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5. Brown, Stephen F.: Historical dictionary of medieval philosophy and theology

Author

Juhl, B.

Subjects
Historical Dictionary of Medieval Philosophy and Theology (Nonfiction work) -- Brown, Stephen F. -- Book reviews, Library and information science, Literature/writing
Abstract

Brown, Stephen F. Historical dictionary of medieval philosophy and theology, by Stephen F. Brown and Juan Carlos Flores. 2nd ed. Rowman & Littlefield, 2018. 429p bibl ISBN 9781538114308 cloth, $110.00; [...]

Published
2019

12. Reviews

Author

Cavanaugh, M.A., Fahey, D.M., Green, S.W., Legon, R.P., Rubin, D., Stewart, N.G., Juhl, B., Carter, C.E., Vincenti, W., Su, M.C., Ridinger, R.B.M., Caine, N., Auchter, D., Siles, D.D., Cottrell, R.C., Blackwell, L.S., Blackwell, J.D., Dyson, R., Broidy, E., Stark, M., Nielson, P.I., Wei, K.T., Tomljanovich, I., Izbicki, T.M., Wilkin, P.W., Williams, C., Grover, M.L., Pollitz, J.H., Strohmeyer, K.L., Doherty, J.J., Larson, C.A., Lewis, L.M., Nash, S.D., and Vega Garcia, S.A.

Subjects
Web sites -- Evaluation, Library and information science, Literature/writing
Abstract

Evaluations are presented of world wide webs sites that may be of interest to academic librarians, including those in the fields of history, geography and area studies, North America and world cultures.

Published
1997

13. Reviews

Author

Schneider, H.E., Hay, C.C., III, Konerding, E.F., Smalley, T.N., Hutto, D.H., Faust, T.R., Lary, M.S., Drew, W.E., Jr., Thomas, P.S., Davidson, J.R., Lorenzen, M., Wondriska, R., Scarth, L.L., Juhl, B., Wick, R.L., Nilsen, M., Glassman, P., Miller, J.I., Thompson, G.B., Abbott, R.L., Sterling, C., Schmitt, D.A., Williamson, S.G., Vega Garcia, S.A., Barton, D.A., Pukkila, M.R., Sheets, J.E., Alexander, J.M., Miller, L.K., Ariew, S.A., Brockman, W.S., Mayer, G.A., Barclay, D.A., Kieft, R.H., Almon, B., and Hanson, R.

Subjects
Web sites -- Evaluation, Library and information science, Literature/writing
Abstract

Evaluations are presented of World Wide Web sites which may be of interest to academic libraries. Fields covered comprise sites relating to reference, humanities, art and architecture, communication and language and literature.

Published
1997

16. Pulmonary Pressure Gradients and Hemodynamics

Author

Juhl, B., Bergmann, H., editor, Brückner, J. B., editor, Gemperle, M., editor, Henschel, W. F., editor, Mayrhofer, O., editor, Meßmer, K., editor, Peter, K., editor, Hossli, Georg, editor, Frey, Pius, editor, and Kreienbühl, Georg, editor

Published
1986
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17. Treatment of antineutrophil cytoplasm autoantibody-associated systemic vasculitis: initiatives of the European Community Systemic Vasculitis Clinical Trials Study Group

