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In–ZnO with oxygen vacancies exhibits a higher sensing response and a shorter recovery time for H2S compared to ZnO.

Optimization of mathematical model of flow field in slab continuous casting mold was performed by means of industrial measurement and mathematical modeling. The rod deflection method was used to quantitatively measure the velocities near the mold surface at high temperature. The measurement results were compared with the simulation results of three mathematical models at different argon gas flow rates of 6, 10 and 14 L min−1. The model 1 neglects the mold powder layer, thermal effect and solidified shell. The model 2 only considers the influence of mold powder layer. The model 3 considers the influence of mold powder layer, thermal effect and solidified shell on the flow field. In all three models, the diameter of argon bubbles obeys Rosin–Rammler distribution fitted according to the experimental data of others’ previous work. With increasing the argon gas flow rate, the velocity of liquid steel near the mold surface decreases. The model 1 seriously underestimates the shear stress of liquid steel near the mold surface, and its calculation results show higher velocity near the mold surface, lower turbulent kinetic energy and wider distribution of argon gas bubbles in the mold. The simulation results of model 2 only considering the viscous resistance of the mold powder layer to liquid steel makes the velocity near the surface lower than the measurement results obviously. The calculated velocities near the mold surface with model 3 are in best agreement with the measured results, showing the reasonable spatial distribution range of argon bubbles in the mold and the moderate turbulent kinetic energy. In the present conditions, the best argon gas flow rate is 10 L min−1 due to the moderate velocity near the mold surface, the appropriate distribution of argon gas bubbles in the mold and the smallest fluctuation amplitude on the mold surface.

Metal oxide sensors face the challenge of high response and fast recovery at low operating temperatures for the detection of toxic and flammable hydrogen sulfide (H

Scutellariae Radix(SR), derived from the dried root of Scutellaria baicalensis in the family Lamiaceae, commonly serves as Chinese medicinal material. Affected by producing areas, growing years, and harvesting periods, the quality of SR fluctuates in the market. However, baicalin≥9% in SR required in the Chinese Pharmacopoeia(2020 edition) can only determine the qualified SR but cannot identify high-quality SR. To improve the quality control methods of SR, the present study analyzed the accumulation of metabolites in SR of different growth years by plant metabolomics, and identified 28 metabolites increasing with growth years(1-3 years). Subsequently, 14 main metabolites were quantitatively analyzed by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry(UPLC-QQQ-MS). Among them, baicalin, wogonoside, baicalein, and wogonin with high content and good activity were selected as the index components of SR for quality evaluation. A high-performance liquid chromatography(HPLC) method was established to determine the content of four index components in 32 batches of SR from different producing areas, harvesting perio-ds, and growth years. The results showed that the growth years could greatly affect the content of index components. The total content of four index components in 2-year SR was the highest, followed by the 3-/4-year SR and 1-year SR. Based on HPLC data and verification results by enterprises, baicalin ≥12.0%, wogonoside ≥2.3%, baicalein ≥0.1%, and wogonin ≥0.03% were proposed as the evaluation criteria for the high-quality SR. The findings of this study are expected to provide a basis for improving the quality of SR.

The TanDEM-X DEM is a valuable data source for estimating glacier mass balance. However, the accuracy of TanDEM-X elevation over glaciers can be affected by microwave penetration and phase decorrelation. To investigate the bias of TanDEM-X DEMs of glaciers on the Tibetan Plateau, these DEMs were subtracted from SPOT-6 DEMs obtained around the same time at two study sites. The average bias over the studied glacier areas in West Kunlun (175.0 km2) was 2.106 ± 0.012 m in April 2014, and it was 1.523 ± 0.011 m in Geladandong (228.8 km2) in October 2013. By combining backscatter coefficients and interferometric coherence maps, we found surface decorrelation and baseline decorrelation can cause obvious bias in addition to microwave penetration. If the optical/laser data and winter TanDEM-X data were used as new and historic elevation sources for mass-balance measurements over an arbitrary observation period of 10 years, the glacier mass loss rates in West Kunlun and Geladandong would be potentially underestimated by 0.218 ± 0.016 and 0.158 ± 0.011 m w.e. a−1, respectively. The impact is therefore significant, and users should carefully treat the bias of TanDEM-X DEMs when retrieving a geodetic glacier mass balance.

