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152 results on '"Jukema, Ruurt A."'

6. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Stuijfzand, Wijnand J., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, de Waard, Guus A., Sprengers, Ralf W., Raijmakers, Pieter G., Nurmohamed, Nick S., Danad, Ibrahim, Jukema, Ruurt A., de Winter, Ruben W., de Groot, Robin J., Driessen, Roel S., Bom, Michiel J., van Diemen, Pepijn, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Katz, Richard J., Stroes, Erik S.G., Wang, Hao, Chan, Chung, Crabtree, Tami, Aquino, Melissa, Min, James K., Earls, James P., Bax, Jeroen J., Choi, Andrew D., Knaapen, Paul, and van Rosendael, Alexander R.

Published
2024
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14. Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging

Author

Hoek, Roel, primary, van Diemen, Pepijn A., additional, Raijmakers, Pieter G., additional, Driessen, Roel S., additional, Somsen, Yvemarie B.O., additional, de Winter, Ruben W., additional, Jukema, Ruurt A., additional, Twisk, Jos W.R., additional, Robbers, Lourens F.H.J., additional, van der Harst, Pim, additional, Saraste, Antti, additional, Lubberink, Mark, additional, Sörensen, Jens, additional, Knaapen, Paul, additional, Knuuti, Juhani, additional, and Danad, Ibrahim, additional

Published
2024
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15. Microvascular resistance reserve before and after PCI: A serial FFR and [15O] H2O PET study

Author

Circulatory Health, Team Medisch, Hoshino, Masahiro, Jukema, Ruurt A., Pijls, Nico, Hoek, Roel, Raijmakers, Pieter, Driessen, Roel, van Diemen, Pepijn, Twisk, Jos, van der Hoef, Tim, Danad, Ibrahim, Kakuta, Tsunekazu, Knaapen, Paul, Circulatory Health, Team Medisch, Hoshino, Masahiro, Jukema, Ruurt A., Pijls, Nico, Hoek, Roel, Raijmakers, Pieter, Driessen, Roel, van Diemen, Pepijn, Twisk, Jos, van der Hoef, Tim, Danad, Ibrahim, Kakuta, Tsunekazu, and Knaapen, Paul

Published
2024

16. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Author

Cardiologie, Team Medisch, Nurmohamed, Nick S., Bom, Michiel J., Jukema, Ruurt A., de Groot, Robin J., Driessen, Roel S., van Diemen, Pepijn A., de Winter, Ruben W., Gaillard, Emilie L., Sprengers, Ralf W., Stroes, Erik S.G., Min, James K., Earls, James P., Cardoso, Rhanderson, Blankstein, Ron, Danad, Ibrahim, Choi, Andrew D., Knaapen, Paul, Cardiologie, Team Medisch, Nurmohamed, Nick S., Bom, Michiel J., Jukema, Ruurt A., de Groot, Robin J., Driessen, Roel S., van Diemen, Pepijn A., de Winter, Ruben W., Gaillard, Emilie L., Sprengers, Ralf W., Stroes, Erik S.G., Min, James K., Earls, James P., Cardoso, Rhanderson, Blankstein, Ron, Danad, Ibrahim, Choi, Andrew D., and Knaapen, Paul

Published
2024

17. Determining Hemodynamically Significant Coronary Artery Disease : Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging

Author

Hoek, Roel, van Diemen, Pepijn A., Raijmakers, Pieter G., Driessen, Roel S., Somsen, Yvemarie B. O., de Winter, Ruben W., Jukema, Ruurt A., Twisk, Jos W. R., Robbers, Lourens F. H. J., van der Harst, Pim, Saraste, Antti, Lubberink, Mark, Sörensen, Jens, Knaapen, Paul, Knuuti, Juhani, Danad, Ibrahim, Hoek, Roel, van Diemen, Pepijn A., Raijmakers, Pieter G., Driessen, Roel S., Somsen, Yvemarie B. O., de Winter, Ruben W., Jukema, Ruurt A., Twisk, Jos W. R., Robbers, Lourens F. H. J., van der Harst, Pim, Saraste, Antti, Lubberink, Mark, Sörensen, Jens, Knaapen, Paul, Knuuti, Juhani, and Danad, Ibrahim

