1. Upregulation of long non‑coding RNA CCAT2 indicates a poor prognosis and promotes proliferation and metastasis in intrahepatic cholangiocarcinoma
- Author
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Rui‑Feng Tang, Chao Sun, Jian‑Guo Bai, Shuai Qi, Guo‑Dong Yu, and Jun‑Feng Shang
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,Gene Expression ,Biochemistry ,Metastasis ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Genetics ,Medicine ,Humans ,Neoplasm Metastasis ,Molecular Biology ,Survival rate ,Lymph node ,Intrahepatic Cholangiocarcinoma ,Aged ,Cell Proliferation ,Neoplasm Staging ,Oncogene ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,Prognosis ,Molecular medicine ,Long non-coding RNA ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Bile Duct Neoplasms ,ROC Curve ,030220 oncology & carcinogenesis ,Cancer research ,Disease Progression ,Molecular Medicine ,Female ,RNA, Long Noncoding ,Neoplasm Grading ,business - Abstract
Intrahepatic cholangiocarcinoma (IHCC) is an aggressive cancer with a poor survival rate and is the second most common type of primary cancer of the hepatobiliary system. At present, the molecular mechanisms of IHCC initiation and progression remain unclear. Recent evidence has indicated that long non‑coding RNAs (lncRNAs) serve a crucial role in cancer development; however, the functional role of lncRNAs in IHCC has not been investigated in detail. In the present study, a marked overexpression of lncRNA colon cancer‑associated transcript 2 (CCAT2) was observed in IHCC cell lines and clinical specimens. Statistical analysis of IHCC clinicopathological characteristics and CCAT2 expression data revealed that high CCAT2 expression levels correlated with microvascular invasion, differentiation grade, tumor (T), lymph node (N), metastasis (M) and overall TNM stages of IHCC (P
- Published
- 2017