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4. Challenges of Perceived Self‐Management in Lupus

Author

Fortin, Paul R., Da Costa, Deborah, Neville, Carolyn, Julien, Anne‐Sophie, Rahme, Elham, Haroun, Vinita, Singer, Wendy, Nimigon‐Young, Jodie, Morrison, Anna‐Lisa, Eng, Davy, Peschken, Christine A., Vinet, Evelyne, Hudson, Marie, Smith, Doug, Matsos, Mark, Pope, Janet E., Clarke, Ann E., Keeling, Stephanie, Avina‐Zubieta, J. Antonio, and Rochon, Murray

Published
2022
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15. Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations

Author

Becker, Yann, Loignon, Renée-Claude, Julien, Anne-Sophie, Marcoux, Geneviève, Allaeys, Isabelle, Lévesque, Tania, Rollet-Labelle, Emmanuelle, Benk-Fortin, Hadrien, Cloutier, Nathalie, Melki, Imène, Eder, Lihi, Wagner, Éric, Pelletier, Martin, Hajj, Hassan El, Tremblay, Marie-Ève, Belleannée, Clémence, Hébert, Marie-Josée, Dieudé, Mélanie, Rauch, Joyce, Fortin, Paul R., and Boilard, Eric

Published
2019
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17. 103 Exploratory segregation of patients upon their levels of anti- mitochondrial antibodies (AMAs) reveals associations between AMAs and disease manifestations

Author

Becker, Yann LC, primary, Boilard, Éric, additional, Rollet-Labelle, Emmanuelle, additional, Lood, Christian, additional, Julien, Anne-Sophie, additional, Leclerc, Joannie, additional, Lévesque, Tania, additional, Urowitz, Murray, additional, Hanly, John, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Clarke, Ann E, additional, Bernatsky, Sasha, additional, Wallace, Daniel, additional, Isenberg, David, additional, Rahman, Anisur, additional, Merrill, Joan, additional, Gladman, Dafna, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Alarcon, Graciela, additional, Vollenhoven, Ronald van, additional, Aranow, Cynthia, additional, Ruiz-Irastorza, Guillermo, additional, Lim, Sam, additional, Inanc, Murat, additional, Kalunian, Kenneth, additional, Jacobsen, Soren, additional, Peschken, Christine, additional, Kamen, Diane, additional, Askanase, Anca, additional, Buyon, Jill, additional, and Fortin, Paul R, additional

Published
2022
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18. Measuring the Impact of MyLupusGuide in Canada: Results of a Randomized Controlled Study

Author

Fortin, Paul R., primary, Neville, Carolyn, additional, Julien, Anne‐Sophie, additional, Rahme, Elham, additional, Haroun, Vinita, additional, Nimigon‐Young, Jodie, additional, Morrison, Anna‐Lisa, additional, Eng, Davy, additional, Peschken, Christine A., additional, Vinet, Evelyne, additional, Hudson, Marie, additional, Smith, Doug, additional, Matsos, Mark, additional, Pope, Janet E., additional, Clarke, Ann E., additional, Keeling, Stephanie, additional, Avina‐Zubieta, J. Antonio, additional, Rochon, Murray, additional, and Da Costa, Deborah, additional

Published
2022
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20. Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus

Author

Becker, Yann L. C., primary, Gagné, Jean‐Philippe, additional, Julien, Anne‐Sophie, additional, Lévesque, Tania, additional, Allaeys, Isabelle, additional, Gougeard, Nadine, additional, Rubio, Vicente, additional, Boisvert, François‐Michel, additional, Jean, Dominique, additional, Wagner, Eric, additional, Poirier, Guy G., additional, Fortin, Paul R., additional, and Boilard, Éric, additional

Published
2022
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21. Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus

Author

Canadian Institutes of Health Research, Fonds de Recherche du Québec, Ministerio de Economía y Competitividad (España), Fundación Ramón Areces, Rubio, Vicente [0000-0001-8124-1196], Becker, Yann L. C., Gagne, Jean-Philippe, Julien, Anne-Sophie, Levesque, Tania, Allaeys, Isabelle, Gougeard, Nadine, Rubio, Vicente, Boisvert, Francois-Michel, Jean, Dominique, Wagner, Eric, Poirier, Guy G., Fortin, Paul R., Boilard, Eric, Canadian Institutes of Health Research, Fonds de Recherche du Québec, Ministerio de Economía y Competitividad (España), Fundación Ramón Areces, Rubio, Vicente [0000-0001-8124-1196], Becker, Yann L. C., Gagne, Jean-Philippe, Julien, Anne-Sophie, Levesque, Tania, Allaeys, Isabelle, Gougeard, Nadine, Rubio, Vicente, Boisvert, Francois-Michel, Jean, Dominique, Wagner, Eric, Poirier, Guy G., Fortin, Paul R., and Boilard, Eric

