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BACKGROUND The FGFR signaling pathway is activated in multiple tumor types through gene amplifications, single base substitutions, or gene fusions. Novel FGFR gene fusions may represent candidate targets for the development of tyrosine kinase inhibitors. CASE SUMMARY Herein, we report a patient with colorectal cancer (CRC) harboring a novel FGFR2 fusion gene. A 59-year-old man felt discomfort in his right upper abdomen with loss of appetite for 6 mo. An abdominal computed tomography scan revealed the existence of a space-occupying lesion in the ascending colon. The pathological diagnosis was a poorly differentiated adenocarcinoma. Subsequent biopsy specimen was subjected to next-generation sequencing analysis, and a novel FGFR2-TSC22D1 fusion with complete kinase structure of FGFR2 protein was identified. CONCLUSION We report the first case of CRC harboring FGFR2-TSC22D1, which enriches the FGFR2 fusion spectrum. FGFR2 inhibitors might be effective in the later treatment for this patient.

BACKGROUND The most common EGFR mutations are in-frame deletions in exon 19 and point mutations in exon 21. Cases with classical EGFR mutations show a good response to EGFR tyrosine kinase inhibitors (TKIs), the standard first-line treatment. With the development of next generation sequencing, some uncommon genomic mutations have been detected. However, the effect of TKIs on such uncommon EGFR mutations remains unclear. CASE SUMMARY Here, we report a case of rare EGFR co-mutation in non-small cell lung cancer and the efficacy of afatinib on this EGFR co-mutation. A 64-year-old woman was diagnosed with thoracolumbar and bilateral local rib bone metastases, bilateral pulmonary nodules, and pericardial and left pleural effusion. The pathological diagnosis was lung adenocarcinoma. To seek potential therapeutic regimens, rare co-mutation comprising rare EGFR G724S/R776H mutations and amplification were identified. The patient experienced a significant clinical response with a progression-free survival of 17 mo. CONCLUSION A case of non-small cell lung cancer with rare EGFR G724S/R776H mutations and EGFR amplification responds well to TKI treatment.

Objective To investigate the protective effects of cimetidine on rats with low dose rate (LDR) 60Co γ-ray cumulative irradiation. Methods Sixty male SD rats (6-8 weeks old) were randomized into 6 groups (10 each): normal control group, model group, positive control group (89.0 mg/kg lentinan), low-dose cimetidine group (23.3 mg/kg cimetidine), medium-dose cimetidine group (70.0 mg/kg cimetidine), and high-dose cimetidine group (210.0 mg/kg cimetidine). Except for rats in normal control group, the rest rats were irradiated with 60Coγ-ray to a cumulative dose of 0.5 Gy with a dose rate of 3.228 mGy/ h. Twenty-four hours after the last irradiation, peripheral blood cells, bone marrow DNA content, frequencies of micronucleated polychromatic erythrocytes (fMNPCE), bone marrow nucleated cells, sperm count, testis HE, sex hormones, superoxide dismutase (SOD), glutathione (GPx), catalase (CAT) activity, and malondialdehyde (MDA) content were measured. Results Compared with normal control group, in model group, WBC, lymphocyte and granulocyte content, bone marrow DNA content and the number of nucleated cells significantly decreased (P2) levels significantly increased (P2 and MDA decreased, the damage of testicular tissue structure decreased (P60Coγ-ray cumulative irradiation. DOI: 10.11855/j.issn.0577-7402.2019.10.03

Psoriasis is a chronic, recurrent skin disease requiring long‐term management. Agents that repair the skin's barrier function are invaluable additives in topical treatments of psoriasis. This multicenter, randomized, controlled trial evaluated the efficacy and safety of a linoleic acid‐ceramide‐containing moisturizer (LA‐Cer) for mild‐to‐moderate psoriasis vulgaris. We randomized 178 patients from both northern and southern regions of China into two groups: 81 patients in the control group received mometasone furoate (MF, 0.1%) cream, while MF in combination with LA‐Cer was administered to 86 patients in the treatment group for 4 weeks. The LA‐Cer‐MF group maintained the use of moisturizer after topical glucocorticoid administration. The primary endpoint, Psoriasis Area and Severity Index 50 (PASI 50) response, revealed the superiority of LA‐Cer‐MF with lower relapse rates at week 8. The use of the LA‐Cer‐containing moisturizer as maintenance therapy resulted in a continuous improvement in the clinical state in terms of body surface area, PASI, investigators' assessment of skin dryness and desquamation, and Physician Global Assessment of Psoriasis score, and in the patients' quality of life. Thus, the LA‐Cer‐containing moisturizer is a promising agent to prevent and treat psoriasis as it enhances the therapeutic effect induced by topical glucocorticoids and delays relapse.