Abstract

Currently, cutoffs of quantitative [15O]H2O PET to detect fractional flow reserve (FFR)-defined coronary artery disease (CAD) were derived from a single cohort that included patients without prior CAD. However, prior CAD, sex, and age can influence myocardial blood flow (MBF). Therefore, the present study determined the influence of prior CAD, sex, and age on optimal cutoffs of hyperemic MBF (hMBF) and coronary flow reserve (CFR) and evaluated whether cutoff optimization enhanced diagnostic performance of quantitative [15O]H2O PET against an FFR reference standard. Methods: Patients with chronic coronary symptoms underwent [15O]H2O PET and invasive coronary angiography with FFR. Optimal cutoffs for patients with and without prior CAD and subpopulations based on sex and age were determined. Results: This multicenter study included 560 patients. Optimal cutoffs were similar for patients with (n = 186) and without prior CAD (hMBF, 2.3 vs. 2.3 mL center dot min-1 center dot g-1; CFR, 2.7 vs. 2.6). Females (n = 190) had higher hMBF cutoffs than males (2.8 vs. 2.3 mL center dot min-1 center dot g-1), whereas CFRs were comparable (2.6 vs. 2.7). However, female sex-specific hMBF cutoff implementation decreased diagnostic accuracy as compared with the cutoff of 2.3 mL center dot min-1 center dot g-1 (72% vs. 82%, P , 0.001). Patients aged more than 70 y (n = 79) had lower hMBF (1.7 mL center dot min-1 center dot g-1) and CFR (2.3) cutoffs than did patients aged 50 y or less, 51-60 y, and 61-70 y (hMBF, 2.3-2.4 mL center dot min-1 center dot g-1; CFR, 2.7). Age-specific cutoffs in patients aged more than 70 y yielded comparable accuracy to the previously established cutoffs (hMBF, 72% vs. 76%, P = 0.664; CFR, 80% vs. 75%, P = 0.289). Conclusion: Patients with and without prior CAD had similar [15O]H2O PET cutoffs for detecting FFR-defined significant CAD. Stratifying patients according to sex and age led to different optimal cutoffs; however, these values did not translate in

Published
2024
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20. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia.

Author

Nurmohamed, Nick S., Danad, Ibrahim, Jukema, Ruurt A., de Winter, Ruben W., de Groot, Robin J., Driessen, Roel S., Bom, Michiel J., van Diemen, Pepijn, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Katz, Richard J., Stroes, Erik S.G., Wang, Hao, Chan, Chung, Crabtree, Tami, Aquino, Melissa, Min, James K., Earls, James P., and Bax, Jeroen J.

