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The ethanolic extract obtained from purple pitanga fruit (Eugenia uniflora – PPE) has been previously described by its potential to reduce lipid accumulation in vitro. In this study, we aim...

Despite all the applications of nanotechnology, limited data are available on their environmental and health risks. Many nanomaterials have been developed; however, their safety evaluation is not performed at the same speed. Toxicity can occur at different trophic levels (microorganisms, invertebrates, and vertebrates), and because of that, alternative/complementary models have been successfully employed. This mini-review aims to report some studies that have successfully used different alternative models to assess nanotoxicology and to stimulate their use by other groups of this important field. This will provide more information about nanomaterials and also to evoke studies to improve formulations.

Made available in DSpace on 2022-04-29T08:38:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The demand for the development of environmentally sustainable, low-cost and controlled-release bioinsecticides for crop protection is emerging. To that end, we have developed biodegradable zein nanoparticles (NP) loaded with clove oil (CO) or its major compound eugenol (EU), which have been widely reported by their insecticide activities. However, the safety and efficacy of these newly developed NPs is unknown. To evaluate the environmental safety of these NPs we have used the nematode Caenorhabditis elegans, a non-target organism. We observed that EU and CO NPs displayed low toxicity to these worms at all endpoints analyzed. We have evidenced a significative insectide activity of both EU and CO-loaded NPs against Drosophila melanogaster, with a higher potential in comparison to the free essential oils. These results suggest that EU and CO nanoencapsulation using zein as biopolymer is promising for further studies aiming the production of eco-friendly botanical insecticides for crop protection. Programa de Pós-Graduação em Bioquímica Grupo de pesquisa em Bioquímica e Toxicologia em Caenorhabditis elegans (GBToxCe) Universidade Federal do Pampa Universidade Estadual Paulista (UNESP) -Júlio de Mesquita Filho Instituto de Ciência e Tecnologia de Sorocaba Laboratório de Nanotecnologia Ambiental, Av. Três de Março, 511, Alto da Boa Vista Laboratório de Biofilmes e Modelos Alternativos (BioModal) Universidade Federal de Ciências da Saúde de Porto Alegre Laboratório de Estudos Físico-Químicos e de Produtos Naturais (LEFQPN) Campus Uruguaiana Universidade Federal do Pampa Universidade Estadual Paulista (UNESP) -Júlio de Mesquita Filho Instituto de Ciência e Tecnologia de Sorocaba Laboratório de Nanotecnologia Ambiental, Av. Três de Março, 511, Alto da Boa Vista FAPESP: 2015/17120-4 FAPESP: 2017/21004-5 CNPq: 453963/2014-5