Jesse J., primary, Chang, Jonathan S., additional, Oellers, Patrick R., additional, Ali, Mohsin H., additional, Do, Brian K., additional, Tseng, Joseph J., additional, Roizenblatt, Roberto, additional, Muni, Rajeev H., additional, Weng, Christina Y., additional, Oakey, Zackery B., additional, Tsao, Sean W., additional, Rofagha, Soraya, additional, Chan, Xavier, additional, Hoang, Quan V., additional, Russ Richardson, Daniel, additional, Toledo-Corral, Jaime, additional, Pandya, Hemang K., additional, Copeland, Victor T., additional, Jonna, Gowtham, additional, Zahid, Sarwar, additional, Lin, James, additional, Thanos, Aristomenis, additional, Ezon, Isaac, additional, Movahedan, Asadolah, additional, Schechet, Sidney A., additional, Mehta, Mitul C., additional, Hamli, Hesham, additional, Puri, Sidharth, additional, Jhaveri, Chirag D., additional, Ridgeley, Jamison R., additional, Sheyman, Alan T., additional, Hu, Jonathan, additional, Lu, Stephanie Y., additional, Browne, Andrew W., additional, Huang, Lynn L., additional, Chee, Yewlin E., additional, Elmann, Solly, additional, Chaudhary, Khurram M., additional, Mehta, Nitish, additional, Kurochkin, Philip, additional, Gjyzeli, Genti, additional, Altaweel, Michael M., additional, Michael Nork, T., additional, Zeng, Anne, additional, Loh, Isabella Q., additional, and Yi Lin, Hong, additional

Published
2022
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27. Impact of Coronavirus Disease 2019 Restrictions on Retinal Detachment: A Multicenter Experience

Author

Russ Richardson, Daniel, Toledo-Corral, Jaime, Pandya, Hemang K., Copeland, Victor T., Jonna, Gowtham, Zahid, Sarwar, Lin, James, Thanos, Aristomenis, Ezon, Isaac, Movahedan, Asadolah, Schechet, Sidney A., Mehta, Mitul C., Hamli, Hesham, Puri, Sidharth, Jhaveri, Chirag D., Ridgeley, Jamison R., Sheyman, Alan T., Hu, Jonathan, Lu, Stephanie Y., Browne, Andrew W., Huang, Lynn L., Chee, Yewlin E., Elmann, Solly, Chaudhary, Khurram M., Mehta, Nitish, Kurochkin, Philip, Gjyzeli, Genti, Altaweel, Michael M., Michael Nork, T., Zeng, Anne, Loh, Isabella Q., Yi Lin, Hong, Jung, Jesse J., Chang, Jonathan S., Oellers, Patrick R., Ali, Mohsin H., Do, Brian K., Tseng, Joseph J., Roizenblatt, Roberto, Muni, Rajeev H., Weng, Christina Y., Oakey, Zackery B., Tsao, Sean W., Rofagha, Soraya, Chan, Xavier, and Hoang, Quan V.

Published
2022
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32. Unexplained Vision Loss Associated With Intraocular Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment Repair

Author

Pakravan, Parastou, Shaheen, Abdulla, Patel, Veshesh, Villalba, Maria F., Dib, Bernard, Lai, James, Rohowetz, Landon, Chau, Viet, Patel, Nimesh A., Tzu, Jonathan H., Wang, Angeline L., Alhoyek, Sandra, Scott, Nathan, Samara, Wasim A., Goduni, Lediana, Jung, Jesse J., Russell, Jonathan F., Mantopoulos, Dimosthenis, Hajrasouliha, Amir R., Savoie, Brian T., Haddock, Luis J., Berrocal, Audina M., Sridhar, Jayanth, West, Matthew R., and Yannuzzi, Nicolas A.