IntroductionAlzheimer’s disease (AD) is the leading cause of dementia in late adult life. Emerging evidence shows that microRNAs (miRNAs) play vital roles in the pathogenesis of AD. The aim of the present study was to eluci-date the underlying role of miR-let-7f in oxidative damage in SH-SY5Y cells.Material and methodsmiRNA microarray analysis was performed to detect the miRNAs’ differential expression in AD patients and normal elderly volun-teers. Cell injury was evaluated on the basis of cell viability and apoptosis. The effect of miR-let-7f on H2O2-induced oxidative damage was estimated after cell transfection. qRT-PCR and western blot were used to measure the expression of miR-let-7f, AKT-2 and apoptosis-related proteins. The target gene of miR-let-7f was analyzed by luciferase reporter gene assay.ResultsMiR-let-7f was overexpressed in AD patients. When exposed to H2O2 in vitro, SH-SY5Y cells showed significant apoptosis accompanied by up-regulation of miR-let-7f and increased expression of apoptosis-related proteins. In the presence of H2O2, the up-regulation of miR-let-7f significant-ly increased the cell viability and inhibited cell apoptosis, while down-regulation showed the opposite effect. The luciferase reporter assay showed that ATK-2 is the direct target gene of miR-let-7f. Western blot analysis further showed that miR-let-7f negatively regulated ATK-2 expression.ConclusionsThe up-regulation of miR-let-7f alleviated the H2O2-induced oxidative damage in SH-SY5Y cells by targeting AKT-2. These findings provided a novel perspective in the role of miR-let-7f in pathogenesis of oxidative damage during AD.

Long non-coding RNA-imprinted maternally expressed transcript (non-protein coding) (H19) has been previously identified to be involved in the development of a number of types of cancer. However, the function of H19 in the pathogenesis of colorectal cancer remains unclear. The expression level of H19 in colorectal tumor tissues, and the association between H19 expression and clinicopathological variables and prognosis was investigated in the present study. In addition, the effect of H19 overexpression on viability, migration and epithelial-mesenchymal transition (EMT) of colon cancer cells was investigated in HCT-116 and SW-480 cells. The results of the present study suggest that overexpression of H19 is associated with decreased recurrence-free survival and overall survival rates in patients with colorectal cancer, and increased viability and migration in colon cancer cells. The induction of the EMT process may be an underlying molecular mechanism associated with the H19-induced increased metastasis potential of colon cancer cells.

Objective To study the protective effects of cimetidine against oxidative stress in rats induced by cumulative low-dose irradiation. Methods Sixty SD rats were randomly divided into 6 groups (10 each): normal control group, model control group, lentinan group [89mg/(kg•d)] and 3 dose groups of cimetidine. After oral administration, all the rats were exposed to γ-ray irradiation 8 hours/day for 12 days, and sacr if iced on the 13th day. The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and the content of malondialdehyde (MDA) in serum, liver, thymus and spleen were determined. By using the superoxide anion radical system, hydroxyl radical system, H2O2 radical system, oxidation system of linoleic acid induced by alkane radical system and diphenylpicryl hydrazinyl radical (DPPH) radical system, the antioxidation activities of cimetidine were detected. R esults The activities of SOD in liver and thymus decreased significantly, the GPx activit y in ser um, liver and spleen decreased significantly and MDA level in ser um, liver and spleen increased significantly after 0.3Gy cumulative ionizing radiation. Cimetidine enhanced the activities of antioxidant enzymes in serum and organs, and reduced the MDA level. In a certain concentration range, cimetidine had different scavenging effects onto these radical systems, and showed good per for mance in hydroxyl radical. Conclusion Cimetidine can effectively ameliorate the oxidative stress from low-dose cumulative irradiation by scavenging free radicals, increase the activity of antioxidant enzymes and reduce the content of lipid peroxidation products, thus presents a potential radio protective effect. DOI: 10.11855/j.issn.0577-7402.2017.02.07

