Search

This article introduces the idea of quantum research as a way of approaching inquiry in spiritual/intuitive domains. This form of research combines scholarly and analytical knowledge with non-rational, non-analytical experiencing variously called direct/intuitive experiences (Tsao and Laszlo, 2019) or holistic consciousness (Goethe, in Bortoft, 1996). The article is written differently (Vachhani, 2019), and combines quantum theorizing with findings from an empirical postmodern text deconstruction study. The theorizing and empirical findings illuminate the beliefs, values, and norms of the Newtonian paradigm that continue to marginalize a quantum ontological perspective. Through a bricolage (Rogers, 2012) of interdisciplinary literature combined with findings from the postmodern (Beiser, 2011) deconstruction/imaginal study, the incommensurability between the Newtonian paradigm and quantum ontology is exposed. The bricolage illuminates the challenges and opportunities for legitimizing a quantum view of research. The article concludes with recommendations for future quantum research; for building a new window of our own.

This article focuses on the concept of worldviews, arguing that a change in managerial worldviews is the key lever for addressing the social and global challenges facing humanity. We draw from a new synthesis of science and spirituality, with the addition of “other ways of knowing” that go beyond rational-empirical analysis, to suggest that what we call Quantum Worldviews are capable of generating the prosocial and pro-environmental behavior consistent with humanistic management. Using the yin-yang symbol as a metaphor, we suggest that a transformation in consciousness, at the level of the paradigmatic assumptions held by managers about the nature of reality, can be understood through adult development theory. We also go beyond the metaphor to propose a quantum worldview based on a more literal interpretation of quantum science to fundamentally re-conceptualize what it means to be human, drawing on quantum research that suggests ontological wholeness and interdependence of all. Quantum Worldviews can help leaders, and the various systems of which they are a part, transition to a new science-based consciousness - long intuited by indigenous and nonwestern spiritual leaders - of an interconnected and dynamically coherent world. We identify a variety of practices that give managers a direct experience of Oneness, changing who they are at the deepest level of self-concept. Our research suggests that only when using such practices, and in sufficient numbers, will business leaders become agents of world benefit with the collective influence to bring about meaningful solutions to climate change and other wicked problems—in other words, needed system transformation.

Most histories of psychological-realist acting identify the mid-twentieth-century style with Lee Strasberg’s eponymous ‘Method,’ tracing its genealogy back to the work of Russian director Konstanti...

Identification of specific antibodies in patient plasma is an essential part of many diagnostic procedures and is critical for safe blood transfusion. Current techniques require laboratory infrastructure and long turnaround times which limits access to those nearby tertiary healthcare providers. Addressing this challenge, a novel and rapid paper-based antibody test is reported. We validate antibody detection with reverse blood typing using IgM antibodies and then generalise the validity by adapting to detect SARS CoV-2 (COVID-19) antibodies in patient serum samples. Reagent red blood cells (RBC) are first combined with the patient plasma containing the screened antibody and a droplet of the mixture is then deposited onto paper. The light intensity profile is analyzed to identify test results, which can be detected by eye and/or with image processing to allow full automation. The efficacy of this test to perform reverse blood typing is demonstrated and the performance and sensitivity of this test using different paper types and RBC reagents was investigated using clinical samples. As an example of the flexibility of this approach, we labeled the RBC reagent with an antibody-peptide conjugate to detect SARS CoV-2 (COVID-19) antibodies in patient serum samples. This concept could be generalized to any agglutination-based antibody diagnostics with blood plasma.

Pain is one of the most common and deleterious symptoms experienced by individuals with sickle cell disease (SCD). There is a paucity of studies identifying potential genetic mechanisms of pain in this population.Examine associations between 11 functional single nucleotide polymorphisms in 9 candidate genes with reports of average pain intensity in individuals with sickle cell disease.Cross-sectional analyses were performed on data and blood samples collected through the Duke SCD Implementation Consortium Registry. Participants were asked to rate their pain "on the average" using an 11-point numeric rating scale (0 = no pain; 10 = pain as bad as you can imagine). We genotyped 11 single nucleotide polymorphisms in 9 pain-related genes using TaqMan® Genotyping Assays. Associations between each polymorphism and reports of average pain were evaluated.The 86 participants (mean age: 28.7 years; 64% female) included in this study reported moderate pain on average (Mean = 4, Standard Deviation = 2.4). ICAM1 rs1799969 was the only genetic polymorphism that was significantly associated with pain (p = .01). Individuals with one or more minor alleles had lower average pain (Mean = 1.25, Standard Deviation = 1.50) than individuals without a minor allele (Mean = 4.13, Standard Deviation = 2.25). The effect size for ICAM1 rs1799969 was 1.30, which is considered large. The effect sizes for all other single nucleotide polymorphisms ranged from small to medium (range: 0-0.3).Our findings provide preliminary evidence that the minor allele in ICAM1 rs1799969 had protective effects against experiencing more severe pain in sickle cell disease.

