3,480 results on '"Jun, Tian"'
Search Results
2. Asthma prescribing trends, inhaler adherence and outcomes: a Real-World Data analysis of a multi-ethnic Asian Asthma population
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Toh, Ming Ren, Ng, Gerald Xuan Zhong, Goel, Ishita, Lam, Shao Wei, Wu, Jun Tian, Lee, Chun Fan, Ong, Marcus Eng Hock, Matchar, David Bruce, Tan, Ngiap Chuan, Loo, Chian Min, and Koh, Mariko Siyue
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- 2024
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3. Identification of potential crucial genes and therapeutic targets for epilepsy
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Wang, Shitao, Xie, Zhenrong, Jun, Tian, Ma, Xuelu, Zhang, Mengen, Rao, Feng, Xu, Hui, Lu, Jinghong, Ding, Xiangqian, and Li, Zongyou
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- 2024
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4. Clinical characteristics, complications and satisfaction of megameatus intact prepuce (MIP) hypospadias variant: a 15 year retrospective study
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Meng He, Songqiao Fan, Ning Sun, Jun Tian, Minglei Li, Hongcheng Song, and Weiping Zhang
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MIP ,Curvature ,Complications ,Satisfaction ,Children ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background To analyze the clinical characteristics, complications and patients satisfaction of MIP hypospadias variant. Methods A retrospective analysis was performed for 31 patients with MIP admitted to our hospital from January 2008 to February 2023. All enrolled patients underwent telephone follow-up and a survey was conducted on the satisfaction of patients and their families. Outcome analysis was focused on clinical data includes age, position of the meatus, penile curvature, type of repair, complications and satisfaction survey results. Statistical analyses were performed using R software. Results The average age of 31 MIP patients was 92.1 ± 40.7 months, and the median follow-up time was 49.0 [21.0–82.2] months. Twenty one patients (67.7%, 21/31) had ventral curvature and no dorsal curvature was observed. All cases were divided into chordee group and no chordee group. There was a statistical difference in age (80.4 ± 41.6 Vs 117.0 ± 26.0 months) and weight (22.7 [15.8–35.0] Vs 45.0 [32.0–46.0] kg) between the two groups. Six children (19.4%, 6/31) experienced post-operative complications; however, none required reoperation. The only risk factors for complications were the meatus position and whether urethroplasty was performed.Only the occurrence of complications may affect patients satisfaction. Conclusions MIP hypospadias variants can exhibit severe ventral curvature. Surgery can achieve good results with a low incidence of complications. A satisfactory skin appearance and adequate curvature correction are key concerns for both patients and parents. more...
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- 2025
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5. How Pedagogical Modes Influence Students' Employability: The Evidence from China
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Zhi-ting Liu and Li-jun Tian
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This study explores how two typical pedagogical modes, namely, problem-based and employment-based pedagogical mode, contribute to the employability of university and college students. Based on analysis of a total sample of 428 undergraduates from Chinese universities and colleges using structural equation modelling, the results show that students' absorptive capacity was positively related to their employability. The employment-based pedagogical mode, considering the absorptive capacity as a partial mediator, was positively related to students' employability. The problem-based pedagogical mode, considering the absorptive capacity as a complete mediator, was positively related to students' employability. Absorptive capacity act as an important mediator variable when the employment-based and problem-based pedagogical mode influence students' employability. Based on the findings, specific suggestions and managerial implications for higher education policy, manpower training, and future research are provided. more...
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- 2024
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6. Ultraviolet photon-counting single-pixel imaging
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Ye, Jun-Tian, Yu, Chao, Li, Wenwen, Li, Zheng-Ping, Lu, Hai, Zhang, Rong, Zhang, Jun, Xu, Feihu, and Pan, Jian-Wei
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Physics - Optics ,Physics - Instrumentation and Detectors ,Quantum Physics - Abstract
We demonstrate photon-counting single-pixel imaging in the ultraviolet region. Toward this target, we develop a high-performance compact single-photon detector based on a 4H-SiC single-photon avalanche diode (SPAD), where a tailored readout circuit with active hold-off time is designed to restrain detector noise and operate the SPAD in free-running mode. We use structured illumination to reconstruct 192$\times$192 compressed images at a 4 fps frame rate. To show the superior capability of ultraviolet characteristics, we use our single-pixel imaging system to identify and distinguish different transparent objects under low-intensity irradiation, and image ultraviolet light sources. The results provide a practical solution for general ultraviolet imaging applications., Comment: 5 pages, 5 figures, accepted for publication in Applied Physics Letters more...
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- 2023
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7. Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators
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Jun Tian and Weizhi Chen
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Gastrointestinal stromal tumor ,Contrast-enhanced CT ,Serological indicators·Ki-67 ,Malignant potential ,Model ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose To identify more reliable imaging and serological indicators for predicting Ki-67 expression and malignant potential in gastrointestinal stromal tumors, as well as to develop a preoperative prediction model with clinical utility. Patients and methods This study retrospectively analyzed patients with gastrointestinal stromal tumors (GIST) diagnosed at the First Affiliated Hospital of Jinzhou Medical University between May 2018 and May 2024. Univariate logistic analyses, two-way stepwise regression, P-value stepwise regression, and LASSO regression were employed to screen for Ki-67 high expression and high malignant potential risk factors associated with GIST. Models were established using various regression methods; Nomograms, calibration curves, and clinical decision curves were generated for the two best prediction models. Results Two-way stepwise regression analysis revealed that diameter (P=0.037; OR=1.22; 95% CI: 1.01 - 1.46), growth pattern (extraluminal type: P=0.028; OR=3.54; 95% CI: 1.14 - 10.94), enhancement model (P=0.099; OR=0.39; 95% CI: 0.12 - 1.20), EVFDM (P=0.069; OR=0.43; 95% CI: 0.17 - 1.07), PLR (P=0.099; OR=3.06; 95% CI: 0.81 - 11.59), and OPNI (P=0.058; OR=2.38; 95% CI: 0.97 - 5.84) are identified as independent risk factors for Ki-67 expression. Utilizing the two-way stepwise regression model to predict Ki-67 expression, the area under the curve (AUC) for the training group was 0.865 (95% CI: 0.807-0.922), while for the validation group it was 0.784 (95% CI: 0.631-0.937). The Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) for the training group were 153.360 and 174.619, respectively. Two-way stepwise regression analysis revealed that volume (P < .001, OR = 1.06; 95% CI: 1.03 - 1.09), contour (P = 0.066; OR = 0.17; 95% CI: 0.05 - 0.62), ulcer (P = 0.094; OR = 0.16; 95% CI: 0.03 - 0.98), IBSC (P = 0.008; OR = 5.27; 95% CI: 1.57 - 17.69), and OPNI (P = 0.045; OR = 0.22; 95% CI: 0.05 - 0.96) are independent risk factors for malignant potential. Utilizing the two-way stepwise regression model to predict malignant potential, the AUC for the training group was 0.950 (95% CI: 0.920 - 0.980), while for the validation group it was 0.936 (95% CI: 0.867 - 1.000). The AIC and BIC values for the training group were 96.330 and 114.552, respectively. Conclusion Diameter, growth pattern, enhancement pattern, EVFDM, PLR, and OPNI are independent risk factors for GIST with high Ki-67 expression. Additionally, volume, contour, ulceration, IBSC, and OPNI serve as independent risk factors for GIST with high malignant potential. The preoperative models developed using CT images can predict the malignant potential and Ki-67 expression status of GIST to a certain extent. When combined with serological indicators, these models' predictive performance can be further enhanced. more...
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- 2024
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8. Analysis of heritability and environmental factors in preschool children with eczema: a case-control study
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Qingfang Du, Lei Zhang, Chongzhi Ma, Li Yang, Jun Tian, and Zijian Cao
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Case control study ,Eczema ,Preschool children ,Medicine ,Science - Abstract
Abstract Eczema is common in children, and its onset is affected by both genetic and environmental factors. We investigated the effects of genetic and environmental factors on the incidence of eczema in preschool children. 515 preschool children with eczema and 515 children participating in the physical examination were enrolled. The study included the incidence of childhood eczema, the child’s birth and feeding conditions, the history of eczema in the parents, and relevant environmental risk factors, and to comprehensively analyze the genetic and environmental factors influencing childhood eczema. Among 1030 children, 173 parents (8.4%) had eczema, with a heritability of 73.59% for boys’ parents and 58.59% for girls’ parents. Multivariate logistic regression results showed that premature infants, low birth weight, children who had used antibiotics before the age of 1 year the living environment between the first year of mother pregnancy and the first year of the child is humid, a father with a history of eczema, a mother with a history of eczema are risk factors for eczema in children. Actively preventing environmental factors related to eczema may be an effective means to reduce the risk of eczema in children. more...
