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406 results on '"Jürgenliemk-Schulz, Ina M."'

1. Efficacy of a nurse-led sexual rehabilitation intervention for women with gynaecological cancers receiving radiotherapy: results of a randomised trial

Author

Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan-Willem M., Tuijnman-Raasveld, Charlotte C., Tsonaka, Roula, Velema, Laura A., Westerveld, Henrike, Cnossen, Jeltsje S., Snyers, An, Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C. H. W., Beukema, Jannet C., Haverkort, Marie A. D., Nowee, Marlies E., Nout, Remi A., de Kroon, Cor D., van den Hout, Wilbert B., Creutzberg, Carien L., van Doorn, Helena C., and ter Kuile, Moniek M.

Published
2024
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2. Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry

Author

Vermij, Lisa, Jobsen, Jan J., León-Castillo, Alicia, Brinkhuis, Mariel, Roothaan, Suzan, Powell, Melanie E., de Boer, Stephanie M., Khaw, Pearly, Mileshkin, Linda R., Fyles, Anthony, Leary, Alexandra, Genestie, Catherine, Jürgenliemk-Schulz, Ina M., Crosbie, Emma J., Mackay, Helen J., Nijman, Hans. W., Nout, Remi A., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Horeweg, Nanda, and Bosse, Tjalling

Published
2023
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3. Dose evaluation of fast synthetic-CT generation using a generative adversarial network for general pelvis MR-only radiotherapy

Author

Maspero, Matteo, Savenije, Mark H. F., Dinkla, Anna M., Seevinck, Peter R., Intven, Martijn P. W., Jurgenliemk-Schulz, Ina M., Kerkmeijer, Linda G. W., and Berg, Cornelis A. T. van den

Subjects
Physics - Medical Physics
Abstract

To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic-CT (sCT) images need to be generated. Considering the application of MR-guided radiotherapy and online adaptive replanning, sCT generation should occur within minutes. This work aims at assessing whether an existing deep learning network can rapidly generate sCT images to be used for accurate MR-based dose calculations in the entire pelvis. A study was conducted on data of 91 patients with prostate, rectal and cervical cancer who underwent external beam radiotherapy acquiring both CT and MRI for patients' simulation. Dixon reconstructed water, fat and in-phase images obtained from a conventional dual gradient-recalled echo sequence were used to generate sCT images. A conditional generative adversarial network (cGAN) was trained in a paired fashion on 2D transverse slices of 32 prostate cancer patients. The trained network was tested on the remaining patients to generate sCT images. For 30 patients in the test set, dose recalculations of the clinical plan were performed on sCT images. Dose distributions were evaluated comparing voxel-based dose differences, gamma and dose-volume histogram (DVH) analysis. The sCT generation required 5.6 s and 21 s for a single patient volume on a GPU and CPU, respectively. On average, sCT images resulted in a higher dose to the target of maximum 0.3%. Results suggest that accurate MR-based dose calculation using sCT images generated with a cGAN trained on prostate cancer patients is feasible for the entire pelvis. The sCT generation was sufficiently fast to be integrated into an MR-guided radiotherapy workflow., Comment: Accepted for publication in Physics in Medicine and Biology, in press (2018)

Published
2018
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5. Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

Author

Horeweg, Nanda, Workel, Hagma H., Loiero, Dominik, Church, David N., Vermij, Lisa, Léon-Castillo, Alicia, Krog, Ricki T., de Boer, Stephanie M., Nout, Remi A., Powell, Melanie E., Mileshkin, Linda R., MacKay, Helen, Leary, Alexandra, Singh, Naveena, Jürgenliemk-Schulz, Ina M., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Koelzer, Viktor H., Nijman, Hans W., Bosse, Tjalling, and de Bruyn, Marco

Published
2022
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6. Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials

Author

Wakkerman, Famke C, primary, Wu, Jiqing, additional, Putter, Hein, additional, Jürgenliemk-Schulz, Ina M, additional, Jobsen, Jan J, additional, Lutgens, Ludy C H W, additional, Haverkort, Marie A D, additional, de Jong, Marianne A, additional, Mens, Jan Willem M, additional, Wortman, Bastiaan G, additional, Nout, Remi A, additional, Léon-Castillo, Alicia, additional, Powell, Melanie E, additional, Mileshkin, Linda R, additional, Katsaros, Dionyssios, additional, Alfieri, Joanne, additional, Leary, Alexandra, additional, Singh, Naveena, additional, de Boer, Stephanie M, additional, Nijman, Hans W, additional, Smit, Vincent T H B M, additional, Bosse, Tjalling, additional, Koelzer, Viktor H, additional, Creutzberg, Carien L, additional, and Horeweg, Nanda, additional

Published
2024
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7. Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation

Author

MS Radiotherapie, Cancer, Kaya, Merve, Post, Cathalijne C.B., Tops, Carli M., Nielsen, Maartje, Crosbie, Emma J., Leary, Alexandra, Mileshkin, Linda R., Han, Kathy, Bessette, Paul, de Boer, Stephanie M., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy, Jobsen, Jan J., Haverkort, Marie A.D., Nout, Remi A., Kroep, Judith, Creutzberg, Carien L., Smit, Vincent T.H.B.M., Horeweg, Nanda, van Wezel, Tom, Bosse, Tjalling, MS Radiotherapie, Cancer, Kaya, Merve, Post, Cathalijne C.B., Tops, Carli M., Nielsen, Maartje, Crosbie, Emma J., Leary, Alexandra, Mileshkin, Linda R., Han, Kathy, Bessette, Paul, de Boer, Stephanie M., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy, Jobsen, Jan J., Haverkort, Marie A.D., Nout, Remi A., Kroep, Judith, Creutzberg, Carien L., Smit, Vincent T.H.B.M., Horeweg, Nanda, van Wezel, Tom, and Bosse, Tjalling

