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1. Topical ruxolitinib 1.5% (JAK1/JAK2 inhibitor) improves clinical and patient‐reported outcomes in moderate to severe chronic hand dermatitis: Data from a small open‐label trial

Author

Hannah D. Smith, Jag S. Lally, Alison Moy, Julie Ryan‐Wolf, and Anna De Benedetto

Subjects
chronic hand dermatitis, clinical trials, hand eczema, itch, JAK inhibitor, ruxolitinib, Dermatology, RL1-803, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Chronic hand dermatitis (CHD) has suboptimal treatments and a negative impact on quality of life (QoL). Topical ruxolitinib, a JAK1/JAK2 inhibitor, is approved for vitiligo and mild‐to‐moderate atopic dermatitis, but has not previously been studied specifically for CHD. Objectives Evaluate the impact of ruxolitinib in CHD. Methods A 12‐week, investigator‐initiated, open‐label trial evaluated ruxolitinib 1.5% in 15 adults with recalcitrant moderate‐to‐severe CHD. Primary outcomes included the proportion of patients: (1) achieving an Investigator Global Assessment (IGA) treatment success (0 or 1 score with a two‐step improvement) (2) a Hand Eczema Severity Index (HECSI)‐75 improvement at 12 weeks. Additional outcomes: clinical improvement at 4 and 8 weeks, improvement in itch (Numerical Rating Scale [NRS]) and QoL outcomes (i.e., Dermatology Life Quality Index [DLQI] and Skindex‐Mini). Results At 12 weeks, 13/15 participants (86%) achieved a HECSI‐75, 12/15 participants (80%) had a two‐point reduction in IGA and 8/15 participants (53%) achieved an IGA treatment success. Both atopic dermatitis (AD; n = 7) and non‐AD (n = 8) CHD participants had clinical improvement in HECSI at 12 weeks (p

Published
2024
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2. Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidance for the prevention of breast cancer-related arm lymphoedema (BCRAL): international Delphi consensus-based recommendationsResearch in context

Author

Henry C.Y. Wong, Matthew P. Wallen, Adrian Wai Chan, Narayanee Dick, Pierluigi Bonomo, Monique Bareham, Julie Ryan Wolf, Corina van den Hurk, Margaret Fitch, Edward Chow, Raymond J. Chan, Muna AlKhaifi, Belen Alonso Alvarez, Suvam Banerjee, Kira Bloomquist, Pinar Borman, Yolande Borthwick, Dominic Chan, Sze Man Chan, Yolanda Chan, Ngan Sum Jean Cheng, J. Isabelle Choi, Yin Ping Choy, Kimberly Corbin, Elizabeth Dylke, Pamela Hammond, Satoshi Hirakawa, Kimiko Hirata, Shing Fung Lee, Marianne Holt, Peter Johnstone, Yuichiro Kikawa, Deborah Kirk, Haruru Kotani, Carol Kwok, Jessica Lai, Mei Ying Lim, Michael Lock, Brittany Lorden, Page Mack, Stefano Magno, Icro Meattini, Gustavo Nader Marta, Margaret McNeely, Tammy Mondry, Luis Enrique Lopez Montoya, Mami Ogita, Misato Osaka, Stephanie Phan, Philip Poortmans, Bolette Skjødt Rafn, Abram Recht, Agata Rembielak, Angela Río-González, Jolien Robijns, Naoko Sanuki, Charles B. Simone, II, Mateusz Spałek, Kaori Tane, Luiz Felipe Nevola Teixeira, Mitsuo Terada, Mark Trombetta, Kam Hung Wong, and Katsuhide Yoshidome

Subjects
Prevention, Breast cancer related arm lymphoedema, Delphi consensus, Medicine (General), R5-920
Abstract

