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4,242 results on '"Joyce, K."'

1. This Is Why We Do It: Faculty Motivations for Embracing Community-Engaged Pedagogy

Author

Magdalena Denham, Lee M. Miller, Joyce K. Mccauley, Danica Schieber, Taylor L. Morrison, and Chuck Drumm

Abstract

Institutions of higher education are increasingly highlighting community engagement activities to make the benefits of higher education more visible. The most transformational community engagement is linked to curriculum, so it is faculty who must incorporate community-engaged pedagogy. This content analysis of faculty narratives about community engagement reveals motivations for faculty to engage in this work. These findings connect to social capital theory and suggest a new direction for faculty development efforts to promote community engagement.

Published
2024

2. Implantable silicon neural probes with nanophotonic phased arrays for single-lobe beam steering

Author

Chen, Fu-Der, Sharma, Ankita, Xue, Tianyuan, Jung, Youngho, Govdeli, Alperen, Mak, Jason C. C., Chameh, Homeira Moradi, Movahed, Mandana, Brunk, Michael G. K., Luo, Xianshu, Chua, Hongyao, Lo, Patrick Guo-Qiang, Valiante, Taufik A, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Biological Physics
Abstract

In brain activity mapping experiments using optogenetics, patterned illumination is crucial for deterministic and localized stimulation of neurons. However, due to optical scattering in brain tissue, light-emitting implantable devices are needed to bring precise patterned illumination to deep brain regions. A promising solution is silicon neural probes with integrated nanophotonic circuits that form tailored beam emission patterns without lenses. Here, we demonstrate neural probes with grating-based light emitters that generate a single steerable light beam across $> 60\%$ of the steering range with $\ge 4$ dB of background suppression for optogenetic photostimulation. The light emitters, optimized for blue or amber light, combine end-fire optical phased arrays with slab gratings to suppress higher-order sidelobes., Comment: 32 pages, 7 figures

Published
2024

3. Implantable Photonic Neural Probes with Out-of-Plane Focusing Grating Emitters

Author

Xue, Tianyuan, Stalmashonak, Andrei, Chen, Fu-Der, Ding, Peisheng, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics
Abstract

We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes., Comment: 11 pages, 6 figures

Published
2024

4. NeuroQuantify -- An Image Analysis Software for Detection and Quantification of Neurons and Neurites using Deep Learning

Author

Dang, Ka My, Zhang, Yi Jia, Zhang, Tianchen, Wang, Chao, Sinner, Anton, Coronica, Piero, and Poon, Joyce K. S.

Subjects
Quantitative Biology - Quantitative Methods, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

The segmentation of cells and neurites in microscopy images of neuronal networks provides valuable quantitative information about neuron growth and neuronal differentiation, including the number of cells, neurites, neurite length and neurite orientation. This information is essential for assessing the development of neuronal networks in response to extracellular stimuli, which is useful for studying neuronal structures, for example, the study of neurodegenerative diseases and pharmaceuticals. However, automatic and accurate analysis of neuronal structures from phase contrast images has remained challenging. To address this, we have developed NeuroQuantify, an open-source software that uses deep learning to efficiently and quickly segment cells and neurites in phase contrast microscopy images. NeuroQuantify offers several key features: (i) automatic detection of cells and neurites; (ii) post-processing of the images for the quantitative neurite length measurement based on segmentation of phase contrast microscopy images, and (iii) identification of neurite orientations. The user-friendly NeuroQuantify software can be installed and freely downloaded from GitHub https://github.com/StanleyZ0528/neural-image-segmentation.

