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1. Trim33 masks a non-transcriptional function of E2f4 in replication fork progression

Author

Vanessa Rousseau, Elias Einig, Chao Jin, Julia Horn, Mathias Riebold, Tanja Poth, Mohamed-Ali Jarboui, Michael Flentje, and Nikita Popov

Subjects
Science
Abstract

Abstract Replicative stress promotes genomic instability and tumorigenesis but also presents an effective therapeutic endpoint, rationalizing detailed analysis of pathways that control DNA replication. We show here that the transcription factor E2f4 recruits the DNA helicase Recql to facilitate progression of DNA replication forks upon drug- or oncogene-induced replicative stress. In unperturbed cells, the Trim33 ubiquitin ligase targets E2f4 for degradation, limiting its genomic binding and interactions with Recql. Replicative stress blunts Trim33-dependent ubiquitination of E2f4, which stimulates transient Recql recruitment to chromatin and facilitates recovery of DNA synthesis. In contrast, deletion of Trim33 induces chronic genome-wide recruitment of Recql and strongly accelerates DNA replication under stress, compromising checkpoint signaling and DNA repair. Depletion of Trim33 in Myc-overexpressing cells leads to accumulation of replication-associated DNA damage and delays Myc-driven tumorigenesis. We propose that the Trim33-E2f4-Recql axis controls progression of DNA replication forks along transcriptionally active chromatin to maintain genome integrity.

Published
2023
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2. Protein Expression of AEBP1, MCM4, and FABP4 Differentiate Osteogenic, Adipogenic, and Mesenchymal Stromal Stem Cells

Author

Thorben Sauer, Giulia Facchinetti, Michael Kohl, Justyna M. Kowal, Svitlana Rozanova, Julia Horn, Hagen Schmal, Ivo Kwee, Arndt-Peter Schulz, Sonja Hartwig, Moustapha Kassem, Jens K. Habermann, and Timo Gemoll

Subjects
protein profiling, data-independent acquisition mass spectrometry, SWATH, human stromal/mesenchymal stem cells, differentiation markers, machine learning, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Mesenchymal stem cells (MSCs) gain an increasing focus in the field of regenerative medicine due to their differentiation abilities into chondrocytes, adipocytes, and osteoblastic cells. However, it is apparent that the transformation processes are extremely complex and cause cellular heterogeneity. The study aimed to characterize differences between MSCs and cells after adipogenic (AD) or osteoblastic (OB) differentiation at the proteome level. Comparative proteomic profiling was performed using tandem mass spectrometry in data-independent acquisition mode. Proteins were quantified by deep neural networks in library-free mode and correlated to the Molecular Signature Database (MSigDB) hallmark gene set collections for functional annotation. We analyzed 4108 proteins across all samples, which revealed a distinct clustering between MSCs and cell differentiation states. Protein expression profiling identified activation of the Peroxisome proliferator-activated receptors (PPARs) signaling pathway after AD. In addition, two distinct protein marker panels could be defined for osteoblastic and adipocytic cell lineages. Hereby, overexpression of AEBP1 and MCM4 for OB as well as of FABP4 for AD was detected as the most promising molecular markers. Combination of deep neural network and machine-learning algorithms with data-independent mass spectrometry distinguish MSCs and cell lineages after adipogenic or osteoblastic differentiation. We identified specific proteins as the molecular basis for bone formation, which could be used for regenerative medicine in the future.

Published
2022
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3. Fake-talk and the Spaza Shop: A Fake Food Furore and the Spectre of Public Health Emergencies in South Africa

Author

Julia Hornberger, Sarah Hodges, and Edmore Chitukutuku

Subjects
fake food, protest, health emergency, south africa, xenophobia, Anthropology, GN1-890, Medicine (General), R5-920
Abstract

At the end of August 2018, a controversy erupted in South Africa. Accusations of potentially poisonous ‘fake food’ had been circulating on social media for a month or so, and by early September reports were common on South African news programmes. Accusations fell at the door of foreign-run spaza shops (convenience stores), some of which were looted and their shopkeepers harmed. Many commentators read these events as another outbreak of the xenophobic violence that has flared up across South African townships for more than a decade. Our reading is different. In this Research Article, rather than dismissing accusations of fake-ness as merely a pretext for popular protest and violence, we tackle the question of what work ‘fake-talk’ does. We show that in this instance, accusations of fake-ness brought a distinctive urgency to events, framing what might otherwise have been seen as concerns about inequality in the language of a public health crisis. In response, a state normally hesitant to act on citizens’ long-standing complaints about ‘the duplicity of foreigners’ intervened with a new speed and decisiveness. ‘Fake-talk’, we conclude, is an important site of inquiry because of how it may enable certain actions, regardless of whether suspicions are founded.