Objective To investigate the radioprotective effect of cimetidine on survival rate and hematopoietic system in acutely irradiated mice. Methods The total body irradiation doses were 6.0Gy and 8.0Gy respectively at 1.01Gy/min rate. Sixty healthy male C57BL/6 mice were randomly divided into control group, model group, positive-drug (523) group and cimetidine groups (33.3mg/kg, 100mg/kg and 300mg/kg). Each group had ten mice. The mice were given intragastric administration of cimetidine for 6d before the irradiation in cimetidine groups, and 523 was administered before irradiation once a day for one day in 523 group, and at 5h after irradiation, was given again. The 30d survival rate after 8.0Gy irradiation was recorded. The peripheral blood cells, bone marrow DNA content and frequency of micronucleated polychromatic erythrocytes (fMNPCE) were determined 30d after 6.0Gy irradiation. Results After 8.0Gy irradiation, all the mice died on 21th day in model control group. The survival rates in cimetidine groups were 50%, 20% and 30%, respectively. After 6.0Gy irradiation on 30th day, compared with control group, the peripheral white blood cells (WBC) and bone marrow DNA content were decreased significantly (P

In this study, 24 male and female broiler chickens at 30-day-old were divided into three groups with 8 animals in each group. The animals were administered with recombinant chicken interferon-α (rChIFN-α) at a dose of 1.0 × 106 IU/kg intravenously, intramuscularly or subcutaneously, respectively. Serum samples were collected at different time points post administration, and the titers of rChIFN-α in the blood were determined by cytopathic effect inhibition assay. The results showed that the pharmacokinetic characteristics of rChIFN-α by intramuscular injection and subcutaneous injection were fitted to one compartment open model, and the Tmax was 3.21 ± 0.79 hr and 3.95 ± 0.85 hr, respectively, and the elimination half-life (T1/2) was 6.20 ± 2.77 hr and 5.03 ± 3.70 hr, respectively. In contrast, the pharmacokinetics of rChIFN-α via intravenous injection was in line with the open model of two-compartment and was eliminated in the first order, and the elimination half-life (T1/2) was 4.61 ± 0.84 hr. In addition, compared with those in the intravenous group and the subcutaneous group, the bioavailability of rChIFN-α in the intramuscular group was 82.80%. In conclusion, rChIFN-α was rapidly absorbed and slowly eliminated after intramuscular administration of single dose of rChIFN-α aqueous formulations. Thus, rChIFN-α can be used as a commonly-used therapeutic agent.

Overyielding in intercropping compared to monoculture has been widely reported. One of the mechanisms may be the alteration of the microbial community in intercropping and especially the amelioration of the negative effects of pathogens that can accumulate in monocultures. Here we test whether inoculation with arbuscular mycorrhizal fungi (AMF) and wheat take-all disease influences overyielding and whether changes in the microbial communities generate feedbacks on plant growth. In Experiment 1, wheat and faba bean were grown in monoculture or intercropping to form three planting patterns. Plants were inoculated with or without wheat take-all disease (Gaeumannomyces graminis), and one, six, or no AM fungi, to create 6 soil conditioned treatments. Soils from Experiment 1 were used as inocula in Experiment 2 to test the feedback on plant growth from monocultures and the legacy benefits of intercropping. No significant influence of AMF on plant growth was observed in either experiment. In Experiment 1, AMF had no significant effect in suppressing take-all but take-all tended to decrease AMF colonization. Shoot biomass and competitive ability of wheat was suppressed by take-all in both experiments. Wheat and faba bean showed overyielding in both the take-all and non-take-all treatment in Experiment 1 but only overyielding in the take-all treatment in Experiment 2. Growth of wheat and faba bean were suppressed in conspecific soil, and this negative feedback was observed across all take-all and AMF treatments, and regardless of competition. Biomass of wheat and faba bean was higher in soil from intercropping than in monoculture soil, and this positive legacy benefit of intercropping did not depend on take-all, AMF or plant competition. We find support for alterations of the soil community causing negative plant soil feedback and positive legacy benefits of intercropping. Our results are consistent with microbial dynamics generating overyielding in intercropping by reducing the negative influence of soil pathogen build-up on conspecific host plants and simultaneously compensatively improving growth of neighbor plants.