Published
2023

5. Room-temperature waveguide-coupled silicon single-photon avalanche diodes

Author

Govdeli, Alperen, Straguzzi, John N., Yong, Zheng, Lin, Yiding, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Single photon detection is important for a wide range of low-light applications, including quantum information processing, spectroscopy, and light detection and ranging (LiDAR). A key challenge in these applications has been to integrate single-photon detection capability into photonic circuits for the realization of complex photonic microsystems. Short-wavelength ($\lambda$ < 1.1 $\mu$m) integrated photonics platforms that use silicon (Si) as photodetectors offer the opportunity to achieve single-photon avalanche diodes (SPADs) that operate at or near room temperature. Here, we report the first waveguide-coupled Si SPAD. The device is monolithically integrated in a Si photonic platform and operates in the visible spectrum. The device exhibited a single photon detection efficiency of > 6% for wavelengths of 488 nm and 532 nm with an excess voltage less than 20% of the breakdown voltage. The dark count rate was below 100 kHz at room temperature, with the possibility of improving by approximately 35% by reducing the temperature to -5$^{\circ}$C.

Published
2023

6. Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma

Author

Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, and Costas A. Lyssiotis

Subjects
Science
Abstract

Abstract H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells. Here, we establish in vitro models that recapitulate DMG-OPC-like and AC-like phenotypes and perform transcriptomics, metabolomics, and bioenergetic profiling to identify metabolic programs in the different cellular states. We then define strategies to target metabolic vulnerabilities within specific tumor populations. We show that AC-like cells exhibit a mesenchymal phenotype and are sensitized to ferroptotic cell death. In contrast, OPC-like cells upregulate cholesterol biosynthesis, have diminished mitochondrial oxidative phosphorylation (OXPHOS), and are accordingly more sensitive to statins and OXPHOS inhibitors. Additionally, statins and OXPHOS inhibitors show efficacy and extend survival in preclinical orthotopic models established with stem-like H3K27M DMG cells. Together, this study demonstrates that cellular subtypes within DMGs harbor distinct metabolic vulnerabilities that can be uniquely and selectively targeted for therapeutic gain.

Published
2024
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7. Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma

Author

Mbah, Nneka E., Myers, Amy L., Sajjakulnukit, Peter, Chung, Chan, Thompson, Joyce K., Hong, Hanna S., Giza, Heather, Dang, Derek, Nwosu, Zeribe C., Shan, Mengrou, Sweha, Stefan R., Maydan, Daniella D., Chen, Brandon, Zhang, Li, Magnuson, Brian, Zhu, Zirui, Radyk, Megan, Lavoie, Brooke, Yadav, Viveka Nand, Koo, Imhoi, Patterson, Andrew D., Wahl, Daniel R., Franchi, Luigi, Agnihotri, Sameer, Koschmann, Carl J., Venneti, Sriram, and Lyssiotis, Costas A.

Published
2024
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10. Implantable Photonic Neural Probes with 3D-Printed Microfluidics and Applications to Uncaging

Author

Mu, Xin, Chen, Fu-Der, Dang, Ka My, Brunk, Michael G. K., Li, Jianfeng, Wahn, Hannes, Stalmashonak, Andrei, Ding, Peisheng, Luo, Xianshu, Chua, Hongyao, Lo, Guo-Qiang, Poon, Joyce K. S., and Sacher, Wesley D.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Advances in chip-scale photonic-electronic integration are enabling a new generation of foundry-manufacturable implantable silicon neural probes incorporating nanophotonic waveguides and microelectrodes for optogenetic stimulation and electrophysiological recording in neuroscience research. Further extending neural probe functionalities with integrated microfluidics is a direct approach to achieve neurochemical injection and sampling capabilities. In this work, we use two-photon polymerization 3D printing to integrate microfluidic channels onto photonic neural probes, which include silicon nitride nanophotonic waveguides and grating emitters. The customizability of 3D printing enables a unique geometry of microfluidics that conforms to the shape of each neural probe, enabling integration of microfluidics with a variety of existing neural probes while avoiding the complexities of monolithic microfluidics integration. We demonstrate the photonic and fluidic functionalities of the neural probes via fluorescein injection in agarose gel and photoloysis of caged fluorescein in solution and in flxed brain tissue.