Published
2023
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4. Fake-talk as Concept and Method

Author

Julia Hornberger and Sarah Hodges

Subjects
fake, pharmaceuticals, health, evidence, suspicion, Anthropology, GN1-890, Medicine (General), R5-920
Abstract

In a world seemingly awash with fakes—or at least accusations of fake-ness—it is not only difficult to discern what is ‘real’ but also to know what to make of such a proliferation of worries about fakes. In this article, a manifesto of sorts for the Special Section, we outline how the problem of ‘fake drugs’ in particular allows us to understand the phenomenon of fakes in general. We introduce the conceptual and methodological tool of ‘fake-talk’ as it allows us to make sense of claims about fake drugs and of the power these claims hold. We develop our argument through a close reading of specific ethnographic examples drawn from the work of our colleagues in the project ‘What’s at Stake in the Fake? Indian Pharmaceuticals, African Markets and Global Health’. We show that fake-talk thrives on a lack of evidence, imports urgency, and is expressive. Taking fakes seriously as a force in themselves enables us to see how fakes are freighted with—and deploy—everyday articulations of otherwise unfathomable discomforts, predicaments, and anxieties of our time.

Published
2023
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5. The Long Shadow of Fake Drugs and the Social Lives of Fake-ness

Author

Sarah Hodges and Julia Hornberger

Subjects
fake-talk, pharmaceuticals, fake drugs, Anthropology, GN1-890, Medicine (General), R5-920
Abstract

Introduction to the Special Section 'The Long Shadow of Fake Drugs and the Social Lives of Fake-ness', guest edited by Sarah Hodges and Julia Hornberger.

Published
2023
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6. Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy

Author

Caroline Burgard, Mathias Johannes Zacherl, Andrei Todica, Julia Hornung, Freba Grawe, Isabell Pekrul, Petra Zimmermann, Christine Schmid-Tannwald, Roland Ladurner, Detlef Krenz, Arnold Trupka, Johanna Wagner, Peter Bartenstein, Christine Spitzweg, and Vera Wenter

Subjects
thyroid carcinoma, radioiodine therapy, pediatric oncology, children, adolescents, patient outcome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionDifferentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC commonly presents with advanced disease at diagnosis including a high prevalence of cervical lymph node metastases and pulmonary metastases. Studies in children with DTC are limited. Therefore, we aimed to evaluate the initial presentation, effectiveness of radioiodine therapy (RIT), and long-term outcome of prepubertal in comparison to pubertal/postpubertal patients.MethodsEighty-five pediatric and young patients aged 6.4 to 21.9 years with histopathologically confirmed DTC were retrospectively included. They all underwent total thyroidectomy followed by RIT. Initial presentation and outcome of prepubertal and pubertal/postpubertal patients were compared 1 year after RIT, during follow-up, and at the last visit of follow-up.ResultsPrepubertal patients presented with significantly higher T and M stages. One year after RIT, 42/81 (52%) patients still presented with evidence of disease (ED). During follow-up of a median of 7.9 years, prepubertal patients were less often in complete remission (58% vs. 82% in pubertal patients). At the last visit of follow-up, 19/80 (24%) patients still had ED without statistical differences between the two groups (42% prepubertal vs. 18% pubertal/postpubertal, p-value 0.06). None of our patients died disease-related over the observed period.ConclusionPrepubertal children with DTC presented with a more advanced tumor stage at the initial presentation. During follow-up, they present more often with ED. However, at the end of our study, we did not observe statistically relevant differences in patient outcomes between the prepubertal and pubertal/postpubertal groups.

