Search

Your search keyword '"Julien Autier"' showing total 8 results
Start Over Author "Julien Autier"
8 results on '"Julien Autier"'

1. Significance of metallothioneins in differential cadmium accumulation kinetics between two marine fish species

Author

Nicolas Le Bayon, Sébastien Artigaud, Virginie Penicaud, Gaël Le Croizier, Stéphane Le Floch, Julien Autier, Valérie Coquillé, Marie-Laure Rouget, Luis Tito de Morais, Raymond Laë, Jean Raffray, Camille Lacroix, Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de documentation de recherche et d'expérimentations sur les pollutions accidentelles des eaux (Cedre), Cedre, Institut de Recherche pour le Développement (IRD), Université de Brest (UBO), Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), ANR-11-CEPL-0005,ÉPURE,Éléments trace métalliques Perturbations climatiques Upwelling et REssources(2011), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne)

Subjects
0106 biological sciences, Health, Toxicology and Mutagenesis, Solea senegalensis, 010501 environmental sciences, Toxicology, 01 natural sciences, Metallothionein, oxidative stress, heavy metals, bass dicentrarchus-labrax, Cadmium, biology, Metal, Muscles, trace-elements, western indian-ocean, General Medicine, Chronic dietary exposure, Pollution, cd, Liver, Metals, Bioaccumulation, Flatfishes, Trace element, Dicentrarchus, Kinetics, Dietary Cadmium, chemistry.chemical_element, Zoology, Excretion, Animals, Dicentrarchus labrax, 14. Life underwater, Sea bass, 0105 earth and related environmental sciences, 010604 marine biology & hydrobiology, ACL, biology.organism_classification, rainbow-trout, chemistry, 13. Climate action, atomic-absorption-spectrometry, Bass, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Water Pollutants, Chemical, trout oncorhynchus-mykiss
Abstract

International audience; Impacted marine environments lead to metal accumulation in edible marine fish, ultimately impairing human health. Nevertheless, metal accumulation is highly variable among marine fish species. In addition to ecological features, differences in bioaccumulation can be attributed to species-related physiological processes, which were investigated in two marine fish present in the Canary Current Large Marine Ecosystem (CCLME), where natural and anthropogenic metal exposure occurs. The European sea bass Dicentrarchus labrax and Senegalese sole Solea senegalensis were exposed for two months to two environmentally realistic dietary cadmium (Cd) doses before a depuration period. Organotropism (i.e., Cd repartition between organs) was studied in two storage compartments (the liver and muscle) and in an excretion vector (bile). To better understand the importance of physiological factors, the significance of hepatic metallothionein (MT) concentrations in accumulation and elimination kinetics in the two species was explored. Accumulation was faster in the sea bass muscle and liver, as inferred by earlier Cd increase and a higher accumulation rate. The elimination efficiency was also higher in the sea bass liver compared to sole, as highlighted by greater biliary excretion. In the liver, no induction of MT synthesis was attributed to metal exposure, challenging the relevance of using MT concentration as a biomarker of metal contamination. However, the basal MT pools were always greater in the liver of sea bass than in sole. This species-specific characteristic might have enhanced Cd biliary elimination and relocation to other organs such as muscle through the formation of more Cd/MT complexes. Thus, MT basal concentrations seem to play a key role in the variability observed in terms of metal concentrations in marine fish species.

Published
2018
Full Text
View/download PDF

2. Enhanced bioaccumulation of mercury in deep-sea fauna from the Bay of Biscay (north-east Atlantic) in relation to trophic positions identified by analysis of carbon and nitrogen stable isotopes

Author

Julien Autier, Tiphaine Chouvelon, Aurélie Lassus-Débat, Jérôme Spitz, Paco Bustamante, Alexis Chappuis, Florence Caurant, Paula Méndez-Fernandez, LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), and Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, marine environment, Fauna, Biodiversity, 010501 environmental sciences, Aquatic Science, Biology, Oceanography, 01 natural sciences, mollusc, trophic transfer, stable isotope, Marine ecosystem, Ecosystem, 14. Life underwater, 0105 earth and related environmental sciences, Trophic level, fish, Metal, crustaceans, Ecology, 010604 marine biology & hydrobiology, Habitat, 13. Climate action, Bioaccumulation, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, Bay
Abstract