Published
2023
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11. Implantable photonic neural probes with out-of-plane focusing grating emitters

Author

Tianyuan Xue, Andrei Stalmashonak, Fu-Der Chen, Peisheng Ding, Xianshu Luo, Hongyao Chua, Guo-Qiang Lo, Wesley D. Sacher, and Joyce K. S. Poon

Subjects
Medicine, Science
Abstract

Abstract We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.

Published
2024
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16. Monolithically Integrated Visible-Light MEMS Switch

Author

Govdeli, Alperen, Chen, Hong, Azadeh, Saeed S., Straguzzi, John N., Chua, Hongyao, Lo, Guo-Qiang, Poon, Joyce K. S., Sacher, Wesley D., Witzens, Jeremy, editor, Poon, Joyce, editor, Zimmermann, Lars, editor, and Freude, Wolfgang, editor

Published
2024
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17. Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Author

Horwitz, Leora I, Thaweethai, Tanayott, Brosnahan, Shari B, Cicek, Mine S, Fitzgerald, Megan L, Goldman, Jason D, Hess, Rachel, Hodder, SL, Jacoby, Vanessa L, Jordan, Michael R, Krishnan, Jerry A, Laiyemo, Adeyinka O, Metz, Torri D, Nichols, Lauren, Patzer, Rachel E, Sekar, Anisha, Singer, Nora G, Stiles, Lauren E, Taylor, Barbara S, Ahmed, Shifa, Algren, Heather A, Anglin, Khamal, Aponte-Soto, Lisa, Ashktorab, Hassan, Bassett, Ingrid V, Bedi, Brahmchetna, Bhadelia, Nahid, Bime, Christian, Bind, Marie-Abele C, Black, Lora J, Blomkalns, Andra L, Brim, Hassan, Castro, Mario, Chan, James, Charney, Alexander W, Chen, Benjamin K, Chen, Li Qing, Chen, Peter, Chestek, David, Chibnik, Lori B, Chow, Dominic C, Chu, Helen Y, Clifton, Rebecca G, Collins, Shelby, Costantine, Maged M, Cribbs, Sushma K, Deeks, Steven G, Dickinson, John D, Donohue, Sarah E, Durstenfeld, Matthew S, Emery, Ivette F, Erlandson, Kristine M, Facelli, Julio C, Farah-Abraham, Rachael, Finn, Aloke V, Fischer, Melinda S, Flaherman, Valerie J, Fleurimont, Judes, Fonseca, Vivian, Gallagher, Emily J, Gander, Jennifer C, Gennaro, Maria Laura, Gibson, Kelly S, Go, Minjoung, Goodman, Steven N, Granger, Joey P, Greenway, Frank L, Hafner, John W, Han, Jenny E, Harkins, Michelle S, Hauser, Kristine SP, Heath, James R, Hernandez, Carla R, Ho, On, Hoffman, Matthew K, Hoover, Susan E, Horowitz, Carol R, Hsu, Harvey, Hsue, Priscilla Y, Hughes, Brenna L, Jagannathan, Prasanna, James, Judith A, John, Janice, Jolley, Sarah, Judd, SE, Juskowich, Joy J, Kanjilal, Diane G, Karlson, Elizabeth W, Katz, Stuart D, Kelly, J Daniel, Kelly, Sara W, Kim, Arthur Y, Kirwan, John P, Knox, Kenneth S, Kumar, Andre, Lamendola-Essel, Michelle F, Lanca, Margaret, Lee-lannotti, Joyce K, Lefebvre, R Craig, and Levy, Bruce D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Emerging Infectious Diseases, Infectious Diseases, Infection, Good Health and Well Being
Abstract

Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility– and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross– validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.

