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Your search keyword '"Jung, Bo Hyun"' showing total 154 results
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154 results on '"Jung, Bo Hyun"'

1. A Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Tacrolimus and Corticosteroids in Combination With or Without Mycophenolate Mofetil in Liver Transplantation Recipients Infected With Hepatitis B Virus

Author

Park, Jeong-Ik, Song, Gi-Won, Ryu, Je Ho, Choi, Sang-Tae, Choi, Nam-Gyu, Jung, Bo-Hyun, Chu, Chong Woo, Kim, Keon-Kuk, Jung, Dong-Hwan, Ha, Tae-Yong, Moon, Deok-Bog, Yang, Kwangho, Shin, Min-Ho, Chung, Yong-Kyu, Hwang, Shin, Yoon, Young-In, and Lee, Sung-Gyu

Published
2023
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4. Lactobacillus fermentum attenuates the alveolar bone loss in ligature‐induced periodontitis in mice.

Author

Lee, Yuni, Jung, Bo Hyun, Yoo, Ki‐Yeon, Lim, Hye Ji, Shin, Kum‐Joo, and Lee, Jae‐Kwan

Subjects
*INFLAMMATION prevention, *BONE resorption, *BIOLOGICAL models, *RESEARCH funding, *BONE density, *COMPUTED tomography, *DESCRIPTIVE statistics, *IN vivo studies, *MICE, *LACTOBACILLUS, *ANIMAL experimentation, *HISTOLOGICAL techniques, *PROBIOTICS, *CYTOKINES, *COMPARATIVE studies, *PERIODONTITIS, *DISEASE progression, *CONNECTIVE tissues
Abstract

Objective: This study investigated the effects of Lactobacillus fermentum BELF11 on periodontitis in mice (LIP). Methods: Sixty mice were randomly assigned to a control group (CTL), LIP/PBS group (LIP and PBS applied), or LIP/BELF11 group (LIP and L. fermentum BELF11 applied). For 14 days, PBS or L. fermentum BELF11 was applied twice daily to the mice in the LIP/PBS or LIP/BELF11 group, respectively. After 14 days, radiographic, histological, and pro‐inflammatory cytokine assessments were conducted. Results: The LIP/PBS and LIP/BELF11 groups demonstrated greater alveolar bone loss than the CTL group (p < 0.05). The LIP/BELF11 group showed significantly reduced alveolar bone loss on the mesial side compared to the LIP/PBS group. Histologically, the LIP/BELF11 group showed consistent patterns of connective tissue fiber arrangement, lower levels of inflammatory infiltration, less alveolar bone loss, and higher alveolar bone density than the LIP/PBS group, despite showing more signs of destruction than the CTL group. The LIP/BELF11 group also exhibited significantly lower levels of pro‐inflammatory cytokines than the LIP/PBS group. Conclusions: L. fermentum BELF11 inhibits alveolar bone loss and periodontitis progression by regulating pro‐inflammatory cytokine production. These findings suggest that L. fermentum BELF11 may be a potential adjunctive therapy in periodontal treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Clinical implication of tumor site in terms of node metastasis for intrahepatic cholangiocarcinoma

Author

Lee, Woohyung, Jeong, Chi-Young, Jang, Jae Yool, Roh, Young Hoon, Kim, Kwan Woo, Kang, Sung Hwa, Yoon, Myung Hee, Seo, Hyung Il, Park, Jeong-Ik, Jung, Bo-Hyun, Shin, Dong Hoon, Choi, Young Il, Moon, Hyung Hwan, Ryu, Je Ho, Yang, Kwangho, Choi, Chang Soo, Park, Yo-Han, Nah, Yang Won, Kim, Ryounggo, Navarro, Jonathan, Han, Dae-Hoon, Choi, Gi Hong, Kang, Chang Moo, Kim, Kyung-Sik, and Hong, Soon-Chan

Published
2020
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11. Do hepatic-sided tumors require more extensive resection than peritoneal-sided tumors in patients with T2 gallbladder cancer? Results of a retrospective multicenter study

Author

Lee, Woohyung, Jeong, Chi-Young, Jang, Jae Yool, Kim, Young Hoon, Roh, Young Hoon, Kim, Kwan Woo, Kang, Sung Hwa, Yoon, Myung Hee, Seo, Hyung Il, Yun, Sung Pil, Park, Jeong-Ik, Jung, Bo-Hyun, Shin, Dong Hoon, Choi, Young Il, Moon, Hyung Hwan, Chu, Chong Woo, Ryu, Je Ho, Yang, Kwangho, Park, Young Mok, and Hong, Soon-Chan

Published
2017
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37. Effect of Weissella cibaria on the reduction of periodontal tissue destruction in mice.