Abstract

Purpose:To evaluate the visual outcomes with unexplained vision loss during or after silicone oil (SO) tamponade. Methods:This multicenter retrospective case series comprised patients with unexplained vision loss associated with SO tamponade or its removal. Eyes with other clear secondary identifiable causes of vision loss were excluded. Results:Twenty-nine eyes of 28 patients (64% male) were identified. The mean age was 50 ± 13 years (range, 13-78 years). The mean duration of SO tamponade was 148 ± 38 days. Eighteen eyes (62%) developed unexplained vision loss while under SO; 11 (38%) had vision loss after SO removal. The most common optical coherence tomography (OCT) finding was ganglion cell layer (GCL) thinning (55%). Eyes with vision loss after SO removal had a mean logMAR best-corrected visual acuity (BCVA) of 0.6 ± 0.7 (Snellen 20/85) before SO tamponade and 1.2 ± 0.4 (20/340) before SO removal. By the last follow-up after SO removal, the BCVA had improved to 1.1 ± 0.4 (20/235). In eyes with vision loss after SO removal, the BCVA before SO removal was 0.7 ± 0.7 (20/104), which deteriorated to 1.4 ± 0.4 (20/458) 1 month after SO removal. By the last follow-up, the BCVA had improved to 1.0 ± 0.5 (20/219). Conclusions:Unexplained vision loss can occur during SO tamponade or after SO removal. Vision loss was associated with 1000-centistoke and 5000-centistoke oil and occurred in macula-off and macula-on retinal detachments. The duration of tamponade was 3 months or longer in the majority of eyes. Most eyes had GCL thinning on OCT. Gradual visual recovery can occur yet is often incomplete.

Published
2023
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33. Reply

Author

Soh, Yu Qiang, primary, Hoang, Quan V., additional, Freund, K. Bailey, additional, and Jung, Jesse J., additional

Published
2022
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34. Bacillary Layer Detachment Due to Macular Neovascularization

Author

Jung, Jesse J., Soh, Yu Qiang, Yu, Daryle Jason G., Rofagha, Soraya, Lee, Scott S., Freund, K. Bailey, and Hoang, Quan V.

Subjects
Article
Abstract

PURPOSE: To describe the clinical and multimodal imaging (MMI) features of bacillary layer detachment (BD), and its response to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy, in eyes with macular neovascularization (MNV). DESIGN: Retrospective, observational case series METHODS: Fourteen eyes (14 patients, 7 male) were imaged with spectral-domain optical coherence tomography (OCT), and either fluorescein angiography or OCT angiography. Therapeutic response was monitored with serial imaging and best-corrected visual acuity (BCVA) assessments. RESULTS: Mean age was 75±13 (range: 45–96) years, with mean follow-up duration of 27±21 (range: 1–56) months. Neovascular age-related macular degeneration (nAMD) was found in 71% (10/14) eyes. Type 2 MNV lesions were associated with BD in all 14 eyes. Subretinal hemorrhage was noted in 79% (11/14) eyes. BD promptly resolved following intravitreal anti-VEGF therapy in all eyes. Baseline BCVA improved from LogMar 0.84±0.32 (Snellen equivalent 20/138) to LogMar 0.48±0.31 (Snellen equivalent 20/60) at last follow-up, with treatment of the MNV. CONCLUSIONS: Type 2 MNV and subretinal hemorrhage are associated with BDs, which may be due to a rapid influx of exudative fluid into the potential space between the external limiting membrane and ellipsoid zone. Intravitreal anti-VEGF therapy results in rapid resolution of BDs and visual improvement in most eyes.

Published
2021

37. Haptic Erosion Following Sutureless Scleral-fixated Intraocular Lens Placement

Author

Pakravan, Parastou, Patel, Veshesh, Chau, Viet, Rohowetz, Landon, Lai, James, Fan, Kenneth C., Al-khersan, Hasenin, Melo, Isabela M., Muni, Rajeev H., Tsao, Sean W., Kaplan, Richard, Jung, Jesse J., Hoyek, Sandra, Patel, Nimesh A., Kuriyan, Ajay E., Laura, Diana M., Mantopoulos, Dimosthenis, Syed, Zeba A., and Yannuzzi, Nicolas A.