The detection of volatile organic gas triethylamine (TEA) is of great significance to environment quality and human health. However, it is still a challenge to achieve high-sensitivity detection at low temperatures. In this work, a TEA sensor with a low operating temperature and high response was successfully prepared by designing ZnO/SnO2 composite material rich in oxygen vacancy defects. A camellia-like ZnO material was synthesized by a hydrothermal method using surfactant, bis(2-ethylhexyl)sulfosuccinate sodium salt (AOT) as a soft template. SnO2 nanoparticles with a diameter of 20 nm were dispersed on ZnO nanosheets to form a ZnO/SnO2 heterostructure. The sensor based on ZnO/SnO2-10 demonstrates an extremely high response of 780 to 100 ppm TEA. More importantly, the response value of 1 ppm TEA detected is 6 and the detection limit is as low as 0.43 ppm. Besides, the sensor has a low working temperature of 100 °C. The enhancement of TEA sensing performance could be attributed to the synergistic effect of oxygen vacancy (Vo), ZnO–SnO2 heterojunction, and the ZnO (001) exposure plane. Vo can be used as the active center of oxygen molecule adsorption to produce highly active O2− species. Furthermore, Vo–ZnO has higher adsorption energy for TEA molecules than pure ZnO, which was determined using first-principles calculations, confirming the strong interaction between Vo–ZnO and TEA. The sensor shows a broad application prospect in food safety detection and environmental monitoring.

Hyperlipidemia is a common complication after liver transplantation (LT) and develops mostly in the early posttransplant period. Recently, some studies have reported a positive correlation between hyperlipidemia and favorable prognosis in patients with hepatocellular carcinoma (HCC) undergoing hepatectomy. This study aimed to evaluate the possibility of predicting prognosis in HCC patients receiving LT by early posttransplant dyslipidemia.From January 2015 to December 2017, a total of 806 HCC patients from China Liver Transplant Registry database were retrospectively enrolled. The prognostic relevance of early posttransplant hypertriglyceridemia or hypercholesterolemia was examined using survival analysis, and subgroup analysis was implemented based on LT criteria.Early posttransplant hypercholesterolemia (EPHC) was independently inversely associated with the risk of recurrence [hazard ratio (HR) = 0.630; P = 0.022], but was not significantly correlated with the mortality. However, early posttransplant hypertriglyceridemia was not related to prognosis. Intriguingly, with further classification, we found that borderline EPHC (B-EPHC), instead of significant EPHC, was a predictor of lower risk for both recurrence (HR = 0.504; P = 0.006) and mortality (HR = 0.511; P = 0.023). Compared with non-EPHC patients, B-EPHC patients achieved significantly superior 1-year and 3-year tumor-free survival (89.6% and 83.7% vs. 83.8% and 72.7% respectively; P = 0.023), and 1-year and 3-year overall survival (95.8% and 84.8% vs. 94.6% and 77.6% respectively; P = 0.039). In the subgroup analysis, B-EPHC remained an independent predictor of better prognosis in patients beyond Milan criteria and those within Hangzhou criteria; whereas there was no significant relationship between B-EPHC and prognosis in patients within Milan criteria and those beyond Hangzhou criteria. More interestingly, patients beyond Milan criteria but within Hangzhou criteria were identified as the crucial subpopulation who benefited from B-EPHC (recurrence HR = 0.306, P = 0.011; mortality HR = 0.325, P = 0.031).B-EPHC could assist transplant teams in dynamically evaluating prognosis after LT for HCC as a postoperative non-oncological biomarker, especially in patients beyond Milan criteria but within Hangzhou criteria.