Published
2023

19. 3D printed titanium carbide MXene-coated polycaprolactone scaffolds for guided neuronal growth and photothermal stimulation

Author

Jianfeng Li, Payam Hashemi, Tianyi Liu, Ka My Dang, Michael G. K. Brunk, Xin Mu, Ali Shaygan Nia, Wesley D. Sacher, Xinliang Feng, and Joyce K. S. Poon

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract The exploration of neural circuitry is paramount for comprehending the computational mechanisms and physiology of the brain. Despite significant advances in materials and fabrication techniques, controlling neuronal connectivity and response in 3D remains a formidable challenge. Here, we introduce a method for engineering the growth of 3D neural circuits with the capability for optical stimulation. We fabricate bioactive interfaces by melt electrospinning writing (MEW) 3D polycaprolactone (PCL) scaffolds followed by coating with titanium carbide (Ti3C2Tx MXene). Beyond enhancing hydrophilicity, cell adhesion, and electrical conductivity, the Ti3C2Tx MXene coating enables optocapacitance-based neuronal stimulation, induced by localized temperature increases upon illumination. This approach offers a pathway for additive manufacturing of neural tissues endowed with optical control, facilitating functional tissue engineering and neural circuit computation.

Published
2024
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20. Optimization of a programmable λ/2-pitch optical phased array

Author

Sharma Ankita, Straguzzi John N., Xue Tianyuan, Govdeli Alperen, Chen Fu Der, Stalmashonak Andrei, Sacher Wesley D., and Poon Joyce K. S.

Subjects
silicon photonics, optical phased array, programmable photonics, optimization, crosstalk, Physics, QC1-999
Abstract

A challenge in optical phased arrays (OPAs) is to achieve single-lobe emission using densely spaced emitters without incurring inter-waveguide optical crosstalk. Here, we propose to heuristically optimize the amplitude and phase of each grating antenna in an OPA to correct for optical non-idealities, including fabrication variations and inter-waveguide crosstalk. This method was applied to a silicon photonic integrated circuit with 1 mm-long gratings at 775 nm spacing for operation in a wavelength range of 1450–1650 nm. We achieved a wide two-dimensional beam-steering range of 110° × 28°, evaluated over a 127° × 47° field-of-view (FOV). Within this FOV, we measured an average sidelobe suppression of 8.2 dB and focused on average, 34.5 % of the emitted power into the main lobe. We achieved a peak sidelobe suppression of 14.5 dB and 50 % of the power concentrated in the main lobe. The approach is suitable for applications that require alias-free out-of-plane emission.

Published
2024
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21. Microcantilever-integrated photonic circuits for broadband laser beam scanning

Author

Azadeh, Saeed Sharif, Mak, Jason C. C., Chen, Hong, Luo, Xianshu, Chen, Fu-Der, Chua, Hongyao, Weiss, Frank, Alexiev, Christopher, Stalmashonak, Andrei, Jung, Youngho, Straguzzi, John N., Lo, Guo-Qiang, Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Laser beam scanning is central to many applications, including displays, microscopy, three-dimensional mapping, and quantum information. Reducing the scanners to microchip form factors has spurred the development of very-large-scale photonic integrated circuits of optical phased arrays and focal plane switched arrays. An outstanding challenge remains to simultaneously achieve a compact footprint, broad wavelength operation, and low power consumption. Here, we introduce a laser beam scanner that meets these requirements. Using microcantilevers embedded with silicon nitride nanophotonic circuitry, we demonstrate broadband, one- and two-dimensional steering of light with wavelengths from 410 nm to 700 nm. The microcantilevers have ultracompact ~0.1 mm$^2$ areas, consume ~31 to 46 mW of power, are simple to control, and emit a single light beam. The microcantilevers are monolithically integrated in an active photonic platform on 200-mm silicon wafers. The microcantilever-integrated photonic circuits miniaturize and simplify light projectors to enable versatile, power-efficient, and broadband laser scanner microchips.

Published
2022
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24. Triple-drug therapy with ivermectin, diethylcarbamazine and albendazole for the acceleration of lymphatic filariasis elimination in Kenya: Programmatic implementation and results of the first impact assessment.