Published
2023
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7. Wenn die Rolle nicht mehr reicht. Im Chaos von Lesbos

Author

Julia Horn

Subjects
Psychiatry and Mental health, Neuropsychology and Physiological Psychology
Abstract

Julia Horn arbeitet seit 27 Jahren als freie Fernsehjournalistin und Filmemacherin vorwiegend fur WDR, arte, ZDF und ist als Dozentin und Coach tatig. Auf Lesbos wollte sie eigentlich einen Film uber eine Hilfsaktion von Rupert Neudeck drehen, doch dann kam alles ganz anders. Konfrontiert mit der Not der auf Lesbos ankommenden Fluchtenden, konnte sie nicht langer objektive Beobachterin bleiben. Fur Communicatio Socialis reflektiert sie ihren Rollenwechsel und berichtet uber ihre Erfahrungen.

Published
2016

8. Educational Enhancement in the Disciplines: Models, Lessons and Challenges from Three Research-Intensive Universities

Author

Herman Buelens, Mieke Clement, Julia Horn, Camilla Østerberg Rump, Kathleen M. Quinlan, Stensaker, Bjorn, Breslow, Lori, Bilbow, Grahame, and van der Vaart, Rob

Subjects
LB2300, Engineering, business.industry, 05 social sciences, 050301 education, Conceptual framework, 0502 economics and business, Pedagogy, University teaching, Centrality, business, 0503 education, Discipline, 050203 business & management, Educational development
Abstract

In this chapter, we argue for the centrality of the unique languages, cultures and traditions of the academic disciplines to university teaching and learning and for the need to redefine the relationship between disciplinary and educational experts when enhancing education in research-intensive universities. We propose a conceptual framework that privileges the discipline as a key factor in designing educational enhancement strategies, while acknowledging institutional and national contexts. This framework guides an examination of three specific case studies from three different research-intensive universities (University of Copenhagen (UCPH), University of Leuven (KU Leuven), University of Oxford), each with its own history of educational development and enhancement strategies over the past several decades. We outline the method for writing and interrogating those cases. The cases highlight challenges associated with efforts to enhance teaching and learning in research-intensive universities and the role the disciplines can play in those efforts. We conclude with recommendations for educational enhancement practice drawn from this analysis of multi-institutional cases.

Published
2017

9. Signature pedagogy/powerful pedagogy: The Oxford tutorial system in the humanities

Author

Julia Horn

Subjects
Visual Arts and Performing Arts, Higher education, business.industry, Teaching method, Signature (logic), Education, Writing instruction, Pedagogy, ComputingMilieux_COMPUTERSANDEDUCATION, Mathematics education, Educational administration, business, Psychology, Humanities, Tutorial system
Abstract

Lee Shulman’s concept of signature pedagogies in the professions has captured the imagination of many researchers and educators. In higher education, the concept has been extended to teaching in particular disciplines, and it is here argued that the concept of signature pedagogy can be usefully extended to an influential teaching system in the humanities: the Oxford tutorial. Some of the specific aspects of the tutorial system, and the habits of teaching and learning that tutors and students develop are described; and some of the limitations of the term ‘signature pedagogy’ for this case are also identified. The term ‘powerful pedagogy’ is proposed as a useful extension of ‘signature pedagogy’, to identify ambivalent features of influential teaching systems.

Published
2013

10. Closeness and distance:Using close reading as a method of educational enquiry in English studies

Author

Julia Horn and Helen Brookman

Subjects
Visual Arts and Performing Arts, 05 social sciences, 050301 education, English studies, Education, Scholarship, Educational research, Critical reading, 0502 economics and business, Close reading, Pedagogy, Mathematics education, ComputingMilieux_COMPUTERSANDEDUCATION, Literary criticism, Scholarship of Teaching and Learning, Sociology, 0503 education, Discipline, 050203 business & management
Abstract

This article draws on a pedagogical case study in order to reflect on the value of using a Humanities disciplinary practice (the ‘close reading’ of literary studies) as a method of educational enquiry and to provide a worked example of this approach. We explore the introduction of a pedagogic strategy – students writing abstracts for essays and sharing them in advance of group discussion – into the tutorial at the University of Oxford, and an evaluation of it. We then read the student ‘texts’ (written abstracts and evaluation forms) more closely, to problematize the initial evaluation findings and reveal hidden aspects of student learning and the teaching relationship. We reflect upon our approach and suggest some of the difficulties and advantages of ‘close reading’ student texts while achieving scholarly ‘distance’ as a pedagogic research practice. In addition, we explore further the relations between social science and humanities approaches to educational enquiry.