Author

Jayne, D, Rasmussen, N, Abramowicz, D, Tesar, V, Petersen, J, Juhl, B, Wiik, A, Gronhagenriska, C, Guillevin, L, Lhote, F, Landais, P, Lesavre, P, Vanhille, P, Andrassy, K, Degroot, K, Gross, W, Vanderwoude, F, Boki, K, Tervaert, J, Kallenberg, C, Vanes, L, Hermans, J, Siegert, C, Hagen, E, Feighery, C, Gregorini, G, Ferrario, F, Dadoniene, J, Vasconcelos, C, Mirapeix, E, Heigl, Z, Pettersson, E, Westman, K, Bacon, P, Savage, C, Lockwood, C, Luqmani, R, Gaskin, G, Pusey, C, Specks, U., SINICO, RENATO ALBERTO, Jayne, D, Rasmussen, N, Abramowicz, D, Tesar, V, Petersen, J, Juhl, B, Wiik, A, Gronhagenriska, C, Guillevin, L, Lhote, F, Landais, P, Lesavre, P, Vanhille, P, Andrassy, K, Degroot, K, Gross, W, Vanderwoude, F, Boki, K, Tervaert, J, Kallenberg, C, Vanes, L, Hermans, J, Siegert, C, Hagen, E, Feighery, C, Gregorini, G, Ferrario, F, Sinico, R, Dadoniene, J, Vasconcelos, C, Mirapeix, E, Heigl, Z, Pettersson, E, Westman, K, Bacon, P, Savage, C, Lockwood, C, Luqmani, R, Gaskin, G, Pusey, C, and Specks, U

Subjects
Vasculitis, medicine.medical_specialty, International Cooperation, PLASMA-EXCHANGE, Birmingham Vasculitis Activity Score, PULSE CYCLOPHOSPHAMIDE, DISEASE-ACTIVITY, Methylprednisolone, Severity of Illness Index, Drug Administration Schedule, Antibodies, Antineutrophil Cytoplasmic, law.invention, Randomized controlled trial, Adrenal Cortex Hormones, law, Azathioprine, Necrotizing Vasculitis, medicine, Humans, Intensive care medicine, Cyclophosphamide, Anti-neutrophil cytoplasmic antibody, Clinical Trials as Topic, business.industry, NECROTIZING VASCULITIS, General Medicine, medicine.disease, Europe, Clinical trial, POLYARTERITIS, Methotrexate, Immunology, IMMUNOGLOBULIN, INTRAVENOUS GAMMA-GLOBULIN, MICROSCOPIC, WEGENERS GRANULOMATOSIS, Microscopic polyangiitis, business, RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS, Immunosuppressive Agents, CYCLOPHOSPHAMIDE THERAPY, Systemic vasculitis
Abstract

The diagnosis, treatment, and monitoring of the primary systemic vasculitides associated with circulating antineutrophil cytoplasm autoantibodies (ANCA) have formed the focus of a multicenter collaborative study. Consensus has been reached on criteria for classification, clinical subgroupings by extent and severity of disease, and ''standard'' and ''best alternative'' therapeutic regimens. Two series of randomized controlled trials have been designed; their aims are (1) to harmonize current approaches to treatment and (2) to test the value of newer therapeutic agents, In support of these trials, semiobjective scoring systems have been created and validated, and previous standardization of ANCA serologic and histologic analysis has been adopted. The systems of classification and clinical management described herein represent the recommendations of a multidisciplinary study group that hopes to improve the outcome of patients with primary systemic vasculitis by wide dissemination of the collective experience from interested centers.

Published
1997

18. Oxford Reference

Author

Juhl, B.

Subjects
Web sites (World Wide Web) -- Evaluation, Internet services -- Evaluation, Online information services -- Evaluation, Cable television/data services, Company Web site/Web page, Online information service, Online services, Library and information science, Literature/writing
Abstract

Oxford Reference. Quick Reference Collection starts at $650.00. Premium Collection starts at $900.00. Both are concurrent or unlimited use. One-time purchase available for over 300 titles. URL: http://www.oxfordreference.com/ [e] 52-3390 [...]

Published
2015

19. March, Jenny. Dictionary of classical mythology

Author

Juhl, B.

Subjects
Dictionary of Classical Mythology (Nonfiction work) -- March, Jenny -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Abstract

March, Jenny. Dictionary of classical mythology. Oxbow Books, 2014. 528p bibl index ISBN 9781782976356 pbk, $49.95 52-1744 BL715 2014-12803 CIP Originally published as The Cassell Dictionary of Classical Mythology (1998), [...]