Abstract

Objective: Mitochondria are organelles that exhibit several bacterial features, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes. In systemic lupus erythematosus (SLE), mitochondria and their inner components are released into the extracellular space, potentially eliciting a proinflammatory response from the immune system. While cardiolipin and mitochondrial DNA and RNA are confirmed targets of autoantibodies, other antigenic mitochondrial proteins in SLE remain to be identified. The present study was undertaken to characterize the protein repertoire recognized by antimitochondrial antibodies (AMAs) in patients with SLE. Methods: Using shotgun proteomic profiling, we identified 1,345 proteins, 431 of which were associated with the mitochondrial proteome. Immunoreactivities to several of these candidate proteins were assessed in serum samples from a local cohort (n = 30 healthy donors and 87 patients with SLE) using enzyme-linked immunosorbent assay, and further analyzed for associations with demographic and disease characteristics. Results: We determined that IgG antibodies to the complement component C1q binding protein were significantly elevated in the patients with SLE (P = 0.049) and were also associated with lupus anticoagulant positivity (P = 0.049). Elevated levels of IgG antibodies against mitochondrial protein mitofusin 1 (MFN-1) were promising predictors of SLE diagnosis in our cohort (adjusted odds ratio 2.99 [95% confidence interval 1.39-6.43], P = 0.0044). Moreover, increased levels of anti-MFN-1 were associated with the presence of antiphospholipids (P = 0.011) and anti-double-stranded DNA (P = 0.0005). Conclusion: In this study, we characterized the mitochondrial repertoire targeted by AMAs in the setting of SLE. Our results indicate that autoantibodies can recognize secreted and/or surface proteins of mitochondrial origin. Profiling of the AMA repertoire in large prospective

Published
2022

23. Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial

Author

Michou, Laëtitia, primary, Julien, Anne-Sophie, additional, Witteman, Holly O., additional, Légaré, Jean, additional, Ratelle, Lucie, additional, Godbout, Alexandra, additional, Tardif, Johanne, additional, Côté, Suzanne, additional, Boily, Geneviève, additional, Lui, Rebecca, additional, Ikic, Alena, additional, Trudeau, Judith, additional, Tremblay, Jean-Luc, additional, Fortin, Isabelle, additional, Bessette, Louis, additional, Chetaille, Anne-Laure, additional, and Fortin, Paul R, additional

Published
2021
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24. 67 Are NICUs too busy?

Author

Beltempo, Marc, primary, Platt, Robert, additional, Julien, Anne-Sophie, additional, Blais, Regis, additional, Valerie, Bertelle, additional, Lapointe, Anie, additional, Lacroix, Guy, additional, Gravel, Sophie, additional, Cabot, Michèle, additional, and Piedboeuf, Bruno, additional

Published
2021
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25. Measuring the Impact of MyLupusGuidein Canada: Results of a Randomized Controlled Study

Author

Fortin, Paul R., Neville, Carolyn, Julien, Anne‐Sophie, Rahme, Elham, Haroun, Vinita, Nimigon‐Young, Jodie, Morrison, Anna‐Lisa, Eng, Davy, Peschken, Christine A., Vinet, Evelyne, Hudson, Marie, Smith, Doug, Matsos, Mark, Pope, Janet E., Clarke, Ann E., Keeling, Stephanie, Avina‐Zubieta, J. Antonio, Rochon, Murray, and Da Costa, Deborah

