5 results on '"Julien Bertolino"'
Search Results
2. Pericardial effusion in giant cell arteritis is associated with increased inflammatory markers: a retrospective cohort study
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Quentin Gomes de Pinho, Aurélie Daumas, Audrey Benyamine, Julien Bertolino, Pascal Rossi, Nicolas Schleinitz, Jean-Robert Harlé, Pierre André Jarrot, Gilles Kaplanski, Julie Berbis, and Brigitte Granel more...
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Hemoglobins ,Rheumatology ,Polymyalgia Rheumatica ,Giant Cell Arteritis ,Immunology ,Humans ,Pericarditis ,Immunology and Allergy ,Biomarkers ,Pericardial Effusion ,Retrospective Studies - Abstract
Giant cell arteritis (GCA) is the most frequent vasculitis affecting adults aged 50 years. Cardiac involvement in GCA is considered rare, and only a few cases of pericarditis have been reported. The aim of this study was to determine the characteristics and prognosis of GCA patients suffering from pericardial involvement at diagnosis.We conducted a single-centre, retrospective chart review of patients with GCA in internal medicine departments (from 2000 to 2020). Patients were identified through a centralized hospital database. We retrospectively collected demographic, clinicobiological, histological, imaging, treatment and outcome data. Patients with pericardial effusion, defined as an effusion visible on the CT-scan performed at GCA diagnosis were compared to those without pericardial involvement.Among the 250 patients with GCA, 23 patients (9.2%) had pericardial effusion on CT-scan. The comparison between the groups revealed similar distribution of age, gender, cranial symptoms and ocular ischaemic complications. Patients with pericardial effusion had a higher frequency of weight loss. They also had lower haemoglobin levels and higher platelet levels (p = 0.006 and p = 0.002, respectively), and they more frequently had positive temporal artery biopsy. There were no differences concerning the treatment, relapses, follow-up duration or deaths.This case series sheds light on GCA as a cause of unexplained pericardial effusion or symptomatic pericarditis among adults aged 50 years and elevated inflammatory biological markers. Fortunately, pericardial involvement is a benign GCA manifestation. In that context, the search for constitutional symptoms, cranial symptoms and associated signs of polymyalgia rheumatica is crucial for rapidly guiding GCA diagnosis. more...
- Published
- 2022
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Catalog
3. Predictors of Relapses or Recurrences in Patients with Giant Cell Arteritis: A Retrospective Study
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Quentin Gomes de Pinho, Aurélie Daumas, Audrey Benyamine, Julien Bertolino, Mikaël Ebbo, Nicolas Schleinitz, Jean-Robert Harlé, Pierre André Jarrot, Gilles Kaplanski, Julie Berbis, Mohamed Boucekine, Pascal Rossi, and Brigitte Granel more...
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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4. Use of Direct Oral Anticoagulants in Patients with Sickle Cell Disease and Venous Thromboembolism: A Prospective Cohort Study of 12 Patients
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Julien Bertolino, Jean-Robert Harlé, Mikael Ebbo, Emmanuelle Bernit, E. Jean, Gabrielle Sarlon, Laurence Camoin, Jacques-Robert Christen, Nicolas Schleinitz, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Médecine Interne [Hôpital Saint-Joseph - Marseille], Aix Marseille Université (AMU)-Hôpital Saint-Joseph [Marseille], Service de Chirurgie, Assistance Publique - Hôpitaux de Marseille (APHM)-Hospices Civiles de Marseille-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Hôpital de la Timone [CHU - APHM] (TIMONE), Département de Médecine Interne (DMI - MARSEILLE), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and Assistance Publique-Hôpitaux de Marseille (AP-HM) more...
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Adult ,Male ,medicine.medical_specialty ,Pyridones ,Clinical Biochemistry ,Hemorrhage ,Disease ,Anemia, Sickle Cell ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Rivaroxaban ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Medicine ,Humans ,In patient ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,cardiovascular diseases ,Prospective Studies ,Prospective cohort study ,Genetics (clinical) ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,business.industry ,Biochemistry (medical) ,Hematology ,Venous Thromboembolism ,Middle Aged ,equipment and supplies ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Increased risk ,Treatment Outcome ,Young population ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Pyrazoles ,Apixaban ,Female ,business ,Venous thromboembolism ,030215 immunology ,medicine.drug ,Factor Xa Inhibitors - Abstract
Patients with sickle cell disease have an increased risk of venous thromboembolism (VTE) and with a mortality 2-fold higher. The anticoagulation of VTE in a young population is an important question. Indeed, hemorrhagic complications of anticoagulation may occur more frequently than in the general population. The use of a direct oral anticoagulant (DOAC) is not recommended for VTE in patients with sickle cell disease because those patients were not included in the clinical studies. We aimed to study the safety of using DOACs in a prospective cohort of patients with sickle cell disease and VTE. We prospectively followed the cohort of all sickle cell disease patients undergoing recent DOAC treatment for VTE at a sickle cell disease reference center. Twelve patients received rivaroxaban for VTE (eight women and four men). The median age was 27 years (20-45). The sickle cell disease variants included homozygous Hb SS ( more...
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- 2019
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5. Intravenous immunoglobulin in patients with acquired Von Willebrand syndrome: A single referral centre experience
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Catherine Pouymayou, Jean-Robert Harlé, Mikael Ebbo, Julien Bertolino, Hajar Khibri, J. Seguier, Elodie Masson, Nicolas Schleinitz, Pierre-Emmanuel Morange, Véronique Veit, Manal Ibrahim, Emmanuelle Bernit, Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), and Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) more...
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0301 basic medicine ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,03 medical and health sciences ,0302 clinical medicine ,Acquired von Willebrand syndrome ,von Willebrand Factor ,medicine ,Humans ,In patient ,Genetics (clinical) ,ComputingMilieux_MISCELLANEOUS ,Aged ,Aged, 80 and over ,biology ,business.industry ,Immunoglobulins, Intravenous ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Hematology ,General Medicine ,Middle Aged ,Hospitals ,3. Good health ,von Willebrand Diseases ,030104 developmental biology ,Treatment Outcome ,Referral centre ,biology.protein ,Female ,Antibody ,business ,030215 immunology - Abstract
International audience
- Published
- 2018
- Full Text
- View/download PDF
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