Author

Kim, Jae‐Won, Jung, Bo Hyun, Lee, Jong Hun, Yoo, Ki‐Yeon, Lee, Heesu, Kang, Mi‐Sun, Lee, Jae‐Kwan, Kim, Jae-Won, Yoo, Ki-Yeon, Kang, Mi-Sun, and Lee, Jae-Kwan

Abstract

Background: Periodontitis is associated with dysbiosis of microbial flora in the oral cavity. We evaluated the effects of an oral care probiotic, Weissella cibaria CMU, on periodontal tissue destruction and regulation of inflammatory cytokines in mice with ligature-induced periodontitis (LIP).Methods: Fourteen-day LIP model was used. Ninety animals were randomly divided into six groups: negative control (Ctrl), positive control (LIP/Ctrl), PBS-treated (LIP/PBS), W. cibaria-low (1 × 107 colony forming unit (CFU)/d; LIP/WC-L), W. cibaria-medium (1 × 108 CFU/d; LIP/WC-M), and W. cibaria-high (1 × 109  CFU/d; LIP/WC-H). After the 14-day treatment, alveolar bone loss was determined using micro-computed tomography. The gingival tissue and serum samples from Ctrl, LIP/Ctrl, and LIP/WC-H groups were immunoassayed for cytokines. Measurements of Porphyromonas gingivalis, total bacteria, and W. cibaria in the gingiva were performed using real-time polymerase chain reaction.Results: Mice in the LIP/WC-H group showed significant reduction in alveolar bone loss at the distal aspect of the ligatured teeth compared to those in the LIP/Ctrl group. There was a dose-dependent reduction (non-significant) in periodontal tissue destruction with increased W. cibaria concentration. Pro- and anti-inflammatory cytokines were significantly lower in LIP/WC-H than in LIP/Ctrl. The LIP/WC-H group showed significantly fewer total bacteria compared to the LIP/Ctrl group but it was similar to that in Ctrl groups, and P. gingivalis was not detected in the gingival tissue.Conclusions: W. cibaria CMU reduces periodontal tissue destruction apparently by regulating the production of inflammatory cytokines and by reducing oral bacteria in a model for periodontal disease. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Increased survival in hepatitis c patients who underwent living donor liver transplant: a case-control study with propensity score matching

Author

Kim, Jong Man, primary, Lee, Kwang-Woong, additional, Song, Gi-Won, additional, Jung, Bo-Hyun, additional, Lee, Hae Won, additional, Yi, Nam-Joon, additional, Kwon, Choon Hyuck David, additional, Hwang, Shin, additional, Suh, Kyung-Suk, additional, Joh, Jae-Won, additional, Lee, Suk-Koo, additional, and Lee, Sung-Gyu, additional

Published
2017
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49. Effect of Weissella cibariaon the reduction of periodontal tissue destruction in mice

Author

Kim, Jae‐Won, Jung, Bo Hyun, Lee, Jong Hun, Yoo, Ki‐Yeon, Lee, Heesu, Kang, Mi‐Sun, and Lee, Jae‐Kwan

Abstract

Periodontitis is associated with dysbiosis of microbial flora in the oral cavity. We evaluated the effects of an oral care probiotic, Weissella cibariaCMU, on periodontal tissue destruction and regulation of inflammatory cytokines in mice with ligature‐induced periodontitis (LIP). Fourteen‐day LIP model was used. Ninety animals were randomly divided into six groups: negative control (Ctrl), positive control (LIP/Ctrl), PBS‐treated (LIP/PBS), W. cibaria‐low (1 × 107colony forming unit (CFU)/d; LIP/WC‐L), W. cibaria‐medium (1 × 108CFU/d; LIP/WC‐M), and W. cibaria‐high (1 × 109CFU/d; LIP/WC‐H). After the 14‐day treatment, alveolar bone loss was determined using micro‐computed tomography. The gingival tissue and serum samples from Ctrl, LIP/Ctrl, and LIP/WC‐H groups were immunoassayed for cytokines. Measurements of Porphyromonas gingivalis, total bacteria, and W. cibariain the gingiva were performed using real‐time polymerase chain reaction. Mice in the LIP/WC‐H group showed significant reduction in alveolar bone loss at the distal aspect of the ligatured teeth compared to those in the LIP/Ctrl group. There was a dose‐dependent reduction (non‐significant) in periodontal tissue destruction with increased W. cibariaconcentration. Pro‐ and anti‐inflammatory cytokines were significantly lower in LIP/WC‐H than in LIP/Ctrl. The LIP/WC‐H group showed significantly fewer total bacteria compared to the LIP/Ctrl group but it was similar to that in Ctrl groups, and P. gingivaliswas not detected in the gingival tissue. W. cibariaCMU reduces periodontal tissue destruction apparently by regulating the production of inflammatory cytokines and by reducing oral bacteria in a model for periodontal disease.

Published
2020
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