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2. Cell stress in cortical organoids impairs molecular subtype specification

Author

Bhaduri, Aparna, Andrews, Madeline G, Mancia Leon, Walter, Jung, Diane, Shin, David, Allen, Denise, Jung, Dana, Schmunk, Galina, Haeussler, Maximilian, Salma, Jahan, Pollen, Alex A, Nowakowski, Tomasz J, and Kriegstein, Arnold R

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Biotechnology, Stem Cell Research, Pediatric, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research - Nonembryonic - Human, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Good Health and Well Being, Cerebral Cortex, Humans, Neurogenesis, Neurons, Organoids, Single-Cell Analysis, Stress, Physiological, Tissue Culture Techniques, General Science & Technology
Abstract

Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex1,2. However, the fidelity of organoid models remains unclear3-5. Here we analyse the transcriptomes of individual primary human cortical cells from different developmental periods and cortical areas. We find that cortical development is characterized by progenitor maturation trajectories, the emergence of diverse cell subtypes and areal specification of newborn neurons. By contrast, organoids contain broad cell classes, but do not recapitulate distinct cellular subtype identities and appropriate progenitor maturation. Although the molecular signatures of cortical areas emerge in organoid neurons, they are not spatially segregated. Organoids also ectopically activate cellular stress pathways, which impairs cell-type specification. However, organoid stress and subtype defects are alleviated by transplantation into the mouse cortex. Together, these datasets and analytical tools provide a framework for evaluating and improving the accuracy of cortical organoids as models of human brain development.

Published
2020

6. Landscape variation in defense traits along gradients of multiple resources in a tropical savanna plant.

Author

Mohanbabu, Neha, Veldhuis, Michiel P., Jung, Dana, and Ritchie, Mark E.

Subjects
SAVANNA plants, SAVANNAS, TROPICAL plants, EGGPLANT, PLANT defenses, RAINFALL, CARBON in soils
Abstract

Many plant species are widely distributed and consequently are exposed to multiple abiotic factors and diverse herbivores, each of which may distinctly affect the magnitude of different defense traits. Alternative theories for optimal allocation to plant defense traits predict both positive and negative associations between magnitude of defense and resource availability. These predictions may apply even within species. This suggests potential for a single species' patterns of association of defense traits and resources to vary with both the type of defense and identity of resource, but relatively few studies have explored intraspecific variation in multiple defense traits along several resource gradients simultaneously. In order to address this gap, especially in an ecosytem dominated by large mammalian herbivores, we assessed relationships between multiple resources (rainfall, soil N, and soil P) and plant defense traits (prickle density, phenolics, and lignin content) using a widely distributed tropical savanna herb, Solanum incanum, growing in naturally occuring resource gradients within the Serengeti National Park. We found substantial intraspecific variation in all three defense traits across sites (n = 43). Variation in prickle density was positively associated with rainfall and soil P, but not soil N. In contrast to prickle density, phenolics and lignin were uncorrelated with all three resource gradients. This independent association of soil P with a carbon‐based defense, prickle density, suggests potential for resources that are not components of defenses to influence allocation to defense traits. Such influence may reflect association between resource and herbivore abundance and/or preference. These varied patterns in resource–defense associations further emphasize the tremendous variation in anti‐herbivore traits which may be influenced by different plant resources and highlight the need to consider multiple resource gradients in understanding evolution of plant traits. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Integrating defense and leaf economic spectrum traits in a tropical savanna plant

Author

Mohanbabu, Neha, Veldhuis, Michiel P., Jung, Dana, and Ritchie, Mark E.

Subjects
Plant Science
Abstract

SummaryAllocation to plant defense traits likely depends on resource supply, herbivory, and other plant functional traits such as the leaf economic spectrum (LES) traits. Yet, attempts to integrate defense and resource acquisitive traits remains elusive.We assessed intraspecific correlations between different defense and LES traits in a widely distributed tropical savanna herb,Solanum incanum, a unique model species for studying allocations to physical, chemical, and structural defenses to mammalian herbivory.In a multivariate trait space, the structural defenses - lignin and cellulose - were positively related to the resource conservative traits - low SLA and low leaf N. Phenolic content, a chemical defense, was positively associated with resource acquisitive traits - high SLA and high leaf N - while also being associated with an independent third component axis. Both principal components 1 and 3 were not associated with resource supply and herbivory intensity. In contrast, spine density - a physical defense - was orthogonal to the LES axis and positively associated with soil P and herbivory intensity.Synthesis: These results suggest a hypothesized “pyramid” of trade-offs in allocation to defense along the LES and herbivory intensity axes. Therefore, future attempts to integrate defense traits with the broader plant functional trait framework needs a multifaceted approach that accounts for unique influences of resource acquisitive traits and herbivory intensity.