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- 2024
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9. Wear characteristics and micro-cutting damage model of cemented carbide by deep cryogenic treatment
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Weiguo Zhang, Jun Tian, Xiaowei Wu, Yu Zheng, Jingyun Yuan, and Mingfang Zheng
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Cemented carbide ,Deep cryogenic treatment ,Wear rate ,η phase ,Martensite phase transformation ,Residual compressive stress ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Wear failure of oil drill bits leads to cost increase, and how to improve the abrasion resistance of cemented carbide (WC–Co) drill bits is an urgent problem, and deep cryogenic treatment (DCT) is a feasible method. The effect of DCT time (i.e., 0, 3, 6, 9, 12, 24, and 48 h) on the Vickers hardness, flexural strength, and wear rate of WC-Co with different Co contents (i.e., 5 wt%, 8 wt%, 10 wt%, and 12 wt%) was investigated. The results showed that the best DCT time for hardness, flexure strength, and abrasion resistance of WC-Co was 12 h. Compared with untreated (e.g., 0 h), the wear rates of WC-Co with different Co contents were reduced by 36%, 34%, 30%, and 19%, respectively at DCT-12. Compared with WC-12Co, the wear rate of WC-5Co with different DCT times was reduced by 75%, 77%, 78%, 78%, 80%, 79%, and 78%, respectively. The precipitation of η phase (Co6W6C), martensite phase transformation (α-Co to ε-Co), and the increase of residual compressive stress (RCS) of WC after DCT improved the hardness, flexural strength and reduced the wear rate of WC-Co. Based on the principle of frictional wear, a micro-cutting wear model considering Co content and DCT time is proposed, which can predict the evolution of the wear rate of WC-Co. The results of the study guide improving the wear resistance of drill materials. more...
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- 2024
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10. The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway
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Shu Li, Yan Su, Jun Tian, Ke Wang, Xiaotong Wang, Lin Ding, and Chunli Li
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SASH1 ,PI3K ,Akt ,mTOR ,Breast cancer ,Prognosis ,Medicine ,Science - Abstract
Abstract SASH1 (SAM and SH3 domain containing 1) has been increasingly reported as a tumor suppressor gene. However, there is limited research on the role of SASH1 in breast cancer. This manuscript aims to investigate the mechanism of SASH1 in the occurrence, development, and prognosis of breast cancer. Firstly, we obtained RNA-sequencing data of the tumors from the Genomic Data Commons data portal website, along with the corresponding clinical information of patients. Pan-cancer analysis was performed to analyze the expression of SASH1 across all tumors. Univariate Cox regression analysis was used to assess the correlation between SASH1 expression and the prognosis of breast cancer patients. Then, immunohistochemistry was utilized to evaluate the expression levels of SASH1, p-Akt, p-PI3K, and p-mTOR in breast cancer tissue. Finally, a cell assay was employed to analyze the impact of SASH1 on the proliferation and invasion of breast cancer cells (MDA-MB-231). The results revealed that SASH1 expression is decreased in BRCA, LUSC, LUAD, CESC, ESCA, and COAD. Meta-analysis also found that SASH1 is downregulated in most tumor tissues, and the expression level of SASH1 in breast cancer was significantly lower than that in the control group (OR = 0.14, 95% CI = 0.08–0.25; P more...
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- 2024
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11. Metabolomic profiling identifies metabolites in the pheromone glands of Agriophara rhombata associated with the synthesis and release of female pheromone signals
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Hao Qu, Yaqin Long, Long Chen, Ziwen Luo, Hongyun Chen, Xuesong Wang, Lixue Long, Jun Tian, Tingting Jing, and Linbo Chen
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Tea moth ,Pheromone glands ,Metabolomic profiling ,Sex pheromones ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The tea moth pest, Agriophara rhombata is an economically important and highly damaging pest that drastically affects tea plant leaves. The chemical composition of its pheromone glands metabolites before and during calling period has not been reported yet. Therefore, the present study aimed at the metabolomic profiling of female moths’ sex pheromones glands before and during calling period using gas chromatography time-of-flight mass spectrometry. A total of 114 significant differentially expressed metabolites were identified including 54 up- and 70 down-regulated metabolites in pheromone glands of the female moth. Two of the important previously recognized moth pheromones were identified including E,Z-5,7-dodecadien-1-ol acetate and Z-12-Octadecen-1-ol acetate, which were downregulated. The top ten up-regulated metabolites were “dodecanamide”, “tetradecanamide”, “2-propyn-1-amine, N,N-dimethyl”, “cyclohexane, (1-methylethyl)”, “tetradecane, 2-methyl”, “1-cyclopentyleicosane”, “cyclohexane, octyl”, “1-decan-3-one”, “cyclopentane, decyl” and “cyclopentadecane”. In conclusion, while most of the identified compounds have not previously been identified as primary pheromones in moths, their differential expression in A. rhombata's pheromone glands during the calling period strongly suggests their supporting roles in the synthesis, stabilization, or release of the active pheromone components. more...
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- 2024
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12. DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway
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Si-chen Di, Wen-jin Chen, Wei Yang, Xiang-min Zhang, Ke-qin Dong, Yi-jun Tian, Ye Sun, Cheng Qian, Jia-xin Chen, Zi-chang Liu, Zi-xuan Gong, Jian Chu, Wang Zhou, Xiu-wu Pan, and Xin-gang Cui
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Cytology ,QH573-671 - Abstract
Abstract Renal cell carcinoma (RCC) is considered a “metabolic disease” characterized by elevated glycolysis in patients with advanced RCC. Tyrosine kinase inhibitor (TKI) therapy is currently an important treatment option for advanced RCC, but drug resistance may develop in some patients. Combining TKI with targeted metabolic therapy may provide a more effective approach for patients with advanced RCC. An analysis of 14 RCC patients (including three needle biopsy samples with TKI resistance) revealed by sing-cell RNA sequencing (scRNA-seq) that glycolysis played a crucial role in poor prognosis and drug resistance in RCC. TCGA-KIRC and glycolysis gene set analysis identified DEPDC1 as a target associated with malignant progression and drug resistance in KIRC. Subsequent experiments demonstrated that DEPDC1 promoted malignant progression and glycolysis of RCC, and knockdown DEPDC1 could reverse TKI resistance in RCC cell lines. Bulk RNA sequencing (RNA-seq) and non-targeted metabolomics sequencing suggested that DEPDC1 may regulate RCC glycolysis via AKT/mTOR/HIF1α pathway, a finding supported by protein-level analysis. Clinical tissue samples from 98 RCC patients demonstrated that DEPDC1 was associated with poor prognosis and predicted RCC metastasis. In conclusion, this multi-omics analysis suggests that DEPDC1 could serve as a novel target for TKI combined with targeted metabolic therapy in advanced RCC patients with TKI resistance. more...
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- 2024
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13. Procyanidin C1 inhibits tumor growth and metastasis in colon cancer via modulating miR-501-3p/HIGD1A axis
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Jun-lin Lv, Yu-jun Tan, Yu-shan Ren, Ru Ma, Xiao Wang, Shu-yan Wang, Wan-qing Liu, Qiu-sheng Zheng, Jing-chun Yao, Jun Tian, and Jie Li
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COADREAD ,HIGD1A ,miR-501-3p ,Tumor growth ,Metastasis ,Procyanidin C1 ,Medicine (General) ,R5-920 ,Science (General) ,Q1-390 - Abstract
Introduction: Although colon (COAD) and rectal adenocarcinoma (READ) combined to refer to colorectal cancer (CRC), substantial clinical evidence urged that CRC should be treated as two different cancers due to compared with READ, COAD showed higher morbidity and worse 5-year survival. Objectives: This study has tried to screen for the crucial gene that caused the worse prognosis and investigate its mechanism for mediating tumor growth and metastases in COAD. Meanwhile, the potential anti-COAD compound implicated in this mechanism was identified and testified from 1,855 food-borne chemical kits. This study aims to bring a new perspective to the development of new anti-COAD drugs and personalized medicine for patients with COAD. Methods and results: The survival-related hub genes in COAD and READ were screened out from The Cancer Genome Atlas (TCGA) database and the results showed that HIGD1A, lower expressed in COAD than in READ, was associated with poor prognosis in COAD patients, but not in READ. Over-expressed HIGD1A suppressed CRC cell proliferation, invasion, and migration in vitro and in vivo. Meanwhile, the different expressed microRNA profiles between COAD and READ showed that miR-501-3p was highly expressed in COAD and inhibited HIGD1A expression by targeting 3′UTR of HIGD1A. MiR-501-3p mimics promoted cell proliferation and metastasis in CRC cells. In addition, Procyanidin C1 (PCC1), a kind of natural polyphenol has been verified as a potential miR-501-3p inhibitor. In vitro and in vivo, PCC1 promoted HIGD1A expression by suppressing miR-501-3p and resulted in inhibited tumor growth and metastasis. Conclusion: The present study verified that miR-501-3p/HIGD1A axis mediated tumor growth and metastasis in COAD. PCC1, a flavonoid that riched in food exerts anti-COAD effects by inhibiting miR-501-3p and results in the latter losing the ability to suppress HIGD1A expression. Subsequently, unfettered HIGD1A inhibited tumor growth and metastasis in COAD. more...