Published
2024

8. Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials

Author

MS Radiotherapie, Cancer, Wakkerman, Famke C., Wu, Jiqing, Putter, Hein, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Lutgens, Ludy C.H.W., Haverkort, Marie A.D., de Jong, Marianne A., Mens, Jan Willem M., Wortman, Bastiaan G., Nout, Remi A., Léon-Castillo, Alicia, Powell, Melanie E., Mileshkin, Linda R., Katsaros, Dionyssios, Alfieri, Joanne, Leary, Alexandra, Singh, Naveena, de Boer, Stephanie M., Nijman, Hans W., Smit, Vincent T.H.B.M., Bosse, Tjalling, Koelzer, Viktor H., Creutzberg, Carien L., Horeweg, Nanda, MS Radiotherapie, Cancer, Wakkerman, Famke C., Wu, Jiqing, Putter, Hein, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Lutgens, Ludy C.H.W., Haverkort, Marie A.D., de Jong, Marianne A., Mens, Jan Willem M., Wortman, Bastiaan G., Nout, Remi A., Léon-Castillo, Alicia, Powell, Melanie E., Mileshkin, Linda R., Katsaros, Dionyssios, Alfieri, Joanne, Leary, Alexandra, Singh, Naveena, de Boer, Stephanie M., Nijman, Hans W., Smit, Vincent T.H.B.M., Bosse, Tjalling, Koelzer, Viktor H., Creutzberg, Carien L., and Horeweg, Nanda

Published
2024

9. Adaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging

Author

Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Van Vliet-van den Ende, Katelijne M., Hoogendoorn-Mulder, Paulien G., Schokker, Rogier I., Moerland, Marinus A., Kroon, Petra S., Roesink, Judith M., Fajardo, Raquel Dávila, Van der Leij, Femke, Jürgenliemk-Schulz, Ina M., Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Van Vliet-van den Ende, Katelijne M., Hoogendoorn-Mulder, Paulien G., Schokker, Rogier I., Moerland, Marinus A., Kroon, Petra S., Roesink, Judith M., Fajardo, Raquel Dávila, Van der Leij, Femke, and Jürgenliemk-Schulz, Ina M.

Published
2024

10. Efficacy of a nurse-led sexual rehabilitation intervention for women with gynaecological cancers receiving radiotherapy: results of a randomised trial

Author

MS Radiotherapie, Cancer, Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan Willem M., Tuijnman-Raasveld, Charlotte C., Tsonaka, Roula, Velema, Laura A., Westerveld, Henrike, Cnossen, Jeltsje S., Snyers, An, Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Beukema, Jannet C., Haverkort, Marie A.D., Nowee, Marlies E., Nout, Remi A., de Kroon, Cor D., van den Hout, Wilbert B., Creutzberg, Carien L., van Doorn, Helena C., ter Kuile, Moniek M., MS Radiotherapie, Cancer, Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan Willem M., Tuijnman-Raasveld, Charlotte C., Tsonaka, Roula, Velema, Laura A., Westerveld, Henrike, Cnossen, Jeltsje S., Snyers, An, Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Beukema, Jannet C., Haverkort, Marie A.D., Nowee, Marlies E., Nout, Remi A., de Kroon, Cor D., van den Hout, Wilbert B., Creutzberg, Carien L., van Doorn, Helena C., and ter Kuile, Moniek M.

Published
2024

11. Efficacy of a nurse-led sexual rehabilitation intervention for women with gynaecological cancers receiving radiotherapy:results of a randomised trial

Author

Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan Willem M., Tuijnman-Raasveld, Charlotte C., Tsonaka, Roula, Velema, Laura A., Westerveld, Henrike, Cnossen, Jeltsje S., Snyers, An, Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Beukema, Jannet C., Haverkort, Marie A.D., Nowee, Marlies E., Nout, Remi A., de Kroon, Cor D., van den Hout, Wilbert B., Creutzberg, Carien L., van Doorn, Helena C., ter Kuile, Moniek M., Suvaal, Isabelle, Hummel, Susanna B., Mens, Jan Willem M., Tuijnman-Raasveld, Charlotte C., Tsonaka, Roula, Velema, Laura A., Westerveld, Henrike, Cnossen, Jeltsje S., Snyers, An, Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Beukema, Jannet C., Haverkort, Marie A.D., Nowee, Marlies E., Nout, Remi A., de Kroon, Cor D., van den Hout, Wilbert B., Creutzberg, Carien L., van Doorn, Helena C., and ter Kuile, Moniek M.

Abstract

Background: The multicentre randomised SPARC trial evaluated the efficacy of a nurse-led sexual rehabilitation intervention on sexual functioning, distress, dilator use, and vaginal symptoms after radiotherapy for gynaecological cancers. Methods: Eligible women were randomised to the rehabilitation intervention or care-as-usual. Four intervention sessions were scheduled over 12 months, with concurrent validated questionnaires and clinical assessments. Primary outcome was the Female Sexual Function Index (FSFI). A generalised-mixed-effects model compared groups over time. Results: In total, 229 women were included (n = 112 intervention; n = 117 care-as-usual). No differences in FSFI total scores were found between groups at any timepoint (P = 0.37), with 12-month scores of 22.57 (intervention) versus 21.76 (care-as-usual). The intervention did not significantly improve dilator use, reduce sexual distress or vaginal symptoms compared to care-as-usual. At 12 months, both groups had minimal physician-reported vaginal stenosis; 70% of women were sexually active and reported no or mild vaginal symptoms. After radiotherapy and brachytherapy, 85% (intervention) versus 75% (care-as-usual) of participants reported dilation twice weekly. Discussion: Sexual rehabilitation for women treated with combined (chemo)radiotherapy and brachytherapy improved before and during the SPARC trial, which likely contributed to comparable study groups. Best practice involves a sexual rehabilitation appointment 1 month post-radiotherapy, including patient information, with dilator guidance, preferably by a trained nurse, and follow-up during the first year after treatment. Clinical trial registration: NCT03611517.