Increasing water content in fixed beds is a prospective way to improve the gas storage density by means of hydrate formation. However, the high water content strongly hinders the hydrate formation. In this study, diesel oil was mixed into highly water-saturated activated carbon beds to establish gas channels so that to improve methane hydrate formation. Hydrate formation experiments in four activated carbons with different particle sizes were conducted at 274.15 K and 6.0 MPa. For wet carbon beds without diesel oil, both of the storage capacity of hydrate (Sw) and the storage density of bed (Sb) increased with an decrease in particle size. When the mass ratio of water to activated carbon was set to 2.0, the highest Sw of 67.98 V/Vw and corresponding Sb of 51.92 V/Vbed among the beds were obtained in the bed with particle size of 100–400 mesh. Sodium dodecyl sulfate (SDS) was found to suppress hydrate formation in fine-particle beds. By adding diesel oil, both the formation kinetics and Sw in highly water-saturated beds especially in small-particle ones were significantly improved. The Sw and Sb in the bed with particle size of 100–400 mesh were increased to 180.41 V/Vw and 111.75 V/Vbed, respectively. Furthermore, by adjusting the proportions of water, oil and activated carbon in the bed, the Sw was further improved. The successive gas storage tests suggested that the oil-contained bed can be simply renewed by manual stirring. Gas recovery experiments showed that the hydrate dissociated faster in the oil-contained bed than that in SDS solution, suggesting more efforts should be made to control the hydrate dissociation to drive this method into practical application.

Focusing on 84 Chinese–English dual language learners (DLLs) in U.S. preschool programs serving children from low-income backgrounds, this study investigated which aspects of the home language and literacy environment and which parenting styles may be related to these DLLs’ oral receptive and expressive language abilities in Chinese and English. Key findings were: (1) the frequency of parental book reading was associated with better expressive English in DLLs; (2) parental book reading (whether in English or in a combination of English and Chinese) was linked to better expressive English in DLLs; (3) DLLs whose parents read to them in Chinese (Chinese-dominant) and those whose parents read to them in both Chinese and English (bilingual language-dominant) achieved better receptive Chinese than those whose parents did not read to them at all; (4) DLLs whose parents used both English and Chinese (bilingual language-dominant) when conversing with them achieved better expressive English than those whose parents used exclusively Chinese (Chinese-dominant); and (5) authoritative parenting was associated with better receptive Chinese in DLLs. Interpretations of the findings were discussed in the context of bilingualism.

Core–shell Cu2O@ZnO composites were synthesized successfully based on a one-pot hydrothermal method in the presence of dioctyl sulfosuccinate sodium salt (AOT) surfactant. The Cu2O can be converted to rough core–shell Cu2O@ZnO structure by adjusting the amount of zinc powder added. The as-synthesized Cu2O@ZnO composites exhibited excellent photocatalytic activity and the amount of H2 generated using these composites was 4.5-fold more than that produced with Cu2O cubes. A possible photocatalytic mechanism for the Cu2O@ZnO composites with enhanced photocatalytic activity could be the separation by ZnO of the effective charge carriers.

Monodisperse Cu 2 O-cubes, Cu 2 O-concave cubes and Cu 2 O-octapods supercrystals have been synthesized successfully using a self-assembly approach in the presence of dioctyl sulfosuccinate sodium salt (AOT) surfactant. Specifically, the supercrystals can be prepared by adding aqueous Cu(Ac) 2 solution into butyl alcohol solution of AOT to first assemble nanoreactors and then perform hydrothermal reactions. The structures of the supercrystals can be tailored by simply varying the amount of Cu (Ac) 2 with the same ratio of the Cu(Ac) 2 to ascorbic acid. AOT surfactant was crucial to precisely control the supercrystal morphology. It was demonstrated that the ratio of growth rate along different planes varied by adjusting the amount of Cu(Ac) 2 and the volume ratio of alcohol to water, thus Cu 2 O crystals with cubes, concave cubes, and octapods with the size of 1.2–2.2 μm were obtained. The morphology evolution from cubes, concave cubes to octapods was systematically studied and a facet etching mechanism is proposed. Hence, precise control of the amount of Cu(Ac) 2 enables this facet etching, novel Cu 2 O with concave {100} facets can be fabricated. Photocatalysis investigation on the morphology-controlled Cu 2 O indicates that the Cu 2 O-octapods supercrystals showed the highest amount of H 2 and the best cyclic-stability. This work reveals that morphology-control of supercrystals is important to the development of novel photocatalysis.

Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial cells (BMECs) which underwent oxygen-glucose deprivation (OGD) for 2h. Our data showed that FA significantly reversed the oxidative stress state of OGD-treated BMECs and reduced mitochondrial dysfunction. In further study, we found that FA upregulated the expression of LC3-II, a marker of autophagy. Besides, mitophagy was observed by transmission electron microscopy. The mechanism of FA inducing autophagy was found to be related to mitochondrial fission, according to the effects of siRNA and inhibitor of dynamin-related protein 1, which was responsible for fission. All above suggested that FA mitigated OGD-induced mitochondrial oxidative damage by punctate-mitochondria-dependent autophagy.

