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Your search keyword '"Julia Soto Rizzato"' showing total 6 results
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6 results on '"Julia Soto Rizzato"'

1. Myrciaria jaboticaba Fruit Peel: Bioactive Composition as Determined by Distinct Harvest Seasons and In Vitro Anti-Cancer Activity

Author

Roberto de Paula do Nascimento, Julia Soto Rizzato, Gabriele Polezi, Hatim Boughanem, Non Gwenllian Williams, Renata Galhardo Borguini, Manuela Cristina Pessanha de Araujo Santiago, Mario Roberto Marostica Junior, and Lee Parry

Subjects
agro-industrial byproduct, anthocyanins, anti-colony-forming activity, anti-proliferative action, Caco-2 cells, colorectal cancer, Botany, QK1-989
Abstract

Jaboticaba (Myrciaria jaboticaba) is a recognizable and unique crop from Brazil. The fruit’s byproducts are currently being studied, given their bioactive composition and promising anti-cancer potential. It is not evident, however, if different harvesting seasons can modify the chemical profile and antioxidant capacity of jaboticaba fruit fractions. Furthermore, as there is limited data for jaboticaba’s anti-proliferative effects, additional assessments are required to improve the robustness of these findings. Therefore, this study aimed to determine the composition of the peel of jaboticaba collected in two periods (May—off-season, sample 1—and August–October—peak season, sample 2) and test the peel’s richest anthocyanin sample against colorectal cancer (CRC) cell lines. To accomplish this, proximate, spectrophotometric, and chromatographic analyses were performed in two freeze-dried samples; and anti-proliferative and/or colony-forming assays were carried out in Caco-2, HT29, and HT29-MTX cells. As a result, sample 2 showed the highest levels of polyphenols overall, including flavonoids and anthocyanins. This sample displayed significative higher contents of cyanidin-3-O-glucoside (48%) and delphinidin-3-O-glucoside (105%), in addition to a superior antioxidant capacity (23% higher). Sample 1 showed higher amounts of total protein, gallic acid (20% higher), and specific carotenoids. An aqueous extract from sample 2 was tested against CRC, showing anti-proliferative effects for Caco-2 cells at 1 and 2 mg/mL concentrations, with IC50 values of 1.2–1.3 mg/mL. Additionally, the extract was able to inhibit cell colony formation when tested at both low and high concentrations. In conclusion, jaboticaba collected in the main season stands out regarding its polyphenol composition and holds potential against cancer cell growth.

Published
2024
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2. Contributors

Author

Francesca Algieri, Luiz Domingues de Almeida-Junior, Mariana da Rocha Alves, Henrique Silvano Arruda, Maria de Lourdes Setsuko Ayrizono, Rafaela de Carvalho Baptista, Levi Nascimento Bellinazzi, Joana Breves, Fabíola Vieira de Carvalho, Hugo Dugolin Ceccato, Karina Nascimento da Silva, Luiz Claudio Di Stasi, Cilene Bicca Dias, Patricia Diez-Echave, Elizabethe Adriana Esteves, Marciane Milanski Ferreira, Julio Galvez, Livia Moreira Genaro, Marina Villar Geraldi, Luis Eduardo Miani Gomes, Laura Hidalgo-Garcia, Raquel Franco Leal, Amanda Pereira Lima, Dyana Carla Lima, Ana Paula da Fonseca Machado, Juliana Kelly da Silva Maia, Mario Roberto Maróstica Junior, Carlos Augusto Real Martinez, Fábio Perez de Mello, Jose Alberto Molina-Tijeras, Andréa Cristina de Moraes Malinverni, Lauane Gomes Moreno, Ludmilla David de Moura, Roberto de Paula do Nascimento, Nathan Hargreaves Noguera, Mariah Zajankauskas Orçati, Ana Paula Ribeiro Paiotti, José Aires Pereira, Gabriele Polezi, Cíntia Lacerda Ramos, Lívia Mateus Reguengo, Beatriz Elias Ribeiro, Daniel Araki Ribeiro, Julia Soto Rizzato, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, Maria Jesús Rodríguez-Sojo, Antonio Jesús Ruiz-Malagón, Maciej Salaga, Débora Salles, Julian Furtado Silva, Carina de Sousa Santos, Heitor Siffert Pereira de Souza, Karine Mariane Steigleder, Mikołaj Świerczyński, Aleksandra Tarasiuk, and Teresa Vezza