Published
2024

12. Symptomatic lymphocele after robot-assisted pelvic lymphadenectomy as part of the primary surgical treatment for cervical and endometrial cancer: a retrospective cohort study

Author

MS Gynaecologische Oncologie, Cancer, MS Radiotherapie, de Jong, Alise, Baeten, Ilse G T, Jansen, Anna, Hoogendam, Jacob P, Jürgenliemk-Schulz, Ina M, Zweemer, Ronald P, Gerestein, Cornelis G, MS Gynaecologische Oncologie, Cancer, MS Radiotherapie, de Jong, Alise, Baeten, Ilse G T, Jansen, Anna, Hoogendam, Jacob P, Jürgenliemk-Schulz, Ina M, Zweemer, Ronald P, and Gerestein, Cornelis G

Published
2024

13. Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation

Author

Kaya, Merve, primary, Post, Cathalijne C.B., additional, Tops, Carli M., additional, Nielsen, Maartje, additional, Crosbie, Emma J., additional, Leary, Alexandra, additional, Mileshkin, Linda R., additional, Han, Kathy, additional, Bessette, Paul, additional, de Boer, Stephanie M., additional, Jürgenliemk-Schulz, Ina M., additional, Lutgens, Ludy, additional, Jobsen, Jan J., additional, Haverkort, Marie A.D., additional, Nout, Remi A., additional, Kroep, Judith, additional, Creutzberg, Carien L., additional, Smit, Vincent T.H.B.M., additional, Horeweg, Nanda, additional, van Wezel, Tom, additional, and Bosse, Tjalling, additional

Published
2024
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16. 2293: Acute gastrointestinal toxicity of concurrent chemoradiation in cervix cancer: EMBRACE-II findings

Author

Charnalia, Mayuri S., Tanderup, Kari, Pötter, Richard, Chopra, Supriya, Pelizzola, Marta, Jurgenliemk-Schulz, Ina M., Schmid, Maximilian P., Bruheim, Kjersti, Segedin, Barbara, Westerveld, Henrike G., Wiebe, Ericka, Valgma, Margit, Velema, Laura A., Verhoef, Lia C.G., Tan, Li Tee, Lindegaard, Jacob C., Cooper, Rachel, Mathiesen, Hanne F., Kirisits, Christian, Serban, Monica, Jain, Jeevanshu, Kirchheiner, Kathrin, Nout, Remi A., and Spampinato, Sofia

Published
2024
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17. In Reply to Murakami et al

Author

Vittrup, Anders Schwartz, Spampinato, Sofia, Jensen, Nina Boje Kibsgaard, Tanderup, Kari, Kirchheiner, Kathrin, Pötter, Richard, Nout, Remi, and Jürgenliemk-Schulz, Ina M.

Published
2023

19. Abstract 5695: Deep learning risk prediction model of distant recurrence from H&E endometrial cancer slides

Author

Fremond, Sarah, primary, Andani, Sonali, additional, Wolf, Jurriaan Barkey, additional, Ørtoft, Gitte, additional, Høgdall, Estrid, additional, Dijkstra, Jouke, additional, Jobsen, Jan J., additional, Jürgenliemk-Schulz, Ina M., additional, Lutgens, Ludy CHW, additional, Powell, Melanie E., additional, Singh, Naveena, additional, Mileshkin, Linda R., additional, Mackay, Helen J., additional, Leary, Alexandra, additional, Katsaros, Dionyssios, additional, Nijman, Hans W., additional, de Boer, Stephanie M., additional, Nout, Remi A., additional, Smit, Vincent T.H.B.M, additional, Creutzberg, Carien L., additional, Horeweg, Nanda, additional, Koelzer, Viktor H., additional, and Bosse, Tjalling, additional

Published
2023
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20. Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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21. Supplementary Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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22. Association of persistent morbidity after radiotherapy with quality of life in locally advanced cervical cancer survivors

Author

Spampinato, Sofia, primary, Tanderup, Kari, additional, Lindegaard, Jacob C., additional, Schmid, Maximilian P., additional, Sturdza, Alina, additional, Segedin, Barbara, additional, Jürgenliemk-Schulz, Ina M., additional, De Leeuw, Astrid, additional, Bruheim, Kjersti, additional, Mahantshetty, Umesh, additional, Chargari, Cyrus, additional, Rai, Bhavana, additional, Cooper, Rachel, additional, van der Steen-Banasik, Elzbieta, additional, Sundset, Marit, additional, Wiebe, Ericka, additional, Villafranca, Elena, additional, Van Limbergen, Erik, additional, Pieters, Bradley R., additional, Tee Tan, Li, additional, Lutgens, Ludy C.H.W., additional, Hoskin, Peter, additional, Smet, Stéphanie, additional, Pötter, Richard, additional, Nout, Remi, additional, Chopra, Supriya, additional, and Kirchheiner, Kathrin, additional

Published
2023
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23. Multi-center dosimetric predictions to improve plan quality for brachytherapy for cervical cancer treatment

Author

Reijtenbagh, Dominique M.W., Godart, Jérémy, de Leeuw, Astrid A.C., Jürgenliemk-Schulz, Ina M., Mens, Jan Willem M., Huge, Michèle, Hoogeman, Mischa S., Reijtenbagh, Dominique M.W., Godart, Jérémy, de Leeuw, Astrid A.C., Jürgenliemk-Schulz, Ina M., Mens, Jan Willem M., Huge, Michèle, and Hoogeman, Mischa S.