Published
2016

11. Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance

Author

Julia Horn, Monika Engelhardt, Annette Schmitt-Gräff, Ralph Wäsch, Stefanie Hieke, and Martina Kleber

Subjects
Male, Bendamustine, medicine.medical_specialty, Lymphoma, B-Cell, Frail Elderly, Antibodies, Monoclonal, Murine-Derived, International Prognostic Index, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Bendamustine Hydrochloride, Humans, Neoplasm Invasiveness, Progression-free survival, Aged, Aged, 80 and over, business.industry, Drug Tolerance, Hematology, General Medicine, Middle Aged, medicine.disease, Comorbidity, Confidence interval, Surgery, Lymphoma, Survival Rate, Treatment Outcome, Nitrogen Mustard Compounds, Cohort, Female, Rituximab, business, Follow-Up Studies, medicine.drug
Abstract

We analyzed the safety and efficacy of rituximab plus bendamustine (R-B) in elderly and frail patients with aggressive B-non-Hodgkin lymphoma (a-B-NHL). Few reports have as yet reported on R-B in a-B-NHL, albeit its value for indolent lymphoma vs. R-CHOP has impressively been shown. We assessed 20 consecutive patients with a-B-NHL receiving R-B as first-line or relapse treatment after (R)-CHOP in our department. Besides patient- and lymphoma-specific characteristics, comorbidity indices were determined. The median patient age was 72 years (51-86), the median Karnofsky performance status was 55 % (40-90 %), and according to the international prognostic index, 15 had high-intermediate or high-risk disease. The comorbidity indices revealed a median Kaplan-Feinstein index of 3 (range 1-3), Charlson comorbidity index of 4 (range 0-9), hematopoietic cell transplantation-specific comorbidity index of 3 (range 0-11), and Freiburg comorbidity index of 2 (range 0-2). Moreover, eight patients had echocardiographic and laboratory signs of cardiac insufficiency, all leading to R-B rather than R-CHOP treatment. The overall response rate was 55 %, with complete response and partial response rates of 20 and 35 %, respectively. In our frail and elderly patient cohort, R-B therapy was well-tolerated. Median progression free survival and overall survival were 8.3 months (95 % confidence interval [CI], 2.8--not reached [n.r.]) and 19.4 months (95 % CI, 4.6--n.r.), respectively. We conclude that R-B is a feasible and safe therapy option in a-B-NHL patients not qualifying for R-CHOP but needs to be further assessed in larger subsequent trials, these currently being under way.

Published
2012

13. Human endothelial and platelet septin SEPT11: Cloning of novel variants and characterisation of interaction partners

Author

Hansjörg Rempp, Ingrid Bartsch, Sabrina Röseler, Barbara Zieger, Julia Horn, Susanne Bläser, Anja Busse, Cornelia Brendle, Kirstin Sandrock, Michael Huber, and Mareike Lieber

Subjects
Blood Platelets, SEPT2, Synaptobrevin, Vesicle-Associated Membrane Protein 1, Cell Cycle Proteins, Biology, Septin, Exocytosis, Tubulin, Two-Hybrid System Techniques, Protein Interaction Mapping, Receptors, Transferrin, Fluorescence Resonance Energy Transfer, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, Cytoskeleton, Actin, Gene Library, Alternative splicing, Endothelial Cells, Hematology, Blotting, Northern, Molecular biology, Actins, Alternative Splicing, Microscopy, Fluorescence, Septins, Cytokinesis, Protein Binding
Abstract

