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9. Venomous Peptides as Cardiac Ion Channel’s Modulators

Author

Kamal, Mohammad Amjad, primary, Junapudi, Sunil, primary, Yerramsetty, Sree Vandana, additional, Chopra, Hitesh, additional, Pangi, Viajaya Nirmala, additional, Pallaval, Veera Bramhachari, additional, Jaganathan, Anitha, additional, and Mohanta, Yugal Kishore, additional

Published
2022
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13. Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction

Author

Matta Reddy, Alavala, Iqbal, Mumtaz, Chopra, Hitesh, Urmi, Shaheda, Junapudi, Sunil, Bibi, Shabana, Kumar Gupta, Santosh, Nirmala Pangi, Viajaya, Singh, Inderbir, and Abdel-Daim, Mohamed M.

Subjects
cell damage, inflammation, mitochondrial dysfunction, oxidative stress, vitamin D, cardiac diseases
Abstract

Vitamin D, a secosteroid hormone, appears to have significant beneficial effects on various physiological systems, including the musculoskeletal system. Vitamin D assists in the regulation of numerous critical biological functions and physiological processes in humans, including inflammation, oxidative stress, and mitochondrial respiration, and is also linked to cardiac diseases. It is also reported that vitamin D plays a central role in molecular and cellular mechanisms, which reduce oxidative stress, and tissue damage and regulate cellular health. On the other side, hypovitaminosis D reduces mitochondrial activity and increases oxidative stress and inflammation in the body. Hypervitaminosis D increases the prevalence and severity of cellular damage. It has also been reported that vitamin D is involved in many functions of the reproductive system in human and critically play an important role in the reproductive tissues of women and men. Its role is very well defined, starting from female menarche to menopause, pregnancy, and lactation, and finally in male fertility. Hence, the appropriate amount of vitamin D is necessary to maintain the normal function of cell organelles. Based on recent studies, it is understood that vitamin D is involved in the biological activities of mitochondria in cells, especially in cardiomyocytes. In this review, we emphasized the role of vitamin D in mitochondrial respiration, which could significantly influence heart health and human reproduction., EXCLI Journal; 21:Doc967; ISSN 1611-2156

Published
2022
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16. ANTIBIOTIC USE IN PEDIATRIC INFECTIONS; A STUDY IN TERTIARY CARE HOSPITAL

Author

Gungam, Praveena, Yadav, Y. Sunil Kumar, Junapudi, Sunil, Gungam, Praveena, Yadav, Y. Sunil Kumar, and Junapudi, Sunil

Abstract

Objectives: Antibiotics are frequently used in tertiary care hospitals. We conducted an observational study on children admitted to a teaching hospital in south India, to make a profile of antibiotics use and suspected adverse drug reactions (ADRs) owing to them. Methods: Hospitalized children of either sex, aged between 1 month and 12 years, were inspected. Baseline demographic and clinical features, duration of hospital stay, antibiotics received in hospital along with dosing and indications and interest of suspected ADRs attributable to their use were recorded. Every patient was followed up till discharge, admission to the Pediatric Intensive Care Unit, or passing. Results: Over the year and a half report period 364 confirmations were screened. The prevalence of Antibiotics use was 80.22%. The majority of the 292 children who received Antibiotics were males (63.35%). Median age was 35 months, five children died. In most instances, either two (41%) or a single antibiotic (37.32%) was used. Ceftriaxone, co-amoxiclav, amikacin, vancomycin, and ampicillin were predominantly used. Antimalarials, antivirals and antiprotozoals were used occasionally. Average number of Antibiotics per patient was 2.2 ± 1.1 the majority (81.15%) were by parenteral route and initial choice was usually empirical. Prescriptions were usually in generic name. The antibiotic treatment went somewhere in the range of 1 and 32 days, with a middle of 8 days. Five ADRs were noted of which half were skin rash and the rest loose stools. Conclusions: The profile of Antibiotic utilize is comprehensively like prior Indian investigations. Apparent overuse of multiple Antibiotics per prescription and the parenteral route requires exploration. Antibiotics are being used empirically in the absence of policy. ADRs to Antibiotics are occasional and usually mild. The benchmark information can serve in situation analysis for antibiotic prescribing guidelines. Keywords: Antibiotic; Pediatric infections; Adverse d

Published
2018

17. Bioassay guided isolation and identification of the antioxidant constituent from Holostemma Ada-kodien shcult

Author

Pallaval Veera Bramhachari, Yasodha Krishna Janapati, and Junapudi Sunil

Subjects
0301 basic medicine, Antioxidant, Traditional medicine, biology, Chemistry, medicine.medical_treatment, Cell Biology, biology.organism_classification, Isolation (microbiology), Biochemistry, 03 medical and health sciences, 030104 developmental biology, medicine, Bioassay, Identification (biology), Molecular Biology, Holostemma, Biotechnology
Published
2017

20. Hepatoprotective Activity of Talinumportulacifolium forsk, Extract against Paracetamol Induced Hepatic Damage in Rats.

