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1. La censura en la literatura infantil y juvenil: una historia interminable

Author

Juana Ruiz Arriaza

Subjects
literatura infantil y juvenil, censura, richmal cromtom, dictadura, Education
Abstract

El adulto, como intermediario entre las obras literarias y los niños o jóvenes, ha utilizado unos instrumentos de control con criterios basados en aspectos religiosos, psicológicos, pedagógicos y morales, que han influido en el proceso de creación del autor y en sus publicaciones. Es ineludible la reflexión sobre antiguos mecanismos de censura y los que aún perduran en la actualidad.

Published
2020

2. LA CULTURA TRIBUTARIA Y LA GESTIÓN MUNICIPAL

Author

Juana Ruiz Vásquez

Subjects
municipalidad distrital, obligaciones tributarias, arbitrios municipales, cultura tributaria, conciencia tributaria, morosidad tributaria, Accounting. Bookkeeping, HF5601-5689, Finance, HG1-9999
Abstract

El presente estudio pretende establecer la existencia de una relación entre la cultura tributaria, operacionalizada en este caso como la morosidad en los pagos de arbitrios municipales y la calidad de gestión de los servicios públicos municipales en el distrito de Lince, durante el periodo comprendido entre 2011 y 2014. Para desarrollar la investigación, se ha utilizado el enfoque mixto (cuantitativo y cualitativo), de alcance descriptivo y correlacional, diseño no experimental de corte transversal, y fue dirigida a la población de ciudadanos inscritos en el registro de contribuyentes de la Municipalidad distrital de Lince, con una muestra probabilística de 298 sujetos de estudio. Las técnicas utilizadas han sido la encuesta y la recopilación documental, una vez que se obtuvieron los resultados se procedió a tabularlos, los datos han sido procesados con el software estadístico de Microsoft Excel. Del procesamiento de datos recopilados y el análisis de los resultados se verificó empíricamente el incremento de la morosidad en el pago de arbitrios, el bajo nivel de información sobre los tributos municipales y la deficiente calidad de gestión tributaria de la administración municipal de Lince percibida en la prestación de servicios municipales de limpieza pública, de ornato y de seguridad ciudadana.

Published
2017
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3. Social Anxiety Scale for Adolescents (SAS-A): Psychometric properties in a Spanish-speaking population

Author

José Olivares, Juana Ruiz, María Dolores Hidalgo, Luis Joaquín García-López, Ana Isabel Rosa, and José Antonio Piqueras

Subjects
Psychology, BF1-990
Abstract

El objetivo de este estudio instrumental fue estudiar la estructura factorial y propiedades psicométricas de la Escala de Ansiedad Social para Adolescentes (SASA). Participaron 2407 adolescentes (1263 chicos y 1144 chicas), con una edad media de 15 años, alumnos de nueve institutos de la región de Murcia. Los resultados obtenidos apoyan la estructura tri-factorial propuesta por los autores de la escala (FNE, SAD-New, SAD-General). Se encontraron correlaciones interescalas significativas y niveles de consistencia interna elevados para las subescalas, así como respecto de los efectos del sexo en la puntuación SAS-A/Total y en sus subescalas, alcanzando las chicas las puntuaciones más elevadas. Sólo se hallaron diferencias significativas para la edad en la subescala FNE y no se constataron efectos de interacción entre los dos factores. Estos hallazgos parecen avalar el uso de la SAS-A en población adolescente de habla española.

Published
2005

6. El léxico humorístico en la literatura juvenil: la serie Manolito Gafotas, de Elvira Lindo

Author

JUANA RUIZ ARRIAZA and Didáctica de la Lengua y la Literatura

Subjects
Humor, Juego Lingüístico, humour, Manolito Gafotas, Character (symbol), Lexicon, Linguistics, Léxico, Linguistic Game, Humour, lexicon, Criticism, Sociology, linguistic game
Abstract

Este trabajo mostrará la relación entre el léxico y el humor. Se trata de una investigación de tipo bibliográfico y teórico, por medio de la cual se emprende un ejercicio de hermenéutica, utilizando como corpus los textos del que ya se puede considerar un clásico de la literatura infantil y juvenil: Manolito Gafotas, de Elvira Lindo. El objetivo principal fue identificar y analizar algunos de los juegos lingüísticos que utilizó la autora en la voz de su personaje como estrategia comunicativa para llevar a cabo una crítica reflexiva y humorística sobre la vida y la realidad., This work focuses on the analysis of the relationship between lexicon and humour. It is a survey of literature and theoretical nature, by which a hermeneutic study was undertaken, using as a primary source of study the children and youth literature classic: Manolito Gafotas, by Elvira Lindo. The main goal of the study was to identify and to examine some of the linguistic games the author drew on through her main character’s voice as a communicative strategy. This allowed observing her thoughtful and humorous criticism of life and reality.

Published
2020
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7. Una perspectiva didáctica interdisciplinar a través de la literatura juvenil

Author

Elena Campillo Ruiz and Juana Ruiz Arriaza

Subjects
Spanish language, Sociology, Humanities
Abstract

Se propone en este artículo una visión interdisciplinar de las áreas de Lengua y Literatura y Ciencias Sociales e Historia, a través del análisis de la obra de Elvira Lindo, Manolito Gafotas, en la que se pueden ver reflejadas numerosas características de la época en que fue escrita. El objetivo es motivar a los alumnos a la lectura, que aprecien la capacidad comunicativa de los textos literarios y, a la vez, facilitar la comprensión del panorama histórico y del entorno sociocultural en el que se desarrolla la obra. Para ello es necesario un trabajo coordinado entre profesores de dichas áreas.