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- 2024
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14. The impact of apparent temperature on the emergency visits for traumatic fractures in Hangzhou, China
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Feng Li, Xuejiao Liu, Yanlin Niu, Jinghong Gao, Maoqiang Li, Yipin Zhao, Cheng Ji, Guobiao Pan, Mingxing Zhao, Boliang Wu, Xiaoxiang Tang, Gang Wu, Jun Tian, Jianwei Chen, Shiyu Yan, Jianlu Tan, Yunqing Li, Wentao Zhao, Lingyun Li, Yinmiao Qiu, Wangxiang Yao, and Liulong Zhu more...
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Apparent temperature ,Distributed lag nonlinear model ,Traumatic fracture ,Emergency visits ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Traumatic fractures occur frequently worldwide. However, research remains limited on the association between short-term exposure to temperature and traumatic fractures. This study aims to explore the impact of apparent temperature (AT) on emergency visits (EVs) due to traumatic fractures. Methods Based on EVs data for traumatic fractures and the contemporary meteorological data, a generalized Poisson regression model along with a distributed lag nonlinear model (DLNM) were undertaken to determine the impact of AT on traumatic fracture EVs. Subgroup analysis by gender and age and sensitivity analysis were also performed. Results A total of 25,094 EVs for traumatic fractures were included in the study. We observed a wide “J”-shaped relationship between AT and risk of traumatic fractures, with AT above 9.5 °C positively associated with EVs due to traumatic fractures. The heat effects became significant at cumulative lag 0–11 days, and the relative risk (RR) for moderate heat (95th percentile, 35.7 °C) and extreme heat (99.5th percentile, 38.8 °C) effect was 1.311 (95% CI: 1.132–1.518) and 1.418 (95% CI: 1.191–1.688) at cumulative lag 0–14 days, respectively. The cold effects were consistently non-significant on single or cumulative lag days across 0–14 days. The heat effects were higher among male and those aged 18–65 years old. The sensitivity analysis results remained robust. Conclusion Higher AT is associated with cumulative and delayed higher traumatic fracture EVs. The male and those aged 18–65 years are more susceptible to higher AT. more...
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- 2024
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15. A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating oxidative stress
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Mengjie Li, Jun Tian, Kangkang Yu, He Liu, Xiaoqi Yu, Nan Wang, Qimei Gong, Kun Li, Ya Shen, and Xi Wei
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Small extracellular vesicle ,Dental follicle stem cell ,Pulpitis ,Oxidative stress ,ROS-Responsive hydrogel ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Pulpitis, an inflammatory disease of dental pulp tissues, ultimately results in the loss of pulp defense properties. Existing clinical modalities cannot effectively promote inflamed pulp repair. Oxidative stress is a major obstacle inhibiting pulp repair. Due to their powerful antioxidative capacity, mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) exhibit potential for treating oxidative stress-related disorders. However, whether MSC-sEVs shield dental pulp tissues from oxidative damage is largely unknown. Here, we showed that dental follicle stem cell-derived sEVs (DFSC-sEVs) have antioxidative and prohealing effects on a rat LPS-induced pulpitis model by enhancing the survival, proliferation and odontogenesis of H2O2-injured dental pulp stem cells (DPSCs). Additionally, DFSC-sEVs restored the oxidative/antioxidative balance in DPSC mitochondria and had comparable effects on ameliorating mitochondrial dysfunction with the mitochondrion-targeted antioxidant Mito-Tempo. To improve the efficacy of DFSC-sEVs, we fabricated an intelligent and injectable hydrogel to release DFSC-sEVs by combining sodium alginate (SA) and the ROS sensor RhB-AC. The newly formed SA-RhB hydrogel efficiently encapsulates DFSC-sEVs and exhibits controlled release of DFSC-sEVs in a HClO/ClO− concentration-dependent manner, providing a synergistic antioxidant effect with DFSC-sEVs. These results suggest that DFSC-sEVs-loaded SA-RhB is a promising minimally invasive treatment for pulpitis by enhancing tissue repair in the pulp wound microenvironment. more...
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- 2024
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16. Rolling Bearing Fault Diagnosis Based on Improved Multi-scale Dispersion Entropy and Deep Extreme Learning Machine.
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Haojie Zhu, Chen Feng, and Jun Tian
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- 2024
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17. Sampling Method of MCMC Algorithm after Neural Network Optimization in Visual Recognition Field.
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XiaoJun Zhan, Ren Zhang, Yuxia Wang, and Jun Tian
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- 2024
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18. An Improved Hippopotamus Optimization Algorithm Utilizing Swarm-Elite Learning Mechanism's Levy Flight and Quadratic Interpolation Operators for Optimal Parameters Extraction in Photovoltaic Models.
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Wentao Wang and Jun Tian
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- 2024
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19. MiKey: Human Key-points Detection Using Millimeter Wave Radar.
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Lili Xie, Hongchun Li, Jun Tian, Qian Zhao, Masahiro Shiraishi, Kenta Ide, Takahiro Yoshioka, and Takeshi Konno
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- 2024
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20. No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies
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Jinhua Chen, Qiuhan Xu, Yiling Wang, Sisi Jiang, Baorong Zhang, and Jun Tian
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Parkinson's disease ,Ankylosing spondylitis ,Mendelian randomization ,Single nucleotide polymorphisms ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Retrospective cohort and cross-sectional studies have indicated an association between ankylosing spondylitis (AS) and Parkinson's disease (PD). However, owing the multitude of limitations, a consistent conclusion has not been determined. Furthermore, whether a causal relationship exists between these two diseases remains unclear. Methods: We conducted a two-way Mendelian randomization (MR) analysis using genome-wide association study data. For patients with PD, we utilised data from the ieu-b-7 database, whereas for patients with AS, we employed the three databases with the largest sample sizes for a combined analysis. These databases included ebi-a-GCST005529, finn-b-M13 ANKYLOSPON, and finn-b-M13 ANKYLOSPON STRICT. Our primary method of analysis was inverse variance weighting (IVW), supplemented by four other effective methods, to comprehensively infer a potential causal relationship between AS and PD. Additionally, we conduct various sensitivity analyses to assess the robustness of our estimates. Results: Based on our IVW MR analysis, no significant causal relationship between AS and PD was observed (odds ratio [OR] = 1.01, 95 % confidence interval [CI] = 0.99–1.03, P = 0.26). Additionally, our reverse MR analysis found no evidence supporting a significant causal relationship between PD and AS (OR = 0.93, 95 % CI = 0.85–1.01, P = 0.068). These results were substantiated by comprehensive sensitivity analyses that indicated minimal bias in the causal estimates. Conclusion: In contrast to numerous existing clinical studies, this study failed to provide evidence supporting a significant impact of AS on PD risk, or vice versa. Further investigations regarding the potential causal mechanisms linking AS and PD are warranted. more...
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- 2024
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21. Bladder cancer immune-related markers: diagnosis, surveillance, and prognosis
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Tiantian Yang, Wanru Luo, Jie Yu, Huiping Zhang, Meichun Hu, and Jun Tian
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bladder cancer ,immune-related markers ,tumor immune microenvironment ,diagnosis ,treatment ,prognosis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
As an immune-related tumor type, bladder cancer has been attracting much attention in the study of its markers. In recent years, researchers have made rapid progress in the study of immune-related markers for bladder cancer. Studies have shown that immune-related markers play an important role in the diagnosis, prognosis assessment and treatment of bladder cancer. In addition, the detection of immune-related markers can also be used to evaluate the efficacy of immunotherapy and predict the treatment response of patients. Therefore, in depth study of the expression of immune-related markers in bladder cancer and their application in the clinic is of great significance and is expected to provide new breakthroughs for individualized treatment of bladder cancer. Future studies will focus more on how to detect immune-related markers with low cost and high accuracy, as well as develop new immunotherapeutic strategies to bring better therapeutic outcomes to bladder cancer patients. more...