Summary: Background: Developing strategies to prevent breast cancer-related arm lymphoedema (BCRAL) is a critical unmet need because there are no effective interventions to eradicate it once it reaches a chronic state. Certain strategies such as prospective surveillance programs and prophylactic lymphatic reconstruction have been reported to be effective in clinical trials. However, a large variation exists in practice based on clinician preference, organizational standards, and local resources. Methods: A two-round international Delphi consensus process was performed from February 27, 2023 to May 25, 2023 to compile opinions of 55 experts involved in the care and research of breast cancer and lymphoedema on such interventions. Findings: Axillary lymph node dissection, use of post-operative radiotherapy, relative within-arm volume increase one month after surgery, greater number of lymph nodes dissected, and high body mass index were recommended as the most important risk factors to guide selection of patients for interventions to prevent BCRAL. The panel recommended that prospective surveillance programs should be implemented to screen for and reduce risks of BCRAL where feasible and resources allow. Prophylactic compression sleeves, axillary reverse mapping and prophylactic lymphatic reconstruction should be offered for patients who are at risk for developing BCRAL as options where expertise is available and resources allow. Recommendations on axillary management in clinical T1–2, node negative breast cancer patients with 1–2 positive sentinel lymph nodes were also provided by the expert panel. Routine axillary lymph node dissection should not be offered in these patients who receive breast conservation therapy. Axillary radiation instead of axillary lymph node dissection should be considered in the same group of patients undergoing mastectomy. Interpretation: An individualised approach based on patients' preferences, risk factors for BCRAL, availability of treatment options and expertise of the healthcare team is paramount to ensure patients at risk receive preventive interventions for BCRAL, regardless of where they are receiving care. Funding: This study was not supported by any funding. RJC received investigator grant support from the Australian National Health and Medical Research Council (APP1194051).

Published
2024
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3. Barrier films or dressings for the prevention of acute radiation dermatitis in breast cancer: a systematic review and network meta-analysis

Author

Wong, Henry C. Y., Lee, Shing Fung, Caini, Saverio, Chan, Adrian Wai, Kwan, Jennifer Y. Y., Waddle, Mark, Sonis, Stephen, Herst, Patries, Alcorn, Sara, Bonomo, Pierluigi, Wong, Cindy, Corbin, Kimberly, Choi, J. Isabelle, Rembielak, Agata, AlKhaifi, Muna, Marta, Gustavo Nader, Rades, Dirk, van den Hurk, Corina, Wolf, Julie Ryan, Chan, Raymond J., Schmeel, Leonard Christopher, Lock, Michael, Hijal, Tarek, Cao, Jeffrey, Kim, Hayeon, and Chow, Edward

Published
2024
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6. Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidance for the prevention of breast cancer-related arm lymphoedema (BCRAL): international Delphi consensus-based recommendations

Author

AlKhaifi, Muna, Alvarez, Belen Alonso, Banerjee, Suvam, Bloomquist, Kira, Bonomo, Pierluigi, Borman, Pinar, Borthwick, Yolande, Chan, Dominic, Chan, Sze Man, Chan, Yolanda, Jean Cheng, Ngan Sum, Choi, J. Isabelle, Chow, Edward, Choy, Yin Ping, Corbin, Kimberly, Dylke, Elizabeth, Hammond, Pamela, Hirakawa, Satoshi, Hirata, Kimiko, Lee, Shing Fung, Holt, Marianne, Johnstone, Peter, Kikawa, Yuichiro, Kirk, Deborah, Kotani, Haruru, Kwok, Carol, Lai, Jessica, Lim, Mei Ying, Lock, Michael, Lorden, Brittany, Mack, Page, Magno, Stefano, Meattini, Icro, Marta, Gustavo Nader, McNeely, Margaret, Mondry, Tammy, Lopez Montoya, Luis Enrique, Ogita, Mami, Osaka, Misato, Phan, Stephanie, Poortmans, Philip, Rafn, Bolette Skjødt, Recht, Abram, Rembielak, Agata, Río-González, Angela, Robijns, Jolien, Sanuki, Naoko, Simone, Charles B., II, Spałek, Mateusz, Tane, Kaori, Nevola Teixeira, Luiz Felipe, Terada, Mitsuo, Trombetta, Mark, Wong, Kam Hung, Yoshidome, Katsuhide, Wong, Henry C.Y., Wallen, Matthew P., Chan, Adrian Wai, Dick, Narayanee, Bareham, Monique, Wolf, Julie Ryan, van den Hurk, Corina, Fitch, Margaret, and Chan, Raymond J.