Published
2019
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8. Moderate Weight Loss Modifies Leptin and Ghrelin Synthesis Rhythms but Not the Subjective Sensations of Appetite in Obesity Patients

Author

Juana Ruiz, Juan José Hernández Morante, Horacio Pérez Sánchez, Carlos Martinez, Inmaculada Díaz Soler, Mª del Carmen Barberá Ortega, and Joaquín S. Galindo Muñoz

Subjects
0301 basic medicine, Adult, Blood Glucose, Male, circadian rhythm, medicine.medical_specialty, media_common.quotation_subject, satiety, Appetite, 030209 endocrinology & metabolism, lcsh:TX341-641, Satiety Response, leptin, Article, hunger, 03 medical and health sciences, 0302 clinical medicine, Rhythm, Weight loss, appetite sensation, Internal medicine, Weight Loss, medicine, Humans, Circadian rhythm, Longitudinal Studies, Obesity, media_common, Nutrition and Dietetics, business.industry, Leptin, digestive, oral, and skin physiology, Middle Aged, medicine.disease, 030104 developmental biology, Endocrinology, ghrelin, Ghrelin, Female, medicine.symptom, business, lcsh:Nutrition. Foods and food supply, hormones, hormone substitutes, and hormone antagonists, Food Science, Hormone
Abstract

Obesity is characterized by a resistance to appetite-regulating hormones, leading to a misalignment between the physiological signals and the perceived hunger/satiety signal. A disruption of the synthesis rhythm may explain this situation. The aim of this study was to evaluate the effect of dietary-induced weight loss on the daily rhythms of leptin and ghrelin and its influence on the daily variability of the appetite sensations of patients with obesity. Twenty subjects with obesity underwent a hypocaloric dietary intervention for 12 weeks. Plasma leptin and ghrelin were analyzed at baseline and at the end of the intervention and in 13 normal-weight controls. Appetite ratings were analyzed. Weight loss decreased leptin synthesis (pauc &lt, 0.001) but not the rhythm characteristics, except the mean variability value (pmesor = 0.020). By contrast, the mean ghrelin level increased after weight loss. The rhythm characteristics were also modified until a rhythm similar to the normal-weight subjects was reached. The amount of variability of leptin and ghrelin was correlated with the effectiveness of the dietary intervention (p &lt, 0.020 and p &lt, 0.001, respectively). Losing weight partially restores the daily rhythms of leptin and modifies the ghrelin rhythms, but appetite sensations are barely modified, thus confirming that these hormones cannot exercise their physiological function properly.

Published
2020

9. Children & youth literature censorship: a never-ending story

Author

Juana Ruiz Arriaza and Voces de la educación, Voces de la educación

Subjects
children and youth literature, richmal cromtom, [SHS.EDU] Humanities and Social Sciences/Education, Richmal Crompton, censorship, dictatorship, dictadura, literatura infantil y juvenil, [SHS] Humanities and Social Sciences, lcsh:L, censura, lcsh:Education
Abstract

The adult, as an intermediary between literature and children or young people, has used religious, psychological, pedagogical and moral control instruments that have influenced the author's creation process itself and its publications. The reflection about past censorship mechanisms and those that still exist today is unavoidable., Resumen: El adulto, como intermediario entre las obras literarias y los niños o jóvenes, ha utilizado unos instrumentos de control con criterios basados en aspectos religiosos, psicológicos, pedagógicos y morales, que han influido en el proceso de creación del autor y en sus publicaciones. Es ineludible la reflexión sobre antiguos mecanismos de censura y los que aún perduran en la actualidad.

Published
2020

10. Comparative reading of two youth literature works and their didactical implications: Elvira Lindo and Richmal Crompton

Author

Elena Campillo Ruiz, Juana Ruiz Arriaza, and Didáctica de la Lengua y la Literatura

Subjects
literary analysis, profesionales de la educación, students, enseñanza y formación, estudiante, literary history, educational population, literature, teaching and training, análisis literario, literatura, reading habit, historia literaria
Abstract

Se presenta una investigación de tipo bibliográfico y teórico, por medio de la cual emprendemos un ejercicio de hermenéutica comparatista, utilizando como corpus las series de literatura juvenil Manolito Gafotas, de Elvira Lindo, y Guillermo Brown, de Richmal Crompton. Se propone este tipo de ejercicios como una alternativa didáctica interdisciplinar que, lejos de ser un planteamiento historicista basado en el conocimiento memorístico de la literatura, facilita el desarrollo de la competencia literaria y del intertexto lector, procurando la formación integral del individuo. Finalmente, la interpretación y valoración de las obras en relación con su contexto histórico y literario ofrece al alumnado nuevos modos de lectura que lo motiven y lleven a una mayor comprensión de los textos y del cosmopolitismo intercultural en el que vivimos We present a bibliographic-theoretical research by means of which we carry out a comparatist hermeneutic exercise using as a corpus the youth literature work series Manolito Gafotas by Elvira Lindo, and Just William by Richmal Crompton. This sort of exercises is proposed as an interdisciplinary didactive alternative, which far from being a historicist proposal based on rote literature knowledge, facilitates the development of literature competences and reading intertext, fostering the individual’s integral education. Finally, the interpretation and valuing of the works regarding their historic and literary context offer the students new modes of reading that motivate and lead them to a better understanding of the texts and the intercultural cosmopolitanism we live in.