International audience; The Bay of Biscay (north-east Atlantic) is an open marine ecosystem of particular concern in current European environmental policies. Indeed, it supports both a high biological diversity and numerous anthropogenic activities such as important fisheries. For the first time, stable isotope analyses (SIA) of carbon and nitrogen and analysis of total mercury (T-Hg) concentrations in the muscle (edible flesh) were performed on adult stages of a wide range of species (i.e., 120 species) from various taxa and various habitats of this ecosystem. Concentrations of this non-essential metal, toxic to all living organisms, ranged from 39 to 5074 ng.g-1 dry weight. Calculations of species' trophic positions (TPs) through SIA revealed a limited effect of TP in explaining Hg bioaccumulation by high trophic level consumers in particular. On the contrary, our results suggest an important role of habitat and/or feeding zone, which strongly influence muscle Hg bioaccumulation. Deep-sea fish species effectively presented the highest Hg concentrations. Possible interactions between biological factors (e.g., age of deep-sea organisms) and bioavailability of the metal in the deep-sea environment are discussed to explain such enhanced bioaccumulation of Hg by deep-sea fauna in the Bay of Biscay. This study also highlights a potential risk for human health when deep-sea fish are consumed frequently.

Published
2012
Full Text
View/download PDF

3. Cutaneous Waldenström's macroglobulinemia with 'deck-chair' sign treated with cyclophosphamide

Author

Nathalie Franck, Julien Autier, Nicolas Dupin, Agnès Carlotti, Isabelle Gorin, Marc Buffet, Anne-Isabelle Merlat-Guitard, and L Pinquier

Subjects
Male, Pathology, medicine.medical_specialty, Cyclophosphamide, Erythema, Dermatology, Skin Diseases, chemistry.chemical_compound, Immunopathology, medicine, Humans, Antineoplastic Agents, Alkylating, integumentary system, business.industry, Macroglobulinemia, Waldenstrom macroglobulinemia, Middle Aged, medicine.disease, Trunk, Nitrogen mustard, chemistry, Immunohistochemistry, Waldenstrom Macroglobulinemia, medicine.symptom, business, medicine.drug
Abstract

Specific skin lesions are rare in Waldenstrom's macroglobulinemia (WM). We report a case of a 58-year-old man who presented macules, papules, and an erythema of the trunk with the "deck-chair" sign revealing the relapse of WM. Histologic and immunohistochemical examinations confirmed that cutaneous lesions were related to specific infiltration with neoplastic cells. Remission of both skin lesions and immunological abnormalities was obtained with oral cyclophosphamide.

Published
2005
Full Text
View/download PDF

4. Contents Vol. 211, 2005

Author

Christos C. Zouboulis, M. Monika Weber, Selim Aractingi, Venkata Putcha, Isabelle Daigle, M.A. Duchosal, J.L. Arranz López, Hiroyuki Matsue, E. Gambillara, Jann Lübbe, D.A. Fairhurst, P. Dellamonica, Christian Surber, Dominique Bonneau, Emmanuel Laffitte, Olivier Sorg, Katrin Kerl, Dan Lipsker, Karin Thoss, Wolfram Sterry, Henrik Møller, Maria Morales, E. Counillon, Alice Quinart, P. Del Giudice, Andreas J. Bircher, Mohammad Reza Fallahi, Agustin Llopis, Uwe Trefzer, Alexander C. Katoulis, Jean-Hilaire Saurat, Nicholas G. Stavrianeas, Jørn Olsen, Marc Buffet, Pierre Carraux, Thomas J. Brill, N. Kunzle, Mohammad Nikbakhsh, Hans-Peter Baum, J.-H. Saurat, Ambros Hügin, M. Grelier, Paulette Bioulac-Sage, Naohito Hatta, Farshad Farnaghi, Lutz Kowalzick, Philippe Revel, Carol M. Artlett, Gholamhosein R. Omrani, T. Rodriguez Bravo, Sébastien Lepreux, Katharina Spanaus Schlapbach, Carolina Pellanda, Günter Burg, Günther F.L. Hofbauer, Christine Labreze, N. Widmer, H. Zeller, Jürgen Quietzsch, Hassan Seirafi, A. Carlotti, I. Schuffenecker, Sylvie De Maricourt, Luca Borradori, Rahman Nazari, Sofia Georgala, Roland Blum, Laurence Doelker, Christian Tran, Emmanuel Molinari, Christophe Antille, Jürgen Lademann, Akiko Nagasaka, I. Masouyé, P. Lesavre, Mitra Amini, J.-M. Pönnighaus, Renato G. Panizzon, Amin Parhizgar, L.A. Decosterd, H. Zachariae, Daniel Mischke, S.M. Clark, Julie De Quatrebarbes, E. Laffitte, Ute Jacobi, Evelyne Leemans, Giovanni Luigi Capella, Diamant Thaçi, Nicolas Dupin, Hans-Uwe Simon, Reinhard Dummer, Eva M. Valesky, Julien Gautier, Denise Grand, Behrooz Kasraee, Jörg Willers, Thierry André, F. Vandenbos, T. Kovacsovics, Parisa Mansoori, Aiko Miyahara, Heidrun Ziegler, L. Garcia Martinez, Gürkan Kaya, Shinji Shimada, Julien Autier, J.-P. Venetz, Farhad Handjani, M. Pascual, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Regina Treudler, Martine Neau-Cransac, Pierre Vabres, E. Elena Sorando, Maryam Akhyani, Jean Saric, Helen S. Evans, Isabelle Gorin, and Silvio Hemmi