Copy number variations (CNVs) play an important role in many types of cancer. With the rapid development of next generation sequencing (NGS) techniques, many methods for detecting CNVs of a single sample have emerged: (i) require genome-wide data of both case and control samples, (ii) depend on sequencing depth and GC content correction algorithm, (iii) rely on statistical models built on CNV positive and negative sample datasets. These make them costly in the data analysis and ineffective in the targeted sequencing data. In this study, we developed a novel alignment-free method called DL-CNV to call CNV from the target sequencing data of a single sample. Specifically, we collected two sets of samples. The first set consists of 1301 samples, in which 272 have CNVs in ERBB2 and the second set is composed of 1148 samples with 63 samples containing CNVs in MET. Finally, we found that a testing AUC of 0.9454 for ERBB2 and 0.9220 for MET. Furthermore, we hope to make the CNV detection could be more accurate with clinical "gold standard" (e.g. FISH) information and provide a new research direction, which can be used as the supplement to the existing NGS methods.

In this study, the immunoadjuvant effects of recombinant porcine interferon alpha (rPoIFNα) on the killed virus vaccine (KV) of porcine reproductive and respiratory syndrome virus (PRRSV) ...

Ethnopharmacological relevance The fungus Hericium erinaceus (Bull.) Pers is used in Chinese traditional medicine to treat symptoms related to gastric ulcers. Different extracts from the fungus were assessed for anti-Helicobacter pylori activity to investigate the antibacterial activity of the ethanol extracts from H. erinaceus and verify the traditional indication of use. Materials and methods The fruiting bodies of H. erinaceus were concentrated with ethanol by HPD-100 macroporous resin and the whole extract was partitioned by petroleum ether and chloroform to afford fractions with using a silica gel column. Several pure compounds of petroleum ether extracts were obtained and analyzed using nuclear magnetic resonance (NMR). The activity of the extracts and fractions towards H. pylori was assessed by the microdilution assay and by the disk diffusion assay in vitro. From the most active fraction, two pure compounds were isolated and identified as the main components with anti-H. pylori activity from the fungus H. erinaceus. The cytotoxicity of these two compounds against the human erythroleu-kemia cell line K562 was also evaluated. Results The crude ethanol extracts from the fungus H. erinaceus were inhibitory to H. pylori. The petroleum ether extracts (PE1s, PE2s) and the chloroform extracts (TEs) demonstrated strong inhibition to H. pylori. The inhibition of H. pylori was observed through an agar dilution test with minimal inhibition concentration (MIC) values from 400 μg/mL to 12.5 µg/mL. Two pure compounds, 1-(5-chloro-2-hydroxyphenyl)-3-methyl-1-butanone and 2,5-bis(methoxycarbonyl)terephthalic acid were isolated from the petroleum ether fractions and identified using 1H NMR and 13C NMR spectra analysis. The MIC value for 1-(5-chloro-2-hydroxyphenyl)-3-methyl-1-butanone was 12.5–50 µg/mL and the MIC value for 2,5-bis(methoxycarbonyl)terephthalic acid was 6.25–25 µg/mL. Both two compounds showed weak cytotoxicity against K562 with IC50 Conclusions This study revealed that the extracts from petroleum ether contribute to the anti-H. pylori activity. The compounds obtained from petroleum ether extracts, 1-(5-chloro-2-hydroxyphenyl)-3-methyl-1-butanone and 2,5-bis(methoxycarbonyl)terephthalic acid, inhibit the growth of H. pylori.