Published
2020

12. The common marmoset genome provides insight into primate biology and evolution

Author

San Juana Ruiz, Daniel Gerlach, Tomas Vinar, Brona Brejova, Saba Sajjadian, Miriam K. Konkel, Muthuswamy Raveendran, Yih Shin Liu, Paul Flicek, Lubomir Tomaska, Donna M. Muzny, Daniel R. Schrider, Megan C. Ranck, Kjersti Aagaard, Huyen Dinh, Jayantha B. Tennakoon, Lucinda Fulton, Lynne V. Nazareth, Brygg Ullmer, George M. Weinstock, Kim D. Delehaunty, Xose S. Puente, Charles E. Vejnar, Shyam Prabhakar, Matthew W. Hahn, J. Scott Moncrieff, Mark A. Batzer, Tina Graves, Catherine C. Fontenot, Carlos López-Otín, Corinna N. Ross, Catrina Fronick, Jeffrey Rogers, Nirmala Arul Rayan, Mario Ventura, Pieter J. De Jong, Elaine R. Mardis, Steve Searle, Christie LKovar, David Haig, Ngoc Nguyen, Shalini N. Jhangiani, Margaret Morgan, Crystal M. Warner, Mimi M. Chandrabose, Keith G. Mansfield, Vandita Joshi, Kathryn Beal, Saverio B. Capuano, Magali Ruffier, Ling Ling Pu, Jerilyn A. Walker, Marvin Diep Dao, John Lopez, Irene Newsham, Yuanqing Wu, Jan Hinnerk Vogel, Arian F.A. Smit, Javier Herrero, Andrew Cree, Tomas Marques-Bonet, Oronzo Capozzi, LaDeana W. Hillier, Robert S. Fulton, Claudio Casola, Mariano Rocchi, Benjamin Soibam, Suzette D. Tardif, Derek E. Wildman, Evgenia V. Kriventseva, Kim C. Worley, Baoli Zhu, Jennifer F. Hughes, Robert Hubley, Geoffrey Okwuonu, Jennifer Hume, Lora Lewis, Ricardo C.H. del Rosario, Devin P. Locke, Lora Perales, David Rio Deiros, David J. Witherspoon, Yi Han, Brian J. Raney, David Rodríguez, Stephen Fitzgerald, Jireh Santibanez, Albert J. Vilella, R. Gerald Fowler, Qing Wang, Belen Lorente-Galdos, Ramatu Ayiesha Gabisi, Víctor Quesada, Weimin Xiao, Nicoletta Archidiacono, Emre Karakor, Helen Skaletsky, R. Alan Harris, Evgeny M. Zdobnov, Richard A. Gibbs, Wesley C. Warren, Patrick Minx, Preethi H. Gunaratne, Rita A. Wright, Doriana Misceo, Jinchuan Xing, Evan E. Eichler, Lynn B. Jorde, Carolin Kosiol, Rick K. Wilson, Sandra L. Lee, University of St Andrews. School of Biology, University of St Andrews. Centre for Biological Diversity, National Human Genome Research Institute (US), National Institutes of Health (US), National Science Foundation (US), Howard Hughes Medical Institute, Louisiana State University, Cullen Foundation, European Research Council, Ministerio de Ciencia e Innovación (España), Instituto Nacional de Bioinformática (España), Gerlach, Daniel, Kriventseva, Evgenia, and Zdobnov, Evgeny

Subjects
endocrine system, animal structures, Evolució molecular, Evolution, QH301 Biology, animal diseases, Molecular Sequence Data, QH426 Genetics, Polymorphism, Single Nucleotide, Genome, Article, Evolution, Molecular, QH301, Phylogenetics, biology.animal, Genetics, Animals, ddc:576.5, Primate, Amino Acid Sequence, Polymorphism, QH426, Phylogeny, New World monkey, biology, Reproduction, Polimorfisme genètic, Callithrix/genetics, Molecular, Marmoset, Callithrix, Single Nucleotide, Sequence Analysis, DNA, biology.organism_classification, Reproduction/genetics, DNA/methods, body regions, MicroRNAs/genetics, MicroRNAs, Evolutionary biology, Female, Sequence Analysis
Abstract

The Marmoset Genome Sequencing and Analysis Consortium.-- Worley, Kim C. et al., We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. © 2014 Nature America, Inc., The marmoset genome project was funded by the National Human Genome Research Institute (NHGRI), including from grants U54 HG003273 (R.A. Gibbs) and U54 HG003079 (R.K.W.), with additional support from the US National Institutes of Health (NIH), including from grants R01 DK077639 (S.D.T.), R01 GM59290 (L.B.J. and M.A.B.), HG002385 (E.E.E.) and P51-OD011133 (Southwest NPRC), and support from the National Science Foundation (NSF BCS-0751508 to D.E.W.) and the VEGA grant agency: 1/0719/14 (T.V.) and 1/1085/12 (B.B.). C.C.F. and M.C.R. were supported in part by a Howard Hughes Medical Institute grant to Louisiana State University through the Undergraduate Biological Sciences Education program. J.X. was supported by NHGRI grant K99 HG005846. P.H.G. was supported by the Cullen Foundation. T.M.-B. was supported by European Research Council Starting Grant (260372) and MICINN (Spain) grant BFU2011-28549. B.L.-G. was supported by the Spanish National Institute of Bioinformatics (see URLs).