Published
2022
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11. Nanodiamond as a Cytokine Sponge in Infectious Diseases

Author

Yoo, Wonbeak, primary, Lee, Wonhwa, additional, Kim, Hong Nam, additional, Jeong, Jiyoung, additional, Park, Hee Ho, additional, Ahn, June Hong, additional, Jung, Dana, additional, Lee, Juheon, additional, Kim, Ji-su, additional, Lee, Seung Whan, additional, Cho, Wan-Seob, additional, and Kim, Seokho, additional

Published
2022
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12. Professionalität und Autorität des Waldorfklassenlehrers in seinen Schülerbeziehungen – eine Theoretisierung.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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13. BackMatter.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Published
2007

14. Die reformorientierte Waldorfschule C.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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15. Interschulische Kontrastierung.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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16. Zum Wandel des Aufwachsens in Modernisierungsambivalenzen – Konsequenzen für die Lehrer-Schüler-Beziehung und die pädagogische Autorität.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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17. Schule A – eine traditionsreiche Waldorfschule in Westdeutschland.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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18. Schule B - eine Waldorfschule im Aufbau.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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19. Der Klassenlehrer in der Freien Waldorfschule.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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20. Anlage der Studie und Methoden.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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21. FrontMatter.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Published
2007

22. Weekend in Dallas.

Author

HANSCHE, MELANIE and JUNG, DANA

Subjects
BUTCHERS, COMIC books, strips, etc., SMALL business, GROCERS, MEATBALLS
Abstract

The article informs that chef Misti Norris is a butcher and self-proclaimed comic-book nerd with a passion for farming, foraging, fermenting, and fire. Topuics include obsessions come to life on the trailblazing menu of her small business, Petra and the Beast restaurant; and old-school Italian grocer with a deli counter their meatball subs especially their pork chop and cocktails.

Published
2022

23. Nachwort.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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24. Einleitung.

Author

Helsper, Werner, Ullrich, Heiner, Stelmaszyk, Bernhard, Höblich, Davina, Graβhoff, Gunther, and Jung, Dana

Abstract

Copyright of Autorität und Schule is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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25. The YAP1–NMU Axis Is Associated with Pancreatic Cancer Progression and Poor Outcome: Identification of a Novel Diagnostic Biomarker and Therapeutic Target.

Author

Yoo, Wonbeak, Lee, Jaemin, Jun, Eunsung, Noh, Kyung Hee, Lee, Sangmin, Jung, Dana, Jung, Kwang Hwa, Kim, Ji-Su, Park, Yun-Yong, Kim, Song Cheol, and Kim, Seokho

Subjects
ANIMAL experimentation, CARRIER proteins, MICE, PANCREATIC tumors, PHOSPHOPROTEINS, TREATMENT effectiveness, DISEASE progression, METABOLISM
Abstract

Yes-associated protein (YAP)-1 is highly upregulated in pancreatic cancer and associated with tumor progression. However, little is known about the role of YAP1 and related genes in pancreatic cancer. Here, we identified target genes regulated by YAP1 and explored their role in pancreatic cancer progression and the related clinical implications. Analysis of different pancreatic cancer databases showed that Neuromedin U (NMU) expression was positively correlated with YAP1 expression in the tumor group. The Cancer Genome Atlas data indicated that high YAP1 and NMU expression levels were associated with poor mean and overall survival. YAP1 overexpression induced NMU expression and transcription and promoted cell motility in vitro and tumor metastasis in vivo via upregulation of epithelial–mesenchymal transition (EMT), whereas specific inhibition of NMU in cells stably expressing YAP1 had the opposite effect in vitro and in vivo. To define this functional association, we identified a transcriptional enhanced associate domain (TEAD) binding site in the NMU promoter and demonstrated that YAP1–TEAD binding upstream of the NMU gene regulated its transcription. These results indicate that the identified positive correlation between YAP1 and NMU is a potential novel drug target and biomarker in metastatic pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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