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Con la ayuda de varios documentos conservados en el Archivo del Palau, se dan a conocer diferentes enseres que Doña Mencía de Mendoza tenía en el Palacio del Real en Valencia, destacando camas de lujo como la de la Emperatriz Isabel de Portugal o la de María de Francia. Se dan a conocer algunos pintores activos en su corte como Juan de Bolaños.

El castillo de Jadraque, conocido como castillo del Cid, es una de las fortalezas situadas en la cuenca del río Henares. El Cardenal Mendoza, don Pedro de Mendoza, lo adquirió, siendo Obispo de Sigüenza, el 27 de enero de 1470, ante Alonso Dávila, por permuta con don Alonso Carrillo, Arzobispo de Toledo, a quien dio la villa de Maqueda y la Alcaldía Mayor de Toledo. Este castillo fue uno de los que se salvaron de la demolición ordenada por los Reyes Católicos, a finales del siglo xv, de todos aquellos enclaves estratégicos que suponían un peligro para la monarquía. De ahí que el Cardenal decidiera reconstruirlo y años más tarde lo legó a su hijo don Rodrigo de Mendoza, 1° Marqués del Cénete y éste, a su vez, a su primogénita, doña Mencía de Mendoza. El castillo de Jadraque, aún hoy día, se levanta sobre una elevada atalaya, está rodeado…

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Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine (DA) levels in brain regions receiving dense VTA input. Since the role of stress in drug addiction is well established, the present study examined the possible involvement of CRF1 receptor in the interaction between morphine withdrawal and catecholaminergic pathways in the reward system. The effects of naloxone-precipitated morphine withdrawal on signs of withdrawal, hypothalamo-pituitary-adrenocortical (HPA) axis activity, dopamine (DA) and noradrenaline (NA) turnover in the nucleus accumbens (NAc) and activation of VTA dopaminergic neurons, were investigated in rats pretreated with vehicle or CP-154,526 (selective CRF1R antagonist). CP-154,526 attenuated the increases in body weight loss and suppressed some of withdrawal signs. Pretreatment with CRF1 receptor antagonist resulted in no significant modification of the increased NA turnover at NAc or plasma corticosterone levels that were seen during morphine withdrawal. However, blockade of CRF1 receptor significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropin (ACTH) levels, DA turnover and TH phosphorylation at Ser40 in the NAc. In addition, CP-154,526 reduced the number of TH containing neurons expressing c-Fos in the VTA after naloxone-precipitated morphine withdrawal. Altogether, these results support the idea that VTA dopaminergic neurons are activated in response to naloxone-precipitated morphine withdrawal and suggest that CRF1 receptors are involved in the activation of dopaminergic pathways which project to NAc.

The female patronage in Spain is studied through ten women belonging to the Mendoza family who lived during the 16th century and the beginning of the 17th century. Eight of these women had a connection with Alcalá de Henares where they performed all their patronage. Besides, it is proved that their family circumstances were decisive to develop different patronages.