High-throughput and rapid serology assays to detect the antibody response specific to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in human blood samples are urgently required to improve our understanding of the effects of COVID-19 across the world. Short-term applications include rapid case identification and contact tracing to limit viral spread, while population screening to determine the extent of viral infection across communities is a longer-term need. Assays developed to address these needs should match the ASSURED criteria. We have identified agglutination tests based on the commonly employed blood typing methods as a viable option. These blood typing tests are employed in hospitals worldwide, are high-throughput, fast (10–30 min), and automated in most cases. Herein, we describe the application of agglutination assays to SARS-CoV-2 serology testing by combining column agglutination testing with peptide–antibody bioconjugates, which facilitate red cell cross-linking only in the presence of plasma containing antibodies against SARS-CoV-2. This simple, rapid, and easily scalable approach has immediate application in SARS-CoV-2 serological testing and is a useful platform for assay development beyond the COVID-19 pandemic.

In an effort to design novel chelating polymers, polyacrylates with biscarboxylic acid containing repeating units were synthesised by reversible addition–fragmentation chain-transfer (RAFT) polymerisation of a new ethylenediaminetetraacetic acid (EDTA) mimicking monomer bearing two carboxylic acids bridged by a tertiary amine group. The monomer presented is accessible in a simple two step strategy and can be polymerised in a controlled fashion enabling the synthesis of defined homopolymers (Đ < 1.3) and the chain extension of a N-acryloyl morpholine chain transfer agent (CTA) to afford block copolymers of tailored composition. Upon deprotection of the carboxylic acid groups, the polymers showed similar pKa values as EDTA and were able to efficiently complex Zr(IV) in aqueous solution. Specifically, complexation studies using block copolymers revealed the formation of defined nanostructures, which were stable in serum containing cell media for at least 24 h. Their negligible cell toxicity and ability to encapsulate 89Zr render the polymers and nanostructures presented suitable candidates for future diagnostic and radiotherapeutic applications in biomedicine.

Rapid serology platforms are essential in disease pandemics for a variety of applications, including epidemiological surveillance, contact tracing, vaccination monitoring, and primary diagnosis in resource-limited areas. Laboratory-based enzyme-linked immunosorbent assay (ELISA) platforms are inherently multistep processes that require trained personnel and are of relatively limited throughput. As an alternative, agglutination-based systems have been developed; however, they rely on donor red blood cells and are not yet available for high-throughput screening. Column agglutination tests are a mainstay of pretransfusion blood typing and can be performed at a range of scales, ranging from manual through to fully automated testing. Here, we describe a column agglutination test using colored microbeads coated with recombinant SARS-CoV-2 spike protein that agglutinates when incubated with serum samples collected from patients recently infected with SARS-CoV-2. After confirming specific agglutination, we optimized centrifugal force and time to distinguish samples from uninfected vs SARS-CoV-2-infected individuals and then showed concordant results against ELISA for 22 clinical samples, and also a set of serial bleeds from one donor at days 6-10 postinfection. Our study demonstrates the use of a simple, scalable, and rapid diagnostic platform that can be tailored to detect antibodies raised against SARS-CoV-2 and can be easily integrated with established laboratory frameworks worldwide.

How do ideas take shape? How do concepts emerge into form? This book argues that they take shape quite literally in the human body, often appearing on stage in new styles of performance. Focusing on the historical period of modernity, Performance and Modernity: Enacting Change on the Globalizing Stage demonstrates how the unforeseen impact of economic, industrial, political, social, and psychological change was registered in bodily metaphors that took shape on stage. In new styles of performance-acting, dance, music, pageantry, avant-garde provocations, film, video and networked media-this book finds fresh evidence for how modernity has been understood and lived, both by stage actors, who, in modelling new habits, gave emerging experiences an epistemological shape, and by their audiences, who, in borrowing the strategies performers enacted, learned to adapt to a modernizing world.