Baicalin, a plant-derived flavonoid, has been reported to exert neuroprotective effects on ischemia-like or excitotoxic injury. To confirm this function and explore the possible mechanism, we investigated the protective effect of baicalin on an in-vitro model of ischemia (oxygen-glucose deprivation-treated endothelial cell). In the present study, we found that baicalin (100 μM) inhibited cell death, reduced cell membrane damage, and maintained the integrity of the nucleus. Flow cytometric analysis and Hoechst 33258/propidium iodide double staining results showed that the necroptosis ratio decreased with baicalin treatment. Western blot analysis showed that baicalin regulated the expression of RIP-1 and RIP-3 in bEnd.3 cells and the use of detection kits showed that baicalin inhibited the production of reactive oxygen species and malondialdehyde, and increased the activity of superoxide dismutase in oxygen-glucose deprivation-treated bEnd.3 cells. These results indicated that baicalin effectively alleviated the oxidative stress, decreased the proportion of cells undergoing necrosis, and reduced cell damage.

The CO sensing and magnetic properties of pristine and metal-doped MoS2 monolayers (defined as MoS2M, where M = Pd, Co, and Fe) were investigated by anchoring CO onto 2D nanosheets with first-principles calculations. Pristine MoS2 exhibits weak physisorption to CO, whereas MoS2-M monolayers show enhanced interaction with CO by forming a metal CO bond, and narrow band gaps and spontaneous magnetization upon CO adsorption. MoS2-Co and MoS2-Fe systems are ferromagnetic (FM) half metals (HM), whereas MoS2-Pd is a nonmagnetic (NM) metal. After CO adsorption, MoS2-Fe coverts to NM metal to maintain the unchanged ground states. Results indicate that MoS2-M systems are promising candidates for future applications in designing novel gas sensors, nanoelectronics, and spintronics. (C) 2017 Elsevier B.V. All rights reserved.

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Resveratrol gains a great interest for its strong antioxidant properties, while the molecular mechanisms underlie the beneficial effects on psychosocial stress remain controversial. In this study, we demonstrated that resveratrol protected peritoneal macrophages and RAW 264.7 cells from stress-induced decrease in the total cell count, phagocytic capability, reactive oxygen species generation, monodansylcadaverine and mitochondrial membrane potential in stressed mice. Resveratrol promoted stress-induced autophagy in both models. Modulation of autophagy by rapamycin or 3-methyladenine regulated the protective effect of resveratrol, suggesting a role of autophagy in the protective mechanisms of resveratrol. The comparison studies revealed that distinct mechanisms were implicated in the protective effect of resveratrol and other antioxidants (vitamin C and edaravone). Resveratrol promoted autophagy via upregulating SIRT3 expression and phosphorylation of AMP-activated protein kinase (AMPK). Knockdown of SIRT3 resulted in decreased autophagy and abolished protective effect of resveratrol. SIRT1 was also involved in the protective mechanism of resveratrol, although its effect on autophagy was unnoticeable. Pharmacological manipulation of autophagy modulated the effects of resveratrol on SIRT3 and AMPK, revealing the engagement of a positive feedback loop. In sharp contrast, vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK/autophagy network orchestrates in the protective effect of resveratrol in macrophages.

