1. Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development
- Author
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Amanda Rocío González Ramírez, Sandra Ríos Arrabal, Pablo Torne Poyatos, Alejandro Alonso, Angela Ximena Argote Camacho, María Auxiliadora Olivares Urbano, Juan David Rejón García, María Isabel Núñez, [Argote Camacho,AX] Department of Surgery, Clínico San Cecilio University Hospital, Granada, Spain. [González Ramírez,AR] Bio-Health Research Foundation of Eastern Andalusia—Alejandro Otero (FIBAO), Granada, Spain. [Pérez Alonso,AJ] Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain. [Rejón García,JD] Andalusian Tumour Bank Network, Granada, Spain. [Olivares Urbano,MA, Ríos Arrabal,S, Nuñez,MI] Department of Radiology and Physical Medicine, University of Granada, Granada, Spain. [Torné Poyatos,P] Department of Surgery and Its Specialties, University of Granada, Granada, Spain. [Nuñez,MI] Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Granada, Spain. [Nuñez,MI] Biosanitary Research Institute, ibs.Granada, Granada, Spain., and This research was funded by Fundación Progreso Salud, grant number PI-0730-2013, and by ISCIII, grant number PIE16/00045.
- Subjects
Oncology ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 2 [Medical Subject Headings] ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Metalloproteases [Medical Subject Headings] ,Metaloproteinasas de la matriz ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings] ,Disease ,Matrix metalloproteinase ,medicine.disease_cause ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 1 [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Cohort Studies ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Matrix Metalloproteinases::Matrix Metalloproteinases, Secreted::Matrix Metalloproteinase 3 [Medical Subject Headings] ,MMP inhibitors ,Medicine ,Breast ,Biology (General) ,Spectroscopy ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Aged, 80 and over ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Metalloproteases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 9 [Medical Subject Headings] ,Mortality rate ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Proteinase Inhibitory Proteins, Secretory::Tissue Inhibitor of Metalloproteinases [Medical Subject Headings] ,Proteolytic enzymes ,Tissue Inhibitor of Metalloproteinases ,General Medicine ,Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis::Cocarcinogenesis [Medical Subject Headings] ,Middle Aged ,Immunohistochemistry ,Computer Science Applications ,Chemistry ,Matrix Metalloproteinase 9 ,Disease Progression ,Matrix Metalloproteinase 2 ,Female ,Matrix Metalloproteinase 3 ,Matriz extracelular ,MMPs ,Matrix Metalloproteinase 1 ,Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings] ,medicine.medical_specialty ,QH301-705.5 ,extracellular matrix ,Breast Neoplasms ,Catalysis ,Article ,metalloproteinases ,Inorganic Chemistry ,Breast cancer ,breast cancer ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings] ,Internal medicine ,Biomarkers, Tumor ,Humans ,Metaloproteasas ,immunohistochemical expression ,Physical and Theoretical Chemistry ,Molecular Biology ,QD1-999 ,Linfedema del cáncer de mama ,Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] ,Aged ,Retrospective Studies ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings] ,business.industry ,Organic Chemistry ,Inhibidores de la metaloproteinasa de la matriz ,biomarkers ,Retrospective cohort study ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,medicine.disease ,Biomarcadores ,Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings] ,Spain ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,diagnostic factors ,Case-Control Studies ,Metalloproteases ,business ,Carcinogenesis ,epithelial-to-mesenchymal transition (EMT) - Abstract
Breast cancer continues to be one of the main causes of morbidity and mortality globally and was the leading cause of cancer death in women in Spain in 2020. Early diagnosis is one of the most effective methods to lower the incidence and mortality rates of breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading the extracellular matrix and plays important roles in most steps of breast tumorigenesis. This retrospective cohort study shows the immunohistochemical expression levels of MMP-1, MMP-2, MMP-3, and MMP-9 in 154 women with breast cancer and 42 women without tumor disease. The samples of breast tissue are assessed using several tissue matrices (TMA). The percentages of staining (≤50%–>, 50%) and intensity levels of staining (weak, moderate, or intense) are considered. The immunohistochemical expression of the MMP-1-intensity (p = 0.043) and MMP-3 percentage (p = 0.018) and intensity, (p = 0.025) present statistically significant associations with the variable group (control–case), therefore, expression in the tumor tissue samples of these MMPs may be related to the development of breast cancer. The relationships between these MMPs and some clinicopathological factors in breast cancer are also evaluated but no correlation is found. These results suggest the use of MMP-1 and MMP-3 as potential biomarkers of breast cancer diagnosis.
- Published
- 2021