Published
2014

20. Letters to the editor

Author

Bain, J. A., Spoerel, W. E., Dunn, A. J., Smith, Roger P., Davies, D. W., Stokke, D. B., Rosendal, T., Rasmussen, N. J., Juhl, B., Hole, P., Christensen, K. N., and Andersen, P. K.

Published
1978
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22. The Historical text archive

Author

Juhl, B.

Subjects
Online services -- Evaluation, Information services -- Evaluation, History -- Study and teaching, Online information service, Library and information science, Literature/writing
Published
2003

23. Voice of the shuttle

Author

Juhl, B.

Subjects
Humanities -- Study and teaching, Online services -- Evaluation, Information services -- Evaluation, Arts/humanities software, Online information service, Library and information science, Literature/writing
Published
2003

24. Clinical nephrology-epidemiology-clinical trials: Determinants of outcome in ANCA-associated glomerulonephritis: A prospective clinico-histopathological analysis of 96 patients

Author

Hauer, Herbert A., Bajema, Ingeborg M., Van Houwelingen, Hans C., Ferrario, Franco, Noã«l, Laure Hélène, Waldherr, Rã¼diger, Jayne, David R. W., Rasmussen, Niels, Bruijn, Jan A., Hagen, E. Christiaan, Rasmussen, N., Jayne, D. R. W., Neumann, I., Mad Houn, P., Sennesael, J., Tesar, V., Rychlik, I., Bartunkova, J., Luk, J., Juhl, B. Ravn, Petersen, J., Andersen, C. B., Szpirt, W., Wiik, A., Lokkegaard, H., Nielsen, H., Ring, T., Sorensen, S. Freiesleben, Bacon, P. A., Exley, A., Savage, C. O. S., Gaskin, G., Pusey, C., Lockwood, C. M., Luq Mani, R., Gronhagen Riska, C., Ekstrand, A., Guillevin, L., Lhote, F., Lesavre, P., Noel, L. H., Landais, P., Vanhille, P., Bataille, P., Esnault, V., Woude, F. Van Der, Waldherr, R., Schmitt, W., Andrassy, K., Hergesell, O., Nowack, R., Groot, K. De, Herlyn, K., Gross, W. L., Boki, K. A., Boletis, J. N., Emmanouel, D. S., Feighery, C., Ferra Rio, Y., Sinico, R. A., Gregorini, G., Dadoniene, J., Hagen, E. C., Kallenberg, C. G. M., Stegeman, C., Tervaert, J. W. Cohen, Verburgh, C. A., Siegert, C. E. H., Bruijn, J. A., Hauer, H. A., Hermans, J., Houwelingen, J. C. Van, Vergunst, C. E., Gurp, E. Van, Bajema, I. M., Vasconcelos, C., Mirapeix, E., Sole, M., Petterson, E. E., Bruchfeld, A., Westman, K. W. A., Heigl, Z., Chizzolini, C., Maclahan, D., Depierreux, M., van Damme, B., Stejskalova, A., Vernerova, Z., Tornroth, T., Feller, A. C., Gaffney, E., Tardanico, R., Consalonieri, R., Garibotto, Giacomo, Tiebosch, A. T. M. G., Kooijman, C. D., Arques, M. S., Algaba, F., Carreras, M., Perez, M. Vaquero, Bernardo, L., Sundelin, B., Alm, P., Wernersson, A., Veress, B., Landells, W., Howie, A. J., Fleming, S., Griffith, A. P., Furness, P. N., Cook, H. T., Hauer, H, Bajema, I, Van Houwelingen, H, Ferrario, F, Noël, L, Waldherr, R, Jayne, D, Rasmussen, N, Bruijn, J, Hagen, E, Neumann, I, Mad Houn, P, Sennesael, J, Tesar, V, Rychlik, I, Bartunkova, J, Luk, J, Juhl, B, Petersen, J, Andersen, C, Szpirt, W, Wiik, A, Lokkegaard, H, Nielsen, H, Ring, T, Sorensen, S, Bacon, P, Exley, A, Savage, C, Gaskin, G, Pusey, C, Lockwood, C, Luq Mani, R, Gronhagen Riska, C, Ekstrand, A, Guillevin, L, Lhote, F, Lesavre, P, Noel, L, Landais, P, Vanhille, P, Bataille, P, Esnault, V, Woude, F, Schmitt, W, Andrassy, K, Hergesell, O, Nowack, R, Groot, K, Herlyn, K, Gross, W, Boki, K, Boletis, J, Emmanouel, D, Feighery, C, Ferra Rio, Y, Sinico, R, Gregorini, G, Dadoniene, J, Kallenberg, C, Stegeman, C, Tervaert, J, Verburgh, C, Siegert, C, Hermans, J, Houwelingen, J, Vergunst, C, Gurp, E, Vasconcelos, C, Mirapeix, E, Sole, M, Petterson, E, Bruchfeld, A, Westman, K, Heigl, Z, Chizzolini, C, Maclahan, D, Depierreux, M, van Damme, B, Stejskalova, A, Vernerova, Z, Tornroth, T, Feller, A, Gaffney, E, Tardanico, R, Consalonieri, R, Garibotto, G, Tiebosch, A, Kooijman, C, Arques, M, Algaba, F, Carreras, M, Perez, M, Bernardo, L, Sundelin, B, Alm, P, Wernersson, A, Veress, B, Landells, W, Howie, A, Fleming, S, Griffith, A, Furness, P, and Cook, H