Abstract

To describe the clinical features and visual outcomes of eyes with conjunctival haptic erosion after sutureless intrascleral (SIS) fixated intraocular lens (IOL) placement.

Published
2023
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42. Contributors

Author

Abrams, Gary W., Afshar, Armin R., Agarwal, Aniruddha, Agarwal, Anita, Ahmed, Ishrat, Aiello, Lloyd Paul, Ajlan, Radwan S., Albert, Daniel M., Andreoli, Michael T., Arepalli, Sruthi, Aronow, Mary E., Ashraf, Mohamed, Au, Adrian, Ávila, Marcos, Aylward, G. William, Bagger, Mette M., Balaratnasingam, Chandrakumar, Barry, Robert J., Belfort, Rubens, Jr., Bennett, Jean, Berry, Jesse L., Besirli, Cagri G., Bessette, Angela, Bharti, Kapil, Bhende, Muna, Bhende, Pramod S., Binder, Susanne, Binkley, Elaine M., Bird, Alan C., Blumenkranz, Mark S., Boldt, H. Culver, Boon, Camiel Jan Fons, Borrelli, Enrico, Boulton, Michael E., Brantley, Milam A., Jr., Bressler, Neil M., Bressler, Susan B., Bringmann, Andreas, Brinton, Daniel A., Brown, Gary C., Brown, Melissa M., Brunner, Simon, Budoff, Greg, Bujakowska, Kinga M., Canto-Soler, M. Valeria, Cao, Dingcai, Capone, Antonio, Jr., Carroll, Joseph, Carruthers, David, Caspi, Rachel R., Chaikitmongkol, Voraporn, Chan, Hwei Wuen, Chang Chusan, Yuilyn A., Charles, Steve, Charteris, David G., Chen, Jeannie, Chen, Judy J., Cheung, Carol Y., Cheung, Chui Ming Gemmy, Chew, Emily Y., Chhablani, Jay, Chiang, Michael F., Chon, Brian, Clegg, Dennis O., Comander, Jason, Corradetti, Giulia, Coupland, Sarah E., Cozzi, Mariano, Cruess, Alan F., Cunningham, Emmett T., Jr., Curcio, Christine A., Damato, Bertil E., Davis, Janet L., Davoudi, Samaneh, Ghafoori, Shelley Day, Denniston, Alastair K., de Smet, Marc D., Zaeytijd, Julie De, Dhaliwal, Ranjit S., Dick, Andrew D., Ding, Xiaoyan, Do, Diana V., Dugel, Pravin, Duker, Jay S., Dunbar, Hannah M.P., Duncan, Jacque L., Ehlers, Justis P., Eldred, Kiara C., Eliott, Dean, Wardani, Mohamad El, Engelbert, Michael, Faia, Lisa J., Falsini, Benedetto, Fekrat, Sharon, Ferrington, Deborah A., Ferris, Frederick L., III, Finger, Paul T., Fisher, Steven K., Fisher, Yale L., Fishman, Gerald A., Fleckenstein, Monika, Flynn, Harry W., Jr., Francelin, Carolina, Francis, Jasmine H., Freeman, William R., Freund, K. Bailey, Fu, Arthur D., Garcia-Valenzuela, Enrique, Garg, Sunir J., Gaudric, Alain, Gayed, Mary, George, Roshan