Abstract

This study was undertaken to assess the effects of a web‐based program, MyLupusGuide,developed to facilitate self‐management in systemic lupus erythematosus (SLE). In this randomized controlled online study, participants received either immediate access to the MyLupusGuide site or delayed access starting on month 3. The primary outcome was the patient activation measure (PAM) score. Secondary outcomes included measurements of health status, self‐efficacy, coping, perceived patient–physician relationship, and medication adherence. Outcomes were measured at the baseline visit and at the 3‐month and 6‐month follow‐up visits. We used linear mixed modeling to compare PAM scores between the 2 groups at months 3 and 6. There were 541 participants included in this study. The mean ± SE age was 50 ± 14 years; 93% were female and 74% were White. The mean ± SE disease duration was 17 ± 12 years, and 56% visited MyLupusGuide at least once. The baseline mean ± SE PAM score was 61.2 ± 13, with 36% scoring low for perceived self‐management skills. After 3 months of exposure to MyLupusGuide, there were no differences in terms of PAM scores between groups. In exploratory analyses, we found significant improvement in PAM scores in those who had low PAM scores at baseline and in male individuals. We observed significant improvements in self‐efficacy before and after access to MyLupusGuide and delayed improvements at month 6 compared to month 3 in terms of mental health and emotional coping. MyLupusGuide increases self‐efficacy but not patient activation. A total of 56% of participants visited the MyLupusGuide site during the study period. Individuals with lupus need support to become activated toward self‐management behaviors.

Published
2023
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26. Response to Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38: 1339–1346

Author

Tang, An, Rabasa-Lhoret, Rémi, Castel, Hélène, Wartelle-Bladou, Claire, Gilbert, Guillaume, Massicotte-Tisluck, Karine, Chartrand, Gabriel, Olivié, Damien, Julien, Anne-Sophie, de Guise, Jacques, Soulez, Gilles, and Chiasson, Jean-Louis

Published
2015
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28. Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial.

Author

Michou, Laëtitia, Julien, Anne-Sophie, Witteman, Holly O., Légaré, Jean, Ratelle, Lucie, Godbout, Alexandra, Tardif, Johanne, Côté, Suzanne, Boily, Geneviève, Lui, Rebecca, Ikic, Alena, Trudeau, Judith, Tremblay, Jean-Luc, Fortin, Isabelle, Bessette, Louis, Chetaille, Anne-Laure, and Fortin, Paul R

Subjects
*BIOTHERAPY, *ANTIRHEUMATIC agents, *RANDOMIZED controlled trials, *PRE-tests & post-tests, *RHEUMATOID arthritis, *HEALTH behavior, *QUESTIONNAIRES, *PATIENT education, *STATISTICAL sampling, *EDUCATIONAL outcomes
Abstract

Objectives: This study aims to determine whether patients with active rheumatoid arthritis (RA), either starting on or changing biological or targeted synthetic disease-modifying antirheumatic drugs (DMARDs), demonstrate better self-management safety skills three months after receiving a multidisciplinary educational intervention compared to patients receiving usual care. Patients and methods: Between October 2015 and October 2018, this open-label, randomized-controlled trial included a total of 107 RA patients (27 males, 80 females; mean age: 60.2±10.4 years; range, 54 to 71 years) who were on treatment or in whom treatment was changed with a biological or targeted synthetic DMARD. The patients were randomized into two groups: Group 1 (n=57) received additional intervention with educational DVD and one teleconference session and Group 2 (n=55) received usual care and were offered the intervention at three months. All patients underwent a final visit at six months. At each visit, the patients completed the BioSecure questionnaire measuring the self-care safety skills, a behavioral intention questionnaire, and the Beliefs about Medicines Questionnaire (BMQ). Results: No significant difference was observed in the Biosecure score at three months between the two groups (p=0.08). After pooling the first three-month data in Group 1 and the last three-month data in Group 2, the mean score of the BioSecure questionnaire increased to 7.10±0.92 in the group receiving educational intervention (p<0.0001). This increase was maintained at six months in Group 2 (p=0.88). The rate of appropriate behavioral intention increased over time (76% at baseline and 85% at six months for both groups). There was no significant change in the BMQ (p=0.44 to 0.84). Conclusion: The development of an educational DVD followed by a teleconference seem to improve self-care safety skills of the patients in practical situations. [ABSTRACT FROM AUTHOR]

Published
2022
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29. User Involvement in the Design and Development of Patient Decision Aids and Other Personal Health Tools: A Systematic Review

Author

Vaisson, Gratianne, primary, Provencher, Thierry, additional, Dugas, Michèle, additional, Trottier, Marie-Ève, additional, Chipenda Dansokho, Selma, additional, Colquhoun, Heather, additional, Fagerlin, Angela, additional, Giguere, Anik M. C., additional, Hakim, Hina, additional, Haslett, Lynne, additional, Hoffman, Aubri S., additional, Ivers, Noah M., additional, Julien, Anne-Sophie, additional, Légaré, France, additional, Renaud, Jean-Sébastien, additional, Stacey, Dawn, additional, Volk, Robert J., additional, and Witteman, Holly O., additional

Published
2021
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30. Comparison of Three Nursing Workload Assessment Tools in the Neonatal Intensive Care Unit and Their Association with Outcomes of Very Preterm Infants.