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- 2024
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22. Multilevel threshold segmentation of rice plant images utilizing tuna swarm optimization algorithm incorporating quadratic interpolation and elite swarm genetic operators.
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Wentao Wang, Chen Ye, Zhongjie Pan, and Jun Tian
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- 2025
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23. p‐Anisaldehyde suppresses Aspergillus flavus infection and aflatoxin biosynthesis via targeting cell structure and Ap1‐regulatory antioxidant system
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Tongzheng Sun, Ninghui Zhang, Yue Luo, Han Qiu, Qingru Geng, Yongxin Li, Xue Peng, Fengqin Song, Jun Tian, and Kunlong Yang
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aflatoxin ,antifungal activity ,Aspergillus flavus ,p‐anisaldehyde ,reactive oxygen species ,superoxide dismutase ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Aflatoxin, mainly produced by Aspergillus flavus, is one of the most notorious mycotoxin for its toxicity and carcinogenicity. Despite extensive efforts, effective strategies to control A. flavus and AFB1 contamination remain elusive. Here, we investigate the potential of p‐anisaldehyde (AS), an aldehyde derived from plant essential oils, as a natural antifungal agent against A. flavus and its ability to modulate AFB1 biosynthesis. We found that AS exhibited broad‐spectrum antifungal activities against Aspergillus spp. and effectively inhibited A. flavus asexual development, AFB1 production, and pathogenicity. AS treatment disrupted the cell surface structure and membrane integrity, as observed by scanning electron microscopy and PI staining. RNA‐sequencing analysis revealed that AS significantly altered the expression of genes involved in redox homeostasis, plasma membrane function, and cell cycle progression. Further investigation demonstrated that AS induced a reduction in mitochondrial membrane potential (Δψm) and accumulation of reactive oxygen species (ROS), leading to cell cycle arrest at the G2/M phase. The AS‐induced ROS accumulation was found to be mitigated by the superoxide dismutase‐mediated antioxidant system, which is regulated by transcriptional factor Ap1. Notably, the Ap1‐regulatory ROS detoxification system was also found to be involved in A. flavus pathogenicity and AFB1 production. Overall, these findings provide valuable insights into the inhibitory mechanism of AS against A. flavus, paving the way for its potential application as a natural strategy to mitigate AFB1 contamination in both food and agriculture crops. more...
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- 2024
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24. The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson’s disease
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Wenyi Yang, Xueqin Bai, Xiaojun Guan, Cheng Zhou, Tao Guo, Jingjing Wu, Xiaojun Xu, Minming Zhang, Baorong Zhang, Jiali Pu, and Jun Tian
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Parkinson’s disease ,Magnetic resonance imaging ,Subcortical nuclei ,Putamen ,Pallidum ,Medicine ,Science - Abstract
Abstract Brain structural changes in Parkinson’s disease (PD) are progressive throughout the disease course. Changes in surface morphology with disease progression remain unclear. This study aimed to assess the volumetric and shape changes of the subcortical nuclei during disease progression and explore their association with clinical symptoms. Thirty-four patients and 32 healthy controls were enrolled. The global volume and shape of the subcortical nuclei were compared between patients and controls at baseline. The volume and shape changes of the subcortical nuclei were also explored between baseline and 2 years of follow-up. Association analysis was performed between the volume of subcortical structures and clinical symptoms. In patients with PD, there were significantly atrophied areas in the left pallidum and left putamen, while in healthy controls, the right putamen was dilated compared to baseline. The local morphology of the left pallidum was correlated with Mini Mental State Examination scores. The left putamen shape variation was negatively correlated with changes in Unified Parkinson’s Disease Rating Scale PART III scores. Local morphological atrophy of the putamen and pallidum is an important pathophysiological change in the development of PD, and is associated with motor symptoms and cognitive status in patients with PD. more...
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- 2024
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25. Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances
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Xiangya Huang, Yaxin Lou, Yihong Duan, He Liu, Jun Tian, Ya Shen, and Xi Wei
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Biomaterial scaffolds ,Maxillofacial region ,Bone regeneration ,Tissue engineering ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape, complex structure, and unique biological functions. Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity, costs, operational convenience. etc. In this review, we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy, which provide basis and directions for future scaffold design. Latest advances of these scaffolds are then discussed, as well as future perspectives and challenges. Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering. more...
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- 2024
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26. Development of Optical Fiber Light-Transmitting Concrete (LTC)—A Review
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Jian Bai, Weiguo Zhang, Jun Tian, Xiaowei Wu, and Mingfang Zheng
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light-transmitting concrete ,transmittance ,mechanical properties ,durability ,microstructure ,Building construction ,TH1-9745 - Abstract
In recent years, the use of new and unique building materials to achieve green building goals has attracted a lot of attention. Optical fiber light-transmitting concrete (LTC) makes it possible for light to pass through concrete. Its ornamental value and excellent light transmission have received much attention from scholars. However, the application of optical fiber LTC in the construction industry has not yet been promoted due to the tedious preparation process and insufficient research on its mechanical properties and durability. This paper reviews the research results of optical fiber LTC in terms of product preparation, light transmission, mechanical properties, durability, and microstructures. The light transmission of optical fiber LTCs is positively correlated with fiber content and negatively correlated with fiber diameter and fiber spacing. However, how the combination of these factors affects LTC transmittance remains to be investigated. In addition to fiber parameters, cement matrix properties and other environmental factors (light intensity, incidence angle, and aging) should also be considered to explore the suitability of LTC. The fiber–matrix interface bond strength needs further investigation and efforts should be made to improve it. This paper also summarizes the future challenges and research directions of optical fiber LTC, which is expected to provide guidance for the application of optical fiber LTC. It is anticipated that fiber-optic LTC will be promoted as a new building material. more...
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- 2024
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27. Carbon emissions of durable FRP composite structures in civil engineering
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Liu, TianQiao, Tang, Jun-Tian, Zhang, Shaojie, Dong, Li, Hu, Lili, Meng, Xinmiao, Zhao, Yange, and Feng, Peng
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- 2024
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28. Model-free visual servoing based on active disturbance rejection control and adaptive estimator for robotic manipulation without calibration.
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Jun Tian, Xungao Zhong, Xiafu Peng, Huosheng Hu, and Qiang Liu 0003
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- 2024
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29. Imbalanced Open Set Domain Adaptation via Moving-Threshold Estimation and Gradual Alignment.
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Jinghan Ru, Jun Tian, Chengwei Xiao, Jingjing Li 0001, and Heng Tao Shen
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- 2024
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30. Study on deterioration of mechanical properties and voltage-strength theoretical model of CFRP/ conductive ECC composites under coupling effect of anode polarization, load and erosion environment
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Jun Tian, Wentao Yu, Xiaowei Wu, Yu Zheng, Jinyun Yuan, Wen-Wei Wang, Kang Gao, Weiguo Zhang, and Mingfang Zheng
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ICCP-SS technology ,CFRP ,Current density ,ECC ,Tensile strength ,Voltage-strength theoretical model ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
This study aims to systematically investigate the deterioration of tensile properties, voltage variation, and voltage-strength theoretical model of CFRP/ conductive ECC composites under coupling effect of anode polarization, load and erosion environment. The effects of testing parameters including conductive ECC mixture type, electric current density, polarization time, tensile stress value, sulfate soak time, and sulfate attack-wet and dry cycle time were synthetically investigated. The experimental results indicated that the voltage increases approximately linearly with the increase of degradation time in the voltage-deterioration time curves. The stress-strain curve can be divided into three stages: the stress-strain linear increase stage, the strain hardening characteristic stage, and the decline stage during failure. The conductive ECC mixture type, polarization time, current density, tensile stress value, sulfate soak time, and sulfate attack-wet and dry cycle time all have significant effects the deterioration of tensile strength and the voltage change ratio of CFRP/ conductive ECC composite. More importantly, an innovative voltage-strength theoretical model was proposed, which can predict the relationship between voltage and material deterioration strength. The theoretical model is in good agreement not only with the experimental results of this study, but also with the results of other studies. The model proposed can be used to predict deterioration degree of materials in real time, which has very important guiding significance for impressed current cathodic protection-structural strengthening technology (ICCP-SS) technology. This study is expected to promote a more comprehensive understanding of the deterioration of mechanical properties and voltage-strength theoretical model of CFRP/conductive ECC composites for ICCP-SS technology. more...