T., Goldberg, Morton F., Gopal, Lingam, Gordon, Caroline, Goto, Hiroshi, Gragoudas, Evangelos S., Grant, Maria B., Gregg, Ronald G., Gregory-Evans, Kevin, Groenewald, Carl, Grossniklaus, Hans E., Grover, Sandeep, Gullapalli, Vamsi K., Hahn, Paul, Haller, Julia A., Han, Ian C., Handa, James T., Haritoglou, Christos, Haug, Sara, Hawkins, Barbara S., He, Shikun, Heimann, Heinrich, Henderson, Robert H., Herwig-Carl, Martina C., Heussen, Florian M.A., Hisatomi, Toshio, Holder, Graham E., Holz, Frank G., Hou, Kirk K., Hui, Yan-Nian, Humayun, Mark S., Idrees, Sana, Ikuno, Yasushi, Invernizzi, Alessandro, Ip, Michael S., Isaac, David L.C., Ishibashi, Tatsuro, Ishikawa, Keijiro, Jabs, Douglas A., Jaffe, Glenn J., Jager, Martine J., Jampol, Lee M., Jeng-Miller, Karen, Joffe, Leonard, Johnson, Mark, Johnson, Mark W., Johnson, Robert N., Joussen, Antonia M., Jumper, J. Michael, Jung, Jesse J., Kaiser, Peter K., Kamermans, Maarten, Kampik, Anselm, Karanjia, Rustum, Kashani, Amir H., Keane, Pearse A., Kenney, M. Cristina, Kiilgaard, Jens F., Kiliç, Emine, Kim, Ivana K., Kim, Jonathan W., Kim, Leo A., Kim, Stephen J., Kiss, Szilárd, Klufas, Michael A., Konstantinidis, Lazaros, Koronyo-Hamaoui, Maya, Kowluru, Renu, Kozak, Igor, Kuriyan, Ajay E., Lam, Dennis Shun Chiu, Lam, Linda A., Lane, Anne Marie, Lavik, Erin B., Leary, James F., Ledesma-Gil, Gerardo, Lee, Aaron Y., Lee, Richard W., Lee, Sun Young, Lee, Thomas C., Lee, Won Ki, Leung, Loh-Shan B., Lewis, Geoffrey P., Leys, Anita, Li, Xiaoxin, Liakopoulos, Sandra, Lin, Chang-Ping, Lin, Phoebe, Lin, Xihui, Lois, Noemi, London, Nikolas J.S., Luo, Yan, Lutty, Gerard A., MacLaren, Robert E., Maguire, Albert M., Mahroo, Omar A., Mainster, Martin A., Markoe, Arnold M., Marmor, Michael F., Massey, Stephen C., McCall, Maureen A., McCannel, Tara A., McCutchan, J. Allen, McDonald, H. Richard, Meier, Petra, Meredith, Travis A., Meyer, Carsten H., Mieler, William F., Miller, Joan W., Mirza, Rukhsana G., Mittra, Robert A., Montemagno, Carlo, Moore, Anthony T., Mruthyunjaya, Prithvi, Muccioli, Cristina, Mullins, Robert F., Murphree, A. Linn, Murray, Philip I., Murray, Timothy G., Nagiel, Aaron, Nagpal, Manish, Namperumalsamy, Perumalsamy, Nanda, Sumit K., Narala, Ramsudha, Nascimento, Heloisa, Nashine, Sonali, Nguyen, Quan Dong, Oellers, Patrick, Ohji, Masahito, Ohno-Matsui, Kyoko, Palanker, Daniel, Papakostas, Thanos