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1. Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression

3. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

4. Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders

5. ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency.

6. Targeted exon capture and sequencing in sporadic amyotrophic lateral sclerosis.

7. Screening for toxic amyloid in yeast exemplifies the role of alternative pathway responsible for cytotoxicity.

8. CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

9. Evolution of a Human-Specific Tandem Repeat Associated with ALS

10. Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

11. Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2

12. Phenotypic Heterogeneity among

13. Confirming Pathogenicity of the F386L

14. Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

15. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

16. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

17. Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease

18. A memory of eS25 loss drives resistance phenotypes

19. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

20. CRISPR/Cas9 Screen in Human iPSC-Derived Cortical Neurons Identifies NEK6 as a Novel Disease Modifier of C9orf72 Poly (PR) Toxicity

21. Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

22. 'A memory of RPS25 loss drives resistance phenotypes'

23. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

24. These violent repeats have violent extends

25. P1‐135: RARE MISSENSE VARIANTS ON ZNF679 AND CTD‐3214H19.16 SEGREGATE IN A FAMILY WITH A HISTORY OF SYNUCLEINOPATHY

26. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

27. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions

28. [P2–096]: NOVEL MISSENSE VARIANT ON EPHA1 IN A PROTECTED APOE4 FAMILY

29. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

30. Exome sequencing to identify de novo mutations in sporadic ALS trios

31. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

32. Congenital muscular dystrophy and generalized epilepsy caused by GMPPB mutations

33. Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy

34. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

35. A yeast functional screen predicts new candidate ALS disease genes

36. The toxicity of an 'artificial' amyloid is related to how it interacts with membranes

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