Published
2024
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10. Mepitel film for the prevention and treatment of acute radiation dermatitis in breast cancer: a systematic review and meta-analysis of randomized controlled trials

Author

Shariati, Saba, Behroozian, Tara, Kennedy, Samantha, Caini, Saverio, Herst, Patries M., Zhang, Liying, Ding, Keyue, Karam, Irene, van den Hurk, Corina, Wolf, Julie Ryan, Lee, Shing Fung, Wong, Henry, Chan, Adrian Wai, Ogita, Mami, Ye, Jason C., Chan, Raymond J., Gojsevic, Milena, Rajeswaran, Thenugaa, Bonomo, Pierluigi, and Chow, Edward

Published
2023
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11. StrataXRT for the prevention of acute radiation dermatitis in breast cancer: a systematic review and meta-analysis of randomized controlled trials

Author

Lee, Shing Fung, Shariati, Saba, Caini, Saverio, Wong, Henry, Chan, Adrian W, Gojsevic, Milena, Ogita, Mami, Ye, Jason C., Chia, David, Chao, Michael, Sung, KiHoon, Kennedy, Samantha K.F., Rajeswaran, Thenugaa, van den Hurk, Corina, Wolf, Julie Ryan, Chan, Raymond J, Behroozian, Tara, Bonomo, Pierluigi, and Chow, Edward

Published
2023
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28. Effect of Attribute Alignment on Action Sequence Variability: Evidence from Electronic Medical Records

Author

Kim, Inkyu, Pentland, Brian T., Wolf, Julie Ryan, Xie, Yunna, Frank, Kenneth, Pentland, Alice P., van der Aalst, Wil, Series Editor, Mylopoulos, John, Series Editor, Rosemann, Michael, Series Editor, Shaw, Michael J., Series Editor, Szyperski, Clemens, Series Editor, Hildebrandt, Thomas, editor, van Dongen, Boudewijn F., editor, Röglinger, Maximilian, editor, and Mendling, Jan, editor

Published
2019
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30. Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidance for the prevention of breast cancer-related arm lymphoedema (BCRAL): international Delphi consensus-based recommendations

Author

Wong, Henry C.Y., primary, Wallen, Matthew P., additional, Chan, Adrian Wai, additional, Dick, Narayanee, additional, Bonomo, Pierluigi, additional, Bareham, Monique, additional, Wolf, Julie Ryan, additional, van den Hurk, Corina, additional, Fitch, Margaret, additional, Chow, Edward, additional, Chan, Raymond J., additional, AlKhaifi, Muna, additional, Alvarez, Belen Alonso, additional, Banerjee, Suvam, additional, Bloomquist, Kira, additional, Borman, Pinar, additional, Borthwick, Yolande, additional, Chan, Dominic, additional, Chan, Sze Man, additional, Chan, Yolanda, additional, Jean Cheng, Ngan Sum, additional, Choi, J. Isabelle, additional, Choy, Yin Ping, additional, Corbin, Kimberly, additional, Dylke, Elizabeth, additional, Hammond, Pamela, additional, Hirakawa, Satoshi, additional, Hirata, Kimiko, additional, Lee, Shing Fung, additional, Holt, Marianne, additional, Johnstone, Peter, additional, Kikawa, Yuichiro, additional, Kirk, Deborah, additional, Kotani, Haruru, additional, Kwok, Carol, additional, Lai, Jessica, additional, Lim, Mei Ying, additional, Lock, Michael, additional, Lorden, Brittany, additional, Mack, Page, additional, Magno, Stefano, additional, Meattini, Icro, additional, Marta, Gustavo Nader, additional, McNeely, Margaret, additional, Mondry, Tammy, additional, Lopez Montoya, Luis Enrique, additional, Ogita, Mami, additional, Osaka, Misato, additional, Phan, Stephanie, additional, Poortmans, Philip, additional, Rafn, Bolette Skjødt, additional, Recht, Abram, additional, Rembielak, Agata, additional, Río-González, Angela, additional, Robijns, Jolien, additional, Sanuki, Naoko, additional, Simone, Charles B., additional, Spałek, Mateusz, additional, Tane, Kaori, additional, Nevola Teixeira, Luiz Felipe, additional, Terada, Mitsuo, additional, Trombetta, Mark, additional, Wong, Kam Hung, additional, and Yoshidome, Katsuhide, additional