Abstract

Noninvasive stress testing is commonly used for detection of coronary ischemia but possesses variable accuracy and may result in excessive health care costs. This study aimed to derive and validate an artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT) model for the diagnosis of coronary ischemia that integrates atherosclerosis and vascular morphology measures (AI-QCT ISCHEMIA) and to evaluate its prognostic utility for major adverse cardiovascular events (MACE). A post hoc analysis of the CREDENCE (Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia) and PACIFIC-1 (Comparison of Coronary Computed Tomography Angiography, Single Photon Emission Computed Tomography [SPECT], Positron Emission Tomography [PET], and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve) studies was performed. In both studies, symptomatic patients with suspected stable coronary artery disease had prospectively undergone coronary computed tomography angiography (CTA), myocardial perfusion imaging (MPI), SPECT, or PET, fractional flow reserve by CT (FFR CT), and invasive coronary angiography in conjunction with invasive FFR measurements. The AI-QCT ISCHEMIA model was developed in the derivation cohort of the CREDENCE study, and its diagnostic performance for coronary ischemia (FFR ≤0.80) was evaluated in the CREDENCE validation cohort and PACIFIC-1. Its prognostic value was investigated in PACIFIC-1. In CREDENCE validation (n = 305, age 64.4 ± 9.8 years, 210 [69%] male), the diagnostic performance by area under the receiver-operating characteristics curve (AUC) on per-patient level was 0.80 (95% CI: 0.75-0.85) for AI-QCT ISCHEMIA , 0.69 (95% CI: 0.63-0.74; P < 0.001) for FFR CT , and 0.65 (95% CI: 0.59-0.71; P < 0.001) for MPI. In PACIFIC-1 (n = 208, age 58.1 ± 8.7 years, 132 [63%] male), the AUCs were 0.85 (95% CI: 0.79-0.91) for AI-QCT ISCHEMIA , 0.78 (95% CI: 0.72-0.84; P = 0.037) for FFR CT , 0.89 (95% CI: 0.84-0.93; P = 0.262) for PET, and 0.72 (95% CI: 0.67-0.78; P < 0.001) for SPECT. Adjusted for clinical risk factors and coronary CTA-determined obstructive stenosis, a positive AI-QCT ISCHEMIA test was associated with aHR: 7.6 (95% CI: 1.2-47.0; P = 0.030) for MACE. This newly developed coronary CTA-based ischemia model using coronary atherosclerosis and vascular morphology characteristics accurately diagnoses coronary ischemia by invasive FFR and provides robust prognostic utility for MACE beyond presence of stenosis. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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21. Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging.

Author

Hoek, Roel, van Diemen, Pepijn A., Raijmakers, Pieter G., Driessen, Roel S., Somsen, Yvemarie B. O., de Winter, Ruben W., Jukema, Ruurt A., Twisk, Jos W. R., Robbers, Lourens F. H. J., van der Harst, Pim, Saraste, Antti, Lubberink, Mark, Sörensen, Jens, Knaapen, Paul, Knuuti, Juhani, and Danad, Ibrahim

Published
2024
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23. Hemodynamic Insights into Combined Fractional Flow Reserve and Instantaneous Wave-Free Ratio Assessment Through Quantitative [15O]H2O PET Myocardial Perfusion Imaging

Author

de Winter, Ruben W., primary, van Diemen, Pepijn A., additional, Schumacher, Stefan P., additional, Jukema, Ruurt A., additional, Somsen, Yvemarie B.O., additional, Hoek, Roel, additional, van Rossum, Albert C., additional, Twisk, Jos W.R., additional, de Waard, Guus A., additional, Nap, Alexander, additional, Raijmakers, Pieter G., additional, Driessen, Roel S., additional, Knaapen, Paul, additional, and Danad, Ibrahim, additional

Published
2024
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24. The validation and clinical applicability of angiography-derived assessment of coronary microcirculatory resistance: a [15O]H2O PET study

Author

Jukema, Ruurt, primary, Raijmakers, Pieter G, additional, Hoshino, Masahiro, additional, Driessen, Roel Sebastiaan, additional, van Diemen, Pepijn A, additional, Knuuti, Juhani, additional, Maaniitty, Teemu, additional, Twisk, Jos W., additional, Kooistra, Rolf A, additional, Timmer, Janny, additional, Reiber, Johan HC, additional, Van der Harst, Pim, additional, Cramer, Maarten Jan, additional, van de Hoef, Tim P., additional, Knaapen, Paul, additional, and Danad, Ibrahim, additional

Published
2023
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25. TCT-526 Same-Day Discharge After Large-Bore Vascular Access in Percutaneous Coronary Intervention of Chronic Total Coronary Occlusions

Author

Somsen, Yvemarie, primary, Wilgenhof, Adriaan, additional, de Winter, Ruben, additional, Schumacher, Stefan, additional, van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Hoek, Roel, additional, Stuijfzand, Wynand, additional, Twisk, Jos, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Henriques, Jose, additional, and Knaapen, Paul, additional