Abstract

Background and purpose: Image-guided adaptive brachytherapy (IGABT) is an important modality in the cervical cancer treatment, and plan quality is sensitive to time pressure in the workflow. Patient anatomy-based quality-assurance (QA) with overlap volume histograms (OVHs) has been demonstrated to detect suboptimal plans (outliers). This analysis quantifies the possible improvement of plans detected as outliers, and investigates its suitability as a clinical QA tool in a multi-center setting. Materials and methods: In previous work OVH-based models were investigated for the use of QA. In this work a total of 160 plans of 68 patients treated in accordance with the current state-of-the-art IGABT protocol from Erasmus MC (EMC) were analyzed, with a model based on 120 plans (60 patients) from UMC Utrecht (UMCU). Machine-learning models were trained to define QA thresholds, and to predict dose D2cm3 to bladder, rectum, sigmoid and small bowel with the help of OVHs of the EMC cohort. Plans out of set thresholds (outliers) were investigated and retrospectively replanned based on predicted D2cm3 values. Results: Analysis of replanned plans demonstrated a median improvement of 0.62 Gy for all Organs At Risk (OARs) combined and an improvement for 96 % of all replanned plans. Outlier status was resolved for 36 % of the replanned plans. The majority of the plans that could not be replanned were reported having implantation complications or insufficient coverage due to tumor geometry. Conclusion: OVH-based QA models can detect suboptimal plans, including both unproblematic BT applications and suboptimal planning circumstances in general. OVH-based QA models demonstrate potential for clinical use in terms of performance and user-friendliness, and could be used for knowledge transfer between institutes. Further research is necessary to differentiate between (sub)optimal planning circumstances.

Published
2023

24. In Reply to Murakami et al

Author

MS Radiotherapie, Cancer, Vittrup, Anders Schwartz, Spampinato, Sofia, Jensen, Nina Boje Kibsgaard, Tanderup, Kari, Kirchheiner, Kathrin, Pötter, Richard, Nout, Remi, Jürgenliemk-Schulz, Ina M, MS Radiotherapie, Cancer, Vittrup, Anders Schwartz, Spampinato, Sofia, Jensen, Nina Boje Kibsgaard, Tanderup, Kari, Kirchheiner, Kathrin, Pötter, Richard, Nout, Remi, and Jürgenliemk-Schulz, Ina M

Published
2023

26. Multi-center dosimetric predictions to improve plan quality for brachytherapy for cervical cancer treatment

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Reijtenbagh, Dominique M W, Godart, Jérémy, de Leeuw, Astrid A C, Jürgenliemk-Schulz, Ina M, Mens, Jan-Willem M, Huge, Michèle, Hoogeman, Mischa S, Klinische Fysica RT, Cancer, MS Radiotherapie, Reijtenbagh, Dominique M W, Godart, Jérémy, de Leeuw, Astrid A C, Jürgenliemk-Schulz, Ina M, Mens, Jan-Willem M, Huge, Michèle, and Hoogeman, Mischa S

Published
2023

27. Introducing a novice surgeon to an experienced robotic gynaecological oncology team: An observational cohort study on the impact of a structured curriculum on outcomes of cervical cancer surgery

Author

MS Gynaecologische Oncologie, Cancer, MS Radiotherapie, Baeten, Ilse G.T., Hoogendam, Jacob P., Schreuder, Henk W.R., Jürgenliemk-Schulz, Ina M., Gerestein, Cornelis G., Zweemer, Ronald P., MS Gynaecologische Oncologie, Cancer, MS Radiotherapie, Baeten, Ilse G.T., Hoogendam, Jacob P., Schreuder, Henk W.R., Jürgenliemk-Schulz, Ina M., Gerestein, Cornelis G., and Zweemer, Ronald P.

Published
2023

28. Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer.

Author

Horeweg, Nanda, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Jobsen, Jan J., Haverkort, Marie A.D., Mens, Jan Willem M., Slot, Annerie, Wortman, Bastiaan G., de Boer, Stephanie M., Stelloo, Ellen, Verhoeven-Adema, Karen W., Putter, Hein, Smit, Vincent T.H.B.M., Bosse, Tjalling, Creutzberg, Carien L., Creutzberg, C.L., Koper, P.C.M., van Putten, W.L.J., and Dercksen, R.

Published
2023
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29. Overall severe morbidity after chemo-radiotherapy and MRI guided adaptive brachytherapy in locally advanced cervical cancer: results from the EMBRACE–I study

Author

Vittrup, Anders S., primary, Kirchheiner, Kathrin, additional, Pötter, Richard, additional, Fokdal, Lars U., additional, Jensen, Nina B.K., additional, Spampinato, Sofia, additional, Haie-Meder, Christine, additional, Schmid, Maximilian P., additional, Sturdza, Alina, additional, Mahantshetty, Umesh, additional, Hoskin, Peter, additional, Segedin, Barbara, additional, Bruheim, Kjersti, additional, Rai, Bhavana, additional, Wiebe, Ericka, additional, van der Steen-Banasik, Elzbieta, additional, Cooper, Rachel, additional, Van Limbergen, Erik, additional, Sundset, Marit, additional, Pieters, Bradley R., additional, Kirisits, Christian, additional, Lindegaard, Jacob C., additional, Jürgenliemk-Schulz, Ina M., additional, Nout, Remi, additional, and Tanderup, Kari, additional

Published
2023
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30. 2022-RA-825-ESGO The impact of age on prognosis in women with endometrial cancer: a pooled analysis of the PORTEC-1, -2 and -3 randomised trials