Subjects
Prognosi, Biopsy, Antineutrophil Cytoplasmic, Predictive Value of Test, Antibodies, Antibodies, Antineutrophil Cytoplasmic, Immunosuppressive Agent, Glomerulonephritis, Predictive Value of Tests, Recurrence, Azathioprine, Humans, Prospective Studies, Microscopic polyangiiti, Glomerulonephriti, Microscopic polyangiitis, Cyclophosphamide, Pauci-immune crescentic necrotizing glomerulonephritis, Medicine (all), Granulomatosis with Polyangiitis, Prognosis, Wegener's granulomatosis, ANCA-associated vasculiti, Prospective Studie, Treatment Outcome, ANCA-associated vasculitis, Renal biopsy, Glomerular Filtration Rate, Immunosuppressive Agents, Sample Size, Nephrology, Wegener's granulomatosi, Pauci-immune crescentic necrotizing glomerulonephriti, Granulomatosis with Polyangiiti, Human
Abstract

Background. The predictive value of clinical and renal histological features for renal outcome in patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis was investigated in a prospective analysis of 96 patients with ANCA-associated vasculitis, and moderate renal involvement (creatinine

Published
2002

25. Kitchell, Kenneth F., Jr.: Animals in the ancient world from A to Z

Author

Juhl, B.

Subjects
Animals in the Ancient World from A to Z (Nonfiction work) -- Kitchell, Kenneth F., Jr. -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Abstract

51-4163 QL355 2013-15009 CIP Kitchell, Kenneth F., Jr. Animals in the ancient world from A to Z. Routledge, 2014. 257p bibl indexes afp ISBN 9780415392433, $115.00 This latest offering in [...]

Published
2014

26. Oxford Classical Dictionary, digital edition

Author

Juhl, B.

Subjects
Web sites (World Wide Web) -- Evaluation, Online information services -- Evaluation, Company Web site/Web page, Online information service, Library and information science, Literature/writing
Abstract

Oxford Classical Dictionary, digital edition, ed. by Sander Goldberg. Oxford. Annual academic subscription is $1,035.00 to $3,115.00, based on institution size/type; simultaneous users/unlimited use options available. [e] 54-0004 [Internet Resource] [...]