The Problem Authentic leadership (AL) has been viewed as an attractive leadership model to combat destructive forms of leadership. On a simple level, it is difficult to argue against authenticity when leading and developing leaders. However, on a deeper level, many scholars have challenged the ideas supporting authentic leadership to highlight the model’s theoretical assumptions and implicit values. Of the critiques, one of the most relevant challenges for HRD (Human Resource Development) is the critique based on identity because this critique aligns with HRD’s focus on diversity and inclusion. The problem is that HRD researchers and practitioners need to understand more about how authentic leadership, as described typically in scholarly and practitioner journals, homogenizes the workplace and discounts diverse ways of being authentic. The Solution The articles in this Special Issue offer a variety of different perspectives on the connection between authentic leadership and identity to make transparent the hidden assumptions, power dynamics, and contextual forces at play. When these unexamined and implicit factors are considered, HRD scholars and practitioners will be in a better position to promote diversity and inclusion in the workplace, as well as in teaching, research, and service. The Stakeholders Researchers and practitioners interested in authentic leadership, diversity and inclusion, and power.

The Problem Research and theory are the lifeblood of academic disciplines along with the peer-reviewed journals that disseminate such scholarship. Journals become critical repositories that capture the histories and evolution of such disciplines, and their scholarly contributions generate new knowledge that can stimulate further research and improve practice. The Academy of Human Resource Development (AHRD) sponsors four peer-reviewed journals that have contributed to the birth and evolution of the discipline of human resource development (HRD). Yet, little is known about how they came into being, how they have evolved, and what their impact has been within the field of HRD. The Solution This article captures the histories of the emergence and evolution of the four refereed journals sponsored by the AHRD through the unique voices of current and recent past editors of these journals. It then considers common themes of scholarship across the four journals that have helped to shape HRD. The Stakeholders Students, researchers, and scholar-practitioners in the field of HRD and related fields who are interested in learning more about the histories of the journals sponsored by the AHRD, along with their contributions to the scholarship in HRD, will benefit from reading this article.

A field survey of recent scholarship in comparative studies, modernist studies, and performance studies, this article maps a new field at their intersection. Calling for the alignment of core concerns and the correction of disciplinary blind spots, the authors propose a comparative model for the study of global modernisms that treats culture not as an object of analysis but rather as a performative process of making meaning. This article outlines a method that acknowledges the different experiences and conceptualizations of historical modernity, the processes of modernization, and modernist strategies of representation around the globe. It argues that, by putting those different experiences and conceptualizations into relation with each other, we can produce a synthetic—but necessarily provisional—heuristic for understanding the modern condition. Emphasizing the performative function of scholarship, the article concludes with six guiding principles to bring the field of Comparative Modernist Performance Studies into being.

We evaluated a transformed core curriculum for the Columbia University, Mailman School of Public Health (New York, New York) master of public health (MPH) degree. The curriculum, launched in 2012, aims to teach public health as it is practiced: in interdisciplinary teams, drawing on expertise from multiple domains to address complex health challenges. We collected evaluation data starting when the first class of students entered the program and ending with their graduation in May 2014. Students reported being very satisfied with and challenged by the rigorous curriculum and felt prepared to integrate concepts across varied domains and disciplines to solve public health problems. This novel interdisciplinary program could serve as a prototype for other schools that wish to reinvigorate MPH training.

Acting on the modern stage ranges from the psychological realism of Konstantin Stanislavsky (1863–1938) to the sensory assault of Antonin Artaud (1896–1948) to the didactic presentation of Bertolt Brecht (1898–1956), to name only three of the best-known styles. While the range and variety of acting styles is not unique to the modern stage, the self-conscious delineation of those styles—both in relation to and as theories of representation—is. Previously, an actor’s performance—often of a well-known dramatic text—was regarded as his or her own interpretation of a role, assessed in relation to other actors’ forays in that part. But with the development of advanced stage machinery, allowing for elaborate scenic and lighting designs, acting became only one of many elements from which to make a theatrical work of art, displacing the actor from the center to the margins of the creative process. Assuming center stage were the playwright and director. The passage of an international copyright agreement in 1891 meant that playwrights could exercise more authorial control over their dramatic designs. And, in order to realize the material dimensions of such dramas in performance, the specialized position of the director emerged to coordinate the increasingly complex elements of the production. Consequently, modernist styles of acting developed in relation to the textual and directorial constraints of the newly configured modern theater.