Subjects
Dermatology
Published
2005
Full Text
View/download PDF

6. Prospective Study of the Cutaneous Adverse Effects of Sorafenib, a Novel Multikinase Inhibitor

Author

Janine Wechsler, Alain Spatz, Bernard Escudier, Julien Autier, and Caroline Robert

Subjects
Adult, Male, Niacinamide, Sorafenib, medicine.medical_specialty, Pyridines, Splinter hemorrhage, Administration, Oral, Antineoplastic Agents, Hand Dermatoses, Dermatology, Placebo, Severity of Illness Index, law.invention, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Prospective Studies, Adverse effect, Prospective cohort study, Carcinoma, Renal Cell, Protein Kinase Inhibitors, Aged, Foot Dermatoses, business.industry, Incidence, Phenylurea Compounds, Benzenesulfonates, General Medicine, Middle Aged, medicine.disease, Kidney Neoplasms, Scalp dysesthesia, Surgery, Clinical trial, Female, Drug Eruptions, France, medicine.symptom, business, medicine.drug
Abstract

Objectives To provide an accurate description and to evaluate the incidence and severity of cutaneous reactions induced by sorafenib tosylate, a new oral multikinase inhibitor. Design Double-blind, prospective dermatologic substudy performed on all consecutive patients included in our center in a large phase 3 trial. Setting Institutional practice at the Gustave Roussy Institute. Patients Eighty-five patients with renal cell cancer treated between November 1, 2003, and February 28, 2005. Interventions Patients were randomized to receive either sorafenib (n = 43) or placebo (n = 42). Dermatologic examination was performed before treatment, every 3 weeks during the first 4 cycles, and every 4 weeks thereafter. Main Outcome Measures Incidence and severity of cutaneous reactions to sorafenib. Results Thirty-nine patients (91%) experienced at least 1 cutaneous reaction in the sorafenib group vs 3 (7%) in the placebo group. A hand-foot skin reaction that appeared to be clinically distinct from the well-known chemotherapy-induced hand-foot syndrome was observed in 26 patients receiving sorafenib (60%). Reversible grade 3 hand-foot skin reaction was documented in 2 patients receiving sorafenib and led to a dose reduction. Other cutaneous reactions were facial erythema, scalp dysesthesia, alopecia, and subungual splinter hemorrhages. Conclusions Sorafenib induces frequent cutaneous adverse events, some of which may lead to a dose reduction. Close collaboration between oncologists and dermatologists is needed to improve both the characterization and the management of these side effects. Appropriate patient education before the initiation of therapy and the introduction of early symptomatic measures may improve management.