Published
2023
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26. Collateral grading systems in retrograde percutaneous coronary intervention of chronic total occlusions

Author

Somsen, Yvemarie B. O., primary, de Winter, Ruben W., additional, Giunta, Rocco, additional, Schumacher, Stefan P., additional, van Diemen, Pepijn A., additional, Jukema, Ruurt A., additional, Stuijfzand, Wijnand J., additional, Danad, Ibrahim, additional, Lissenberg – Witte, Birgit I., additional, Verouden, Niels J., additional, Nap, Alexander, additional, Kleijn, Sebastiaan A., additional, Galassi, Alfredo R., additional, Henriques, José P., additional, and Knaapen, Paul, additional

Published
2023
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27. Prognostic Value of Modified Coronary Flow Capacity Derived From [ 15 O]H 2 O Positron Emission Tomography Perfusion Imaging

Author

de Winter, Ruben W., primary, Jukema, Ruurt A., additional, van Diemen, Pepijn A., additional, Schumacher, Stefan P., additional, Somsen, Yvemarie B.O., additional, van de Hoef, Tim P., additional, van Rossum, Albert C., additional, Twisk, Jos W.R., additional, Maaniitty, Teemu, additional, Knuuti, Juhani, additional, Saraste, Antti, additional, Nap, Alexander, additional, Raijmakers, Pieter G., additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2023
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28. The diagnostic performance of quantitative flow ratio and perfusion imaging in patients with prior coronary artery disease

Author

van Diemen, Pepijn A, primary, de Winter, Ruben W, additional, Schumacher, Stefan P, additional, Everaars, Henk, additional, Bom, Michiel J, additional, Jukema, Ruurt A, additional, Somsen, Yvemarie B, additional, Raijmakers, Pieter G, additional, Kooistra, Rolf A, additional, Timmer, Janny, additional, Maaniitty, Teemu, additional, Robbers, Lourens F, additional, von Bartheld, Martin B, additional, Demirkiran, Ahmet, additional, van Rossum, Albert C, additional, Reiber, Johan H, additional, Knuuti, Juhani, additional, Underwood, S Richard, additional, Nagel, Eike, additional, Knaapen, Paul, additional, Driessen, Roel S, additional, and Danad, Ibrahim, additional

Published
2023
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29. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Author

Nurmohamed, Nick S., primary, Bom, Michiel J., additional, Jukema, Ruurt A., additional, de Groot, Robin J., additional, Driessen, Roel S., additional, van Diemen, Pepijn A., additional, de Winter, Ruben W., additional, Gaillard, Emilie L., additional, Sprengers, Ralf W., additional, Stroes, Erik S.G., additional, Min, James K., additional, Earls, James P., additional, Cardoso, Rhanderson, additional, Blankstein, Ron, additional, Danad, Ibrahim, additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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30. The diagnostic performance of quantitative flow ratio and perfusion imaging in patients with prior coronary artery disease.

Author

Diemen, Pepijn A van, Winter, Ruben W de, Schumacher, Stefan P, Everaars, Henk, Bom, Michiel J, Jukema, Ruurt A, Somsen, Yvemarie B, Raijmakers, Pieter G, Kooistra, Rolf A, Timmer, Janny, Maaniitty, Teemu, Robbers, Lourens F, Bartheld, Martin B von, Demirkiran, Ahmet, Rossum, Albert C van, Reiber, Johan H, Knuuti, Juhani, Underwood, S Richard, Nagel, Eike, and Knaapen, Paul

Subjects
STATISTICS, RESEARCH, PERCUTANEOUS coronary intervention, CONFIDENCE intervals, OPERATIVE surgery, MAGNETIC resonance imaging, MYOCARDIAL infarction, RETROSPECTIVE studies, COMPARATIVE studies, CORONARY artery disease, POSITRON emission tomography, DESCRIPTIVE statistics, INTRACLASS correlation, PERFUSION imaging, DATA analysis software, DATA analysis, PERFUSION, CARDIAC-gated SPECT
Abstract

