1. Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma
- Author
-
Katsunori Katagiri MD, PhD, Kiyoto Shiga MD, PhD, Daisuke Saito MD, Shin-ichi Oikawa MD, PhD, Aya Ikeda MD, PhD, Kodai Tsuchida MD, PhD, Jun Miyaguchi MD, PhD, Takahiro Kusaka MD, Takumi Sariishi MD, and Hisanori Ariga MD, PhD
- Subjects
Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Objective To examine the safety and efficacy of concomitant chemoradiotherapy using a modified TPF regimen (docetaxel + cisplatin + 5-fluorouracil) in patients with advanced sinonasal squamous cell carcinoma (SNSCC). Study Design Retrospective study. Setting Tertiary center (university hospital). Methods Seven patients with previously untreated T3-T4 SNSCC were enrolled. They underwent radiotherapy once daily (total dose, 70 Gy) with 2 courses of concomitant 120-hour infusion of 5-fluorouracil (600 mg/m 2 /d), docetaxel (50 mg/m 2 , day 2), and cisplatin (60 mg/m 2 , day 2) Results Grade 4 leukopenia, grade 4 neutropenia, and grade 3 lymphopenia were observed in 1, 3, and 4 patients, respectively. Grade 4 creatinine elevation was observed in 1 patient. However, other grade 3 or 4 adverse events were not common. Complete response was obtained in all patients. At 60 months there was 85.7% disease-free survival and 100% overall. Conclusion Concomitant chemoradiotherapy with a modified TPF regimen may be feasible and effective in patients with advanced SNSCC.
- Published
- 2021
- Full Text
- View/download PDF