Published
2024
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32. Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations

Author

Tara Behroozian, Pierluigi Bonomo, Partha Patel, Lauren Kanee, Samuel Finkelstein, Corina van den Hurk, Edward Chow, Julie Ryan Wolf, Suvam Banerjee, Carlotta Becherini, Christine Boers-Doets, Marta Carlesimo, Gemma Caro, Maria Caterina Fortuna, Adrian Wai Chan, Lorraine Drapek, Azael Freites-Martinez, Satoshi Hirakawa, Emily Hoffman Smith, Nicola Alessandro Iacovelli, Bernice Kwong, Shing Fung Lee, Alina Markova, Robert Miller, Gustavo Nader Marta, Silvina Pugliese, Claire Marie Reyes Habito, Jolien Robijns, Viola Salvestrini, Leonard Christopher Schmeel, Mateusz Spalek, Mark Trombetta, and Henry Chun Yip Wong

Subjects
Oncology
Published
2023
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33. Current quality of life assessment tools may not fully address dermatological adverse events from anti-cancer therapies

Author

Tara, Behroozian, Sakeena, Fatima, Samuel, Finkelstein, Lauren, Kanee, Pierluigi, Bonomo, Julie Ryan, Wolf, Vassilios, Vassiliou, Corina, van den Hurk, Edward, Chow, and Mara, Beveridge

Subjects
Oncology, Neoplasms, Quality of Life, Humans
Abstract

Supportive oncodermatology is a burgeoning new field within dermatology tasked with caring for the unique dermatologic needs of patients with cancer. Patients with dermatologic adverse events (dAEs) from localized and systemic anti-cancer therapies commonly experience significant distress and reduced health-related quality of life (HRQoL). Emerging dAEs is often overlooked by clinicians and researchers, despite their considerable impacts on treatment completion and patient self-esteem. Specific HRQoL issues experienced by cancer patients with dAEs include psychosocial distress and treatment interruption or cessation. Existing HRQoL assessment indices unfortunately fall short when assessing HRQoL in patients with dAEs from anti-cancer therapies due to the lack of specificity to patients' symptoms and inability to fully encompass the unique needs of this population. Additionally, the variability in HRQoL assessments across studies is substantial, suggesting the need for a standardized HRQoL measure. Here, we review the burden of dAEs and the existing validated tools used to measure them, while outlining strategies for modification to achieve optimal HRQoL assessment in patients with dAEs from anti-cancer therapies and address the HRQoL gap in supportive oncodermatology. Amongst the current tools, Skindex-16 most closely addresses the required skin-specific HRQoL metrics, but still lacks a few key cancer-specific measures. Other general HRQoL tools are well-tailored to cancer patients, but lack skin-specific questions.