Author

Wakkerman, Famke Charlotte, primary, De Boer, Stephanie M, additional, Powell, Melanie E, additional, Leary, Alexandra, additional, Fyles, Anthony, additional, Mileshkin, Linda R, additional, Singh, Naveena, additional, Nout, Remi A, additional, Jürgenliemk-Schulz, Ina M, additional, Jobsen, Jan J, additional, Lutgens, Ludy CHW, additional, van der Steen-Banasik, Elsbieta M, additional, Mens, Jan-Willem M, additional, Slot, Annerie, additional, Nijman, Hans W, additional, Smit, Vincent THBM, additional, Bosse, Tjalling, additional, Creutzberg, Carien L, additional, and Horeweg, Nanda, additional

Published
2022
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31. 2022-RA-450-ESGO Benefit of adjuvant radiotherapy depends on molecular class of early-stage endometrial cancer

Author

Horeweg, Nanda, primary, Nout, Remi A, additional, Stelloo, Ellen, additional, Lutgens, Ludy CHW, additional, Jobsen, Jan J, additional, Jürgenliemk-Schulz, Ina M, additional, van der Steen-Banasik, Elsbieta M, additional, Mens, Jan-Willem M, additional, Slot, Annerie, additional, Smit, Vincent THBM, additional, Bosse, Tjalling, additional, and Creutzberg, Carien L, additional

Published
2022
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32. 2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other thanMLH1promoter hypermethylation

Author

Kaya, Merve, primary, Post, Cathalijne, additional, Tops, Carli M, additional, Stelloo, Ellen, additional, Nielsen, Maartje, additional, Powell, Melanie E, additional, Leary, Alexandra, additional, Mileshkin, Linda R, additional, Bessette, Paul, additional, de Boer, Stephanie M, additional, Jürgenliemk-Schulz, Ina M, additional, Lutgens, Ludy, additional, Jobsen, Jan J, additional, van der Steen-Banasik, Elzbieta M, additional, Nout, Remi A, additional, Horeweg, Nanda, additional, van Wezel, Tom, additional, Smit, Vincent, additional, Creutzberg, Carien L, additional, and Bosse, Tjalling, additional

Published
2022
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33. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Rasing, Marnix J.A., primary, Sikkes, Gonda G., additional, Vissers, Nicole G.P.M., additional, Kotte, Alexis N.T.J., additional, Boudewijn, Joske H., additional, Doornaert, Patricia A.H., additional, Eppinga, Wietse S.C., additional, Intven, Martijn, additional, Rutgers, Reijer H.A., additional, Scheeren, Annick, additional, Snoeren, Louk M.W., additional, Vlig, Tiny B., additional, van der Voort van Zyp, Jochem R.N., additional, Wijkhuizen, Lisa M., additional, van Rossum, Peter S.N., additional, Peters, Max, additional, and Jürgenliemk-Schulz, Ina M., additional

Published
2022
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34. Fluorescent Indocyanine Green versus Technetium-99m and Blue Dye for Bilateral SENTinel Lymph Node Detection in Stage I–IIA Cervical Cancer (FluoreSENT): protocol for a non-inferiority study

Author

Baeten, Ilse G T, primary, Hoogendam, Jacob P, additional, Braat, Arthur J A T, additional, Veldhuis, Wouter B, additional, Jonges, Geertruida N, additional, Jürgenliemk-Schulz, Ina M, additional, Zweemer, Ronald P, additional, and Gerestein, Cornelis G, additional

Published
2022
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36. Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases

Author

Werensteijn-Honingh, Anita M., primary, Kroon, Petra S., additional, Winkel, Dennis, additional, van Gaal, J. Carlijn, additional, Hes, Jochem, additional, Snoeren, Louk M.W., additional, Timmer, Jaleesa K., additional, Mout, Christiaan C.P., additional, Bol, Gijsbert H., additional, Kotte, Alexis N., additional, Eppinga, Wietse S.C., additional, Intven, Martijn, additional, Raaymakers, Bas W., additional, and Jürgenliemk-Schulz, Ina M., additional

Published
2022
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38. First multicentre experience of SABR for lymph node and liver oligometastatic disease on the unity MR-Linac

Author

Janssen, Tomas M., primary, Aitken, Katharine, additional, Alongi, Filippo, additional, Barry, Aisling, additional, Bernchou, Uffe, additional, Boeke, Simon, additional, Hall, William A., additional, Hosni, Ali, additional, Kroon, Petra.S., additional, Nachbar, Marcel, additional, Saeed, Hina, additional, Jürgenliemk-Schulz, Ina M., additional, Schytte, Tine, additional, Verkooijen, Helena M., additional, and Nowee, Marlies.E., additional

Published
2022
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39. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer:An EMBRACE-I sub-study

Author

Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, de Leeuw, Astrid A.C., Radiation Oncology, CCA - Cancer Treatment and Quality of Life, and Radiotherapy

Subjects
Radiotherapy, PIBS, Brachytherapy, RV-RP, Uterine Cervical Neoplasms, Radiotherapy Dosage, Constriction, Pathologic, Hematology, Vaginal morbidity, EMBRACE, SDG 3 - Good Health and Well-being, Oncology, ICRU-R, Vagina, Cervical cancer, Humans, Female, Radiology, Nuclear Medicine and imaging, Dose-effect
Abstract