Si-jun Liu,1,* Cong Yang,2,* Yue Zhang,2,* Ru-yu Su,2 Jun-li Chen,2 Meng-meng Jiao,2 Hui-fang Chen,2 Na Zheng,2 Si Luo,2 Yun-bo Chen,2 Shi-jian Quan,1 Qi Wang21School of Chinese Materia Medica, 2Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally tothis workAim: β-asarone, an active component of Acori graminei rhizome, has been reported to have neuroprotective effects in Alzheimer’s disease. As the underlying mechanism is not known, weinvestigated the neuroprotective effects of β-asarone in an APP/PS1 double transgenic mouse model and in NG108 cells.Materials and methods: APPswe/PS1dE9 double transgenic male mice were randomly assigned to a model group, β-asarone treatment groups (21.2, 42.4, or 84.8 mg/kg/d), or donepezil treatment group (2 mg/kg/d). Donepezil treatment was a positive control, and background- and age-matched wild-type B6 mice were an external control group. β-asarone (95.6% purity) was dissolved in 0.8% Tween 80 and administered by gavage once daily for 2.5 months. Control and model animals received an equal volume of vehicle. After 2.5 months of treatment, behavior of all animals was evaluated in a Morris water maze. Expression of synaptophysin (SYP) and glutamatergic receptor 1 (G1uR1) in the hippocampus and cortex of the double transgenic mice was assayed by Western blotting. The antagonistic effects of β-asarone against amyloid-β peptide (Aβ) were investigated in vitro in the NG108-15 cell line. After 24 hours of incubation, cells were treated with 10 µm Aβ with or without β-asarone at different concentrations (6.25, 12.5, or 25 µM) for an additional 36 hours. The cytotoxicity of β-asarone was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of cell viability, and cell morphology was evaluated by bright-field microscopy after 24 hours of treatment. The expression of SYP and GluR1 in cells was detected by Western blot assay in the hippocampus and brain cortex tissues of mice.Results: β-asarone at a high dose reduced escape latency and upregulated SYP and GluR1 expression at both medium and high doses. Cell morphology evaluation showed that β-asarone treatment did not result in obvious cell surface spots and cytoplasmic granularity. β-asarone had a dose-dependent effect on cell proliferation.Conclusion: β-asarone antagonized the Aβ neurotoxicity in vivo, improved the learning and memory ability of APP/PS1 mice, and increased the expression of SYP and GluR1 both in vivo and in vitro. Thus, β-asarone may be a potential drug for the treatment of Alzheimer’s disease.Keywords: neuroprotective effect, β-asarone, synaptic plasticity, synaptophysin, glutamatergic receptor 1

The relationship between the hydrate-bearing sediments with physical properties such as wave velocity is of importance for the exploration and exploitation of natural gas hydrate. The distribution modes of naturally occurring gas hydrates in sediments are diverse and have significant influence on physical properties of rocks. However, hydrates in homogeneous distribution are in general investigated in laboratory currently. In this work, to simulate the diverse distribution modes of naturally occurring gas hydrates, a novel method to prepare the hydrate-bearing sediments with heterogeneous distribution including layered distribution was proposed by controlling the temperature, water migration, and water saturation distribution. Velocity and amplitude of P-wave are investigated to evaluate the physical properties of hydrate-bearing sediments with homogeneous or heterogeneous distribution. The results showed that the hydrate formation process apparently consists of unconsolidated and consolidated steps according to the amplitude curve. The amplitude of P-wave in the unconsolidated stage increases slowly, while it increases suddenly and rapidly in the consolidated stage. The P-wave velocity of the hydrate deposits with homogeneous distribution is faster than that with heterogeneous distribution when under a same hydrate saturation. This is also verified from the experiments performed on hydrate-bearing sediments with layered distribution, which provided direct evidence and quantification about heterogeneous degree of hydrate distribution in sediment. This difference of the P-wave velocity between heterogeneous and homogeneous hydrate-bearing sediments would provide a guidance in the future development of natural gas hydrate.

CaCu3Ti4O12 (CCTO) ceramics were prepared by the sol–gel process and sintered by the spark plasma sintering (SPS) process at different temperatures. The SPS process temperature has an important effect on the microtopography of CCTO ceramics. The results of EDS and positron annihilation spectroscopy indicate that Cu2+ diffuses from the inside to the surface of grains during the sintering process at high temperature. The permittivity (er) of CCTO ceramics at the corresponding frequencies increases with increasing SPS temperature. However, the frequency stability of er over the frequency range 40–106 Hz wanes gradually. The CCTO ceramics sintered at 900°Cand 950 °C present very low dielectric loss values(about 0.02) near 10 kHz. The change in er and tanδ for CCTO ceramics can be explained by the internal barrier layer capacitance (IBLC) model and AC (alternating current) impedance spectra. The results of I–V nonlinear characteristics for CCTO ceramics make clear that the potential barrier height has a positive effect on the value of nonlinear coefficient.