Published
2014
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13. Elegibilidad de pacientes con esquizofrenia ingresados en una unidad de hospitalización psiquiátrica para participar en ensayos clínicos

Author

Joaquín Lloret, M. Carmen Díaz, David Fraguas, Eliseo Iniesta, Karen Nieto, Juana Ruiz, M. Dolores Martínez, M. Teresa Tolosa, Patricia Romero-Rodenas, Mar Domato, Àngels Mayordomo, Miguel Ángel García Martín, Marta Lucas, and María Angustias Portela

Subjects
Psychiatry and Mental health
Abstract

Resumen Introduccion Este estudio pretende evaluar la potencial elegibilidad para la participacion en los principales ensayos clinicos de tratamiento de esquizofrenia basados en la practica clinica (CATIE, CUtLASS y EUFEST) de los pacientes ingresados en una unidad de hospitalizacion de psiquiatria. Material y metodos Evaluacion retrospectiva, mediante consulta de la historia clinica, de los 241 sujetos (59,8% varones y 40,2% mujeres, edad 39,7 ± 13,0 anos), ingresados de forma consecutiva a lo largo de un ano en una unidad de hospitalizacion de psiquiatria con diagnostico de esquizofrenia u otra psicosis. La influencia de los factores implicados en la no elegibilidad en cada uno de los ensayos clinicos se analizo mediante analisis de regresion logistica. Resultados Un 20,7, un 22,3, y un 22,5% de los pacientes con esquizofrenia u otra psicosis serian elegibles para participar en los estudios CATIE, CUtLASS y EUFEST, respectivamente. Los principales factores implicados en la no elegibilidad fueron la politerapia con antipsicoticos (2 o mas) (Odds Ratio (OR): 7,64, intervalo de confianza (IC) 95%: 3,06-19,06, p Conclusiones Tres de cada cuatro pacientes con esquizofrenia u otra psicosis ingresados en una unidad de hospitalizacion de psiquiatria no estan representados en los grandes ensayos clinicos de tratamiento de esquizofrenia.

Published
2012
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14. Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

Author

Carolin Kosiol, Belinda Giardine, Janet A. Hopkins, Andrew G. Clark, Ryan D. Hernandez, Peng Wang, Peter D. Stenson, Yu-Hui Rogers, Aaron L. Halpern, Andrew D. Kern, Webb Miller, Kymberlie H. Pepin, Melissa J. Hubisz, Kimberly D. Delehaunty, Robert E. Palermo, Matthew W. Hahn, Erica Sodergren, Brian P. Walenz, Scott M. Smith, Sandra L. Lee, Xiang Qin, Yucheng Feng, Ewen F. Kirkness, Vandita Joshi, Xiaoqiu Huang, Amanda F. Svatek, Fan Yang, Young Ho Kim, Laura Clarke, John E. Karro, Courtney Sherell White, Jessica Kolb, David Glenn Smith, Clay Davis, Jian Ma, Shobha Patil, Todd Wylie, Arian F.A. Smit, Shalini N. Jhangiani, Michael G. Katze, Edward V. Ball, Jennifer Godfrey, Heather A. Lawson, Brian J. Raney, Michael Holder, Ross C. Hardison, Christian J. Buhay, Zhangwan Li, Alicia Hawes, Eric J. Vallender, David A. Wheeler, James C. Wallace, Galt P. Barber, Jinchuan Xing, Yufeng Shen, Kayla E. Smith, Marvin Diep Dao, Jeffrey Rogers, Evan E. Eichler, Cynthia Pfannkoch, Jireh Santibanez, Kateryna D. Makova, Kashif Hirani, Robert M. Kuhn, Yanru Ren, David Neil Cooper, David Haussler, Carlos Bustamante, Adam Siepel, Mimi N. Chandrabose, Xiaoming Liu, George M. Weinstock, Teresa Utterback, Jarret Glasscock, Tomas Vinar, R. Alan Harris, Anis Karimpour-Fard, San Juana Ruiz, Lucinda Fulton, Asif T. Chinwalla, Aniko Sabo, Xinwei She, Charles Addo-Quaye, David L. Nelson, Lora Lewis, Hui Ke, Eli Venter, Donna M. Muzny, Alison Marklein, Bruce T. Lahn, Grace Pai, Brian W. Schneider, Shannon Dugan-Rocha, Henry Xing-Zhi Song, Jeremiah D. Degenhardt, Kyudong Han, Huaiyang Jiang, Stephanie M. Moore, Ian Schenck, Dinh Ngoc Ngo, Michael J. Cox, Heidie A. Paul, Ann S. Zwieg, Kim C. Worley, Craig Pohl, Rui Chen, Robert L. Strausberg, Ling-Ling Pu, Donna Karolchik, Jonathan R. Pollack, Geoffrey Okwuonu, Jennifer Hume, Elaine R. Mardis, David N. Messina, W. James Kent, William E. O'Brien, Fan Hsu, Andrew R. Jackson, Huyen Dinh, Hui Wang, LaDeana W. Hillier, Richard A. Gibbs, Alexandra Denby, Wesley C. Warren, Brygg Ullmer, Laura J. Dumas, Yih-shin Liu, Tony Attaway, Richard K. Wilson, Patrick Minx, James M. Sikela, Lan Zhang, Sandra Hines, Steven J. M. Jones, Amit Indap, Ze Cheng, Karin A. Remington, Stephanie Bell, Jungnam Lee, Kelly E. Bernard, Sang-Gook Han, Mariano Rocchi, Judith Hernandez, Betsy Ferguson, Hildegard Kehrer-Sawatzki, Ziad Khan, Aleksandar Milosavljevic, Joanne O. Nelson, Jeffery P. Demuth, Richard Burhans, David A. Parker, Lynne V. Nazareth, Roger E. Bumgarner, Marco A. Marra, Robert Baertsch, Andrew Cree, Paul Havlak, J. Craig Venter, Kay Prüfer, Rasmus Nielsen, Ewan Birney, Miriam K. Konkel, Mark A. Batzer, Arthur M. Lesk, Jacqueline E. Schein, Granger G. Sutton, Yan Ding, Yue Liu, Andy Peng Xiang, Miklós Csürös, Selina Vattathil, John W. Wallis, R. Gerald Fowler, Shiaw-Pyng Yang, Ramatu Ayiesha Gabisi, and Toni T. Garner