SummarySeptins are cytoskeletal GTPases forming heteropolymeric complexes involved in processes characterised by active membrane movement such as cytokinesis, vesicle trafficking, and exocytosis. Septins are expressed in non-mitotic cells such as neurons and platelets. SEPT11 belongs to the SEPT6 group and was identified as interaction partner of SEPT5. We cloned and characterised novel SEPT11 variants and investigated interaction partners of SEPT11 in platelets and human umbilical vein endothelial cells. An endothelial cell library was used for cloning novel SEPT11 variants. Using Northern analysis the different SEPT11 transcripts were illustrated. Interaction studies were performed using yeast two-hybrid system, precipitation, FRET, and immunofluorescence microscopy. We demonstrate that SEPT11 partners with SEPT2, SEPT4 and SEPT7 using yeast two-hybrid system and precipitation. The interaction of SEPT11 with SEPT7 is also demonstrated by FRET. In addition to the known SEPT11 transcript (SEPT11_v1) we identified a novel SEPT11 variant (SEPT11_v2) as interaction partner of SEPT4 and SEPT7. Library screening of an endothelial cell library also revealed the presence of this novel SEPT11_v2 transcript. In addition, a third SEPT11 variant (SEPT11_v3) was identified. Expression of SEPT11_v1 and of SEPT11_v2 and SEPT11_v3 in human brain regions was investigated by Northern analysis. Further interaction partners of SEPT11 are characterised using immunofluorescence. Co-localisation of SEPT2, SEPT4, SEPT7 and SEPT11 with tubulin and transferrin receptor (endocytotic marker) is demonstrated. In addition, co-localisation of SEPT4 and SEPT11 with the vesicle-associated protein synaptobrevin 1 (VAMP1), but not clearly with actin, was shown. Only SEPT2 and SEPT7 definitely co-localised with actin, but not clearly with VAMP1.

Published
2010

14. The novel human platelet septin SEPT8 is an interaction partner of SEPT4

Author

Barbara Zieger, Julia Horn, Heike Bauer, Daniela Wunderle, Sandra Strümpell, Paquita Nurden, Paul Würmell, Ina Hainmann, Susanne Bläser, Axel Pagenstecher, and Anja Busse

Subjects
Blood Platelets, Macromolecular Substances, macromolecular substances, Biology, Septin, Serotonin secretion, Exocytosis, GTP Phosphohydrolases, GTP-binding protein regulators, Two-Hybrid System Techniques, Protein Interaction Mapping, Humans, Platelet, Secretion, Septin complex, Gene Library, Secretory Vesicles, fungi, Membrane Proteins, Hematology, Cell biology, Cytoskeletal Proteins, Protein Transport, biological phenomena, cell phenomena, and immunity, Septins, Cytokinesis, Protein Binding
Abstract

SummarySeptins are a family of GTP-binding proteins, which are essential for active membrane movement such as cytokinesis and vesicle trafficking. In non-dividing cells (such as platelets and neurons) septins are implicated in exocytosis. Platelets from a SEPT5 knockout mouse showed an altered serotonin secretion and platelet aggregation, suggesting that SEPT5 is involved in secretion in platelets. Septins form complexes consisting of multiple septin polypeptides. Using the yeast two-hybrid system we had demonstrated that SEPT5 partners with SEPT8.The aim of this study was to identify other interaction partners of the human platelet septin SEPT8. Using the yeast two-hybrid system with SEPT8 as bait protein we identified the human septin SEPT4 as an interaction partner of SEPT8. The interaction between SEPT4 and SEPT8 was confirmed by immunoprecipitation. Expression analysis revealed that SEPT4 is also expressed in human platelets. Thus, SEPT4 is the third described platelet septin besides SEPT5 and SEPT8.Transmission electron microscopy of platelets revealed that SEPT8 and SEPT4 are localized surrounding α-granules (as it had been shown for the septin SEPT5) suggesting that the three septins may be components of the septin complex in platelets and contribute in such a way to platelet biology. Activation of platelets by agonists resulted in the translocation of SEPT4 and SEPT8 to the platelet surface indicating a possible functional role of these proteins in platelet granular secretion.

Published
2004

16. Contents Vol. 140, 2006

Author

F. de la Torre-Martínez, Christian Betzel, Miki Abo, Françoise André, Makoto Hattori, T. Hansson, Michel Laviolette, Philippe Moingeon, Philippe Harzic, Masaki Fujimura, Julia Horn, S. Ahlstedt, Redwan Moqbel, Conny Höflich, Marie-Noëlle Couret, Volker Wahn, Yuko Waseda, Toshiyuki Yamamoto, Thierry Batard, J. Magnusson, Henri Chabre, Fook Tim Chew, M.P. Borres, J. Ring, M.D. Ibáñez, Alexandre Hrabina, Kirsten Gehlhar, Shiho Furusho, I. Münster, Wolfgang Weber, Johsuke Hara, Claudine Ferland, K. R. Rajashankar, Bertrand Villet, Masahide Yasui, C. Traidl-Hoffmann, M. Boquete, Hans-Dieter Volk, U. Bengtsson, Yoriko Herai, Francis Davoine, Hanae Wada, L. Hulthén, A.I. Tabar, Robert Bunk, Takashi Sone, Tsukasa Uno, Eckhard Hofmann, Tadashi Yoshida, Kazuo Kasahara, Yoshitaka Oribe, Albrecht Bufe, Joo Eun Lee, Dominique Faccenda, Sandra Werner, Aki Hirano, Noriyuki Ohkura, Jamila Chakir, Kathrin Schmolke, Darryl J. Adamko, Koji Takahashi, P. Lemoine, F. Rodriguez, C.G.B. Peterson, Ilka Schulze, H. Behrendt, Shigeharu Myou, Sock Yong Goh, Xue Zhi Bi, Anna-Maria Dittrich, Claude André, and J. van Odijk