Background and purpose: To evaluate dose–effect relationships between vaginal dose points and vaginal stenosis in patients treated for locally advanced cervical cancer with radio(chemo)therapy and image-guided adaptive brachytherapy. Material and methods: Patients from six centres participating in the EMBRACE-I study were included. Information on doses to different vaginal dose points, including the Posterior-Inferior Border of Symphysis (PIBS) points and recto-vaginal reference (RV-RP) point, were retrieved from the treatment planning system. In addition, the vaginal reference length (VRL) was evaluated. Vaginal stenosis was prospectively assessed according to the CTCAEv3.0 system at baseline and follow-up. Primary endpoint was grade 2 or higher (G ≥ 2) vaginal stenosis. Impact of dose to the vaginal dose points, and impact of VRL, age, vaginal involvement and applicator on vaginal stenosis G ≥ 2 was evaluated with a Cox proportional-hazard regression model. Results: 301 patients were included. Median follow-up was 49 months. During follow-up, the incidence of G0, G1, G2, and G3 vaginal stenosis was 25% (76), 52% (158), 20% (59) and 3% (8), respectively. Median total doses to PIBS+2 cm, PIBS, PIBS-2 cm and the RV-RP were 52.9 (IQR 49.3–64.7), 41.0 (IQR 15.4–49.0), 4.1 (IQR 2.9–7.0) and 64.6 (IQR 60.0–70.6) Gy EQD23, respectively. Higher doses to the PIBS, PIBS + 2 cm and RV-RP points were significantly associated with increased risk for vaginal stenosis G ≥ 2. Other risk factors for vaginal stenosis were: vaginal involvement at diagnosis, higher age, shorter VRL and use of a tandem-ovoid applicator. Conclusion: Higher doses to the PIBS+2 cm, PIBS and RV-RP dose points are associated with vaginal stenosis G ≥ 2.

Published
2022

40. Role of Brachytherapy in the Postoperative Management of Endometrial Cancer : Decision-Making Analysis among Experienced European Radiation Oncologists

Author

Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M, Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, Tselis, Nikolaos, Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M, Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, and Tselis, Nikolaos

Abstract

BACKGROUND: There are various society-specific guidelines addressing adjuvant brachytherapy (BT) after surgery for endometrial cancer (EC). However, these recommendations are not uniform. Against this background, clinicians need to make decisions despite gaps between best scientific evidence and clinical practice. We explored factors influencing decision-making for adjuvant BT in clinical routine among experienced European radiation oncologists in the field of gynaecological radiotherapy (RT). We also investigated the dose and technique of BT. METHODS: Nineteen European experts for gynaecological BT selected by the Groupe Européen de Curiethérapie and the European Society for Radiotherapy & Oncology provided their decision criteria and technique for postoperative RT in EC. The decision criteria were captured and converted into decision trees, and consensus and dissent were evaluated based on the objective consensus methodology. RESULTS: The decision criteria used by the experts were tumour extension, grading, nodal status, lymphovascular invasion, and cervical stroma/vaginal invasion (yes/no). No expert recommended adjuvant BT for pT1a G1-2 EC without substantial LVSI. Eighty-four percent of experts recommended BT for pT1a G3 EC without substantial LVSI. Up to 74% of experts used adjuvant BT for pT1b LVSI-negative and pT2 G1-2 LVSI-negative disease. For 74-84% of experts, EBRT + BT was the treatment of choice for nodal-positive pT2 disease and for pT3 EC with cervical/vaginal invasion. For all other tumour stages, there was no clear consensus for adjuvant treatment. Four experts already used molecular markers for decision-making. Sixty-five percent of experts recommended fractionation regimens of 3 × 7 Gy or 4 × 5 Gy for BT as monotherapy and 2 × 5 Gy for combination with EBRT. The most commonly used applicator for BT was a vaginal cylinder; 82% recommended image-guided BT. CONCLUSIONS: There was a clear trend towards adjuvant BT for stage IA G3, stage IB, and s, Funding agency:Research Committee of the Kantonsspital St. Gallen 21/01

Published
2022
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41. Role of Brachytherapy in the Postoperative Management of Endometrial Cancer:Decision-Making Analysis among Experienced European Radiation Oncologists

Author

Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M., Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, Tselis, Nikolaos, Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M., Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, and Tselis, Nikolaos

Abstract

Background: There are various society-specific guidelines addressing adjuvant brachytherapy (BT) after surgery for endometrial cancer (EC). However, these recommendations are not uniform. Against this background, clinicians need to make decisions despite gaps between best scientific evidence and clinical practice. We explored factors influencing decision-making for adjuvant BT in clinical routine among experienced European radiation oncologists in the field of gynaecological radiotherapy (RT). We also investigated the dose and technique of BT. Methods: Nineteen European experts for gynaecological BT selected by the Groupe Européen de Curiethérapie and the European Society for Radiotherapy & Oncology provided their decision criteria and technique for postoperative RT in EC. The decision criteria were captured and converted into decision trees, and consensus and dissent were evaluated based on the objective consensus methodology. Results: The decision criteria used by the experts were tumour extension, grading, nodal status, lymphovascular invasion, and cervical stroma/vaginal invasion (yes/no). No expert recommended adjuvant BT for pT1a G1-2 EC without substantial LVSI. Eighty-four percent of experts recommended BT for pT1a G3 EC without substantial LVSI. Up to 74% of experts used adjuvant BT for pT1b LVSI-negative and pT2 G1–2 LVSI-negative disease. For 74–84% of experts, EBRT + BT was the treatment of choice for nodal-positive pT2 disease and for pT3 EC with cervical/vaginal invasion. For all other tumour stages, there was no clear consensus for adjuvant treatment. Four experts already used molecular markers for decision-making. Sixty-five percent of experts recommended fractionation regimens of 3 × 7 Gy or 4 × 5 Gy for BT as monotherapy and 2 × 5 Gy for combination with EBRT. The most commonly used applicator for BT was a vaginal cylinder; 82% recommended image-guided BT. Conclusion: There was a clear trend towards adjuvant BT for stage IA G3, stage IB, and

Published
2022

42. Multi-modal volumetric concept activation to explain detection and classification of metastatic prostate cancer on PSMA-PET/CT

Author

Kraaijveld, Rosa C. J., Philippens, Marielle E. P., Eppinga, Wietse S. C., Jürgenliemk-Schulz, Ina M., Gilhuijs, Kenneth G. A., Kroon, Petra S., van der Velden, Bas H. M., Kraaijveld, Rosa C. J., Philippens, Marielle E. P., Eppinga, Wietse S. C., Jürgenliemk-Schulz, Ina M., Gilhuijs, Kenneth G. A., Kroon, Petra S., and van der Velden, Bas H. M.

