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1. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Author

Wei-Yu Lin, Sarah E. Fordham, Eric Hungate, Nicola J. Sunter, Claire Elstob, Yaobo Xu, Catherine Park, Anne Quante, Konstantin Strauch, Christian Gieger, Andrew Skol, Thahira Rahman, Lara Sucheston-Campbell, Junke Wang, Theresa Hahn, Alyssa I. Clay-Gilmour, Gail L. Jones, Helen J. Marr, Graham H. Jackson, Tobias Menne, Mathew Collin, Adam Ivey, Robert K. Hills, Alan K. Burnett, Nigel H. Russell, Jude Fitzgibbon, Richard A. Larson, Michelle M. Le Beau, Wendy Stock, Olaf Heidenreich, Abrar Alharbi, David J. Allsup, Richard S. Houlston, Jean Norden, Anne M. Dickinson, Elisabeth Douglas, Clare Lendrem, Ann K. Daly, Louise Palm, Kim Piechocki, Sally Jeffries, Martin Bornhäuser, Christoph Röllig, Heidi Altmann, Leo Ruhnke, Desiree Kunadt, Lisa Wagenführ, Heather J. Cordell, Rebecca Darlay, Mette K. Andersen, Maria C. Fontana, Giovanni Martinelli, Giovani Marconi, Miguel A. Sanz, José Cervera, Inés Gómez-Seguí, Thomas Cluzeau, Chimène Moreilhon, Sophie Raynaud, Heinz Sill, Maria Teresa Voso, Francesco Lo-Coco, Hervé Dombret, Meyling Cheok, Claude Preudhomme, Rosemary E. Gale, David Linch, Julia Gaal-Wesinger, Andras Masszi, Daniel Nowak, Wolf-Karsten Hofmann, Amanda Gilkes, Kimmo Porkka, Jelena D. Milosevic Feenstra, Robert Kralovics, David Grimwade, Manja Meggendorfer, Torsten Haferlach, Szilvia Krizsán, Csaba Bödör, Friedrich Stölzel, Kenan Onel, and James M. Allan

Subjects
Science
Abstract

Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.

Published
2021
Full Text
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2. Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Author

Wei-Yu Lin, Sarah E. Fordham, Eric Hungate, Nicola J. Sunter, Claire Elstob, Yaobo Xu, Catherine Park, Anne Quante, Konstantin Strauch, Christian Gieger, Andrew Skol, Thahira Rahman, Lara Sucheston-Campbell, Junke Wang, Theresa Hahn, Alyssa I. Clay-Gilmour, Gail L. Jones, Helen J. Marr, Graham H. Jackson, Tobias Menne, Mathew Collin, Adam Ivey, Robert K. Hills, Alan K. Burnett, Nigel H. Russell, Jude Fitzgibbon, Richard A. Larson, Michelle M. Le Beau, Wendy Stock, Olaf Heidenreich, Abrar Alharbi, David J. Allsup, Richard S. Houlston, Jean Norden, Anne M. Dickinson, Elisabeth Douglas, Clare Lendrem, Ann K. Daly, Louise Palm, Kim Piechocki, Sally Jeffries, Martin Bornhäuser, Christoph Röllig, Heidi Altmann, Leo Ruhnke, Desiree Kunadt, Lisa Wagenführ, Heather J. Cordell, Rebecca Darlay, Mette K. Andersen, Maria C. Fontana, Giovanni Martinelli, Giovanni Marconi, Miguel A. Sanz, José Cervera, Inés Gómez-Seguí, Thomas Cluzeau, Chimène Moreilhon, Sophie Raynaud, Heinz Sill, Maria Teresa Voso, Francesco Lo-Coco, Hervé Dombret, Meyling Cheok, Claude Preudhomme, Rosemary E. Gale, David Linch, Julia Gaal-Wesinger, Andras Masszi, Daniel Nowak, Wolf-Karsten Hofmann, Amanda Gilkes, Kimmo Porkka, Jelena D. Milosevic Feenstra, Robert Kralovics, David Grimwade, Manja Meggendorfer, Torsten Haferlach, Szilvia Krizsán, Csaba Bödör, Friedrich Stölzel, Kenan Onel, and James M. Allan