Abnormal phosphorylation of tau, one of the most common symptoms of dementia, has become increasingly important in the study of the etiology and development of Alzheimer’s disease. Paeoniflorin, the main bioactive component of herbaceous peony, is a monoterpene glycoside, which has been reported to exert beneficial effects on neurodegenerative disease. However, the effect of paeoniflorin on tauopathies remains ambiguous. SH-SY5Y cells were treated with okadaic acid (OA) for 8 h to induce tau phosphorylation and no cell death was observed. Optical microscopy results showed that paeoniflorin ameliorated okadaic acid induced morphological changes, including cell swelling and synapsis shortening. Western blotting data illustrated that paeoniflorin reversed okadaic acid induced tau hyperphosphorylation, which was enhanced by inhibiting the activities of calpain, Akt and GSK-3β. Transmission electron microscopy results showed that paeoniflorin alone can reduce the number of autophagosomes and stabilize the microtubule structure. In addition, calpastain and paeoniflorin enhance the effect of paeoniflorin on stabilizing microtubules. In addition, calpastain markedly enhanced the effect of paeoniflorin on reversing okadaic acid-lowered fluorescence intensity of both MAP-2 and β III-tubulin, two microtubule-associated proteins. This study shows that paeoniflorin protected SH-SY5Y cells against okadaic acid assault by interfering with the calpain/Akt/GSK-3β-related pathways, in which autophagy might be involved. Besides, paeoniflorin is found to relieve the stress response of the microtubule structure system caused by okadaic acid treatment. The results presented in this study suggest that paeoniflorin potentially plays an important role in tauopathies.

In order to study surface structures and properties of wool fabric, plasma treatment, grafting and plasma combined grafting treatment are studied in this paper. The structure of samples was characterized by Fourier transform infrared spectroscopy (FTIR). Furthermore, wetting time, grafting ratio and whiteness were also investigated.

This study examined the quality of preschool teachers’ interactive conversations with three- and four-year-olds in two Head Start classrooms serving children from low-income families in the United States. Over a period of 20 weeks, 10 bi-weekly observations of conversations (totaling 15 h per classroom) were conducted in one small-group (Play Time) and two large-group (Breakfast Time and Circle Time) contexts. The teacher–child verbal interactions were transcribed and coded using the Teacher Interaction and Language Rating Scale (TILRS) to determine the frequency of responsive language strategies employed by the teachers across the three contexts. The two teachers applied Child-Centered Strategies and Interaction-Promoting Strategies the most during Circle Time, followed by Play Time, and the least during Breakfast Time. While it was observed that both teachers did talk to the children face to face frequently across contexts, they rarely used Language Modeling Strategies to engage them in cognitively chal...

Epigenetic modifications are involved in the pathogenesis of cancer, and histone deacetylase inhibitors are considered potential therapeutic agents. Histone tails undergo acetylation at lysine residues, which is associated with transcriptional activation. However, previous studies indicated that as histone deacetylase inhibitors, both (−)-epigallocatechin-3-gallate and valproic acid presented the effects of downregulation of amyloid precursor protein expression, which resulted in the induction of apoptosis. The downregulation of amyloid precursor protein, instead of conventionally activating gene expression as histone deacetylase inhibitor, was attractive. However, there was no relevant report on the correlation of the expression of amyloid precursor protein and histone deacetylase 1 in cancer. In the present study, we detected the expression of amyloid precursor protein and histone deacetylase 1 in hepatocellular carcinoma and adjacent tissues, as well as the correlations among histone deacetylase 1, amyloid precursor protein, and tumor stage. The results showed that the expressions of amyloid precursor protein and histone deacetylase 1 were significantly higher in hepatocellular carcinoma tissues than that in adjacent tissues ( P < .05), however, there was no statistical difference between amyloid precursor protein and histone deacetylase 1 with tumor stages. The present findings provided more foundation for the study on amyloid precursor protein metabolism in cancer, especially on the regulation of amyloid precursor protein by histone deacetylases.

As “Queen of Fibers”, silk is very popular due to its favorable properties. However, unfavorable antibacterial ability has limited the application of silk. In this paper, therefore, the antibacterial treatments containing both silver and chitosan for silk fabric were conducted. X-ray diffraction (XRD), Fourier transform infrared (FTIR), tensile properties and antibacterial ability tests were carried out to characterize the silk fabric containing chitosan and silver. The results showed that chitosan and silver treatment did not destroy the crystalline structure and molecule structure of silk fabric, however, greatly changed the tensile properties and antibacterial ability, i.e. after treatment, the breaking force decreased while elongation at break increased. Especially, the antibacterial ability of silk was greatly improved due to dual effect of chitosan and silver.