Like many women writers of her day, American playwright Sophie Treadwell began her career in journalism, working at the San Francisco Bulletin and the New York Herald Tribune, where she wrote fanciful vignettes before earning the right to cover sensational murder trials of female defendants and report from behind the front lines of war (including an interview with Mexican revolutionary Pancho Villa). These assignments appear to have imprinted her dramatic style, which often tempered realistic situations with surreal, sometimes violent, imagery; a well-made play structure with an episodic logic; and the predictability of a character type with an unexpected act of rebellion. Treadwell, who wrote over forty plays (seven of which were produced on Broadway), is best known for Machinal (1928), an expressionist drama about a ‘young woman’ who is coercively compelled to enact the roles of secretary, daughter, wife, and mother over the short course of her doomed life. Only in an illicit love affair does she find true happiness, taking inspiration from her lover’s tales of renegade justice in Mexico to free herself from her oppressive marriage by killing her husband. But her freedom is short-lived, as the social order hails her back into its defining structures. After being forced to fit the pre-set narratives of a sensationalistic press, her life is condemned by the law before finally being taken from her by way of the electric chair.

Development of antifouling films which selectively capture or target proteins of interest is essential for controlling interactions at the "bio/nano" interface. However, in order to synthesize biofunctional films from synthetic polymers that incorporate chemical "motifs" for surface immobilization, antifouling, and oriented biomolecule attachment, multiple reaction steps need to be carried out at the solid/liquid interface. EKx is a zwitterionic peptide that has previously been shown to have excellent antifouling properties. In this study, we recombinantly expressed EKx peptides and genetically encoded both surface attachment and antibody-binding motifs, before characterizing the resultant biopolymers by traditional methods. These peptides were then immobilized to organosilica nanoparticles for binding IgG, and subsequently capturing dengue NS1 as a model antigen from serum-containing solution. We found that a mixed layer of a short peptide (4.9 kDa) "backfilled" with a longer peptide terminated with an IgG-binding Z-domain (18 kDa) demonstrated selective capture of dengue NS1 protein down to ∼10 ng mL

Purpose: As new quality metrics and interventions for potentially preventable emergency department (ED) visits are implemented, we sought to compare methods for evaluating the prevalence and costs of potentially preventable ED visits that were related to cancer and chronic disease among a commercially insured oncology population in the year after treatment initiation. Methods: We linked SEER records in western Washington from 2011 to 2016 with claims from two commercial insurers. The study included patients who were diagnosed with a solid tumor and tracked ED utilization for 1 year after the start of chemotherapy or radiation. Cancer symptoms from the Centers for Medicare & Medicaid Services metric and a patient-reported outcome intervention were labeled potentially preventable (PpCancer). Prevention Quality Indicators of the Agency for Healthcare Research and Quality were labeled potentially preventable–chronic disease (PpChronic). We reported the primary diagnosis, all diagnosis field coding (1 to 10), and 2016 adjusted reimbursements. Results: Of 5,853 eligible patients, 27% had at least one ED visit, which yielded 2,400 total visits. Using primary diagnosis coding, 49.8% of ED visits had a PpCancer diagnosis, whereas 3.2% had a PpChronic diagnosis. Considering all diagnosis fields, 45.0%, 9.4%, and 18.5% included a PpCancer only, a PpChronic only, and both a PpCancer and a PpChronic diagnosis, respectively. The median reimbursement per visit was $735 (interquartile ratio, $194 to $1,549). Conclusion: The prevalence of potentially preventable ED visits was generally high, but varied depending on the diagnosis code fields and the group of codes considered. Future research is needed to understand the complex landscape of potentially preventable ED visits and measures to improve value in cancer care delivery.