D., Park, Tea Soon, Park, Un Chul, Patel, Purnima S., Patel, Shriji, Pavlick, Anna C., Peereboom, David M., Pellegrini, Marco, Peng, Michelle, Pennesi, Mark E., Pepple, Kathryn L., Perry, Julian D., Pertile, Grazia, Priglinger, Siegfried, Preziosa, Chiara, Pulido, Jose S., Querques, Giuseppe, Quiram, Polly A., Radke, Nishant Vijay, Raja, Vignesh, Raman, Rajiv, Ramchandran, Rajeev S., Rao, Narsing A., Rao, P. Kumar, Rathinam, SR, Raval, Vishal, Reed, David, Reh, Thomas A., Rezaei, Kourous A., Rhodes, Benjamin, Ritch, Robert, Robson, Anthony G., Rodrigues, Eduardo B., Rowan, Sheldon, Rowland, Teisha J., Rubin, Gary S., Sadda, SriniVas R., Sadun, Alfredo A., Sakamoto, Taiji, Sampath, Alapakkam P., Sangave, Amit A., Sarraf, David, Schachat, Andrew P., Schechet, Sidney A., Schmitz-Valckenberg, Steffen, Schwartz, Stephen G., Scott, Adrienne W., Sebag, J., Seddon, Johanna M., Segrè, Ayellet V., Sepah, Yasir Jamal, Sharma, Sanjay, Sharma, Sumit, Sharma, Tarun, Sheu, Shwu-Jiuan, Shields, Carol L., Shields, Jerry A., Shukla, Dhananjay, Sieving, Paul A., Silva, Paolo S., Silverman, Ronald H., Singer, Joshua, Singh, Arun D., Singh, Nakul, Skalet, Alison H., Skugor, Mario, Smith, Sylvia B., Sobrin, Lucia, Sohn, Elliott H., Souied, Eric H., Spaide, Richard F., Spencer, Doran, Spielberg, Leigh, Sridhar, Akshayalakshmi, Srivastava, Sunil K., Starr, Matthew R., Staurenghi, Giovanni, Stern, Marc-Henri, Sternberg, Paul, Jr., Stiefel, Hillary C., Stitt, Alan W., Stone, Edwin M., Strettoi, Enrica, Sugino, Ilene K., Sullivan, Paul, Sun, Jennifer K., Sunness, Janet S., Tadayoni, Ramin, Tang, Shibo, Taylor, Allen, Terasaki, Hiroko, Thompson, John T., Ting, Daniel S.W., Toro, Mario D., Toth, Cynthia A., Toy, Brian, Trese, Michael T., Tsai, Julie H., Tsang, Stephen H., Tufail, Adnan, Tummala, Gayathri, Udar, Nitin, Ueta, Takashi, Ulrich, J. Niklas, Umfress, Allison C., van Dijk, Elon Hendrik Cornelis, van Meurs, Jan C., Vasconcelos-Santos, Daniel Vítor, Vavvas, Demetrios G., Venkat, Arthi, Waheed, Nadia K., Warner, Nathaniel C., Wickham, Louisa, Wiedemann, Peter, Wiley, Henry E., Wilkinson, C.P., Wolf, Sebastian, Wolfensberger, Thomas J., Wong, Tien Yin, Wu, Yue, Yandiev, Yanors, Yang, Chang-Hao, Yang, Chung-May, Yang, Paul, Yeh, Po-Ting, Yonekawa, Yoshihiro, Yoon, Young Hee, Yordi, Sari, Yu, Hyeong Gon, Yue, Lan, Zarbin, Marco A., Zhu, Ivy, and Zinkernagel, Martin