Aims In chronic coronary syndrome (CCS) patients with documented coronary artery disease (CAD), ischaemia detection by myocardial perfusion imaging (MPI) and an invasive approach are viable diagnostic strategies. We compared the diagnostic performance of quantitative flow ratio (QFR) with single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (CMR) in patients with prior CAD [previous percutaneous coronary intervention (PCI) and/or myocardial infarction (MI)]. Methods and results This PACIFIC-2 sub-study evaluated 189 CCS patients with prior CAD for inclusion. Patients underwent SPECT, PET, and CMR followed by invasive coronary angiography with fractional flow reserve (FFR) measurements of all major coronary arteries (N = 567), except for vessels with a sub-total or chronic total occlusion. Quantitative flow ratio computation was attempted in 488 (86%) vessels with measured FFR available (FFR ≤0.80 defined haemodynamically significant CAD). Quantitative flow ratio analysis was successful in 334 (68%) vessels among 166 patients and demonstrated a higher accuracy (84%) and sensitivity (72%) compared with SPECT (66%, P < 0.001 and 46%, P = 0.001), PET (65%, P < 0.001 and 58%, P = 0.032), and CMR (72%, P < 0.001 and 33%, P < 0.001). The specificity of QFR (87%) was similar to that of CMR (83%, P = 0.123) but higher than that of SPECT (71%, P < 0.001) and PET (67%, P < 0.001). Lastly, QFR exhibited a higher area under the receiver operating characteristic curve (0.89) than SPECT (0.57, P < 0.001), PET (0.66, P < 0.001), and CMR (0.60, P < 0.001). Conclusion QFR correlated better with FFR in patients with prior CAD than MPI, as reflected in the higher diagnostic performance measures for detecting FFR-defined, vessel-specific, significant CAD. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Impact of percutaneous coronary intervention of chronic total occlusions on absolute perfusion in remote myocardium

Author

de Winter, Ruben W., Schumacher, Stefan P., van Diemen, Pepijn A., Jukema, Ruurt A., Somsen, Yvemarie B. O., Stuijfzand, Wynand J., Driessen, Roel S., Bom, Michiel J., Everaars, Henk, van Rossum, Albert C., van de Ven, Peter M., Opolski, Maksymilian P., Verouden, Niels J., Danad, Ibrahim, Raijmakers, Pieter G., Nap, Alex, Knaapen, Paul, Cardiology, ACS - Heart failure & arrhythmias, ACS - Atherosclerosis & ischemic syndromes, Radiology and nuclear medicine, AII - Infectious diseases, and AMS - Tissue Function & Regeneration

Subjects
Perfusion, Percutaneous Coronary Intervention, Treatment Outcome, Coronary Occlusion, Coronary Circulation, Myocardium, Chronic Disease, Myocardial Perfusion Imaging, Humans, Hyperemia, Coronary Angiography, Cardiology and Cardiovascular Medicine
Abstract

Background: Revascularisation of a chronic total coronary occlusion (CTO) impacts on the coronary physiology of the remote myocardial territory. Aims: This study aimed to evaluate the intrinsic effect of CTO percutaneous coronary intervention (PCI) on changes in absolute perfusion in remote myocardium. Methods: A total of 164 patients who underwent serial [ 15O]H 2O positron emission tomography (PET) perfusion imaging at baseline and three months after successful single-vessel CTO PCI were included to evaluate changes in hyperaemic myocardial blood flow (hMBF) and coronary flow reserve (CFR) in the remote myocardium supplied by both non-target coronary arteries. Results: Perfusion indices in CTO and remote myocardium showed a positive correlation before (resting MBF: r=0.84, hMBF: r =0.75, and CFR: r =0.77, p–1·g –1 and from 2.48±0.76 to 2.74±0.85, respectively, p