Objective To investigate the hemostatic property of calcium alginate (CA) sponge and its degree of safety on exterior use. Methods The optimal coagulation concentration of CA was determined by Lee-White clotting test, and then the CA was freeze-dried to form a sponge. The coagulation effect in vitro of the CA sponge was determined by Blood Clotting Index (BCI) test. The ear artery bleeding model and full-thickness skin wound model of rabbit were employed to determine the hemostatic property of CA sponge. The degree of safety of CA sponge was evaluated by cell toxicity test. Results The BCI was significantly decreased in CA sponge group (33.08±4.02) than that in gelatin sponge (72.05±10.48, P0.05), though they were all shorter significantly than that in hospital gauze group (101.00±14.71s, P

Objective To study the protection effect of clinoptilolite (Cp) against radiation injury. Methods Fortyeight male BALB/c mice were randomly divided into 6 groups, namely normal control group (distilled water + sham irradiation), radiation control group (distilled water + irradiation), 300mg/kg 523 group (200mg/kg nilestriol 24h before irradiation and 100mg/ kg nilestriol 4h after irradiation), 56mg/kg Cp group (56mg/kg Cp + irradiation), 167mg/kg Cp group (167mg/kg Cp + irradiation) and 500mg/kg Cp group (500mg/kg Cp + irradiation). Seven days after the administration of the drug, all the mice but those from the normal control group were irradiated with γ-ray irradiation of 137Cs in the dose of 4.0Gy, at the rate of 0.75Gy/min. All the mice were given the drug for 14 days after irradiation. RBC, WBC and PLT counts in peripheral blood, superoxide dismutases (SOD) activity, malondialdehyde (MDA) level, glutathione peroxidase (GSH-Px) level in blood serum, the content of deoxyribonucleic acid (DNA) and hematopoietic stem cells in bone marrow were determined. Results Compared with radiation control group, on 10th day after irradiation, RBC counts in peripheral blood of 56mg/kg Cp group and 167mg/kg Cp group were significantly higher (P

Objective To study the radioprotective effect of cimetidine on single low-dose irradiated mice with radiosensitive detection indexes. Methods Forty-eight healthy male C57BL/6 mice were randomly divided into normal control group, model control group, positive group (200mg/kg WR2721) and cimetidine groups (7.5mg/kg, 15mg/kg and 30mg/kg). The mice were given intraperitoneal injection of cimetidine 2h before irradiation in cimetidine groups and WR2721 before irradiation once a day for two days in positive group. All the mice except those in normal control group were irradiated with 0.7Gy 60Co γ-ray at 5.83mGy/min rate. Peripheral blood cells, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content both in serum and liver, bone marrow DNA content and frequency of micronucleated polychromatic erythrocytes (fMPEs) were determined 24h after irradiation. Results Compared with normal control group, the peripheral white blood cells (WBCs) of irradiated mice decreased significantly (P

The Mg-3.0Zn-0.2Ca (wt.%) alloy has been extruded at temperature range of 25–300 °C and the resulting microstructure, texture and mechanical properties are systematically investigated. The results show that the grain size monotonically increases with the increasing of the extrusion temperature and the texture intensity increases firstly and decreases subsequently. In addition, a large number of nano-scale precipitates are formed in alloys extruded above 250 °C. The weakest basal texture developed in the cold extrusion alloy is related to the deformation twinning, while, the combining effects of activation of multiple deformation mechanisms and dynamic precipitates contribute to developing the weaker basal texture in alloys extruded above 250 °C. A sharp basal texture enhances the yield strength of alloy extruded at 150 °C greatly at the cost of work hardening rate. The highest elongation is achieved in the alloy extruded at 300 °C. The enhanced formability is considered to be associated with the dependence of the weaker basal texture and dynamic precipitates on the strain hardening behavior. Among the multiple strengthening mechanisms, the fine grain strengthening and the solid solution strengthening play a dominant role in the increment of strength for the as-extruded alloys.