Published
2016

27. Jesus in history, legend, scripture, and tradition: a world encyclopedia

Author

Juhl, B.

Subjects
Jesus in History, Legend, Scripture, and Tradition: A World Encyclopedia (Reference work) -- Houlden, Leslie -- Minard, Antone -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Abstract

Jesus in history, legend, scripture, and tradition: a world encyclopedia, gen. ed. Leslie Houlden; Antone Minard, ed. ABC-CLIO, 2015. 2v bibl index afp ISBN 9781610698030 cloth, $189.00; ISBN 9781610698047 ebook, [...]

Published
2016

28. Thesaurus Linguae Graecae

Author

Juhl, B.

Subjects
Online information services -- Evaluation, Online services -- Evaluation, Information services -- Evaluation, Online information service, Library and information science, Literature/writing
Abstract

(e) 47-4769 [Internet Resource] Thesaurus Linguae Graecae. University of California, Irvine. Annual academic subscription begins at $900.00 for site license. Other pricing options available. URL: http://www.tlg.uci.edu/ [Visited Feb'l0] Intended to [...]

Published
2010

30. MLA handbook for writers of research papers

Author

Juhl, B.

Subjects
MLA Handbook for Writers of Research Papers, 7th ed. (Nonfiction work) -- Modern Language Association of America -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Abstract

47-0007 L82369 2008-47484 CIP MLA handbook for writers of research papers. 7th ed. Modern Language Association of America, 2009. 292p index afp ISBN 9781603290241 pbk, $22.00 Pity the knight-errant editor [...]

Published
2009

31. Total mercury in feathers of white-tailed eagle (Haliaeetus albicilla L.) from Northern Germany over 50 years

Author

Struwe-Juhl B and Scharenberg W

Subjects
MERCURE, Schleswig holstein, Health, Toxicology and Mutagenesis, Eagles, Zoology, chemistry.chemical_element, Toxicology, biology.animal, Germany, Ecotoxicology, Animals, Tissue Distribution, Retrospective Studies, biology, Haliaeetus albicilla, General Medicine, Environmental Exposure, Mercury, Feathers, Pollution, Mercury (element), chemistry, Feather, visual_art, White-tailed eagle, visual_art.visual_art_medium, Environmental Pollutants, Seasons
Published
2000

32. One-day or two-day procedure for sentinel node biopsy in melanoma?

Author

Chakera, A H, Lock-Andersen, J, Hesse, U, Nürnberg, B M, Juhl, B R, Stokholm, K H, Drzewiecki, K T, Hesse, B, Chakera, A H, Lock-Andersen, J, Hesse, U, Nürnberg, B M, Juhl, B R, Stokholm, K H, Drzewiecki, K T, and Hesse, B

Abstract

Udgivelsesdato: 2009-Jun, PURPOSE: We compared the outcome of a 1-day and a 2-day sentinel node (SN) biopsy procedure, evaluated in terms of lymphoscintigraphic, surgical and pathological findings. METHODS: We studied 476 patients with melanoma from two melanoma centres using static scintigraphy and blue dye. A proportional odds model was used for statistical analysis. RESULTS: The number of SNs visualized at scintigraphy increased significantly with time from injection to scintigraphy and activity left in the patient at scintigraphy, and depended on the melanoma location. The number of SNs removed at surgery increased with the number of SNs visualized at scintigraphy and time from injection to surgery. The frequency of nodal metastasis increased with increasing thickness and Clark level of the melanoma, and was highest for two SNs visualized at scintigraphy. CONCLUSION: This study showed that early vs. late imaging and surgery do make a difference on the outcome of the SN procedure and confirmed the importance of the scintigraphic visualization of all true SNs.

Published
2009

33. ABC-CLIO historical abstracts

Author

Juhl, B.

Subjects
Online services -- Evaluation, Information services -- Evaluation, Online information services -- Evaluation, Abstracting and indexing services, Cable television/data services, Online services, Online information service, Library and information science, Literature/writing
Published
2006

34. The Oxford Companion to World Mythology

Author

Juhl, B.