Author

Junapudi, Sunil, Janapati, Yasodha Krishna, and Bramhachari, Pallaval Veera

Subjects
*PORTULACACEAE, *ACETAMINOPHEN, *HEPATITIS treatment
Abstract

Talinumportulacifolium Forsk (family: Portulacaceae) has been traditionally used in Indian medicine as a result of its curative results of hepatitis, gonorrhea and diabetes. No systemic study has been conducted on the protective effect of Talinum portulacifolium forsk to treat hepatic diseases. Therefore, claims can be made for the protective efficacy of Talinum portulacifolium forsk to treat hepatic diseases. The present study focused on investigating the role of methanolic extract of Talinum portulacifolium forsk (METP). METP at a dose level of 250mg/kg p.o and 500mg/kg p.o significantly produced (p<0.05) hepatoprotection by decreasing the level of serum Aspartate amino transferase (AST), Alanine amino transferase (ALT), alkaline phosphatase (ALP) and Total serum bilirubin (SB) However, they significantly increased the level of glutathione (GSH) in a dose dependent manner. The effects of METP were comparable to that standard drug, silymarin. Histopathological observations confirmed the beneficial role of METP against Paracetamol (PCM) - induced liver injury in rats. The result suggests that the methanolic extract of Talinumportulacifolium forsk possesses significant potential as a hepatoprotective agent. [ABSTRACT FROM AUTHOR]

Published
2018

21. Venomous Peptides as Cardiac Ion Channels Modulators

Author

Yerramsetty, Sree Vandana, Chopra, Hitesh, Pangi, Viajaya Nirmala, Pallaval, Veera Bramhachari, Jaganathan, Anitha, Mohanta, Yugal Kishore, Kamal, Mohammad Amjad, and Junapudi, Sunil

Abstract

Venoms from the deadliest animals, including spiders, scorpians, bees, and centipedes, are composed of a complex mixture of various peptides developed to catch prey and defend other animals. Venoms are composed of several bioactive molecules such as proteins and peptides that modify physiological conditions in other organisms. These bioactive peptides penetrate tissues and blood vessels to encounter numerous receptors and modulate ion channel their activities. Venoms are used to treat various medical issues, including cardiovascular diseases. Venom peptides regulate several ion channel behaviors, such as voltage-gated sodium (Nav), calcium (Cav) and potassium (Kv) channels, and are set as a therapeutic approach. In this perspective, we emphasize the effect of isolated lethal venomous peptides on cardiac ionic channels and their mechanisms of action for the cure. We also summarize the highlights and molecular details of their toxin-receptor interactions and prospects to develop peptide therapeutics for respective cardiac electrophysiological diseases.

Published
2022
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22. Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction.

Author

Matta Reddy A, Iqbal M, Chopra H, Urmi S, Junapudi S, Bibi S, Kumar Gupta S, Nirmala Pangi V, Singh I, and Abdel-Daim MM

Abstract

Vitamin D, a secosteroid hormone, appears to have significant beneficial effects on various physiological systems, including the musculoskeletal system. Vitamin D assists in the regulation of numerous critical biological functions and physiological processes in humans, including inflammation, oxidative stress, and mitochondrial respiration, and is also linked to cardiac diseases. It is also reported that vitamin D plays a central role in molecular and cellular mechanisms, which reduce oxidative stress, and tissue damage and regulate cellular health. On the other side, hypovitaminosis D reduces mitochondrial activity and increases oxidative stress and inflammation in the body. Hypervitaminosis D increases the prevalence and severity of cellular damage. It has also been reported that vitamin D is involved in many functions of the reproductive system in human and critically play an important role in the reproductive tissues of women and men. Its role is very well defined, starting from female menarche to menopause, pregnancy, and lactation, and finally in male fertility. Hence, the appropriate amount of vitamin D is necessary to maintain the normal function of cell organelles. Based on recent studies, it is understood that vitamin D is involved in the biological activities of mitochondria in cells, especially in cardiomyocytes. In this review, we emphasized the role of vitamin D in mitochondrial respiration, which could significantly influence heart health and human reproduction., (Copyright © 2022 Matta Reddy et al.)

Published
2022
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