Author

Lemieux-Bourque, Charlotte, Piedboeuf, Bruno, Gignac, Simon, Taylor-Ducharme, Sharon, Julien, Anne-Sophie, and Beltempo, Marc

Subjects
NEONATAL intensive care, CONFIDENCE intervals, RESEARCH methodology evaluation, NEONATAL intensive care units, DISEASES, HEALTH outcome assessment, RETROSPECTIVE studies, PATIENTS, TERTIARY care, HOSPITAL mortality, HOSPITAL admission & discharge, INDUSTRIAL psychology, DESCRIPTIVE statistics, WORKING hours, EMERGENCY nursing, LONGITUDINAL method, POISSON distribution
Abstract

Objective  Nursing workload assessment tools are widely used to determine nurse staffing requirements in the neonatal intensive care unit (NICU). We aimed to compare three existing workload assessment tools and assess their association with mortality or morbidity among very preterm infants. Study Design  Single-center retrospective cohort study of infants born <33 weeks and admitted to a 52-bed tertiary NICU in 2017 to 2018. Required nurse staffing was estimated for each shift using the Winnipeg Assessment of Neonatal Nursing Needs Tool (WANNNT) used as reference tool, the Quebec Provincial NICU Nursing Ratio (QPNNR), and the Canadian NICU Resource Utilization (CNRU). Poisson regression models with robust error variance estimators were used to assess the association between nursing provision ratios (actual number of nurses/required number of nurses) during the first 7 days of admission and neonatal outcomes. Results  Median number of nurses required per shift using the WANNNT was 25.0 (interquartile range [IQR]: 23.1–26.7). Correlation between WANNNT and QPNNR was high (r  = 0.92, p  < 0.0001), but the QPNNR underestimated the number of nurses per shift by 4.8 (IQR: 4.1–5.4). Correlation between WANNNT and CNRU was moderate (r  = 0.45, p  < 0.0001). The NICU nursing provision ratios during the first 7 days of admission calculated using the WANNNT (adjusted risk ratio [aRR]: 0.96, 95% confidence interval [CI]: 0.93–0.99) and QPNNR (aRR: 0.97, 95% CI: 0.95–0.99) were associated with mortality or morbidity. Conclusion  Lower nursing provision ratio calculated using the WANNNT and CNRU during the first 7 days of admission is associated with an increased risk of mortality/morbidity in very preterm infants. Key Points NICUs use different nursing workload assessment tools. We validated three different nursing workload assessment tools used in the NICU. Nursing provision ratio is associated the risk of mortality/morbidity in preterm infants. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Challenges of Perceived Self‐Managementin Lupus

Author

Fortin, Paul R., Da Costa, Deborah, Neville, Carolyn, Julien, Anne‐Sophie, Rahme, Elham, Haroun, Vinita, Singer, Wendy, Nimigon‐Young, Jodie, Morrison, Anna‐Lisa, Eng, Davy, Peschken, Christine A., Vinet, Evelyne, Hudson, Marie, Smith, Doug, Matsos, Mark, Pope, Janet E., Clarke, Ann E., Keeling, Stephanie, Avina‐Zubieta, J. Antonio, and Rochon, Murray