Published
2022
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33. IMPACT OF SEX-DIFFERENCES ON CHANGES IN MYOCARDIAL PERFUSION FOLLOWING PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL CORONARY OCCLUSIONS

Author

Somsen, Yvemarie, primary, De Winter, Ruben Willem, additional, Van Veelen, Anna, additional, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Hoek, Roel, additional, Stuijfzand, Wijnand, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Appelman, Yolande, additional, Henriques, Jose, additional, and Knaapen, Paul, additional

Published
2023
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34. HIGH DIAGNOSTIC ACCURACY OF AI-ISCHEMIA IN COMPARISON TO PET, FFR-CT, SPECT, AND INVASIVE FFR: A PACIFIC SUB-STUDY

Author

Nurmohamed, Nick S., primary, Danad, Ibrahim, additional, Jukema, Ruurt, additional, Driessen, Roel, additional, Bom, Michiel, additional, Winter, Ruben Willem De, additional, Sprengers, Ralf, additional, Katz, Richard J., additional, Cantlay, Catherine, additional, Knuuti, Juhani M., additional, Min, James K., additional, Earls, James P., additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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35. CORONARY FLOW CAPACITY PREDICTS ADVERSE OUTCOME BEYOND STANDARD PERFUSION METRICS IN STABLE CHEST PAIN PATIENTS

Author

Winter, Ruben Willem De, primary, Jukema, Ruurt, additional, Van Diemen, Pepijn, additional, Schumacher, Stefan, additional, Somsen, Yvemarie, additional, van de Hoef, Tim P., additional, van Rossum, Albert, additional, Twisk, Jos, additional, Maaniitty, Teemu, additional, Knuuti, Juhani M., additional, Saraste, Antti, additional, Nap, Alexander, additional, Raijmakers, Pieter, additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2023
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36. DIAGNOSTIC PERFORMANCE OF QUANTITATIVE CARDIAC MAGNETIC RESONANCE IMAGING IN PATIENTS WITH PRIOR CORONARY ARTERY DISEASE

Author

Hoek, Roel, primary, Borodzicz-Jazdzyk, Sonia, additional, Van Diemen, Pepijn, additional, Somsen, Yvemarie, additional, Willem De Winter, Ruben, additional, Jukema, Ruurt, additional, Raijmakers, Pieter, additional, Knuuti, Juhani M., additional, Maaniitty, Teemu, additional, Underwood, Stephen Richard, additional, Nagel, Eike C., additional, Robbers, Lourens, additional, Demirkiran, Ahmet, additional, von Bartheld, Bob, additional, Driessen, Roel, additional, Danad, Ibrahim, additional, Gotte, Marc, additional, and Knaapen, Paul, additional

Published
2023
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37. QUANTITATIVE PLAQUE STAGING SYSTEM PREDICTS LONG-TERM CARDIOVASCULAR OUTCOMES IN PATIENTS AT RISK FOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Author

Nurmohamed, Nick S., primary, Bom, Michiel, additional, Jukema, Ruurt, additional, De Groot, Robin, additional, Driessen, Roel, additional, Van Diemen, Pepijn, additional, Sprengers, Ralf, additional, Min, James K., additional, Earls, James P., additional, Danad, Ibrahim, additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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38. AI-QCT DEMONSTRATES SUPERIOR ACCURACY FOR THE DIAGNOSIS OF OBSTRUCTIVE CAD BY QCA STANDARD COMPARED TO CORE LAB CCTA INTERPRETATION

Author

Nurmohamed, Nick S., primary, Jukema, Ruurt, additional, Driessen, Roel, additional, Bom, Michiel, additional, Winter, Ruben Willem De, additional, Sprengers, Ralf, additional, Nap, Alexander, additional, Sidahmed, Alfateh, additional, Min, James K., additional, Earls, James P., additional, Choi, Andrew D., additional, Knaapen, Paul, additional, and Danad, Ibrahim, additional