Subjects
Immunology, Immunology and Allergy, General Medicine, Biology
Published
2006

17. Fatal adult-onset antibody deficiency syndrome in a patient with cartilage hair hypoplasia

Author

Klaus Warnatz, Michael Schlesier, Andrea Superti-Furga, Antje Prasse, Julia Horn, Hans-Hartmut Peter, and Ulrich Salzer

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Primary Immunodeficiency Diseases, Immunology, Biology, Osteochondrodysplasias, Short stature, Antibodies, Fatal Outcome, Agammaglobulinemia, Bone Marrow, Internal medicine, Sepsis, Endoribonucleases, medicine, Cartilage–hair hypoplasia, Immunology and Allergy, Humans, Hirschsprung Disease, Lymphocyte Count, Age of Onset, Immunodeficiency, Growth Disorders, Severe combined immunodeficiency, Base Sequence, Common variable immunodeficiency, Immunologic Deficiency Syndromes, General Medicine, Pneumonia, medicine.disease, Metaphyseal dysplasia, Omenn syndrome, Bronchiectasis, Endocrinology, Mutation, Splenomegaly, Primary immunodeficiency, Female, medicine.symptom, Bronchoalveolar Lavage Fluid, Hand Deformities, Congenital, Hair
Abstract

Cartilage hair hypoplasia (CHH) is an autosomal recessive disorder caused by mutations in the ribonuclease mitochondrial RNA-processing (RMRP) gene. Although its most constant feature is metaphyseal dysplasia with short stature, CHH is associated with extraskeletal defects such as thin hair, anemia, immunodeficiency, and increased incidence of lymphomas. The spectrum of immunologic phenotypes in CHH translates into clinical severity. Whereas T-cell deficiency may remain subclinical or may result in severe combined immunodeficiency or Omenn syndrome, humoral immunodeficiency has only rarely been noted in these patients. Here we report the diagnosis of CHH in a woman who presented with severe short stature and a full-blown antibody deficiency, clinically resembling common variable immunodeficiency. Sequencing of the RMRP gene revealed compound heterozygosity for two novel mutations (g.68_69delinsTT and g.76C>T). Despite the late onset of immunodeficiency in the patient, its clinical course was severe, and the patient died 3 years after the first diagnosis.

Published
2009

18. The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells

Author

Julia Horn, Richard A. Kroczek, Sabine Stoll, Eva Huter, Bodo Grimbacher, Mario Hubo, Jürgen Knop, Helmut Jonuleit, and Andrea Tuettenberg

Subjects
Antigens, Differentiation, T-Lymphocyte, T cell, T-Lymphocytes, Immunology, Lymphocyte Activation, T-Lymphocytes, Regulatory, Inducible T-Cell Co-Stimulator Protein, Interleukin 21, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, IL-2 receptor, Antigen-presenting cell, Cells, Cultured, Clonal Anergy, Chemistry, Peripheral tolerance, Cell Differentiation, Dendritic Cells, Natural killer T cell, Coculture Techniques, Cell biology, Interleukin-10, ICOS LIGAND, medicine.anatomical_structure, Common Variable Immunodeficiency, Gene Knockdown Techniques
Abstract