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- 2024
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31. Investigation of basic properties, microscopic characteristics, and optimized ratio prediction model of ultra-high steel fiber reinforced concrete
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Weiguo Zhang, Jun Tian, Xiaowei Wu, Yu Zheng, Yang Zuo, Kang Gao, Wenwei Wang, and Wentong Huang
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Ultra-high steel fiber reinforced concrete (UHSFRC) ,Fly ash (FA) and silica fume (SF) ,Workability ,Mechanical properties ,Microstructure ,Economic and environmental analysis ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Ultra-high steel fiber reinforced concrete (UHSFRC) has poor workability and a low cost-performance ratio, and the application of active admixtures can overcome these shortcomings of UHSFRC. This work investigated the feasibility of fly ash (FA) and silica fume (SF) to improve the performance of SFRC and evaluate the effects of FA and SF on the workability, mechanical properties, microstructure, and economic/environmental performance of UHSFRC. The results showed that FA and SF can increase the slump, compressive, and splitting tensile strength of UHSFRC. Compared with control tests, the slump, 28-d compressive, and 28-d splitting tensile strength increased by 43.25 %, 29.35 %, and 55.72 %, respectively. More importantly, microscopic analysis showed that FA and SF have balling, filling, and adsorption effects, and increase peak intensity of C-S-H gel and ettringite, promoting secondary hydration of cement. According to the experimental data and mechanistic analysis, an innovatively optimized ratio prediction model is adopted to establish the relationship between the slump, compressive, and splitting tensile strength of UHSFRC and the content of FA and SF, and the testing error was less than 5 %, indicating that the model is feasible. Moreover, the effect of FA and SF content on cost-performance ratio, carbon emission, and energy consumption of UHSFRC was predicted. The economic/environmental analysis showed the mixing of FA and SF can improve the cost-performance ratio of UHSFRC and reduce carbon emission and energy consumption. This study can provide theoretical guidance for the improvement of the workability and mechanical properties of UHSFRC, and have important research implications for the improvement of the life cycle assessment of UHSFRCs. The results of the study also have some limitations, and further validation is needed for normal steel fiber concrete (compressive strength of 30–60 MPa, with fibers with a length of 30–60 mm and diameter of approx. 1 mm). more...
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- 2024
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32. Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review
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Zhihao Lai, Qing Shu, Yue Song, Ao Tang, and Jun Tian
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mesenchymal stem cells (MSCs) ,DNA methylation ,DNA methyltransferases (DNMTs) ,Ten-eleven translocation family proteins (TETs) ,osteogenic differentiation ,signaling pathway ,Genetics ,QH426-470 - Abstract
Mesenchymal stem cells (MSCs) have promising potential for bone tissue engineering in bone healing and regeneration. They are regarded as such due to their capacity for self-renewal, multiple differentiation, and their ability to modulate the immune response. However, changes in the molecular pathways and transcription factors of MSCs in osteogenesis can lead to bone defects and metabolic bone diseases. DNA methylation is an epigenetic process that plays an important role in the osteogenic differentiation of MSCs by regulating gene expression. An increasing number of studies have demonstrated the significance of DNA methyltransferases (DNMTs), Ten-eleven translocation family proteins (TETs), and MSCs signaling pathways about osteogenic differentiation in MSCs. This review focuses on the progress of research in these areas. more...
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- 2024
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33. Single‐Stranded Nucleic Acid Transmembrane Molecular Carriers Based on Positively Charged Helical Foldamers
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Yunpeng Ge, Wencan Li, Jun Tian, Hao Yu, Zhenzhu Wang, Ming Wang, and Zeyuan Dong
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electrostatic interactions ,helical foldamers ,molecular carriers ,RNA delivery ,transmembrane transport ,Science - Abstract
Abstract Transmembrane delivery of biologically active nucleic acids is an important process in cells and has inspired one to develop advanced drug delivery techniques. In this contribution, molecular‐level single‐stranded nucleic acid transmembrane carriers are reported based on 3.2 nm long Huc's foldamers (AOrnQ3Q3)8 and (mQ3Q2)8 with linearly and helically aligned positive charges, respectively. These two foldamers not only show very strong DNA affinity via electrostatic interactions but also discriminatively bind single‐stranded DNA (ss‐DNA) and double‐stranded DNA (ds‐DNA), corroborating the importance of precise charge arrangement in the electrostatic interactions. More importantly, these two foldamers are capable of efficiently transporting ss‐DNA across the lipid membranes, and the ss‐DNA transport activity of (AOrnQ3Q3)8 with linearly aligned charges is higher than that of (mQ3Q2)8 with helically aligned charges. Thus a type of novel single‐stranded nucleic acid transmembrane molecular carriers based on positively charged helical foldamers are introduced. Further, effective and enhanced expression in EGFP‐mRNA transfection experiments strongly demonstrates the potential of positively charged foldamers for RNA transmembrane transport and therapy. more...
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- 2024
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34. Design and implementation of a scalable correlator based on ROACH2 + GPU cluster for tianlai 96-dual-polarization antenna array
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Zhao Wang, Ji-Xia Li, Ke Zhang, Feng-Quan Wu, Hai-Jun Tian, Chen-Hui Niu, Ju-Yong Zhang, Zhi-Ping Chen, Dong-Jin Yu, and Xue-Lei Chen
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interferometer ,correlator ,FPGA ,signal processing ,correlation ,radio astronomy ,Astronomy ,QB1-991 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
The digital correlator is one of the most crucial data processing components of a radio telescope array. With the scale of radio interferometeric array growing, many efforts have been devoted to developing a cost-effective and scalable correlator in the field of radio astronomy. In this paper, a 192-input digital correlator with six CASPER ROACH2 boards and seven GPU servers has been deployed as the digital signal processing system for Tianlai cylinder pathfinder located in Hongliuxia observatory. The correlator consists of 192 input signals (96 dual-polarization), 125-MHz bandwidth, and full-Stokes output. The correlator inherits the advantages of the CASPER system, for example, low cost, high performance, modular scalability, and a heterogeneous computing architecture. With a rapidly deployable ROACH2 digital sampling system, a commercially expandable 10 Gigabit switching network system, and a flexible upgradable GPU computing system, the correlator forms a low-cost and easily-upgradable system, poised to support scalable large-scale interferometeric array in the future. more...
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- 2024
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35. Immunotherapy combined with antiangiogenic therapy as third‐ or further‐line therapy for stage IV non‐small cell lung cancer patients with ECOG performance status 2: A retrospective study
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Shuo Li, Ze‐Shun Yu, Hong‐Zhi Liu, Shu‐Jing Li, Ming‐Yue Wang, Fang‐Ling Ning, and Li‐Jun Tian
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antiangiogenic therapy ,Eastern Cooperative Oncology Group ,immunotherapy ,non‐small cell lung cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Patients with Eastern Cooperative Oncology Group performance status (ECOG PS) 2 probably cannot tolerate chemotherapy or other antitumor therapies. Some studies have reported that immunotherapy combined with antiangiogenic therapy is well‐tolerated and shows good antitumor activity. However, the efficacy of this combination as a later‐line therapy in patients with ECOG PS 2 is unclear. This study evaluated the effectiveness and safety of this combination strategy as third‐ or further‐line therapy in stage IV non‐small cell lung cancer (NSCLC) patients with ECOG PS 2. Methods In this retrospective study, patients treated with camrelizumab plus antiangiogenic therapy (bevacizumab, anlotinib, or recombinant human endostatin) were included. Objective response rate (ORR), disease control rate (DCR), progression‐free survival (PFS), overall survival (OS), quality of life (QOL) assessed by ECOG PS, and safety were analyzed. Results Between January 10, 2019, and February 28, 2024, a total of 59 patients were included. The ORR was 35.6% (21/59) and the DCR was 86.4%. With a median follow‐up of 10.5 months (range: 0.7–23.7), the median PFS was 5.5 months (95% confidence interval [CI]: 3.8–7.3) and the median OS was 10.5 months (95% CI: 11.2–13.6). QOL was improved (≥1 reduction in ECOG PS) in 39 patients (66.1%). The most common Grade 3–4 treatment‐related adverse events were hepatic dysfunction (6 [10%]), hypertension (5 [8%]), and hypothyroidism (3 [5%]). There were no treatment‐related deaths. Conclusions Third‐ or further‐line immunotherapy combined with antiangiogenic therapy is well‐tolerated and shows good antitumor activity in stage IV NSCLC patients with ECOG PS 2. Future large‐scale prospective studies are required to confirm the clinical benefits of this combination therapy. more...