Published
2008
Full Text
View/download PDF

7. Subject Index Vol. 211, 2005

Author

P. Del Giudice, Ambros Hügin, Marc Buffet, Regina Treudler, T. Rodriguez Bravo, Arash Taheri, Carolina Pellanda, Thomas J. Brill, Martine Neau-Cransac, Andreas J. Bircher, Emmanuel Molinari, Jørn Olsen, E. Gambillara, Olivier Sorg, J.-M. Pönnighaus, Christophe Antille, Paulette Bioulac-Sage, Denise Grand, Thierry André, Alexander C. Katoulis, I. Masouyé, M.A. Duchosal, Julie De Quatrebarbes, H. Zachariae, Henrik Møller, Alice Quinart, S.M. Clark, Amin Parhizgar, Giovanni Luigi Capella, Hans-Uwe Simon, Carol M. Artlett, M. Grelier, Julien Gautier, Selim Aractingi, Gürkan Kaya, Sébastien Lepreux, Julien Autier, Pierre Vabres, Mohammad Reza Fallahi, Jean-Hilaire Saurat, J.-P. Venetz, I. Schuffenecker, M. Monika Weber, Daniel Mischke, Maryam Akhyani, Günther F.L. Hofbauer, Venkata Putcha, Pierre Carraux, Farhad Handjani, Akiko Nagasaka, E. Counillon, Diamant Thaçi, Jann Lübbe, Farshad Farnaghi, Lutz Kowalzick, M. Pascual, Christian Surber, Dominique Bonneau, Dan Lipsker, Emmanuel Laffitte, Katrin Kerl, T. Kovacsovics, Roland Kaufmann, Thomas Elshorst-Schmidt, Agustin Llopis, Hassan Seirafi, Jörg Willers, Luca Borradori, Parisa Mansoori, Shinji Shimada, Heidrun Ziegler, L.A. Decosterd, N. Kunzle, Rahman Nazari, Sofia Georgala, Christine Labreze, F. Vandenbos, Jürgen Lademann, Nicolas Dupin, Behrooz Kasraee, Christos C. Zouboulis, Isabelle Daigle, P. Lesavre, Mitra Amini, Hiroyuki Matsue, Uwe Trefzer, Philippe Revel, Nicholas G. Stavrianeas, J.L. Arranz López, Karin Thoss, Jürgen Quietzsch, Sylvie De Maricourt, D.A. Fairhurst, P. Dellamonica, Renato G. Panizzon, Hans-Peter Baum, Reinhard Dummer, Ute Jacobi, Evelyne Leemans, Helen S. Evans, Maria Morales, Eva M. Valesky, Isabelle Gorin, Katharina Spanaus Schlapbach, N. Widmer, Laurence Doelker, Christian Tran, Wolfram Sterry, Aiko Miyahara, L. Garcia Martinez, Roland Blum, Silvio Hemmi, E. Elena Sorando, Jean Saric, H. Zeller, E. Laffitte, Gholamhosein R. Omrani, Mohammad Nikbakhsh, A. Carlotti, J.-H. Saurat, Naohito Hatta, and Günter Burg

Subjects
Index (economics), Statistics, Subject (documents), Dermatology, Mathematics
Published
2005
Full Text
View/download PDF

8. Acknowledgement to Referees for Dermatology 2005

Author

M. Grelier, Denise Grand, Thierry André, Paulette Bioulac-Sage, Henrik Møller, Thomas J. Brill, Regina Treudler, Pierre Carraux, Sébastien Lepreux, Carol M. Artlett, Christophe Antille, I. Masouyé, Silvio Hemmi, Amin Parhizgar, Alice Quinart, Gholamhosein R. Omrani, S.M. Clark, D.A. Fairhurst, P. Del Giudice, Ambros Hügin, E. Elena Sorando, A. Carlotti, Nicholas G. Stavrianeas, Martine Neau-Cransac, P. Dellamonica, Jean Saric, Farshad Farnaghi, I. Schuffenecker, Emmanuel Laffitte, Katrin Kerl, Lutz Kowalzick, Marc Buffet, Selim Aractingi, M. Monika Weber, Julien Autier, L.A. Decosterd, Christine Labreze, J.-P. Venetz, Agustin Llopis, Aiko Miyahara, Jürgen Quietzsch, Sylvie De Maricourt, Rahman Nazari, Sofia Georgala, Nicolas Dupin, Venkata Putcha, E. Laffitte, L. Garcia Martinez, Hans-Peter Baum, Maria Morales, Hassan Seirafi, Behrooz Kasraee, Diamant Thaçi, Jann Lübbe, Luca Borradori, Christian Surber, Dominique Bonneau, Laurence Doelker, Christian Tran, E. Counillon, F. Vandenbos, Dan Lipsker, Günter Burg, Gürkan Kaya, Renato G. Panizzon, Helen S. Evans, Ute Jacobi, Evelyne Leemans, Eva M. Valesky, Mohammad Reza Fallahi, Katharina Spanaus Schlapbach, Roland Blum, Isabelle Gorin, N. Widmer, Reinhard Dummer, J.L. Arranz López, M.A. Duchosal, Karin Thoss, Wolfram Sterry, Carolina Pellanda, H. Zeller, Shinji Shimada, Emmanuel Molinari, Akiko Nagasaka, J.-M. Pönnighaus, T. Kovacsovics, Julie De Quatrebarbes, Daniel Mischke, Mohammad Nikbakhsh, Giovanni Luigi Capella, Hans-Uwe Simon, J.-H. Saurat, Julien Gautier, Naohito Hatta, Jörg Willers, Heidrun Ziegler, Günther F.L. Hofbauer, Philippe Revel, N. Kunzle, Pierre Vabres, P. Lesavre, Mitra Amini, Maryam Akhyani, Farhad Handjani, M. Pascual, Jürgen Lademann, Uwe Trefzer, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Andreas J. Bircher, Parisa Mansoori, Jørn Olsen, Hiroyuki Matsue, E. Gambillara, Alexander C. Katoulis, Jean-Hilaire Saurat, H. Zachariae, Isabelle Daigle, T. Rodriguez Bravo, Christos C. Zouboulis, and Olivier Sorg

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results