Tolerogenic dendritic cells (DC) play an important role in maintaining peripheral T cell tolerance in steady-state conditions through induction of anergic, IL-10-producing T cells with suppressive properties. ICOS, an activation-induced member of the CD28 family on T cells, is involved in the induction of IL-10, which itself could contribute to induction of anergy and development of suppressive T cells. Therefore, we analyzed the functional role of ICOS in the differentiation process of human CD4+ T cells upon their interaction with tolerogenic DC. We compared the functional properties of CD4+ T cells from healthy volunteers and ICOS-deficient patients after stimulation with tolerogenic DC. We report that induction of T cell anergy and suppressive capacity is completely blocked after knockdown of ICOS expression in T cells as well as after blocking of ICOS-ICOS ligand interaction in DC/T cell cocultures. Moreover, CD4+ T cells from ICOS-deficient patients were completely resistant to anergy induction and differentiation into suppressive T cells even after supplementation of IL-10. Furthermore, ICOS/ICOS ligand interaction stabilizes IL-10R expression on T cells and thus renders them sensitive to IL-10 effects. Taken together, these results indicate a crucial role for ICOS in the induction of peripheral tolerance maintained by tolerogenic DC mediated mostly via an IL-10-independent mechanism.

Published
2009

19. Immune Thrombocytopenic Purpura

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

20. Irritable Bowel Disease

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

21. Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

22. Idiopathic Inflammatory Myopathy

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

23. Idiopathic Neuromyotonia

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

24. Intestinal Obstruction

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

25. Idiopathic Pulmonary Fibrosis

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

26. Idiopathic Partial Epilepsies of Childhood

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

27. Infantile Cortical Hyperostosis

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

28. Infantile Convulsions

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

29. IPS

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

30. Intestinal Tryptophan Malabsorption

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

31. Idiopathic Pulmonary Hypertension

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

32. Interventricular Septal Defect

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

33. Infiltrative Myelopathy

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

34. Infertility, Female

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

35. Idiopathic Ventricular Fibrillation

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

36. ICOS Deficiency

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

37. Idiopathic Hypoproteinemia

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

38. IDDM-secretory Diarrhea Syndrome

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

39. Intrahepatic Bile Duct Loss

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

40. Idiopathic Ketotic Hypoglycemia

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

41. Intrahepatic Jaundice

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

42. Ischemic Heart Disease

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

43. Idiopathic Thrombocytosis

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

44. Idiopathic Cerebellar Ataxia

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

45. Isolated Pituitary Hormone Deficiency

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

46. Infectious Arthritis

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

47. Idiopathic Dilated Cardiomyopathy

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

48. In-Stent Restenosis

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

49. Incomplete/Partial Androgen Insensitivity Syndrome

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

50. Insulin-like Growth Factor-I Gene Deletion and Growth Retardation

Author

Stanley M. Gartler, R. Scott Hansen, Vinzenz Oji, Heiko Traupe, Julia Horn, Bodo Grimbacher, Srijita Sen-Chowdhry, Deirdre Ward, William J. McKenna, Kar Neng Lai, Silke Hofmann, Leena Bruckner-Tuderman, Peter E. H. Schwarz, Jiang Li, Stefan Bröer, Wallace F. Marshall, Elana Lavine, Chaim M. Roifman, Makoto Miyara, Shimon Sakaguchi, Carla Rautenberg, Are Martin Holm, Marcus D. Säemann, Cord Sunderkötter, Eiji Itoi, Ursula Knirsch, Georg Gosztonyi, Valéria Lamounier-Zepter, Karen Buckingham, Larry Chamley, Alberto Ferlin, Carlo Foresta, Rudi Beyaert, Geert Loo, Egbert Mundt, Elizabeth M. Keithley, Jeffrey P. Harris, Cecilia Camacho-Hübner, Katie A. Woods, Adrian J. L. Clark, Martin O. Savage, Katie Woods, Adrian Clark, Jean-Marc Guettier, Phillip Gorden, Sumeet K. Sharma, P. Syamasundar Rao, Takeshi Uehara, Takayuki Honda, Bernd Hohenstein, Christian P. M. Hugo, Sema Uguralp, Ralf Kubitz, Dieter Häussinger, Thomas Frieling, Marcus Schmitt, Walid Ahmar, Richard W. Harper, Alexander K. C. Leung, Andrew L. Wong, Alessandra Baumer, Albert Schinzel, Orsetta Zuffardi, Roberto Ciccone, Roberto Giorda, Elio Roti, Klaus Schümann, Josef Köhrle, Günter Weiss, Matthias Wenning, Christy T. Oswalt, Christian A. Koch, Martin Schwarz, Freimut Schliess, and Du Toit Loots

Published
2009

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