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- 2024
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36. CNN-LSTM based incremental attention mechanism enabled phase-space reconstruction for chaotic time series prediction
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Xiao-Qian Lu, Jun Tian, Qiang Liao, Zheng-Wu Xu, and Lu Gan
- Subjects
Chaotic time series ,Incremental attention mechanism ,Phase-space reconstruction ,Electronic computers. Computer science ,QA75.5-76.95 ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
To improve the prediction accuracy of chaotic time series and reconstruct a more reasonable phase space structure of the prediction network, we propose a convolutional neural network (CNN)-long short-term memory (LSTM) prediction model based on the incremental attention mechanism. Firstly, a traversal search is conducted through the traversal layer for finite parameters in the phase space. Then, an incremental attention layer is utilized for parameter judgment based on the dimension weight criteria (DWC). The phase space parameters that best meet DWC are selected and fed into the input layer. Finally, the constructed CNN-LSTM network extracts spatiotemporal features and provides the final prediction results. The model is verified using Logistic, Lorenz, and sunspot chaotic time series, and the performance is compared from the two dimensions of prediction accuracy and network phase space structure. Additionally, the CNN-LSTM network based on incremental attention is compared with LSTM, CNN, recurrent neural network (RNN), and support vector regression (SVR) for prediction accuracy. The experiment results indicate that the proposed composite network model possesses enhanced capability in extracting temporal features and achieves higher prediction accuracy. Also, the algorithm to estimate the phase space parameter is compared with the traditional CAO, false nearest neighbor, and C–C, three typical methods for determining the chaotic phase space parameters. The experiments reveal that the phase space parameter estimation algorithm based on the incremental attention mechanism is superior in prediction accuracy compared with the traditional phase space reconstruction method in five networks, including CNN-LSTM, LSTM, CNN, RNN, and SVR. more...
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- 2024
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37. Anomalously bright single-molecule upconversion electroluminescence
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Yang Luo, Fan-Fang Kong, Xiao-Jun Tian, Yun-Jie Yu, Shi-Hao Jing, Chao Zhang, Gong Chen, Yang Zhang, Yao Zhang, Xiao-Guang Li, Zhen-Yu Zhang, and Zhen-Chao Dong
- Subjects
Science - Abstract
Abstract Efficient upconversion electroluminescence is highly desirable for a broad range of optoelectronic applications, yet to date, it has been reported only for ensemble systems, while the upconversion electroluminescence efficiency remains very low for single-molecule emitters. Here we report on the observation of anomalously bright single-molecule upconversion electroluminescence, with emission efficiencies improved by more than one order of magnitude over previous studies, and even stronger than normal-bias electroluminescence. Intuitively, the improvement is achieved via engineering the energy-level alignments at the molecule−substrate interface so as to activate an efficient spin-triplet mediated upconversion electroluminescence mechanism that only involves pure carrier injection steps. We further validate the intuitive picture with the construction of delicate electroluminescence diagrams for the excitation of single-molecule electroluminescence, allowing to readily identify the prerequisite conditions for producing efficient upconversion electroluminescence. These findings provide deep insights into the microscopic mechanism of single-molecule upconversion electroluminescence and organic electroluminescence in general. more...
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- 2024
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38. Toxicokinetics of MDMA and Its Metabolite MDA in Rats
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Wei-guang YU, Qiang HE, Zheng-di WANG, Cheng-jun TIAN, Jin-kai WANG, Qian ZHENG, Fei REN, Chao ZHANG, You-mei WANG, Peng XU, Zhi-wen WEI, Ke-ming YUN
- Subjects
forensic medicine ,toxicology ,toxicokinetics ,3,4-methylenedioxy-n-methylamphetamine ,4,5-methylene dioxy amphetamine ,model ,rats ,Medicine - Abstract
Objective To investigate the toxicokinetic differences of 3,4-methylenedioxy-N-methylamphetamine (MDMA) and its metabolite 4,5-methylene dioxy amphetamine (MDA) in rats after single and continuous administration of MDMA, providing reference data for the forensic identification of MDMA. Methods A total of 24 rats in the single administration group were randomly divided into 5, 10 and 20 mg/kg experimental groups and the control group, with 6 rats in each group. The experimental group was given intraperitoneal injection of MDMA, and the control group was given intraperitoneal injection of the same volume of normal saline as the experimental group. The amount of 0.5 mL blood was collected from the medial canthus 5 min, 30 min, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h after administration. In the continuous administration group, 24 rats were randomly divided into the experimental group (18 rats) and the control group (6 rats). The experimental group was given MDMA 7 d by continuous intraperitoneal injection in increments of 5, 7, 9, 11, 13, 15, 17 mg/kg per day, respectively, while the control group was given the same volume of normal saline as the experimental group by intraperitoneal injection. On the eighth day, the experimental rats were randomly divided into 5, 10 and 20 mg/kg dose groups, with 6 rats in each group. MDMA was injected intraperitoneally, and the control group was injected intraperitoneally with the same volume of normal saline as the experimental group. On the eighth day, 0.5 mL of blood was taken from the medial canthus 5 min, 30 min, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h after administration. Liquid chromatography-triple quadrupole tandem mass spectrometry was used to detect MDMA and MDA levels, and statistical software was employed for data analysis. Results In the single-administration group, peak concentrations of MDMA and MDA were reached at 5 min and 1 h after administration, respectively, with the largest detection time limit of 12 h. In the continuous administration group, peak concentrations were reached at 30 min and 1.5 h after administration, respectively, with the largest detection time limit of 10 h. Nonlinear fitting equations for the concentration ratio of MDMA and MDA in plasma and administration time in the single-administration group and continuous administration group were as follows: T=10.362C-1.183, R2=0.974 6; T=7.397 3C-0.694, R2=0.961 5 (T: injection time; C: concentration ratio of MDMA to MDA in plasma). Conclusions The toxicokinetic data of MDMA and its metabolite MDA in rats, obtained through single and continuous administration, including peak concentration, peak time, detection time limit, and the relationship between concentration ratio and administration time, provide a theoretical and data foundation for relevant forensic identification. more...
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- 2024
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39. Inhibiting oxygen vacancies and twisting NbO6 octahedron in erbium modified KNN-based multifunctional ceramics
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Lulu Gao, Zhiyong Liu, Pengrong Ren, Renhong Liang, Ting Li, Kun Guo, Bing Xie, Jinshan Lu, Pu Mao, Jun Tian, and Longlong Shu
- Subjects
KNN ,Upconversion photoluminescence ,Multifunctional ceramics ,Oxygen vacancy ,Octahedron ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
It is a challenge to obtain highly tunable multifunctional performances in one ferroelectric system by a simple approach to meet the miniaturization, integration, and functionalization requirements of advanced electronic components. Herein, rare earth erbium (Er) modulated 0.9K0.5Na0.5NbO3-0.1Sr(1-x)ErxTi(1-x/4)O3, (0.9KNN-0.1ST: xEr) transparent-photoluminescent-ferroelectric energy storage multifunctional ceramics are prepared to solve this problem. The effect of lattice distortion and oxygen vacancies by Er doping on the optical and electrical properties is systematically investigated. The Er3+ ions can introduce a large distortion of the NbO6 octahedron by replacing the A-site in KNN-based ceramics. Thanks to the higher c/a ratio and lower oxygen vacancy content are simultaneously obtained in 0.9KNN-0.1ST: 0.1Er ceramics. The effective energy storage density (Wrec) of 0.86 J/cm3, excellent near-infrared transmittance of 51.7% (1 100 nm) and strong green upconversion photoluminescence are achieved in this multifunctional ceramic. This study provides a solid basis for rare earth ions doped ferroelectric ceramics with tunable multifunctional properties and has significant potential for applications in optoelectronic devices. more...
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- 2024
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40. Prevalence and genetic evolution of porcine reproductive and respiratory syndrome virus in commercial fattening pig farms in China
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Chao Li, Jing Zhao, Wansheng Li, Hu Xu, Bangjun Gong, Qi Sun, Zhenyang Guo, Jinhao Li, Lirun Xiang, Yan-dong Tang, Chaoliang Leng, Qian Wang, Jinmei Peng, Guohui Zhou, Huairan Liu, Tongqing An, Xuehui Cai, Zhi-Jun Tian, and Hongliang Zhang more...