This study investigated how Chinese immigrant mothers in the USA make meaning of their parenting styles and practices in rearing their young children (aged two to six). Twelve Chinese immigrant mothers were interviewed. A key finding reveals that the Chinese immigrant mothers' parenting practices reflected the indigenous concept of jiaoyang in the Chinese culture (with jiao meaning educating, teaching and training; yang meaning rearing; and jiaoyang implying educating and rearing). Another finding is that except for one mother, the rest practised authoritative parenting, combining high levels of both parental warmth and parental control. The Chinese immigrant mothers' parenting seemed to best reflect what Kagitcibasi described as the psychological interdependence interaction pattern of the family model with the childrearing orientation focusing on parental control, emotional closeness and child autonomy, leading to the child becoming both emotionally autonomous and related. Implications for future researc...

In order to shorten dyeing process, increase yield and reduce consumption of water and alkaline, the one-bath two-stage heating dyeing process was used for reactive/disperse dyes. The key technology of this research was adding alkaline when polyester/viscose (cotton) blended fabrics were dyed by reactive dyes,and then adding acetic acid when dyed by disperse dyes. During this process, acetic acid and alkali neutralize, and sodium acetate and acetic acid form a buffer system, which greatly improves dyeing reproducibility. The results of factory trial showed that color strength and color fastness of polyester/viscose (cotton) blended fabrics dyed by this process were as same as those achieved by the traditional process.

Protein fibers are attractive topics in the past decades. Among them, silk and wool fibers are very popular due to their luster, smooth surface and comfort. In order to reach union dyeing of silk/wool blends, chlorination pretreatment or introduction of low-temperature dyeing auxiliary for wool are selected and compared. The results showed that chlorination pretreated wool/silk dyed with weak acid dyes, can reach union dyeing under 80 oC, possibly under 70 oC. On the other hand, introduction of low-temperature dyeing auxiliary can slightly improve the union dyeing at different temperature ranges according to selection of weak acid dyes.

Protein fibers are attractive topics in the past decades. Among them, soybean protein fiber, the regenerated protein-base fiber, is very popular due to its luster, smooth surface, breathability, and comfort. In order to blend with wool and reach union dyeing, soybean protein fiber was first bleached due to its yellow appearance. Various bleaching processes were introduced in this paper. Reactive dyes for cellulose and for wool, such as Unisol or Megafix dyes, together with proper dyeing process were selected and compared. The results showed that one-time oxidation bleaching is confirmed as the bleaching process due to its compromise of high whiteness and bursting strength. It is unable to reach union dyeing for soybean protein fiber/wool fiber with Unisol or Megafix dyes respectively while it is feasible to reach union dyeing of soybean protein fiber/wool fiber dyeing with Unisol dyes followed by Megafix dyes.

Research has documented that parenting practices, such as parental warmth and parental punishment, play a mediating role in linking individual (e.g., age, gender) and familial characteristics (e.g., economic status, marital quality) to the psychological well-being of children. However, few studies have validated these connections with respect to the Chinese population, especially those in rural areas of China plagued with unfavorable conditions such as poverty and lack of education. In this study, we investigated whether child (age, gender, and sibship size), and familial characteristics (family wealth, parental education, and marital quality) indirectly contribute to the children’s psychological well-being (as indicated by their self-reported internalizing and externalizing problems) through their perceived parental warmth and parental punishment. Using structural equation modeling, we analyzed data collected from 2,000 children (ages 9–13) and their parents in rural China. The results reveal significant, indirect relationships from family wealth and marital quality to these children’s externalizing problems through parental warmth and parental punishment. There are age and gender differences in the children’s experiencing internalizing and externalizing problems. Gender differences are also found in their perceived parental warmth and parental punishment. Directions for future research are discussed.