Subjects
Science
Published
2022
Full Text
View/download PDF

3. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Author

Anne M. Dickinson, Gail Jones, David C. Linch, Clare Lendrem, David Grimwade, Richard A. Larson, Andrew D. Skol, Yaobo Xu, Adam Ivey, Wei-Yu Lin, Manja Meggendorfer, Rosemary E. Gale, Inés Gómez-Seguí, Giovani Marconi, Jean Norden, Jude Fitzgibbon, Mette K. Andersen, M Bornhäuser, Sarah E. Fordham, Amanda F. Gilkes, Heinz Sill, Eric A. Hungate, José Cervera, Friedrich Stölzel, Julia Gaal-Wesinger, Kim Piechocki, Wendy Stock, Theresa Hahn, Konstantin Strauch, David Allsup, Kenan Onel, Claire Elstob, Alyssa I. Clay-Gilmour, Nicola J. Sunter, Jelena D. Milosevic Feenstra, Meyling Cheok, Abrar Alharbi, Ann K. Daly, Sally Jeffries, Lisa Wagenführ, Olaf Heidenreich, Robert Kralovics, Alan K. Burnett, Giovanni Martinelli, Desiree Kunadt, Christian Gieger, Francesco Lo-Coco, Leo Ruhnke, Maria Teresa Voso, Junke Wang, Catherine Park, Nigel H. Russell, Chimène Moreilhon, Robert Kerrin Hills, Claude Preudhomme, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, Heidi Altmann, Richard S. Houlston, Anne S. Quante, Michelle M. Le Beau, Thahira Rahman, Christoph Röllig, Rebecca Darlay, Sophie Raynaud, Helen Marr, Csaba Bödör, Louise Palm, Thomas Cluzeau, Szilvia Krizsán, Heather J. Cordell, Mathew Collin, Torsten Haferlach, Lara E. Sucheston-Campbell, Wolf-Karsten Hofmann, Kimmo Porkka, Andras Masszi, Hervé Dombret, Miguel A. Sanz, Elisabeth Douglas, Tobias Menne, HUS Comprehensive Cancer Center, University Management, Helsinki University Hospital Area, Department of Oncology, and Hematologian yksikkö

Subjects
Oncology, General Physics and Astronomy, Genome-wide association study, Disease, 0302 clinical medicine, AML, HLA Antigens, hemic and lymphatic diseases, Histone methylation, Cancer genomics, RISK, 0303 health sciences, Multidisciplinary, Myeloid leukemia, Middle Aged, CLONAL EVOLUTION, CANCER, 3. Good health, HLA, Leukemia, Myeloid, Acute, 030220 oncology & carcinogenesis, GENE-MUTATIONS, medicine.medical_specialty, Genotype, Science, Locus (genetics), HIF-1-ALPHA, Human leukocyte antigen, Polymorphism, Single Nucleotide, Article, Acute myeloid leukaemia, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Aldehyde Reductase, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, 030304 developmental biology, Genetic association, OLDER PATIENTS, Whites, business.industry, HUMAN-LEUKOCYTE ANTIGEN, Reproducibility of Results, Cancer, General Chemistry, Settore MED/15, medicine.disease, IMMUNE ESCAPE, Risk factors, Case-Control Studies, 3111 Biomedicine, business, Genome-Wide Association Study
Abstract

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA)., Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.

Published
2021

4. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Author

Michelle M. Le Beau, Thahira Rahman, Yaobo Xu, Wendy Stock, Andrew D. Skol, Abrar Alharbi, David Allsup, Claire Elstob, Lara E. Sucheston-Campbell, Lisa Wagenführ, Olaf Heidenreich, Claude Preudhomme, Tobias Menne, Szilvia Krizsán, Rebecca Darlay, Jelena D. Milosevic Feenstra, David C. Linch, Sophie Raynaud, Helen Marr, Christian Gieger, Francesco Lo-Coco, David Grimwade, Maria Teresa Voso, Junke Wang, Christoph Röllig, Clare Lendrem, Wolf-Karsten Hofmann, Mathew Collin, Manja Meggendorfer, Friedrich Stölzel, Wei-Yu Lin, Ann K. Daly, Theresa Hahn, Torsten Haferlach, Sally Jeffries, Julia Gaal-Wesinger, Konstantin Strauch, Giovani Marconi, Amanda F. Gilkes, Chimène Moreilhon, Giovanni Martinelli, Anne M. Dickinson, Robert Kerrin Hills, Alan K. Burnett, Mette K. Andersen, Leo Ruhnke, Kimmo Porkka, Catherine Park, Desiree Kunadt, Nigel H. Russell, M Bornhäuser, Alyssa I. Clay-Gilmour, Hervé Dombret, Sarah E. Fordham, Eric A. Hungate, Miguel A. Sanz, Inés Gómez-Seguí, Csaba Bödör, Jean Norden, Elisabeth Douglas, Rosemary E. Gale, Heinz Sill, Kim Piechocki, Richard A. Larson, Robert Kralovics, Meyling Cheok, Heidi Altmann, Richard S. Houlston, Andras Masszi, Anne S. Quante, Louise Palm, Thomas Cluzeau, Heather J. Cordell, Nicola J. Sunter, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, José Cervera, Kenan Onel, Gail Jones, Adam Ivey, and Jude Fitzgibbon

Subjects
0303 health sciences, Myeloid leukemia, Locus (genetics), Genome-wide association study, Human leukocyte antigen, Biology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Immune system, 030220 oncology & carcinogenesis, Histone methylation, Cancer research, Etiology, 030304 developmental biology, Genetic association
Abstract

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we performed a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identified a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identified a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N=1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology by identifying putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

Published
2021

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