De novo peptide sequencing for large-scale proteomics remains challenging because of the lack of full coverage of ion series in tandem mass spectra. We developed a mirror protease of trypsin, acetylated LysargiNase (Ac-LysargiNase), with superior activity and stability. The mirror spectrum pairs derived from the Ac-LysargiNase and trypsin treated samples can generate full b and y ion series, which provide mutual complementarity of each other, and allow us to develop a novel algorithm, pNovoM, for de novo sequencing. Using pNovoM to sequence peptides of purified proteins, the accuracy of the sequence was close to 100%. More importantly, from a large-scale yeast proteome sample digested with trypsin and Ac-LysargiNase individually, 48% of all tandem mass spectra formed mirror spectrum pairs, 97% of which contained full coverage of ion series, resulting in precision de novo sequencing of full-length peptides by pNovoM. This enabled pNovoM to successfully sequence 21,249 peptides from 3,753 proteins and interpreted 44–152% more spectra than pNovo+ and PEAKS at a 5% FDR at the spectrum level. Moreover, the mirror protease strategy had an obvious advantage in sequencing long peptides. We believe that the combination of mirror protease strategy and pNovoM will be an effective approach for precision de novo sequencing on both single proteins and proteome samples.

In the process of modern mechanical parts production, such as parts surface dust, metal powder, coating will appear "nodules" and "burr", easy to fall off small pit of coating surface. So, to ensure the quality of electroplating products plating, to carry out the study on substrate surface treatment before plating technology of plating is very meaningful.

A country's level of Nc machine tool and ownership, is to measure the level of manufacturing and industrial modernization level of important indicators, is also an important index to measure national comprehensive competitiveness. Therefore, how to better use and maintenance of Nc machine tool is an important issue. This paper introduced how to reasonable use of Nc machine tools, as well as the use of the numerical control system and inspection.

The digital design of mechanical products is usually first reference existing parts, drawings, and experience to make original design data and design requirements, according to the design of digital model is set up, after an analysis of the finite element model according to the analysis results contrast design goal to design or structure parameter changes, to the expected design purpose. Analysis of the product is an essential part of product design.

To improve the designers’ work efficiency, reduce the design strength, transportation pallet modeling was built through three-dimensional software Pro/E, and the model was secondary developed by using Pro/Toolkit, Pro/E secondary development tools. Designer design independent program interface for drive Pro/E parameters of three-dimensional modeling of the transportation pallet.

To improve the designers’work efficiency, reduce the design strength, ceramicgear modeling was built through three-dimensional softwarePro/E, and the model was secondary developed by using Pro/Toolkit, Pro/Esecondary development tools. Designer design independent program interface fordrive Pro/E parameters of three-dimensional modeling of the ceramic gear.

This paper analyzes the stamping process of a rigid gasket, designs a set of progressive die for gasket. Three-position of the die includes the punching, cutting, bending and blanking. And compared with single-process die and compound die, the gasket can obtain better surface quality, the die can prevent poor strength and partial load, and punching hole in the ear and separating bending process can improve the accuracy of stamping parts, it has some reference value for the progressive die of the stamping parts. Throughout the design process, the model of rigid gasket and 3D mold design are established in Pro/E4.0 and PDX, this can significantly shorten the design cycle; the process of open-mode is simulated in the Simulation module.

Globular indexing CAM mechanism is a good indexing mechanism. As the working curve of CAM contour surface is no extending curved surface, there is certain difficulty to design processing. It is new kinds of design method that reverse engineering apply in rapid modeling of curved CAM. In this way, designer can complete curve of CAM reverse modeling, and the rationality of the model is verified. At the same time, it also can reverse modeling and the subsequent development of other products to provide a reference.

As the development of wind generation, traditional methods for determining reserve capacity are no longer appropriate. In order to determine the optimal spinning reserve for system with wind generation, this paper set the reserve capacity based on the reliability index which includes the system reliability and wind generation uncertainties. The model is then calculated by the Lagrangian Relaxation method. According to the result, the method for determining reserve capacity proposed by this paper is applicable.