Researchers have long been interested in understanding factors affecting student achievement. To contribute new insights to the literature, this study investigated grade-level differences in the relationships of students' perceived academic support (from parents, teachers and peers) to academic achievement directly and also indirectly through their perceived academic engagement. Questionnaire data were collected from 270 Hong Kong adolescents in Forms 3—5 (equivalent to Grades 9—11 in the United States). Structural equation modelling analyses revealed important and interesting grade-level differences in the academic support-based achievement relationships. Specifically, perceived parental support was negatively linked to academic achievement for Form 4 students, but it was positively related to academic achievement through perceived academic engagement for Form 3 students. Perceived teacher support was a significant predictor of academic achievement only for Form 3 students. Surprisingly, perceived peer support had no significant direct or indirect relationship to student achievement. These findings were interpreted from cultural, educational, socioeconomic and developmental perspectives. Suggestions for promoting particular sources of academic support for adolescents in different grade levels were discussed.

Gender differences in student achievement have been widely studied. Considering the long‐term effects of externalising behaviour problems on children’s later academic performance, it can be conjectured that gender disparities in student achievement may be rooted in developmental characteristics in early childhood. As an effort towards contributing insights to the growing body of knowledge on child development, this study investigated whether variability in externalising behaviour problems among preschool children could be attributed to gender differences. Participants were 110 parents who completed a sociodemographic questionnaire, and rated their child’s behaviour on the Achenbach Child Behaviour Checklist. The children (mean age in months = 45.62 (SD = 10.12)) consisted of 52 boys and 58 girls. This study revealed that boys were reported to exhibit higher rates of externalising problems than girls, and that higher rates of internalising problems also predicted higher rates of externalising problems amon...

Elevated β-amyloid (Aβ) is a hallmark of Alzheimer’s disease (AD). Recent evidence has suggested that the receptor of advanced glycation end products (RAGE) is a key target for Aβ-induced perturbation in AD, and blockade of RAGE significantly alleviates synaptic injury. Our previous study has suggested that β-asarone could reduce neuronal apoptosis and improve memory deficits in β-amyloid precursor protein and presenilin-1 (APP/PS1) double transgenic AD-model mice. In the present study, we evaluated the effects of β-asarone on amyloidosis in APP/PS1 mice. We found that the survival of neurons of APP/PS1 mice was improved by β-asarone, meanwhile, β-asarone decreased Aβ deposition and down-regulated Aβ1–42 levels in cortex and hippocampus of APP/PS1 mice brain. Interestingly, the level of RAGE was also significantly down-regulated by β-asarone. Our findings suggest that β-asarone might be effective for the treatment of AD, and the decreasing effects of β-asarone on Aβ might associate with its down-regulation of RAGE.

The author tested a model hypothesizing that students' self-perceived academic support (from parents, teachers, and peers) is related to their achievement directly and indirectly through their own perceived academic engagement. The participants were 270 adolescents (M age = 15.41 years, range = 14-20 years) from 3 grade levels (Forms 3-5, equivalent to Grades 9-11 in the United States) in a Hong Kong secondary school. The school principal and teachers helped to collect data based on these adolescents' responses to a self-report questionnaire, consisting of a demographic profile and 4 scales assessing their self-perceptions of the extent of parental, teacher, and peer support, and their own academic engagement. Academic achievement was measured by self-reported grades in math, English, and Chinese. Structural equation modeling analyses revealed that adolescents' perceived parental, teacher, and peer support were all indirectly related to their academic achievement mediated by their own perceived academic engagement. The strength of the relationships, however, varied by support system, with perceived teacher support to achievement being the strongest, followed closely by perceived parental support, and then perceived peer support. In addition, both perceived parental support and perceived teacher support were directly related to academic achievement. However, perceived teacher support made the most total (direct and indirect) contribution to student achievement. Perceived peer support had the smallest, nonetheless significant, indirect relationship to academic achievement. However, the negative, direct influence of perceived peer support canceled out its positive, indirect influence on academic achievement.

This two-part study explored the challenges and teaching strategies of 133 Asian bilingual educators using a detailed questionnaire developed specifically for the purposes of this investigation. Participants were asked to rate how important specific practices, strategies, and challenges were in their teaching of Asian bilingual students. These teachers were also asked to rate each of ten statements concerning their teaching competency, performance, comfort, preparation, satisfaction, and collaboration. Part two of the survey inquired about: (1) teachers' strengths; (2) areas of improvement: (3) beliefs about activities to facilitate improved teaching. Our findings indicated pedagogical challenges such as lack of culturally relevant materials, varying language proficiency, and working with students with different styles of learning. Teachers who were older reported that they were more prepared to address the social, cultural and psychological needs of their bilingual students than were their younger counte...