Published
2023
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41. TCT-231 Correlation and Diagnostic Agreement of Quantitative Flow Ratio With Fractional Flow Reserve in Saphenous Vein Grafts

Author

de Winter, Ruben, primary, Somsen, Yvemarie, additional, van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Hoek, Roel, additional, Jonker, Mathé, additional, van Rossum, Albert, additional, Kooistra, Rolf, additional, Janssen, Jasper, additional, Porouchani, Sina, additional, Wilgenhof, Adriaan, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Reiber, Johan, additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2022
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42. TCT-116 Impact of Sex Differences on Changes in Myocardial Perfusion Following Percutaneous Coronary Intervention of Chronic Total Coronary Occlusions: A Serial [15O]H2O Positron Emission Tomographic Perfusion Imaging Study

Author

Somsen, Yvemarie, primary, de Winter, Ruben, additional, van Veelen, Anna, additional, Schumacher, Stefan, additional, van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Hoek, Roel, additional, Stuijfzand, Wynand, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Henriques, Jose, additional, and Knaapen, Paul, additional

Published
2022
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43. TCT-264 Prognostic Value of Coronary Flow Capacity Derived From [15O]H2O Positron Emission Tomography Perfusion Imaging

Author

de Winter, Ruben, primary, Jukema, Ruurt, additional, van Diemen, Pepijn, additional, Schumacher, Stefan, additional, Somsen, Yvemarie, additional, Van de Hoef, Tim, additional, van Rossum, Albert, additional, Twisk, Jos, additional, Maaniitty, Teemu, additional, Knuuti, Juhani, additional, Saraste, Antti, additional, Nap, Alexander, additional, Raijmakers, Pieter, additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2022
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44. IMPACT OF PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL OCCLUSIONS ON ABSOLUTE PERFUSION IN REMOTE MYOCARDIUM

Author

De Winter, Ruben Willem, primary, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Stuijfzand, Wynand, additional, Driessen, Roel, additional, Bom, Michiel, additional, Everaars, Henk, additional, van Rossum, Albert, additional, van de Ven, Peter, additional, Opolski, Maksymilian, additional, Verouden, Niels, additional, Danad, Ibrahim, additional, Raijmakers, Pieter, additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2022
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45. THE DIAGNOSTIC PERFORMANCE OF QFR AND MYOCARDIAL PERFUSION IMAGING IN PATIENTS WITH PRIOR CORONARY ARTERY DISEASE.

Author

Van Diemen, Pepijn, primary, De Winter, Ruben Willem, additional, Schumacher, Stefan, additional, Everaars, Henk, additional, Bom, Michiel, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Raijmakers, Pieter, additional, Kooistra, Rolf A., additional, Timmer, Janny, additional, Maaniitty, Teemu, additional, Robbers, Lourens FHJ, additional, Bartheld, Bob von, additional, Demirkiran, Ahmet, additional, van Rossum, Albert, additional, Reiber, Johan H.C., additional, Knuuti, Juhani M., additional, Underwood, Stephen Richard, additional, Nagel, Eike C., additional, Knaapen, Paul, additional, Driessen, Roel, additional, and Danad, Ibrahim, additional

Published
2022
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46. THE RELATION OF RENIN-ANGIOTENSIN-ALDOSTERONE-SYSTEM ACTIVITY AND ENDOTHELIN-1 LEVELS TO CORONARY ATHEROSCLEROTIC BURDEN AND MICROVASCULAR DYSFUNCTION IN SYMPTOMATIC CHEST PAIN PATIENTS

Author

Jukema, Ruurt, primary, De Winter, Ruben Willem, additional, Van Diemen, Pepijn, additional, Driessen, Roel, additional, Danser, Jan, additional, Garrelds, Ingrid, additional, Raijmakers, Pieter, additional, van de Ven, Peter, additional, Knaapen, Paul, additional, Danad, Ibrahim, additional, and de Waard, Guus, additional