Abstract

Systemic lupus erythematosus is a chronic autoimmune disease with varied and unpredictable levels of disease activity. The ability to self‐manage lupus is important in controlling disease activity. Our objective was to determine levels of patient activation toward self‐management in lupus. We used baseline results from the MyLupusGuide study, which had recruited 541 lupus patients from 10 lupus centers. We used the Patient Activation Measure (PAM), a validated self‐reported tool designed to measure activation toward self‐management ability, as our primary variable and examined its association with demographic, disease‐related, patient–provider communication and psychosocial variables captured in our study protocol. Univariable and multivariable linear regressions were performed using linear mixed models, with a random effect for centers. The mean ± SD age of participants was 50 ± 14 years, 93% were female, 74% were White, and the mean ± SD disease duration was 17 ± 12 years. The mean ± SD PAM score was 61.2 ± 13.5, with 36% of participants scoring in the 2 lower levels, indicating low activation. Variables associated with low activation included being single, having lower physical health status, lower self‐reported disease activity, lower self‐efficacy, use of more emotional coping and fewer distraction and instrumental coping strategies, and a perceived lack of clarity in patient–doctor communication. Low patient activation was observed in more than one‐third of lupus patients, indicating that a large proportion of patients perceived that they are lacking in lupus self‐management skills. These results highlight a modifiable gap in perceived self‐management ability among patients with lupus.

Published
2022
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37. Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomised, placebo-controlled trial

Author

Lemieux, Patricia, primary, Weisnagel, S John, additional, Caron, Annabelle Z, additional, Julien, Anne-Sophie, additional, Morisset, Anne-Sophie, additional, Carreau, Anne-Marie, additional, Poirier, Jonathan, additional, Tchernof, André, additional, Robitaille, Julie, additional, Bergeron, Jean, additional, Marette, André, additional, Vohl, Marie-Claude, additional, and Gagnon, Claudia, additional

Published
2019
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38. User involvement in the development of patient decision aids: A systematic review

Author

Vaisson, Gratianne, primary, Provencher, Thierry, additional, Dugas, Michele, additional, Trottier, Marie-Eve, additional, Dansokho, Selma Chipenda, additional, Colquhoun, Heather, additional, Fagerlin, Angela, additional, Giguere, Anik, additional, Hakim, Hina, additional, Haslett, Lynne, additional, Hoffman, Aubri, additional, Ivers, Noah Michael, additional, Julien, Anne-Sophie, additional, Legare, France, additional, Renaud, Jean-Sebastien, additional, Stacey, Dawn, additional, Volk, Robert, additional, and Witteman, Holly, additional

Published
2019
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39. Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA

Author

Becker, Yann, primary, Marcoux, Geneviève, additional, Allaeys, Isabelle, additional, Julien, Anne-Sophie, additional, Loignon, Renée-Claude, additional, Benk-Fortin, Hadrien, additional, Rollet-Labelle, Emmanuelle, additional, Rauch, Joyce, additional, Fortin, Paul R., additional, and Boilard, Eric, additional

Published
2019
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40. Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions

Author

Marcoux, Genevieve, primary, Magron, Audrey, additional, Sut, Caroline, additional, Laroche, Audree, additional, Laradi, Sandrine, additional, Hamzeh‐Cognasse, Hind, additional, Allaeys, Isabelle, additional, Cabon, Ophelie, additional, Julien, Anne‐Sophie, additional, Garraud, Olivier, additional, Cognasse, Fabrice, additional, and Boilard, Eric, additional

Published
2019
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41. 191 MyLupusGuide, a lupus-specific web interactive navigator, improves self-efficacy and activation in patients with low activation and in men

Author

Fortin, Paul R, primary, Neville, Carolyn, additional, Julien, Anne-Sophie, additional, Rahme, Elham, additional, Rochon, Murray, additional, Haroun, Vinita, additional, Vinet, Evelyne, additional, Peschken, Christine, additional, Clarke, Ann E, additional, Pope, Janet, additional, Keeling, Stephanie, additional, Avina-Zubieta, Antonio, additional, Smith, Douglas, additional, Matsos, Mark, additional, Hudson, Marie, additional, Young, Jodie, additional, Morrison, Anna-Lisa, additional, Eng, Davy, additional, and DaCosta, Deborah, additional

Published
2019
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46. Effects of 6-Month Vitamin D Supplementation on Insulin Sensitivity and Secretion: A Randomized, Placebo-Controlled Trial

Author

Lemieux, Patricia, primary, Weisnagel, S. John, additional, Caron, Annabelle Z., additional, Julien, Anne-Sophie, additional, Morisset, Anne-Sophie, additional, Poirier, Jonathan, additional, Carreau, Anne-Marie, additional, Tchernof, André, additional, Robitaille, Julie, additional, Bergeron, Jean, additional, Vohl, Marie-Claude, additional, and Gagnon, Claudia, additional

Published
2018
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