Published
2022
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37. Home Phototherapy Improves Access to Dermatologic Care: A Novel Stakeholder Alliance to Facilitate Its Implementation

Author

Fatima Bawany, Julie Ryan Wolff, Christopher T Ritchlin, and Francisco Tausk

Subjects
Clinical, Cosmetic and Investigational Dermatology, Dermatology
Abstract

Fatima Bawany,1 Julie Ryan Wolff,1 Christopher T Ritchlin,2 Francisco Tausk1,2 1Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA; 2Department of Medicine, University of Rochester Medical Center, Rochester, NY, USACorrespondence: Francisco Tausk, Department of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave., Box 697, Rochester, NY, 14642, USA, Email Francisco_Tausk@urmc.rochester.edu

Published
2023

47. THEORIZING PROCESS DYNAMICS WITH DIRECTED GRAPHS: A DIACHRONIC ANALYSIS OF DIGITAL TRACE DATA.

Author

Pentland, Brian T., Vaast, Emmanuelle, and Wolf, Julie Ryan

Abstract

The growing availability of digital trace data has generated unprecedented opportunities for analyzing, explaining, and predicting the dynamics of process change. While research on process organization studies theorizes about process and change, and research on process mining rigorously measures and models business processes, there has so far been limited research that measures and theorizes about process dynamics. This gap represents an opportunity for new information systems research. This research note lays the foundation for such an endeavor by demonstrating the use of process mining for diachronic analysis of process dynamics. We detail the definitions, assumptions, and mechanics of an approach that is based on representing processes as weighted, directed graphs. Using this representation, we offer a precise definition of process dynamics that focuses attention on describing and measuring changes in process structure over time. We analyze process structure over two years at four dermatology clinics. Our analysis reveals process changes that were invisible to the medical staff in the clinics. This approach offers empirical insights that are relevant to many theoretical perspectives on process dynamics. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Administrative Burden of iPLEDGE Deters Isotretinoin Prescriptions: Results From a Survey of Dermatologists

Author

Gayin, Lee, Julie Ryan, Wolf, and Kathryn E, Somers

Subjects
Prescriptions, Surveys and Questionnaires, Acne Vulgaris, Humans, Dermatologic Agents, Isotretinoin, United States, Dermatologists
Abstract

The requirements of the iPLEDGE program place burdens on both patients with severe recalcitrant nodular acne and prescribers of isotretinoin. We sought to investigate the changes in dermatologists' acne treatment patterns due to the administrative burden of iPLEDGE by assessing whether dermatologists chose not to prescribe isotretinoin to appropriate patients because of the labor of iPLEDGE requirements. Additionally, we investigated the medications that were substituted for isotretinoin. An anonymous online survey was created and posted on a dermatology group on social media. The survey respondents (N=510) consisted of board-certified dermatologists across the United States and comprised a wide variety of ages and practice types. This survey ultimately highlighted the burden of iPLEDGE for American clinicians and the need for a more streamlined risk-management program. This program is deterring some US clinicians, especially those younger than 46 years, from prescribing isotretinoin and limiting patient access to an effective medication.

Published
2022
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50. Theorizing Process Dynamics with Directed Graphs: A Diachronic Analysis of Digital Trace Data

Author

Julie Ryan Wolf, Brian T. Pentland, and Emmanuelle Vaast

Subjects
Trace (semiology), Information Systems and Management, Diachronic analysis, Theoretical computer science, Process dynamics, Computer science, Directed graph, Computer Science Applications, Information Systems, Management Information Systems
Abstract

The growing availability of digital trace data has generated unprecedented opportunities for analyzing, explaining, and predicting the dynamics of process change. While research on process organization studies theorizes about process and change, and research on process mining rigorously measures and models business processes, there has so far been limited research that measures and theorizes about process dynamics. This gap represents an opportunity for new information systems research. This research note lays the foundation for such an endeavor by demonstrating the use of process mining for diachronic analysis of process dynamics. We detail the definitions, assumptions, and mechanics of an approach that is based on representing processes as weighted, directed graphs. Using this representation, we offer a precise definition of process dynamics that focuses attention on describing and measuring changes in process structure over time. We analyze process structure over two years at four dermatology clinics. Our analysis reveals process changes that were invisible to the medical staff in the clinics. This approach offers empirical insights that are relevant to many theoretical perspectives on process dynamics.

Published
2021
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