Subjects
The Oxford Companion to World Mythology (Book) -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Published
2006

35. Voice of the shuttle: Web site for humanities research

Author

Juhl, B.

Subjects
Online information services -- Evaluation, Information services -- Evaluation, Online services -- Evaluation, Humanities, Online information service, Cable television/data services, Online services, Library and information science, Literature/writing
Published
2005

38. The Handbook of religions in ancient Europe

Author

Juhl, B.

Subjects
The Handbook of Religions in Ancient Europe (Collection) -- Christensen, Lisbeth Bredholt -- Flammer, Olav -- Warburton, David A. -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Abstract

The Handbook of religions in ancient Europe, ed. by Lisbeth Bredholt Christensen, Olav Flammer, and David A. Warburton. Acumen, 2013. 456p bibl index ISBN 9781844657094, $140.00 51-6120 BL690 MARC The [...]

Published
2014

39. The Historical text archive

Author

Juhl, B

Subjects
Web sites -- Evaluation, Historic documents, Library and information science, Literature/writing
Published
2001

40. [Indicators for an impending need of artificial respiration in patients with muscular dystrophy]

Author

Lyager S, Birgit Steffensen, and Juhl B

Subjects
Adult, Male, Muscular Atrophy, Spinal, Adolescent, Vital Capacity, Humans, Female, Peak Expiratory Flow Rate, Middle Aged, Respiration, Artificial, Muscular Dystrophies
Abstract

In 1990 we examined 25 patients with Duchenne Muscular Dystrophy (DMD) or Spinal Muscular Atrophy type II (SMA-II). The purpose was to elucidate their general physical capability and find indicators for future need of artificial ventilation. We used interviews and measurements. The interviews were based on classifications described as 1) EAMDA, 2) VIGNOS, 3) BROOKE for use with DMD patients. Our own classification (called EK) is described and used. Moreover, we measured five parameters for the mechanical lung function, the strength of eight great muscle groups, and anthropometrical data. In January 1992, between two and 18 months after our examination, seven of the patients (all DMD) required artificial ventilation. Among the patients who needed artificial ventilation, we found the DMDs to have the lowest physical capability, as measured by the interview (EK and EAMDA) and the smallest values for forced vital capacity (FVC) and peak expiratory flow rate (PEF). All 11 patients with SMA-II could administer their lives without ventilator. Comparing their values with the DMD group, we would expect that several would need artificial ventilation. The reason why the SMA-II patients can manage without artificial ventilation is not clarified. Combining our classification (EK) and the value for FVC, we can predict the need for artificial ventilation among the participating DMD patients.

Published
1993

41. The Historical Text Archive

Author

Juhl, B.

Subjects
Web sites -- Evaluation, Library and information science, Literature/writing
Published
1999

42. ABC-CLIO Historical Abstracts

Author

Juhl, B.

Subjects
ABC-CLIO Historical Abstracts (Book) -- Book reviews, Books -- Book reviews, Library and information science, Literature/writing
Published
1999

46. Hypoglycemia-Associated Changes in the Electroencephalogram in Patients With Type 1 Diabetes and Normal Hypoglycemia Awareness or Unawareness.

Author

Sejling, Anne-Sophie, Kjær, Troels W., Pedersen-Bjergaard, Ulrik, Diemar, Sarah S., Frandsen, Christian S. S., Hilsted, Linda, Faber, Jens, Holst, Jens J., Tarnow, Lise, Nielsen, Martin N., Remvig, Line S., Thorsteinsson, Birger, and Juhl, Claus B. Juhl B.