- Subjects
Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background To investigate the prevalence and evolution of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) at commercial fattening pig farms, a total of 1397 clinical samples were collected from a single fattening cycle at seven pig farms in five provinces of China from 2020 to 2021. Results The RT‒PCR results revealed that PRRSV was present on all seven farms, and the percentage of PRRSV-positive individuals was 17.54–53.33%. A total of 344 partial NSP2 gene sequences and 334 complete ORF5 gene sequences were obtained from the positive samples. The statistical results showed that PRRSV-2 was present on all seven commercial fattening farms, and PRRSV-1 was present on only one commercial fattening farm. A total of six PRRSV-2 subtypes were detected, and five of the seven farms had two or more PRRSV-2 subtypes. L1.8 (L1C) PRRSV was the dominant epidemic strain on five of the seven pig farms. Sequence analysis of L1.8 (L1C) PRRSV from different commercial fattening pig farms revealed that its consistency across farms varied substantially. The amino acid alignment results demonstrated that there were 131 aa discontinuous deletions in NSP2 between different L1.8 (L1C) PRRSV strains and that the GP5 mutation in L1.8 (L1C) PRRSV was mainly concentrated in the peptide signal region and T-cell epitopes. Selection pressure analysis of GP5 revealed that the use of the PRRSV MLV vaccine had no significant episodic diversifying effect on L1.8 (L1C) PRRSV. Conclusion PRRSV infection is common at commercial fattening pig farms in China, and the percentage of positive individuals is high. There are multiple PRRSV subtypes of infection at commercial fattening pig farms in China. L1.8 (L1C) is the main circulating PRRSV strain on commercial fattening pig farms. L1.8 (L1C) PRRSV detected at different commercial fattening pig farms exhibited substantial differences in consistency but similar molecular characteristics. The pressure on the GP5 of L1.8 (L1C) PRRSV may not be directly related to the use of the vaccines. more...
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- 2024
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41. Efficacy and safety of chinese herbal medicines combined with chemical drugs for alzheimer's disease: A systematic review and meta-analysis
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Li Xu, Wen-Jun Chen, Cai-Jun Tian, Yan Zhang, Yan Ma, Tian-Hao Li, Hong-Jie Liu, and Zhe Zhang
- Subjects
alzheimer's disease ,chinese herbal medicine ,donepezil ,memantine ,meta-analysis ,randomized controlled trials ,rivastigmine ,Medicine (General) ,R5-920 - Abstract
Objective: To evaluate the efficacy and safety of Chinese herbal medicines (CHMs) combined with chemical drugs for the treatment of Alzheimer's disease (AD). Materials and Methods: Databases were searched to retrieve randomized controlled trials (RCTs) of CHMs combined with tacrine, galantamine, rivastigmine, donepezil, or memantine, following strict inclusion and exclusion criteria. Only research papers published in English, Chinese, and Japanese were considered. The primary outcome was the mini-mental state examination (MMSE) score and the secondary outcomes were AD assessment scale cognitive subscale (ADAS-Cog) score and safety evaluation. Meta-analysis was carried out using RevMan 5.3 and subgroup analysis was conducted to identify the sources of heterogeneity. Results: A total of 15 RCTs with 1386 participants were included in this study. Only donepezil was used in the retrieved literature. Meta-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score (Z = 9.45; P < 0.00001; weighted mean difference [WMD] =2.68, 95% confidence interval [CI]: 2.12–3.24) and a significant decrease in the ADAS-Cog score (Z = 5.53; P < 0.00001; WMD = −3.79; 95% CI: −5.13–−2.44). Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia (risk ratio [RR] =0.20, 95% CI: 0.06–0.68; P = 0.01) and hive (RR = 0.10; 95% CI: 0.01–0.73; P = 0.02). Conclusions: The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone. more...
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- 2024
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42. Enhanced strength-ductility synergy in a wire and arc additively manufactured Mg alloy via tuning interlayer dwell time
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Dong Ma, Chunjie Xu, Shang Sui, Jun Tian, Can Guo, Xiangquan Wu, Zhongming Zhang, Dan Shechtman, and Sergei Remennik
- Subjects
Wire arc additive manufacturing ,Interlayer dwell time ,Strength-ductility ,Magnesium alloys ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Strength-ductility trade-off is a common issue in Mg alloys. This work proposed that a synergistic enhancement of strength and ductility could be achieved through tuning interlayer dwell time (IDT) in the wire and arc additive manufacturing (WAAM) process of Mg alloy. The thermal couples were used to monitor the thermal history during the WAAM process. Additionally, the effect of different IDTs on the microstructure characteristics and resultant mechanical properties of WAAM-processed Mg alloy thin-wall were investigated. The results showed that the stable temperature of the thin-wall component could reach 290 °C at IDT=0s, indicating that the thermal accumulation effect was remarkable. Consequently, unimodal coarse grains with an average size of 39.6 µm were generated, and the resultant room-temperature tensile property was poor. With the IDT extended to 60s, the thermal input and thermal dissipation reached a balance, and the stable temperature was only 170 °C, closing to the initial temperature of the substrate. A refined grain structure with bimodal size distribution was obtained. The remelting zone had fine grains with the size of 15.2 µm, while the arc zone owned coarse grains with the size of 24.5 µm. The alternatively distributed coarse and fine grains lead to the elimination of strength-ductility trade-off. The ultimate tensile strength and elongation of the samples at IDT=60s are increased by 20.6 and 75.0% of those samples at IDT=0s, respectively. The findings will facilitate the development of additive manufacturing processes for advanced Mg alloys. more...
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- 2023
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43. A novel inherited CARD9 deficiency in an otherwise healthy woman with CNS candidiasis
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Zhou, Ling-Hong, Qiu, Wen-Jia, Que, Chun-Xing, Cheng, Jia-Hui, Zhu, Rong-Sheng, Huang, Jun-Tian, Jiang, Ying-Kui, Zhao, Hua-Zhen, Wang, Xuan, Cheng, Xun-Jia, and Zhu, Li-Ping
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- 2024
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44. Single-photon imaging over 200 km
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Li, Zheng-Ping, Ye, Jun-Tian, Huang, Xin, Jiang, Peng-Yu, Cao, Yuan, Hong, Yu, Yu, Chao, Zhang, Jun, Zhang, Qiang, Peng, Cheng-Zhi, Xu, Feihu, and Pan, Jian-Wei
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Physics - Optics - Abstract
Long-range active imaging has widespread applications in remote sensing and target recognition. Single-photon light detection and ranging (lidar) has been shown to have high sensitivity and temporal resolution. On the application front, however, the operating range of practical single-photon lidar systems is limited to about tens of kilometers over the Earth's atmosphere, mainly due to the weak echo signal mixed with high background noise. Here, we present a compact coaxial single-photon lidar system capable of realizing 3D imaging at up to 201.5 km. It is achieved by using high-efficiency optical devices for collection and detection, and what we believe is a new noise-suppression technique that is efficient for long-range applications. We show that photon-efficient computational algorithms enable accurate 3D imaging over hundreds of kilometers with as few as 0.44 signal photons per pixel. The results represent a significant step toward practical, low-power lidar over extra-long ranges., Comment: 6 pages, 6 figures more...
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- 2021
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45. Photometry and Models of Seven Main-Belt Asteroids
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Jun Tian, Haibin Zhao, Bin Li, Yongxiong Zhang, Jian Chen, Leonid Elenin, and Xiaoping Lu
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asteroids ,photometry ,individual (2233) Kuznetsov ,individual (2294) Andronikov ,individual (2253) Espinette ,Elementary particle physics ,QC793-793.5 - Abstract
The China Near-Earth Object Survey Telescope (CNEOST) conducted four photometric surveys from 2015 to 2018 using image processing and aperture photometry techniques to obtain extensive light curve data on asteroids. The second-order Fourier series method was selected for its efficiency in determining the rotation periods of the observed asteroids. Our study successfully derived rotation periods for 892 asteroids, with 648 of those matching values recorded in the LCDB (for asteroids with U > 2). To enhance the reliability of the derived spin parameters and shape models, we also amassed a comprehensive collection of published light curve data supplemented by additional photometric observations on a targeted subset of asteroids conducted using multiple telescopes between 2021 and 2022. Through the application of convex inversion techniques, we successfully derived spin parameters and shape models for seven main-belt asteroids (MBAs): (2233) Kuznetsov, (2294) Andronikov, (2253) Espinette, (4796) Lewis, (1563) Noel, (2912) Lapalma, and (5150) Fellini. Our thorough analysis identified two credible orientations for the rotational poles of these MBAs, shedding light on the prevalent issue of “ambiguity in pole direction” that often accompanies photometric inversion processes. CNEOST continues its observational endeavors, and future collected data combined with other independent photometric measurements will facilitate further inversion to better constrain the spin parameters and yield more refined shape models. more...