Abstract

Explainable artificial intelligence (XAI) is increasingly used to analyze the behavior of neural networks. Concept activation uses human-interpretable concepts to explain neural network behavior. This study aimed at assessing the feasibility of regression concept activation to explain detection and classification of multi-modal volumetric data. Proof-of-concept was demonstrated in metastatic prostate cancer patients imaged with positron emission tomography/computed tomography (PET/CT). Multi-modal volumetric concept activation was used to provide global and local explanations. Sensitivity was 80% at 1.78 false positive per patient. Global explanations showed that detection focused on CT for anatomical location and on PET for its confidence in the detection. Local explanations showed promise to aid in distinguishing true positives from false positives. Hence, this study demonstrated feasibility to explain detection and classification of multi-modal volumetric data using regression concept activation., Comment: Accepted as: Kraaijveld, R.C.J., Philippens, M.E.P., Eppinga, W.S.C., J\"urgenliemk-Schulz, I.M., Gilhuijs, K.G.A., Kroon, P.S., van der Velden, B.H.M. "Multi-modal volumetric concept activation to explain detection and classification of metastatic prostate cancer on PSMA-PET/CT." MICCAI workshop on Interpretability of Machine Intelligence in Medical Image Computing (iMIMIC), 2022

Published
2022

43. Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer

Author

Peters, Elke E.M., León-Castillo, Alicia, Smit, Vincent T.H.B.M., Boennelycke, Marie, Hogdall, Estrid, Hogdall, Claus, Creutzberg, Carien, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Mens, Jan Willem M., Lutgens, Ludy C.H.W., Van Der Steen-Banasik, Elzbieta M., Ortoft, Gitte, Bosse, Tjalling, Nout, Remi, Peters, Elke E.M., León-Castillo, Alicia, Smit, Vincent T.H.B.M., Boennelycke, Marie, Hogdall, Estrid, Hogdall, Claus, Creutzberg, Carien, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Mens, Jan Willem M., Lutgens, Ludy C.H.W., Van Der Steen-Banasik, Elzbieta M., Ortoft, Gitte, Bosse, Tjalling, and Nout, Remi

Abstract

Lymphovascular space invasion (LVSI) occurs in a minority of endometrial cancer (EC) cases, and the extent of LVSI is an important risk factor for recurrence and/or metastases. Our aim was to improve the reproducibility of measuring clinically meaningful LVSI by performing a quantitative analysis of the correlation between LVSI and the risk of pelvic lymph node recurrence in EC. EC samples from PORTEC-1 and PORTEC-2 trials were retrieved and used to collect quantitative data, including the number of LVSI-positive vessels per H&E-stained slide. Using a predefined threshold for clinical relevance, the risk of pelvic lymph node recurrence risk was calculated (Kaplan-Meier method, with Cox regression) using a stepwise adjustment for the number of LVSI-positive vessels. This analysis was then repeated in the Danish Gynecological Cancer Database (DGCD) cohort. Among patients in PORTEC-1 and PORTEC-2 trials who did not receive external beam radiotherapy, the 5-yr pelvic lymph node recurrence risk was 3.3%, 6.7% (P=0.51), and 26.3% (P<0.001), respectively when 0, 1 to 3, or ≥4 vessels had LVSI involvement; similar results were obtained for the DGCD cohort. Furthermore, both the average number of tumor cells in the largest embolus and the number of LVSI-positive H&E slides differed significantly between focal LVSI and substantial LVSI. On the basis of these results, we propose a numeric threshold (≥4 LVSI-involved vessels in at least one H&E slide) for defining clinically relevant LVSI in EC, thereby adding supportive data to the semiquantitative approach. This will help guide gynecologic pathologists to differentiate between focal and substantial LVSI, especially in borderline cases.

Published
2022

44. Automated causal inference in application to randomized controlled clinical trials

Author

Wu, Jiqing, Horeweg, Nanda, de Bruyn, Marco, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C. H. W., Jobsen, Jan J., van der Steen-Banasik, Elzbieta M., Nijman, Hans W., Smit, Vincent T. H. B. M., Bosse, Tjalling, Creutzberg, Carien L., Koelzer, Viktor H., Wu, Jiqing, Horeweg, Nanda, de Bruyn, Marco, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C. H. W., Jobsen, Jan J., van der Steen-Banasik, Elzbieta M., Nijman, Hans W., Smit, Vincent T. H. B. M., Bosse, Tjalling, Creutzberg, Carien L., and Koelzer, Viktor H.

Abstract

Randomized controlled trials (RCTs) are considered as the gold standard for testing causal hypotheses in the clinical domain. However, the investigation of prognostic variables of patient outcome in a hypothesized cause-effect route is not feasible using standard statistical methods. Here, we propose a new automated causal inference method (AutoCI) built upon the invariant causal prediction (ICP) framework for the causal re-interpretation of clinical trial data. Compared to existing methods, we show that the proposed AutoCI allows to efficiently determine the causal variables with a clear differentiation on two real-world RCTs of endometrial cancer patients with mature outcome and extensive clinicopathological and molecular data. This is achieved via suppressing the causal probability of non-causal variables by a wide margin. In ablation studies, we further demonstrate that the assignment of causal probabilities by AutoCI remain consistent in the presence of confounders. In conclusion, these results confirm the robustness and feasibility of AutoCI for future applications in real-world clinical analysis., Comment: Submitted to Nature Machine Intelligence. The code is publicly available via https://github.com/CTPLab/AutoCI