Subjects
HYPOGLYCEMIA, TYPE 1 diabetes, ELECTROENCEPHALOGRAPHY, PEOPLE with diabetes, HORMONE research
Abstract

Hypoglycemia is associated with increased activity in the low-frequency bands in the electroencephalogram (EEG). We investigated whether hypoglycemia awareness and unawareness are associated with different hypoglycemia-associated EEG changes in patients with type 1 diabetes. Twenty-four patients participated in the study: 10 with normal hypoglycemia awareness and 14 with hypoglycemia unawareness. The patients were studied at normoglycemia (5-6 mmol/L) and hypoglycemia (2.0-2.5 mmol/L), and during recovery (5-6 mmol/L) by hyperinsulinemic glucose clamp. During each 1-h period, EEG, cognitive function, and hypoglycemia symptom scores were recorded, and the counterregulatory hormonal response was measured. Quantitative EEG analysis showed that the absolute amplitude of the ϑ band and α-ϑ band up to doubled during hypoglycemia with no difference between the two groups. In the recovery period, the ϑ amplitude remained increased. Cognitive function declined equally during hypoglycemia in both groups and during recovery reaction time was still prolonged in a subset of tests. The aware group reported higher hypoglycemia symptom scores and had higher epinephrine and cortisol responses compared with the unaware group. In patients with type 1 diabetes, EEG changes and cognitive performance during hypoglycemia are not affected by awareness status during a single insulin-induced episode with hypoglycemia. [ABSTRACT FROM AUTHOR]

Published
2015
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47. Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas:immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family

Author

Mandel, U, Hassan, H, Therkildsen, M H, Rygaard, J, Jakobsen, M H, Juhl, B R, Dabelsteen, Erik, Clausen, H, Mandel, U, Hassan, H, Therkildsen, M H, Rygaard, J, Jakobsen, M H, Juhl, B R, Dabelsteen, Erik, and Clausen, H

Abstract

Mucin-type O-glycosylation is initiated by a large family of UDP-GalNAc: polypeptide N -acetyl-galactosaminyltransferases (GalNAc-transferases). Individual GalNAc-transferases appear to have different functions and Northern analysis indicates that they are differently expressed in different organs. This suggests that O-glycosylation may vary with the repertoire of GalNAc-transferases expressed in a given cell. In order to study the repertoire of GalNAc-transferases in situ in tissues and changes in tumors, we have generated a panel of monoclonal antibodies (MAbs) with well defined specificity for human GalNAc-T1, -T2, and -T3. Application of this panel of novel antibodies revealed that GalNAc- transferases are differentially expressed in different cell lines, in spermatozoa, and in oral mucosa and carcinomas. For example, GalNAc-T1 and -T2 but not -T3 were highly expressed in WI38 cells, and GalNAc-T3 but not GalNAc-T1 or -T2 was expressed in spermatozoa. The expression patterns in normal oral mucosa were found to vary with cell differentiation, and for GalNAc-T2 and -T3 this was reflected in oral squamous cell carcinomas. The expression pattern of GalNAc-T1 was on the other hand changed in tumors to either total loss or expression in cytological poorly differentiated tumor cells, where the normal undifferentiated cells lacked expression. These results demonstrate that the repertoire of GalNAc-transferases is different in different cell types and vary with cellular differentiation, and malignant transformation. The implication of this is not yet fully understood, but it suggests that specific changes in sites of O-glycosylation of proteins may occur as a result of changes in the repertoire of GalNAc-transferases.

Published
1999

48. Pleiades: A Community-Built Gazetteer Group of Ancient Places

Author

Juhl, B.

Subjects
Online information services -- Evaluation, Online services -- Evaluation, Information services industry -- Evaluation, Information services -- Evaluation, Cable television/data services, Online services, Online information service, Information services industry, Library and information science, Literature/writing
Abstract

[e] 50-3035 [Internet Resource] Pleiades: A Community-Built Gazetteer Group of Ancient Places, from the Ancient World Mapping Center and Institute for the Study of the Ancient World. URL: http://pleiades.stoa.org/ [Visited [...]

Published
2013

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