Subjects
Male, Biomedical Research, Pan troglodytes, Macaque, Human accelerated regions, Genome, Evolution, Molecular, Species Specificity, Gene Duplication, biology.animal, Animals, Humans, Primate, Gene Rearrangement, Genetics, Whole genome sequencing, Multidisciplinary, biology, Genetic Diseases, Inborn, Genetic Variation, Sequence Analysis, DNA, Gene rearrangement, biology.organism_classification, Macaca mulatta, Rhesus macaque, Homo sapiens, Evolutionary biology, Multigene Family, Mutation, Female
Abstract

The rhesus macaque ( Macaca mulatta ) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

Published
2007
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15. Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development

Author

Joshua Y Shen, Yoko Kuroki, Lynne V. Nazareth, Shafagh Al Nadaf, Terence P. Speed, Katherine Belov, Kevin R. Nicholas, James Lindsay, Yoshiyuki Sakaki, Anthony T. Papenfuss, Arthur Hsu, Stephen Frankenberg, Hannah V. Siddle, Shalini N. Jhangiani, Fremiet Lara, Jireh Santibanez, Thomas N. Heider, Jixin Deng, Margaret Morgan, Xing-Zhi Henry Song, Rebecca Thornton, Benjamin James Lansdell, Frank W. Nicholas, A. Men, Carmen Troon, Shinji Kondo, William A O'Hara, Christophe Lefevre, Susan M. Forrest, San Juana Ruiz, Geoffrey Okwuonu, Chenwei Wang, Andrew Cree, Yanqiu Hu, Matthew Wakefield, Kyall R. Zenger, Rachel J. O’Neill, Donna M. Muzny, Benjamin G. Cocks, Huyen Dinh, Kaighin A. McColl, Geoff Shaw, Kim C. Worley, Hongshi Yu, Jennifer A. Marshall Graves, Asao Fujiyama, Andrew J Pask, Keng Yih Chew, Janine E. Deakin, Lankesha Yapa, Elizabeth Kuczek, Tanya Levchenko, George M. Weinstock, Kirsty R. Short, Malcolm A. Ferguson-Smith, Yutaka Suzuki, Mehlika Hazar-Rethinam, Chyn Jing, Yuichiro Nishida, Gerald R. Fowler, Paul D. Waters, Lora Lewis, Elizabeth A. Pharo, Timothy A. Hore, Nanette Y. Schneider, Susan Fairley, Danielle Hickford, Zhi-Ping Feng, Annette McGrath, Vandita Joshi, Willem Rens, Jianghui Wang, Javier Herrero, Desmond W. Cooper, Christie Kovar, Kathryn Beal, Daniel Thomas, Yogi Sundaravadanam, Stephen M. J. Searle, David L. A. Wood, Marilyn B. Renfree, Yue-E Liu, Dawn M. Carone, A Mohammadi, Amber E. Stephens, Shoji Tatsumoto, Jessica M Stringer, John Davis, Allison Hall, Sumio Sugano, Peter A Wilson, Margaret L. Delbridge, Atsushi Toyoda, Paul Flicek, Emily S. W. Wong, Lei Chen, Ion Mandiou, Shunsuke Suzuki, Brandon R. Menzies, Richard A. Gibbs, Janette Edson, Sarah E. Williams, Chen-Chen Wu, Ferguson-Smith, Malcolm [0000-0001-9372-1381], and Apollo - University of Cambridge Repository

Subjects
0106 biological sciences, Molecular Sequence Data, wallaby, Sequence assembly, Zoology, Genomics, Genome, 010603 evolutionary biology, 01 natural sciences, DNA sequencing, Mammalian reproduction, symbols.namesake, 03 medical and health sciences, Genomic Imprinting, 0302 clinical medicine, Tammar wallaby, Marsupial, Animals, Macropus, In Situ Hybridization, Fluorescence, 030304 developmental biology, Genetics, Sanger sequencing, Whole genome sequencing, Macropodidae, 0303 health sciences, biology, Research, Reproduction, Australia, Correction, Chromosome Mapping, Sequence Analysis, DNA, biology.organism_classification, Research Highlight, Biological Evolution, Chromosomes, Mammalian, kangaroo, MicroRNAs, Gene Expression Regulation, symbols, Female, Transcriptome, Sequence Alignment, 030217 neurology & neurosurgery
Abstract

BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development. RESULTS: The genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements. CONCLUSIONS: Analyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution.