The establishing of a scientific and operable index system is very basic and important to make evaluation. In order to have a reasonable evaluation on the circular economy development in Tianjin area, this paper has carried out some research work. Firstly, based on traditional AHP method, it built a complete index system which consists of 4 parts, that is resource production, resource consumption, comprehensive utilization of resources, waste, including 14 indexes. And this index system was different from the past. Secondly, according to this index system, through establishing comparison matrix and checking the consistency, it made an overall evaluation on the development of circular economy on the basis of collecting and analyzing a large number of relevant data in Tianjin area. Finally, it analyzed the evaluation result and put forward corresponding suggestions. These suggestions mainly included paying further attention to resource recycling and reuse, strengthening the environmental protection measures, and so on.

This paper investigates multiple attribute group decision making (MAGDM) with hesitant fuzzy preference information, which is a significantly import issue to be deeply studied in management and industrial engineering. Firstly, simultaneously considering optimistic and pessimistic attitudinal preference information, an improved distance measure for hesitant fuzzy set is defined. Then, utilizing the newly defined distance measure, a hesitant fuzzy multiple attribute group decision making approach based on TOPSIS method is constructed, which can effectively avoid high complexity of aggregating hesitant fuzzy information in traditional methods. Further, an application study on parts supplier selection has verified the practically and effectiveness of developed methods.

Preference relations are the most common techniques to express decision makers preference information over alternatives or criteria. This paper focus on investigating effective operators for multiple attribute group decision making with intuitionistic fuzzy preference relations. Firstly, we extend arithmetic mean method operator and geometric mean method operator for accommodating intuitionistic fuzzy information to present the intuitionistic arithmetic mean method (IAMM) operator and the intuitionistic geometric mean method (IGMM) operator. Then the compatibility properties of intuitionistic preference relations obtained by IAMM and IGMM are analyzed, we found that aggregation of individual judgments and aggregation of individual priorities provide the same priorities of alternatives, and that if all the individual decision makers have acceptable consensus degree, then the collective preference relations obtained also are of acceptable consensus degree. Finally, the results are verified by an illustrative example carried out in the background of parts supplier selection.

This paper investigates methods for multiple attribute decision making (MADM) under hesitant fuzzy linguistic environment. Firstly, we define two transform functions between hesitant fuzzy linguistic variables and hesitant fuzzy variables. Then, based on the presented transform functions, a hesitant fuzzy linguistic weighted averaging (HFLWA) operator and a hesitant fuzzy linguistic weighted geometric (HFLWG) operator are developed, and some desired properties of the operators are also analyzed. Successively, an integrated approach for MADM with attribute assessments taking form of hesitant fuzzy linguistic variables is constructed. Furthermore, an illustrative study on production strategy decision making is carried out to verify the effectiveness and practicality of proposed methods.

Quantized Fault detection for sensor/actuator faults of networked control systems(NCSs) with time delays both in the sensor-to-controller channel and the controller-to-actuator channel, is concerned in the paper. The fault model is set up based on the possible cases of sensor/actuator faults. Then the model predictive control is used to compensate the time delay. When the sensors and actuators are all healthy, an H? stability criteria of the state predictive observer is obtained in terms of linear matrix inequality. A new threshold computational method that conforms to the actual situations is proposed. Then the thresholds of false alarm rate(FAR) and miss detection rate(MDR) are presented by using our proposed method, which are also compared with the ones given in the existing literatures. Finally, some numerical simulations are shown to demonstrate the effectiveness of the proposed method.