Curricular change is essential for maintaining vibrant, timely, and relevant educational programming. However, major renewal of a long-standing curriculum at an established university presents many challenges for leaders, faculty, staff, and students. We present a case study of a dramatic curriculum renewal of one of the nation’s largest Master of Public Health degree programs: Columbia University’s Mailman School of Public Health. We discuss context, motivation for change, the administrative structure established to support the process, data sources to inform our steps, the project timeline, methods for engaging the school community, and the extensive planning that was devoted to evaluation and communication efforts. We highlight key features that we believe are essential for successful curricular change.

Traditionally recognized as “violence against women,” the research literature on intimate partner violence/abuse (IPV/A; also known asdomestic violence) continually neglects to incorporate subculture populations that do not fit societal understanding of typical victim/offender roles. More than 4 decades of research has expanded our knowledge of IPV/A in Western and developing countries across race, ethnicity, religion, and socioeconomic status. However, identifying the prevalence of IPV/A across all manner of relationships has been difficult. In particular, IPV/A within the transgender population has remained practically invisible. Although frequently recognized as an appendage of lesbian, gay, and bisexual populations, trans people are often overlooked in research because of their invisibility within society. Research that does exist is rarely generalizable because of sample size and selection. Therefore, research is required to assess how trans people are affected by IPV/A, what they understand IPV/A to be, what needs are trans-specific, and what help-seeking barriers exist.An analysis of the literature pertaining to trans people regarding IPV/A and other violence, health, and public relations as well as experiences with law enforcement agencies (LEAs) and judiciary in an attempt to identify any issues that could be relevant to trans people experiencing IPV/A is presented. Implications for practice and future research are discussed.

With the modesty then expected of a daughter of Britain's theatrical royalty, Fanny Kemble attributed the necessity of her 1829 stage debut to the hard circumstance of financial need. As she explained in her journal, hers was not an act of self-promotion; rather, she exposed herself to the scrutiny of London's critical establishment with the hope that interest in her performance might draw much-needed revenue into the cashbox of the Theatre Royal, Covent Garden, a venue jointly managed by her father and uncle, Charles and John Philip Kemble. However rhetorically necessary the narrative was for preserving her respectability, Kemble's financial motivation was also very real. The theatre was fiscally impaired, never quite able to square itself in relation to the expensive footing upon which the new building was erected after the fire of 1808. With construction costs high and materials scarce in the midst of the Napoleonic Wars, Charles attempted to raise ticket prices in the new theatre to help cover his expenses, raising instead public ire, in the form of protracted demonstrations known as the Old Price Riots, which bullied him into restoring the original ticket prices.

The Problem These are the days of grand, interdisciplinary, and global challenges. For example, there is widespread acknowledgment within the scientific community that climate change is happening. The financial meltdown caused thousands of families to lose their homes, and environmental debacles like the BP oil disaster in the Gulf of Mexico generated economic, social, and public health concerns.These are problems—not necessarily human resource development (HRD) problems—but problems nonetheless that impact the people, communities and organizations we lead and serve.We are the leaders, change agents, consultants, and educators whom organizations, communities, and people turn to for their development and training needs. The Solution I believe HRD scholars should proactively develop a critical orientation to economic, social, cultural, and environmental issues currently plaguing the planet. With such a critical perspective, we can develop a CHRD leadership identity and challenge hidden assumptions and work with others to expose environmental, human, and economicexploitation.The accomplish this goal, I believe, we should examine the historical emergence of critical HRD identities and thenintentionally create critical leadership development opportunities for more HRD professionals to enact critical HRD more of the time. The Stakeholders Communities, individuals, organizations, the planet.

In the fall of 1869, Henrik Ibsen represented Norway at the ceremonies marking the inauguration of the Suez Canal. As a sea-faring nation with a robust shipping economy, Norway had strong interests...

The Problem Workforce development is a pressing challenge in today’s society, yet the discipline of HRD is not contributing toward research or practice solutions. This gap is a product of current paradigm undergirding HRD—the paradigm implicitly favors nonworkforce development issues, problems, and challenges. The Solution The article calls for a paradigm shift in HRD to focus the work of the discipline on enhancing the public good through workforce development. The article provides an in-depth description of how paradigms can change in the social sciences, so that stakeholders (HRD researchers and practitioners) can take intentional actions to facilitate and nurture the change. Finally, the article provides specific research and practice suggestions for expanding HRD’s role in the workforce development domain. The Stakeholders HRD researchers and practitioners; employees and employers.