Published
2011

16. The genome sequence of taurine cattle: A window to ruminant biology and evolution

Author

Heather M Deobald, Gerald R. Fowler, Clay Davis, Judith Herdandez, Donna Maglott, Lin Chen, Gonzalo Rincon, Darren E. Hagen, James T. Warren, Evgenia V. Kriventseva, Ingrid Olsaker, Debora L. Hamernik, Charles Moen, Oliver C. Jann, Yuri Kapustin, Erdogan Memili, Timothy Connelley, Ling Ling Pu, Terhi Iso-Touru, Gemma Marie Payne, Ye Cheng, Amy Egan, Alexandre Reymond, Aniko Sabo, J. Bruce German, Jason R. Grant, Joseph Chacko, Ronnie D. Green, Isabel Kinney Ferreira de Miranda Santos, Raffaele Mazza, A.J. Molenaar, Richard A. Moore, Christian J. Buhay, Henry Song, Cham G. Kumar, Marion L. Greaser, Hasan Khatib, Harris A. Lewin, Olga Ermolaeva, Jonathan V. Sweedler, Steven J.M. Jones, Rosemeire Conceição Parra Pastor, Paul Stothard, Adam J. Colley, Antti Livanainen, Francesca Panzitta, Dan Graur, Aaron Ingham, David L. Adelson, Timothy P. L. Smith, Shirley A. Ellis, Andy Cree, Jingkun Zhang, Carolyn T.A. Herzig, Jason Goodell, Colette A. Abbey, Feng-Qi Zhao, Mimi M. Chandrabose, Ross L. Tellam, Alex Astashyn, Yanru Ren, Laura Elnitski, Bella Mayurkumar Patel, Sem Genini, Lassudara G. Almeida, Jacqueline E. Schein, Theresa Casey, Hanni Salih, José Fernando Garcia, Zhiquan Wang, Carolyn Fitzsimmons, Evan E. Eichler, Ngoc Nguyen, Kaitlin E. Donohue, Ariel Fernando Amadio, Clayton R. Boldt, John C. McEwan, Juan Manuel Anzola, Francisco Câmara, Shoba Ranganathan, Eran Elhaik, Stefan Hiendleder, George M. Weinstock, Lora Lewis, Jeremy F. Taylor, Dimos Kapetis, Andrew J. Roberts, Lee Alexander, Nelida Rodriguez-Osorio, Alexandre Souvorov, Justin C. Lee, Bruce R. Southey, Boris Kiryutin, Michael Holder, Xiang Qin, Warren M. Snelling, Abhirami Ratnakumar, Marcelo Fábio Gouveia Nogueira, Angela K. Walker, Hatam A. Hakimov, Fernando H. Biase, Roderic Guigó, Shannon Dugan-Rocha, Sean McWilliam, Rex Lee Williams, Jacqueline Chrast, Huyen Dinh, Robert C. Edgar, Huaiyang Jiang, Justin T. Reese, John W. Keele, George E. Liu, Yufeng Shen, Jireh Santibanez, Kim C. Worley, Sandra L. Lee, Sari S. Khalil, Marta Hernández, Stephen N. White, Suria M. Bahadue, Changxi Li, Kim D. Pruitt, Kirsty Jensen, C. Michael Dickens, Jung-Woo Choi, Jennifer Harrow, Tatiana A. DeCampos, Richard A. Gibbs, Ryan J. Lozado, Yoshikazu Sugimoto, Sigbjam Lien, Anna K. Bennett, Curtis P. Van Tassell, Eve Devinoy, Gustavo Garcia, R. Baxter, Satyanarayana Rachagani, Kevin K. Lahmers, Stylianos E. Antonarakis, D. Kolbehdari, Cynthia L. Baldwin, Lillian Sando, Darryl L. Hadsell, Elen Anatriello, Ze Cheng, Richard C. Waterman, Paul Havlak, Peter Dove, Laura Sherman, Wes Barris, Imke Tammen, Geoffrey Okwuonu, Jennifer Hume, Denis M. Larkin, Robert D. Schnabel, Zhi-Liang Hu, Evgeny M. Zdobnov, Danielle G. Lemay, Stephanie Bell, Roberto Malinverni, Jiuzhou Song, David Steffen, James M. Reecy, Lynne V. Nazareth, Carlo José Freire de Oliveira, E. Marques, Cody J. Gladney, Donna M. Muzny, Candice L. Brinkmeyer-Larigford, Lakshmi K. Matukumalli, Jan Aerts, Stephen S. Moore, Margaret Morgan, Kim L. McLean, Juan F. Medrano, Felix Kokocinski, Marco A. Marra, Gregory P. Harhay, Frank W. Nicholas, Loren C. Skow, Fiona S. L. Brinkman, Tovah Kerr, Krista L. Fritz, Stacey M. Curry, Charlotte N. Henrichsen, Catherine Ucla, David J. Lynn, Victor V. Solovyev, Natasha E. Romero, Sandra Hines, Joy M. Raison, Alessandra Mara Franzin, Selina Vattathil, Jeffery A. Carroll, Brian P. Dalrymple, Katarzyna Wilczek-Boney, Seongwon Seo, Richard J. Leach, Mireya Plass, Paul Kitts, Kris R. Wunderlich, Bhanu Prakash V.L. Telugu, Gary L. Bennett, Ramatu Ayiesha Gabisi, Ravikiran Donthu, Shalini N. Jhangiani, Rita A. Wright, Mary Qu Yang, Nauman J. Maqbool, W. A. Carvalho, Monique Rijnkels, Yuri Tani Utsunomiya, Charles E. Chappie, John L. Williams, Rob Halgren, Stephen M. J. Searle, A.R.R. Abatepaulo, Thomas Junier, Stephanie D. McKay, Anne G. Rosenwald, David A. Wheeler, Rosemarie Weikard, N. Hastings, Roger T. Stone, Eduardo Eyras, Cerissa Hamilton, Wendy C. Brown, Yan Ding, Ylva Strandberg Lutzow, Matthew Hobbs, Annett Eberlein, Carine Wyss, Jennifer M. Urbanski, Matthew Peter Kent, Lilian P.L. Lau, Dinesh Kumar, Penny K. Riggs, Lawrence B. Schook, Matthew Hitchens, Vandita Joshi, Melissa J. Landrum, Tyler Alioto, Nathan Poslusny, Thomas T. Wheeler, Victor Sapojnikov, Natália F. Martins, San Juana Ruiz, Michael D. MacNeil, Alexandre Rodrigues Caetano, Mario Andres Poli, Catherine Jamis, Masaaki Taniguchi, James E. Womack, William F. Martin, Andrej Razpet, James G. R. Gilbert, Daniel G. Bradley, Readman Chiu, Thomas H. Welsh, Clare A. Gill, Erica Sodergren, Carol G. Chitko-McKown, Hari Prasad Nandakumar, Virpi Ahola, Steve M. Kappes, Jennifer E. Chapin, Sandra Regina Maruyama, John Lopez, Krystin M. Logan, Jonathan A. Green, Laurens G. Wilming, Yue Liu, Antti Iivanainen, Robert A. Holt, Barbara T. Moreno, Marcos De Donato, Christie Kovar, Angela Jolivet Johnson, Carl T. Muntean, Robert Ward, K. James Durbin, Matthew D. Whiteside, Christopher P. Childers, Tad S. Sonstegard, Yin Shin Liu, Bin Zhu, Sameer D. Pant, Ashley J. Waardenberg, André Eggen, D.M. Spurlock, Hsiu Chuan Chen, Le Luo Guan, Sandra L. Rodriguez-Zas, Akiko Takasuga, Daniela D. Moré, Jianqi Yang, Wratko Hlavina, Sheila M. Schmutz, Michael J. Brownstein, Christine G. Elsik, Marvin Diep Dao, Daniel Gerlach, E. Hart, Elsa Chacko, Elizabeth Glass, Libing Shen, Chris P. Verschoor, Eliane P. Cervelatti, Department of Biology, Georgetown University, Department of Animal Science, Texas A&M University [College Station], Livestock Industries, Baylor College of Medicine (BCM), Reymond, Alexandre, Zdobnov, Evgeny, Antonarakis, Stylianos, Ucla, Catherine, Gerlach, Daniel, and Junier, Thomas