Published
2023
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43. Focal Scleral Nodule

Author

Fung, Adrian T., primary, Waldstein, Sebastian M., additional, Gal-Or, Orly, additional, Pellegrini, Marco, additional, Preziosa, Chiara, additional, Shields, Jerry A., additional, Welch, R. Joel, additional, Dolz-Marco, Rosa, additional, Sarraf, David, additional, Nagiel, Aaron, additional, Lalane, Robert, additional, Jung, Jesse J., additional, Ghazi, Nicola G., additional, Ramtohul, Prithvi, additional, Arnold, Jennifer J., additional, Sakurada, Yoichi, additional, Choudhry, Netan, additional, Balaratnasingam, Chandrakumar, additional, Freund, K. Bailey, additional, and Shields, Carol L., additional

Published
2020
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49. A Comparison Between Optical Coherence Tomography Angiography and Fluorescein Angiography for the Imaging of Type 1 Neovascularization

Author

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, de Carlo, Talisa E., Inoue, Maiko, Jung, Jesse J., Balaratnasingam, Chandrakumar, Dansingani, Kunal K., Dhrami-Gavazi, Elona, Suzuki, Mihoko, Shahlaee, Abtin, Klufas, Michael A., El Maftouhi, Adil, Duker, Jay S., Ho, Allen C., Maftouhi, Maddalena Quaranta-El, Sarraf, David, Freund, K. Bailey, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, de Carlo, Talisa E., Inoue, Maiko, Jung, Jesse J., Balaratnasingam, Chandrakumar, Dansingani, Kunal K., Dhrami-Gavazi, Elona, Suzuki, Mihoko, Shahlaee, Abtin, Klufas, Michael A., El Maftouhi, Adil, Duker, Jay S., Ho, Allen C., Maftouhi, Maddalena Quaranta-El, Sarraf, David, and Freund, K. Bailey

Abstract

Purpose: To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA. Methods: Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions. Unmasked graders utilized FA and structural OCT data to determine the diagnosis of type 1 NV. Masked graders evaluated FA data alone, en face OCTA data alone and combined en face OCTA and structural OCT data to determine the presence of type 1 NV. Sensitivity analyses were performed using combined FA and OCT data as the reference standard. Results: A total of 105 eyes were diagnosed with type 1 NV using the reference. Of these, 90 (85.7%) could be detected using en face OCTA and structural OCT. The sensitivities of FA data alone and en face OCTA data alone for visualizing type 1 NV were the same (66.7%). Significant factors that precluded visualization of NV using en face OCTA included the height of pigment epithelial detachment, low signal strength, and treatment-naïve disease (P < 0.05, respectively). Conclusions: En face OCTA and structural OCT showed better detection of type 1 NV than either FA alone or en face OCTA alone. Combining en face OCTA and structural OCT information may therefore be a useful way to noninvasively diagnose and monitor the treatment of type 1 NV., LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, Macula Foundation, Inc.

Published
2016

50. A Comparison Between Optical Coherence Tomography Angiography and Fluorescein Angiography for the Imaging of Type 1 Neovascularization.

Author

Inoue, Maiko, Jung, Jesse J., Balaratnasingam, Chandrakumar, Dansingani, Kunal K., Dhrami-Gavazi, Elona, Suzuki, Mihoko, de Carlo, Talisa E., Shahlaee, Abtin, Klufas, Michael A., El Maftouhi, Adil, Duker, Jay S., Ho, Allen C., Maftouhi, Maddalena Quaranta-El, Sarraf, David, Freund, K. Bailey, Inoue, Maiko, Jung, Jesse J., Balaratnasingam, Chandrakumar, Dansingani, Kunal K., Dhrami-Gavazi, Elona, Suzuki, Mihoko, de Carlo, Talisa E., Shahlaee, Abtin, Klufas, Michael A., El Maftouhi, Adil, Duker, Jay S., Ho, Allen C., Maftouhi, Maddalena Quaranta-El, Sarraf, David, and Freund, K. Bailey

Abstract

Purpose: To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA. Methods: Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions. Unmasked graders utilized FA and structural OCT data to determine the diagnosis of type 1 NV. Masked graders evaluated FA data alone, en face OCTA data alone and combined en face OCTA and structural OCT data to determine the presence of type 1 NV. Sensitivity analyses were performed using combined FA and OCT data as the reference standard. Results: A total of 105 eyes were diagnosed with type 1 NV using the reference. Of these, 90 (85.7%) could be detected using en face OCTA and structural OCT. The sensitivities of FA data alone and en face OCTA data alone for visualizing type 1 NV were the same (66.7%). Significant factors that precluded visualization of NV using en face OCTA included the height of pigment epithelial detachment, low signal strength, and treatment-naïve disease (P < 0.05, respectively). Conclusions: En face OCTA and structural OCT showed better detection of type 1 NV than either FA alone or en face OCTA alone. Combining en face OCTA and structural OCT information may therefore be a useful way to noninvasively diagnose and monitor the treatment of type 1 NV.

Published
2016

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