1. Advanced chronic kidney disease is associated with higher serum concentration of monocyte microparticles
- Author
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Francisco Antonio Helfenstein Fonseca, Ana Paula Ballerini, Gláucia Maria Machado-Santelli, Juliana Kato, Paula Rezende, Jonatas do Amaral, Waleria T. Fonzar, Carlos Eduardo dos Santos Ferreira, Maria Cristina de Oliveira Izar, and Carolina Nunes França
- Subjects
Adult ,Blood Platelets ,Male ,0301 basic medicine ,medicine.medical_specialty ,Renal function ,Inflammation ,Disease ,Matrix metalloproteinase ,030226 pharmacology & pharmacy ,Gastroenterology ,Monocytes ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Cell-Derived Microparticles ,Internal medicine ,medicine ,Humans ,Platelet ,Renal Insufficiency, Chronic ,General Pharmacology, Toxicology and Pharmaceutics ,Aged ,business.industry ,Monocyte ,Endothelial Cells ,General Medicine ,Middle Aged ,medicine.disease ,CITOMETRIA DE FLUXO ,Cross-Sectional Studies ,030104 developmental biology ,medicine.anatomical_structure ,Decreased glomerular filtration rate ,Cardiovascular Diseases ,Disease Progression ,Female ,medicine.symptom ,business ,Glomerular Filtration Rate ,Kidney disease - Abstract
Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP), platelet (PMP) and monocytic (MMP) microparticles. Cross-sectional study with blinded endpoints included subjects of both sexes, aged 40-75 years (n = 247), with established cardiovascular disease (coronary heart disease, ischemic stroke, or peripheral artery disease). They were stratified 1:1 by the presence or absence of decreased glomerular filtration rate (GFR 60 mL/min/1.73 m
- Published
- 2020
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