Subjects
Male, genome sequence, [SDV]Life Sciences [q-bio], ved/biology.organism_classification_rank.species, Genome, Genética y Herencia, Segmental duplication, 2. Zero hunger, Genetics, ddc:616, 0303 health sciences, Multidisciplinary, 04 agricultural and veterinary sciences, Bovine genome, Animals, Domestic, Proteins/genetics, Female, CIENCIAS NATURALES Y EXACTAS, Sequence analysis, Evolution, Biotecnología Agropecuaria, Molecular Sequence Data, Tecnología GM, clonación de ganado, selección asistida, diagnósticos, tecnología de producción de biomasa, etc, Biology, Synteny, Article, Ciencias Biológicas, Evolution, Molecular, 03 medical and health sciences, Species Specificity, Animals, Humans, General, Gene, 030304 developmental biology, Whole genome sequencing, ved/biology, Taurine cattle, 0402 animal and dairy science, Genetic Variation, Sequence Analysis, DNA, 040201 dairy & animal science, Bos taurus, Alternative Splicing, MicroRNAs/genetics, CIENCIAS AGRÍCOLAS, cattle, Cattle, genetic
Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production. Fil: Bovine Genome Sequencing and Analysis Consortium. Bovine Genome Sequencing And Analysis Consortium; Estados Unidos Fil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Genética; Argentina

Published
2009
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17. The finished DNA sequence of human chromosome 12