When sows and their litters are kept outdoors, the maternal ability, including maternal behavior, is very important for piglet health and survival. The aim of this study was to compare part of maternal behavior and performance in primiparous sows of two different conventionally bred Min pig hybrid breeds kept in outdoor housing systems. Damin sows ( Large White × Min pig sows, n = 21) and Changmin sows ( Landrace × Min pig sows, n = 21) were farrowed in individual pens. Sows’ postures (lateral, ventral, standing and sitting), changes of posture (lateral recumbency to other postures, ventral recumbency to other postures, standing to lying and sitting to lying), nursing behavior (duration and frequency of nutritive nursing, proportion of nursing terminated by the sow) and proportion of time spent outside the farrowing huts were observed by video for 72 h after parturition and from 07:00 to 09:00 h and 13:00 to 15:00 h on the third and 6th day of each week from the 2nd to the 4th week after parturition. The duration of parturition, farrowing interval, number of live piglets, number of stillbirths, birth weights of the litters, number of piglet deaths during the first 3 days postpartum, number of piglet deaths from the 4th day postpartum to weaning, weaning weights of litters, and estrus interval of sows were compared between the two breeds. The two breeds showed no differences in postural behavior, changes of posture, nursing behavior and proportion of time spent outside the farrowing huts by the sows. The duration of parturition ( P = 0.043) and farrowing interval ( P = 0.032) were significantly higher in Damin sows than in Changmin sows. Birth weights ( P = 0.010) and pre-weaning weights ( P = 0.022) of the piglets were lower in Damin sows than in Changmin sows. Other performance parameters did not differ between the breeds. In conclusion, we understand that the high temperature did not have bad effects to the performance of two Min pig hybrid breeds in the summer, compared with other results, the two Min pig hybrid breeds may have a certain advantage in lateral recumbency during early lactation and piglets mortality. This may provides valuable information about choosing the reasonable outdoor breeds in the future.

This paper tries to construct a five-dimensional informatization performance measurement indicator system on the basis of BSC and Performance Prism for small-and-medium sized enterprises and combined with AHP and Delphi method proposes the firm performance evaluation steps. in order to present a new approach to evaluate the small-and-medium sized enterprises.

The four-point bending method and weight loss method were used to study respectively the stress corrosion cracking behavior and weightlessness corrosion situation of the baosteel BG80S steel in the simulated field environments. The experimental results shown that BG80S won't occur to stress corrosion cracking when the maximum loading stress is 85% Rt0.5 ; the corrosion rates increase with the rising of temperature which is from 40°C to 80°C under the dynamic and static conditions of the simulated environments; the dynamic corrosion rates are between 1.5558 and 1.7523mm/a and the corrosion rates are 0.4827～1.4078mm/a under the static conditions, both of which belong to a serious corrosion category; the form of corrosion is uniform corrosion under the dynamic conditions; because the corrosion products exist micro defects under the static conditions of 80°C, the experimental samples have had the localized corrosion.

The threading dislocation density (TDD) of thick GaN films grown by hydride vapor phase epitaxy (HVPE) was estimated through counting etch pit density (EPD) and calculating full width at half maximum（FWHM）of double crystal X-Ray diffraction (DCXRD). TDD was about 108 through counting EPD, while it was about 109 through calculating the FWHMs of (0002) and (1012). The experiment results show that the two methods are both suited to estimating the TDD of the thick HVPE-GaN films with 350um thickness. But they have some difference: EPD method is fitter in evaluating the dislocation density of the surface of thick GaN film, but FWHM method can gain the total dislocation density of thick GaN film. The method calculating the FWHMs possesses more general statistical significance.

Insulin-like growth factor I (IGF-I) is an important regulator of fish growth and development, and its biological actions are initiated by binding to IGF-I receptor (IGF-IR). Our previous study has revealed that IGF-I could play an important role during metamorphosis of Japanese flounder, Paralichthys olivaceus. The analysis of IGF-IR expression thus helps further elucidate the IGF-I regulation of metamorphic processes. In this study, the spatial-temporal expression of two distinct IGF-IR mRNAs was investigated by real-time RT-PCR. The spatial distribution of two IGF-IR mRNAs in adult tissues is largely overlapped, but they exhibit distinct temporal expression patterns during larval development. A remarkable decrease in IGF-IR-2 mRNA was detected during metamorphosis. In contrast, a significant increase in IGF-IR-1 mRNA was determined from pre-metamorphosis to metamorphic completion. These indicate that they may play different function roles during the flounder metamorphosis. The levels and localization of IGF-IR proteins during larval development were further studied by Western blotting and immunohistochemistry. Immunoreactive IGF-IRs were detected throughout larval development, and the IGF-IR proteins displayed a relatively abundant expression during metamorphosis. Moreover, the IGF-IR proteins appeared in key tissues, such as thickened skin beneath the migrating eye, developing intestine, gills and kidney during metamorphosis. These results further suggest that the IGF-I system may be involved in metamorphic development of Japanese flounder.