Published
2022
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47. MYOCARDIAL DAMAGE IN CHRONIC TOTAL CORONARY OCCLUSION TERRITORY COLLATERALIZED BY AN INFARCT-RELATED ARTERY: DEFINING DOUBLE JEOPARDY

Author

Somsen, Yvemarie, primary, Giunta, Rocco, additional, De Winter, Ruben Willem, additional, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Stuijfzand, Wynand, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Galassi, Alfredo R., additional, Henriques, José P., additional, and Knaapen, Paul, additional

Published
2022
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48. CONCORDANT LOW AND DISCORDANT FRACTIONAL FLOW RESERVE AND INSTANTANEOUS WAVE-FREE RATIO MEASUREMENTS ARE ASSOCIATED WITH REDUCED MYOCARDIAL PERFUSION:A COMPARISON BETWEEN PRESSURE RATIO MEASUREMENTS AND 15O-WATER PET PERFUSION IMAGING

Author

De Winter, Ruben Willem, primary, Van Diemen, Pepijn, additional, Schumacher, Stefan, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Bom, Michiel, additional, Everaars, Henk, additional, van Rossum, Albert, additional, Verouden, Niels, additional, Raijmakers, Pieter, additional, Nap, Alexander, additional, Driessen, Roel, additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2022
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49. PREDICTING SUCCESS OF THE RETROGRADE APPROACH IN PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL CORONARY OCCLUSIONS WITH COLLATERAL GRADING SYSTEMS

Author

Somsen, Yvemarie, primary, Giunta, Rocco, additional, De Winter, Ruben Willem, additional, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Stuijfzand, Wynand, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Galassi, Alfredo R., additional, Henriques, Jose, additional, and Knaapen, Paul, additional

Published
2022
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50. Warranty period of coronary computed tomography angiography and [15O]H2O positron emission tomography in symptomatic patients.

Author

Jukema, Ruurt, Maaniitty, Teemu, Diemen, Pepijn van, Berkhof, Hans, Raijmakers, Pieter G, Sprengers, Ralf, Planken, R Nils, Knaapen, Paul, Saraste, Antti, Danad, Ibrahim, and Knuuti, Juhani

Subjects
BLOOD vessels, PREDICTIVE tests, CORONARY angiography, POSITRON emission tomography, DESCRIPTIVE statistics, COMPUTED tomography
Abstract

Aims Data on the warranty period of coronary computed tomography angiography (CTA) and combined coronary CTA/positron emission tomography (PET) are scarce. The present study aimed to determine the event-free (warranty) period after coronary CTA and the potential additional value of PET. Method and results Patients with suspected but not previously diagnosed coronary artery disease (CAD) who underwent coronary CTA and/or [15O]H2O PET were categorized based upon coronary CTA as no CAD, non-obstructive CAD, or obstructive CAD. A hyperaemic myocardial blood flow (MBF) ≤ 2.3 mL/min/g was considered abnormal. The warranty period was defined as the time for which the cumulative event rate of death and non-fatal myocardial infarction (MI) was below 5%. Of 2575 included patients (mean age 61.4 ± 9.9 years, 41% male), 1319 (51.2%) underwent coronary CTA only and 1237 (48.0%) underwent combined coronary CTA/PET. During a median follow-up of 7.0 years 163 deaths and 68 MIs occurred. The warranty period for patients with no CAD on coronary CTA was ≥10 years, whereas patients with non-obstructive CAD had a 5-year warranty period. Patients with obstructive CAD and normal hyperaemic MBF had a 2-year longer warranty period compared to patients with obstructive CAD and abnormal MBF (3 years vs. 1 year). Conclusion As standalone imaging, the warranty period for normal coronary CTA is ≥10 years, whereas patients with non-obstructive CAD have a warranty period of 5 years. Normal PET yielded a 2-year longer warranty period in patients with obstructive CAD. [ABSTRACT FROM AUTHOR]

Published
2023
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