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- 2024
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46. Exploring the molecular mechanism underlying the psoriasis and T2D by using microarray data analysis
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Li Yang, Lei Zhang, Qingfang Du, Xiaoyu Gong, and Jun Tian
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Medicine ,Science - Abstract
Abstract Although a large number of evidence has identified that psoriasis is significantly correlated with type 2 diabetes (T2D), the common molecular mechanism of its occurrence remains unclear. Our study aims to further elucidate the mechanism of the occurrence of this complication. We obtained the gene expression data of psoriasis (GSE30999) and T2D (GSE28829) from the Gene Expression Omnibus (GEO) dataset. Then the common differentially expressed genes (DEGs) of T2D and psoriasis were identified. After that, we performed three types of analyses about these DEGs, including functional enrichment analysis, protein–protein interaction (PPI) network and module manufacture, hub genes identification and co-expression analysis. 132 common DEGs (14 upregulated genes and 118 downregulated genes) were identified for subsequent a series of analyses. Function enrichment analysis demonstrated that Rap1 signaling pathway, PI3K-Akt signaling pathway, and cGMP-PKG signaling pathway may play a significant role in pathogenesis of psoriasis and T2D. Finally, 3 important hub genes were selected by utilizing cytoHubba, including SNRPN, GNAS, IGF2. Our work reveals the potential common signaling pathways of psoriasis and T2D. These Hub genes and common signaling pathways provide insights for further investigation of molecular mechanism about psoriasis and T2D. more...
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- 2023
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47. Microstructural evolution and mechanical properties of Mg-8.1Gd-2.6Y-0.7Zn-0.5Zr alloy by multi-layer wire arc additive manufacturing
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Dong Ma, Chunjie Xu, Yuanshen Qi, Shang Sui, Jun Tian, Tao Tu, Can Guo, Xiangquan Wu, Zhongming Zhang, Sergei Remennik, and Dan Shechtman
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Wire arc additive manufacturing ,Mg-Gd-Y-Zn-Zr alloys ,Microstructural evolution ,Mechanical properties ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Wire arc additive manufacturing (WAAM) of Mg-RE (rare-earth)-Zn alloys is important for meeting the requirements of lightweight large-scale components with high manufacturing flexibility. The Mg-8.1Gd-2.6Y-0.7Zn-0.5Zr (GWZ831K, wt.%) alloys were fabricated through the use of WAAM technology, and the microstructure evolution along the building direction and corresponding mechanical properties were then studied. The as-built sample in this paper was composed of finely equiaxed ɑ-Mg grains, eutectic (Mg, Zn)3(Gd, Y) phase, cubic phase, and γʹ precipitates. Furthermore, due to the in-suit heat treatments that were induced by the multiple thermal cycles, more γʹ precipitates were observed in the middle region. The microstructures at different heights were characterized by alternatively distributed fine equiaxed grains (melt pool boundaries, MPB) and coarse equiaxed grains (melt pools, MP). The mechanical properties of the as-built component were found to exhibit yield strength (YS), ultimate tensile strength (UTS), and elongation (EL) of 159 ± 1.0 MPa, 237 ± 4.0 MPa, and 6.7 ± 0.4 % in the building direction (BD) and 163 ± 5.1 MPa, 242 ± 8.7 MPa, and 7.0 ± 0.7 % in the traveling direction (TD). This demonstrates that the WAAM-processed GWZ831K alloy has good isotropy. more...
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- 2023
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48. Refining mechanism for TiN and solidification structure through a nucleating chain in magnesium-yttrium-treated ultrapure ferritic stainless steel
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Xing-Zhi Zhou, De-Yong Wang, Hui-Hua Wang, Yan-Ping Wang, Zhi-Xiao Zhang, Tian-Peng Qu, Jun Tian, and Xiang-Long Li
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Magnesium-yttrium treatment ,TiN inclusion ,Disregistry ,Macro-/microstructure ,Heterogeneous nucleation ,Mining engineering. Metallurgy ,TN1-997 - Abstract
To investigate the refining phenomena of TiN inclusion and macro-/microstructure through heterogeneous nucleation of δ-Fe at TiN encapsulating oxide during solidification in ultrapure ferritic stainless steel, five samples were prepared, denoted as the initial, low-yttrium-treated, moderate-yttrium-treated, high-yttrium-treated, and magnesium-yttrium-treated samples. Based on the results of TiN inclusions, the minimum value of the average size (2.61 μm) and the maximum value of the number density (346.70 mm−2) were observed after magnesium-yttrium (Mg–Y) treatment. Combined with the mechanism analysis, these results reveal that the TiN can be refined because of the following three reasons: (ⅰ) the pure oxides, possessing low planar and/or linear disregistry with TiN; (ⅱ) the complex oxides, including the phase, which possesses extremely low disregistry with TiN; and/or (ⅲ) the increasing number of the oxides. By comparison, finer macrostructures were yielded with the addition of Y-/Mg–Y-based modifiers because of the decreasing nucleation barrier, and the finest macrostructure with equiaxed grain ratio of 100% and average grain size of 1.099 mm was observed in the Mg–Y-treated sample. Coupled with the results of TiN inclusions, therefore, the refining efficiency of macrostructure increases with the number of TiN. Referring to the results of differential scanning colorimetry, a general rule of solidification for metallic materials has been revealed. In addition, the in-situ nucleation-growth of δ-Fe was observed using high temperature laser confocal microscopy, and the microstructures were refined after Y/Mg–Y treatment. Eventually, the interfacial wetting-lattice mismatch heterogeneous nucleation model is successfully applied to evaluate the refining phenomenon of macro-/microstructures. more...
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- 2023
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49. Knowledge, attitude, and practice of psoriasis patients toward their diseases: a web-based, cross-sectional study
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Jun Tian, Lei Zhang, Xiangrong Zhao, and Li Yang
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knowledge ,attitude ,practice ,psoriasis ,questionnaire ,cross-sectional study ,Medicine (General) ,R5-920 - Abstract
ObjectiveTo investigate the knowledge, attitude, and practice (KAP) of psoriasis patients toward the disease.MethodsA web-based cross-sectional study was conducted among psoriasis patients who were diagnosed at the outpatient of Shaanxi Provincial People’s Hospital in March 2023. A self-designed questionnaire was administered for data collection and KAP assessment.ResultsA total of 526 valid questionnaires were included, including 257 males (48.86%) psoriasis patients. Their mean KAP scores were 8.09 ± 3.60 (possible range: 0–12), 31.94 ± 4.61 (possible range: 10–50), and 51.92 ± 8.83 (possible range: 15–75), respectively. Pearson’s correlation analysis showed a positive correlation between knowledge and attitude (r = 0.186, p < 0.001), a positive correlation between knowledge and practice (r = 0.313, p < 0.001), and a negative correlation between attitude and practice (r = −0.181, p < 0.001). Moreover, structural equation model showed that medication (β = 2.74, 95% CI: 2.17, 3.32, p < 0.001) has significantly positive effect on knowledge. Education (β = 0.56, 95% CI: 0.31, 0.81, p < 0.001) and duration of psoriasis (β = 1.01, 95% CI: 0.54, 1.49, p < 0.001) have significantly positive effect on attitude. Knowledge (β = 1.03, 95% CI: 0.80, 1.26, p < 0.001) and medication (β = 4.59, 95% CI: 2.78, 6.40, p < 0.001) has significantly positive effect on practice, while attitude (β = −0.41, 95% CI: −0.57, −0.26, p < 0.001) and duration of psoriasis (β = −2.53, 95% CI: −3.49, −1.57, p < 0.001) exhibit significantly negative effect on practice.ConclusionPsoriasis patients have good knowledge, positive attitude, and proactive practice toward the disease. Education, medication, duration of psoriasis might have effect on their KAP. more...
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- 2024
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50. Investigation on shear performance and prediction model of CFRP-ECC-concrete composite interface suffered from anodic polarization and environmental degradation
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Jun Tian, Wenchao Zhu, Xiaowei Wu, Jinyun Yuan, Yu Zheng, Wen-Wei Wang, Liangliang Wei, Weiguo Zhang, and Mingfang Zheng
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Cement based composite material ,CFRP grid ,CFRP-ECC-Concrete composite interface ,Erosion environment ,Interfacial deterioration ,Anodic polarization ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Building construction ,TH1-9745 - Abstract
This study aims to investigate shear performance and prediction model of CFRP-ECC-concrete composite interface suffered from anodic polarization and environmental degradation. The effect of ECC mixtures, cathodic current densities, polarization period, and the duration of sulfate soaking and sulfate attacking by wet and dry cycles on the interface of the composite were studied. The results showed that three failure modes of CFRP-ECC-concrete composite interface were found. Shear load-slip curves showed double broken lines characteristics, while voltage-deterioration time curves showed an approximate linear increase relationship between voltage and polarization time. The five parameters all had significant effects shear strength deterioration on the CFRP-ECC-concrete composite interface. Moreover, this study proposed an innovative prediction model to the interfacial shear strength by the measured voltage, which can provide an important basic theory for ICCP-SS technology. This work makes a contribution to the ICCP-SS technology on the shear performance and prediction model of composite interface. more...
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- 2024
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