Published
2022

45. Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer

Author

MS Radiotherapie, Cancer, Peters, Elke E.M., León-Castillo, Alicia, Smit, Vincent T.H.B.M., Boennelycke, Marie, Hogdall, Estrid, Hogdall, Claus, Creutzberg, Carien, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Mens, Jan Willem M., Lutgens, Ludy C.H.W., Van Der Steen-Banasik, Elzbieta M., Ortoft, Gitte, Bosse, Tjalling, Nout, Remi, MS Radiotherapie, Cancer, Peters, Elke E.M., León-Castillo, Alicia, Smit, Vincent T.H.B.M., Boennelycke, Marie, Hogdall, Estrid, Hogdall, Claus, Creutzberg, Carien, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Mens, Jan Willem M., Lutgens, Ludy C.H.W., Van Der Steen-Banasik, Elzbieta M., Ortoft, Gitte, Bosse, Tjalling, and Nout, Remi

Published
2022

46. Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy

Author

MS Radiotherapie, Cancer, Wortman, Bastiaan G., Post, Cathalijne C.B., Powell, Melanie E., Khaw, Pearly, Fyles, Anthony, D'Amico, Romerai, Haie-Meder, Christine, Jürgenliemk-Schulz, Ina M., McCormack, Mary, Do, Viet, Katsaros, Dionyssios, Bessette, Paul, Baron, Marie Hélène, Nout, Remi A., Whitmarsh, Karen, Mileshkin, Linda, Lutgens, Ludy C.H.W., Kitchener, Henry C., Brooks, Susan, Nijman, Hans W., Astreinidou, Eleftheria, Putter, Hein, Creutzberg, Carien L., de Boer, Stephanie M., MS Radiotherapie, Cancer, Wortman, Bastiaan G., Post, Cathalijne C.B., Powell, Melanie E., Khaw, Pearly, Fyles, Anthony, D'Amico, Romerai, Haie-Meder, Christine, Jürgenliemk-Schulz, Ina M., McCormack, Mary, Do, Viet, Katsaros, Dionyssios, Bessette, Paul, Baron, Marie Hélène, Nout, Remi A., Whitmarsh, Karen, Mileshkin, Linda, Lutgens, Ludy C.H.W., Kitchener, Henry C., Brooks, Susan, Nijman, Hans W., Astreinidou, Eleftheria, Putter, Hein, Creutzberg, Carien L., and de Boer, Stephanie M.

Published
2022

47. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, de Leeuw, Astrid A.C., MS Radiotherapie, Cancer, Klinische Fysica RT, Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, and de Leeuw, Astrid A.C.

Published
2022

48. Role of Brachytherapy in the Postoperative Management of Endometrial Cancer: Decision-Making Analysis among Experienced European Radiation Oncologists

Author

MS Radiotherapie, Cancer, Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M., Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, Tselis, Nikolaos, MS Radiotherapie, Cancer, Glatzer, Markus, Tanderup, Kari, Rovirosa, Angeles, Fokdal, Lars, Ordeanu, Claudia, Tagliaferri, Luca, Chargari, Cyrus, Strnad, Vratislav, Dimopoulos, Johannes Athanasios, Šegedin, Barbara, Cooper, Rachel, Nakken, Esten Søndrol, Petric, Primoz, van der Steen-Banasik, Elzbieta, Lössl, Kristina, Jürgenliemk-Schulz, Ina M., Niehoff, Peter, Hermansson, Ruth S., Nout, Remi A., Putora, Paul Martin, Plasswilm, Ludwig, and Tselis, Nikolaos

Published
2022

49. Risk Factors for Late Persistent Fatigue After Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: An Analysis From the EMBRACE-I Study

Author

MS Radiotherapie, Cancer, Smet, Stéphanie, Spampinato, Sofia, Pötter, Richard, Jürgenliemk-Schulz, Ina M., Nout, Remi A., Chargari, Cyrus, Mahantshetty, Umesh, Sturdza, Alina, Segedin, Barbara, Bruheim, Kjersti, Hoskin, Peter, Rai, Bhavana, Huang, Fleur, Cooper, Rachel, Van der Steen-Banasik, Elzbieta, Sundset, Marit, Van Limbergen, Erik, Tan, Li Tee, Lutgens, Ludy C.H.W., Villafranca, Elena, Pieters, Bradley R., Tanderup, Kari, Kirchheiner, Kathrin, MS Radiotherapie, Cancer, Smet, Stéphanie, Spampinato, Sofia, Pötter, Richard, Jürgenliemk-Schulz, Ina M., Nout, Remi A., Chargari, Cyrus, Mahantshetty, Umesh, Sturdza, Alina, Segedin, Barbara, Bruheim, Kjersti, Hoskin, Peter, Rai, Bhavana, Huang, Fleur, Cooper, Rachel, Van der Steen-Banasik, Elzbieta, Sundset, Marit, Van Limbergen, Erik, Tan, Li Tee, Lutgens, Ludy C.H.W., Villafranca, Elena, Pieters, Bradley R., Tanderup, Kari, and Kirchheiner, Kathrin

Published
2022

50. Automated causal inference in application to randomized controlled clinical trials

Author

MS Radiotherapie, Cancer, Wu, Ji Q., Horeweg, Nanda, de Bruyn, Marco, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Jobsen, Jan J., van der Steen-Banasik, Elzbieta M., Nijman, Hans W., Smit, Vincent T.H.B.M., Bosse, Tjalling, Creutzberg, Carien L., Koelzer, Viktor H., MS Radiotherapie, Cancer, Wu, Ji Q., Horeweg, Nanda, de Bruyn, Marco, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Jobsen, Jan J., van der Steen-Banasik, Elzbieta M., Nijman, Hans W., Smit, Vincent T.H.B.M., Bosse, Tjalling, Creutzberg, Carien L., and Koelzer, Viktor H.

Published
2022

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