Author

Steven E, Scherer, Donna M, Muzny, Christian J, Buhay, Rui, Chen, Andrew, Cree, Yan, Ding, Shannon, Dugan-Rocha, Rachel, Gill, Preethi, Gunaratne, R Alan, Harris, Alicia C, Hawes, Judith, Hernandez, Anne V, Hodgson, Jennifer, Hume, Andrew, Jackson, Ziad Mohid, Khan, Christie, Kovar-Smith, Lora R, Lewis, Ryan J, Lozado, Michael L, Metzker, Aleksandar, Milosavljevic, George R, Miner, Kate T, Montgomery, Margaret B, Morgan, Lynne V, Nazareth, Graham, Scott, Erica, Sodergren, Xing-Zhi, Song, David, Steffen, Ruth C, Lovering, David A, Wheeler, Kim C, Worley, Yi, Yuan, Zhengdong, Zhang, Charles Q, Adams, M Ali, Ansari-Lari, Mulu, Ayele, Mary J, Brown, Guan, Chen, Zhijian, Chen, Kerstin P, Clerc-Blankenburg, Clay, Davis, Oliver, Delgado, Huyen H, Dinh, Heather, Draper, Manuel L, Gonzalez-Garay, Paul, Havlak, Laronda R, Jackson, Leni S, Jacob, Susan H, Kelly, Li, Li, Zhangwan, Li, Jing, Liu, Wen, Liu, Jing, Lu, Manjula, Maheshwari, Bao-Viet, Nguyen, Geoffrey O, Okwuonu, Shiran, Pasternak, Lesette M, Perez, Farah J H, Plopper, Jireh, Santibanez, Hua, Shen, Paul E, Tabor, Daniel, Verduzco, Lenee, Waldron, Qiaoyan, Wang, Gabrielle A, Williams, Jingkun, Zhang, Jianling, Zhou, Carlana C, Allen, Anita G, Amin, Vivian, Anyalebechi, Michael, Bailey, Joseph A, Barbaria, Kesha E, Bimage, Nathaniel P, Bryant, Paula E, Burch, Carrie E, Burkett, Kevin L, Burrell, Eliana, Calderon, Veronica, Cardenas, Kelvin, Carter, Kristal, Casias, Iracema, Cavazos, Sandra R, Cavazos, Heather, Ceasar, Joseph, Chacko, Sheryl N, Chan, Dean, Chavez, Constantine, Christopoulos, Joseph, Chu, Raynard, Cockrell, Caroline D, Cox, Michelle, Dang, Stephanie R, Dathorne, Robert, David, Candi Mon'Et, Davis, Latarsha, Davy-Carroll, Denise R, Deshazo, Jeremy E, Donlin, Lisa, D'Souza, Kristy A, Eaves, Amy, Egan, Alexandra J, Emery-Cohen, Michael, Escotto, Nicole, Flagg, Lisa D, Forbes, Abdul M, Gabisi, Melissa, Garza, Cerissa, Hamilton, Nicholas, Henderson, Omar, Hernandez, Sandra, Hines, Marilyn E, Hogues, Mei, Huang, DeVincent G, Idlebird, Rudy, Johnson, Angela, Jolivet, Sally, Jones, Ryan, Kagan, Laquisha M, King, Belita, Leal, Heather, Lebow, Sandra, Lee, Jaclyn M, LeVan, Lakeshia C, Lewis, Pamela, London, Lorna M, Lorensuhewa, Hermela, Loulseged, Demetria A, Lovett, Alice, Lucier, Raymond L, Lucier, Jie, Ma, Renita C, Madu, Patricia, Mapua, Ashley D, Martindale, Evangelina, Martinez, Elizabeth, Massey, Samantha, Mawhiney, Michael G, Meador, Sylvia, Mendez, Christian, Mercado, Iracema C, Mercado, Christina E, Merritt, Zachary L, Miner, Emmanuel, Minja, Teresa, Mitchell, Farida, Mohabbat, Khatera, Mohabbat, Baize, Montgomery, Niki, Moore, Sidney, Morris, Mala, Munidasa, Robin N, Ngo, Ngoc B, Nguyen, Elizabeth, Nickerson, Ogechi O, Nwaokelemeh, Stanley, Nwokenkwo, Melissa, Obregon, Maryann, Oguh, Njideka, Oragunye, Rodolfo J, Oviedo, Bridgette J, Parish, David N, Parker, Julia, Parrish, Kenya L, Parks, Heidie A, Paul, Brett A, Payton, Agapito, Perez, William, Perrin, Adam, Pickens, Eltrick L, Primus, Ling-Ling, Pu, Maria, Puazo, Miyo M, Quiles, Juana B, Quiroz, Dina, Rabata, Kacy, Reeves, San Juana, Ruiz, Hongmei, Shao, Ida, Sisson, Titilola, Sonaike, Richard P, Sorelle, Angelica E, Sutton, Amanda F, Svatek, Leah Anne, Svetz, Kavitha S, Tamerisa, Tineace R, Taylor, Brian, Teague, Nicole, Thomas, Rachel D, Thorn, Zulma Y, Trejos, Brenda K, Trevino, Ogechi N, Ukegbu, Jeremy B, Urban, Lydia I, Vasquez, Virginia A, Vera, Donna M, Villasana, Ling, Wang, Stephanie, Ward-Moore, James T, Warren, Xuehong, Wei, Flower, White, Angela L, Williamson, Regina, Wleczyk, Hailey S, Wooden, Steven H, Wooden, Jennifer, Yen, Lillienne, Yoon, Vivienne, Yoon, Sara E, Zorrilla, David, Nelson, Raju, Kucherlapati, George, Weinstock, and Richard A, Gibbs

Subjects
Pan troglodytes, Molecular Sequence Data, Biology, Synteny, Linkage Disequilibrium, Evolution, Molecular, Chromosome 16, Chromosome 19, Animals, Humans, Sequence Deletion, Short Interspersed Nucleotide Elements, Genetics, Chromosome 7 (human), Expressed Sequence Tags, Base Composition, Multidisciplinary, Chromosomes, Human, Pair 12, Sequence Analysis, DNA, Chromosome 17 (human), Mutagenesis, Insertional, Chromosome 4, Chromosome 3, Genes, Evolutionary biology, CpG Islands, Chromosome 21, Chromosome 22, Microsatellite Repeats
Abstract

Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.

Published
2005

18. Revista española de orientación y psicopedagogía

Author

Josefina Hernández Fernández and Juana Ruiz del Cerro

Subjects
servicio de empleo, Murcia, trabajador en paro, perfil profesional, orientación profesional, Applied Psychology, Instituto Nacional de Empleo (España), Education
Abstract

RESUMENEn este estudio se ofrece una descripción de los desempleados que pueden acudir a un Servicio de Orientación Laboral. Aunque existen estudios que abordan el fenómeno del desempleo, del mismo modo que hay multitud de programas de Orientación Laboral, no hemos encontrado trabajos de investigación que muestren la realidad de los demandantes inscritos en las Oficina de Empleo. En este estudio se describen los perfiles más característicos, sus condicionantes, necesidades o intereses profesionales. Atendiendo a estos factores en el Servicio de Orientación de una Oficina de Empleo de Murcia se ha realizado una clasificación, en ella aparecen tres grupos bien diferenciados: universitarios, no universitarios y perceptores de rentas para la inserción laboral. La propuesta de esta investigación es que, aprovechando la realidad descrita, se elaboren estrategias de apoyo relacionadas con la orientación para el empleo con actividades acopladas a las características de los colectivos señalados, atendiendo, también, a especificaciones como la edad, el género, la formación o la experiencia profesional.ABSTRACTThe following study describes a job orientation service to a kind of unemployed people. Although there are studies to the unemployed and job guidance service there is no counselling programmes that shows the truth of the unemployed registered in the job centre. So, an analysis on the features of those groups found in an agency of Murcia is described. Combining such data as age, gender, instruction, work experience there are the characteristics of three groups demanding employment: graduate students, undergraduates and salary recipients for reemployment have been defined. These data can help to create new programs.

Published
2002

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