Published
2023
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3. Freeze-Dried Jaboticaba (Myrciaria Jaboticaba (Vell.) O. Berg) Peel Powder, a Rich Source of Anthocyanins and Phenolic Acids, Mitigates Inflammation-Driven Colorectal Cancer in Mice

Author

Roberto de Paula do Nascimento, Julia Soto Rizzato, Gabriele Polezi, Amanda Maria Tomazini Munhoz Moya, Milena Ferreira Silva, Ana Paula da Fonseca Machado, Gilberto Carlos Franchi Junior, Renata Galhardo Borguini, Manuela Cristina Pessanha de A Santiago, Ana Paula Ribeiro Paiotti, José Aires Pereira, Carlos Augusto Real Martinez, and Mario Roberto Maróstica Junior

Published
2023
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5. Freeze-dried jaboticaba (Myrciaria jaboticaba) peel powder, a rich source of anthocyanins and phenolic acids, mitigates inflammation-driven colorectal cancer in mice

Author

Roberto de Paula do Nascimento, Julia Soto Rizzato, Gabriele Polezi, Amanda Maria Tomazini Munhoz Moya, Milena Ferreira Silva, Ana Paula da Fonseca Machado, Gilberto Carlos Franchi Junior, Renata Galhardo Borguini, Manuela Cristina Pessanha de Araújo Santiago, Ana Paula Ribeiro Paiotti, José Aires Pereira, Carlos Augusto Real Martinez, and Mario Roberto Marostica Junior

Subjects
Biochemistry, Food Science
Published
2023
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6. Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage

Author

Cinthia Baú Betim Cazarin, Licio A. Velloso, Carlos Augusto Real Martinez, Gabriele Polezi, Joseane Morari, Paulo Sérgio Loubet Filho, Nathalia Medina dos Santos, Ana Paula Ribeiro Paiotti, José Aires Pereira, Roberto de Paula do Nascimento, Stanislau Bogusz Junior, Patrícia Berilli Batista, Lívia Mateus Reguengo, Mário Roberto Maróstica Júnior, and Julia Soto Rizzato

Subjects
medicine.medical_specialty, business.industry, Inflammatory Bowel Diseases, INFLAMAÇÃO, Body weight, medicine.disease, Biochemistry, Obesity, Gastroenterology, Regimen, Polyphenol, Internal medicine, Medicine, Colitis, medicine.symptom, business, Weight gain, Food Science, Obese Mice
Abstract

This study hypothesized that polyphenol- and fiber-rich Brazilian fruits could elicit preventive effects in inflammatory bowel diseases (IBDs), even when applied to obese subjects. Therefore, the purpose was to investigate the implications of the consumption of acai pulp and jaboticaba peel on obese mice with dextran sodium sulfate (DSS)-induced colitis. First, obesity was induced by a high-fat diet for 13 weeks, followed by the inclusion of DSS in the water for five days. Animals received during the whole experiment a standard or high-fat diet, with the last one containing or not 5% (w/w) freeze-dried acai or jaboticaba. The diets added with the fruits had a higher content in total phenolic compounds (1.1 mg GAE/g) and an increased antioxidant capacity (up to 25.32 μmol TE/g). The high-fat diet promoted weight gain starting from the eighth week of the experiment. While jaboticaba delayed and reduced body weight gain, acai highly exacerbated it, also increasing the accumulation of fats. Colitis was successfully induced as seen by the clinical signs and damaged colonic mucosa. The high-fat diets did not increase the severity of colitis in comparison with the standard regimen, despite promoting additional weight gain. Animals that received acai or jaboticaba did not have many symptoms of colitis and showed a grand recovery in colonic histological parameters. Additionally, acai increased the expression of tight-junction-related molecules. Despite being included in a high-fat diet, the fruits still managed to promote healing effects in colitis, therefore indicating their potential for trials with IBD patients.

Published
2021
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