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EuFeO3 (EFO) nanoparticles were prepared by sol-gel method with an aid of tartaric acid at different calcination temperatures. The prepared EFO samples were characterized by differential thermal analysis-thermogravimetry, X-ray diffraction, Fourier transform infrared spectra, Raman spectra, transmission electron microscopy, UV-visible diffuse reflectance spectrum, N2 adsorption/desorption measurements, and photoluminescence spectra. The photocatalytic activity of the samples was evaluated by the photocatalytic decolorization of rhodamine B aqueous solution under visible-light irradiation. The calcination temperature for the highest photocatalytic activity of the EFO nanoparticles was found to be 750°C. Much enhanced photocatalytic activity was observed when adding a small amount of H2O2 during the photocatalysis, indicating EFO nanoparticles have photo-Fenton-like catalytic activity. EFO nanoparticles were further demonstrated to have an excellent photocatalytic stability, which is useful for the efficient recovery of photocatalyst. [ABSTRACT FROM AUTHOR]

Purpose: The exposure of Ethylene oxide (EO) is linked to systemic inflammatory response and various cardiovascular risk factors. Hemoglobin's binding to ethylene oxide (HbEO) was used to measure serum EO level. This research aims to explore the association between metabolic syndrome (MetS) and HbEO, and between HbEO and components of metabolic syndrome., Method: This research included 1842 participants from 2013 to 2020 in National Health and Nutrition Examination Survey (NHANES) database. Weighted logistic regression models were used to analyze the relationship between HbEO and metabolic syndrome risk, using odds ratio (OR) and 95% confidence interval (CI). The restricted cubic spline plot explores whether there is a dose-response relationship between HbEO and MetS risk. Subgroup analysis was performed to analyze study heterogeneity., Results: Significant differences were found in gender, educational level, marital status, diabetes status and hypertension among different groups ( P < 0.001, P = 0.007, P = 0.003, P < 0.001, P < 0.001, respectively). The serum HbEO level exhibited positive correlation with metabolic syndrome risk in Q2 level (OR=1.64, 1.04~2.48), Q3 level (OR=1.99, 1.29~3.08), and Q4 level (OR=2.89, 1.92~4.34). The dose-response association suggested a possible linear association between serum HbEO and metabolic syndrome risk ( P -overall=0.0359, P -non-linear=0.179). L-shaped association was found between HbEO and the risk of MetS in female population, obese population and mid-age and elder population ( P -overall<0.001, P -non-linear=0.0024; P -overall=0.0107, P -non-linear=0.0055 P -overall<0.001 P -non-linear=0.0157)., Conclusion: This study indicates a linear correlation between MetS and HbEO, with MetS risk escalating as HbEO levels increase. The prevalence of MetS varies depending on BMI, age and gender, and these factors can also influence MetS prevalence when exposed to EO., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhou, Wang, Ju, Zhang, Yang and Liu.)

Early-onset obesity is a rising health concern influenced by heredity. However, many monogenic obesity variants (MOVs) remain to be discovered due to differences in ethnicity and culture. Additionally, patients with known MOVs have shown limited weight loss after bariatric surgery, suggesting it can be used as a screening tool for new candidates. In this study, we performed whole-exome sequencing (WES) combined with postoperative data to detect candidate MOVs in a cohort of 62 early-onset obesity and 9 late-onset obesity patients. Our findings demonstrated that patients with early-onset obesity preferred a higher BMI and waist circumference (WC). We confirmed the efficacy of the method by identifying a mutation in known monogenic obesity gene, PCSK1 , which resulted in less weight loss after surgery. 5 genes were selected for further verification, and a frameshift variant in CAMKK2 gene: NM&#95;001270486.1, c.1614dup, (p. Gly539Argfs*3) was identified as a novel candidate MOV. This mutation influenced the improvement of metabolism after bariatric surgery. In conclusion, our data confirm the efficacy of WES combined with postoperative data in detecting novel candidate MOVs and c.1614dup (CAMKK2) might be a promising MOV, which needs further confirmation. This study enriches the human monogenic obesity mutation database and provides a scientific basis for clinically accurate diagnosis and treatment., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Yang, Wen, Ju, Ren, Zhang and Liu.)