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We propose to present data from both the experimental laboratory and the clinic, together with an analysis of the accumulated literature, in an attempt to further clarify the problem concerning the relationship between the function and structure of the thyroid gland. Extensive clinical and experimental investigations have been conducted with the view of proving or disproving the existence of such a relationship. It is of interest to scrutinize the evidence that has accumulated which may offer an explanation for these widely accepted and possibly correct clinical observations. According to Warthin (1) there do not seem to be any histological criteria, so far as the thyroid epithelium is concerned, that give a pathologic unity to all the clinical forms of thyroid hyperplasia and dysfunction. Rienhoff (2) believes that “associated with a clinical remission, whether artificial or spontaneous, in cases of exophthalmic goiter, involutional changes in the histologic structure of the thyroid gland occur which are...

Excerpt That type of paroxysmal tachycardia associated with a short P-R interval and prolonged QRS complex has long provoked the empirical query of the anatomist, physiologist and clinician alike. ...

The list of medicaments capable of causing agranulocytosis in sensitive persons is steadily increasing. To the list we are adding another, Diamox (2-acetylamino-1,3,4,-thiadiazole-5-sulfonamide), a recently introduced oral diuretic that gives promise of widespread use in the treatment of patients with chronic congestive cardiac failure. REPORT OF A CASE A 66-year-old white woman was admitted to the hospital with vertigo, syncope, numbness of the left hand, weakness, and malaise that had been increasing during the preceding four weeks. In the last four days before admission chills and subacute fever occurred. On admission a blood cell count showed some diminution of the total number of the white blood cells and the presence of three neutrophils, of which only one was a mature form (table 1). The patient's medical history was noncontributory except that she had been treated with Diamox, 250 mg. daily, as an adjunct to digitalis and a low salt diet

Excerpt Syphilitic aortic aneurysms appear with sufficient frequency to be easily recognizable. There is a multitude of complications occurring in combination with this entity, however, which prese...