Author

Sammy M Njenga, Henry Kanyi, Collins Okoyo, Edward Githinji, Cassian Mwatele, Sultani H Matendechero, Wyckliff P Omondi, Patrick N Gitahi, Chrispin Owaga, Joyce K Onsongo, and Katherine Gass

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

The World Health Organization (WHO) endorsed the use of triple-drug mass drug administration (MDA) regimen with ivermectin, diethylcarbamazine (DEC) and albendazole (commonly abbreviated as IDA) to accelerate the elimination of lymphatic filariasis (LF) as a public health problem in settings where onchocerciasis is not co-endemic. The National Programme for Elimination of LF (NPELF) in Kenya was among the first adopters of the IDA-MDA and two annual rounds were provided in 2018 and 2019 to the residents of Lamu County and Jomvu sub-County in the coast region. This study documented the feasibility of successfully delivering the two rounds of IDA-MDA. An operational research study was undertaken to determine efficient sampling strategies, indicators, and the appropriate population groups that could be used for the monitoring and evaluation of LF programs using IDA-MDA for the elimination of the disease as a public health problem. Two cross-sectional surveys were conducted at baseline in 2018 before IDA-MDA and an impact assessment 17 months after the second round of IDA-MDA. The reported epidemiological treatment coverage was at least 80% in all implementation units during each round of IDA-MDA. Blood samples were tested for filarial antigenemia using commercial Filariasis Test Strips (FTS) and any individual found to be positive was tested again at night for the presence of microfilariae in finger prick blood smears using microscopy. The overall prevalence of circulating filarial antigen (CFA) was relatively low at the baseline survey with Jomvu having 1.39% (95% CI: 0.91, 2.11) and Lamu having 0.48% (95% CI: 0.21, 1.13). Significant reduction in CFA prevalence was observed during the impact assessment after the two annual rounds of mass treatment. The overall relative reduction (%) in CFA prevalence following the two rounds of MDA with IDA was significant in both Jomvu (52.45%, Z = -2.46, P < 0.02) and Lamu (52.71%, Z = -1.97, P < 0.05). Heterogeneity, however, was observed in the CFA prevalence reduction between random and purposive clusters, as well as between adult and child populations. The results of the impact assessment survey offered strong evidence that it was safe to stop the IDA-MDA in the two EUs because transmission appears to have been interrupted. It is also important to implement a post-treatment surveillance system which would enable efficient detection of any recrudescence of LF transmission at a sub-evaluation unit level. Our findings show that IDA-MDA may be considered for acceleration of LF elimination in other settings where onchocerciasis is not co-endemic.

Published
2024
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25. Comparing Gender Congruency in Nonsurgical versus Postsurgical Top Surgery Patients: A Prospective Survey Study

Author

Shirley Shue, MD, Alex Joo, BA, Jing Xu, MD, Garrick Gu, MD, Anthony Camargo, BA, Isaac Bronson, BS, Rachel Lister, MD, Nathan Hawley, BS, Daniel Alexander Morrison, BS, and Joyce K. McIntyre, MD

Subjects
Surgery, RD1-811
Abstract

Background:. Gender dysphoria can result in reduced quality of life. Treatments include hormone replacement therapy (HRT) and gender-affirming surgery. Our study compared congruency, satisfaction, and discrimination in patients who underwent top surgery and HRT versus HRT alone. We hypothesized improved outcomes in top surgery patients but that lack of access is a common barrier. Methods:. Transgender and nonbinary subjects who underwent at least 6 months of HRT were recruited and answered questions on gender congruency, discrimination, and barriers to care. Surgical patients were asked about postoperative satisfaction using the BREAST-Q. A Mann-Whitney test compared survey responses between study arms. Results:. One hundred twelve eligible subjects completed the survey. Surgical subjects answered significantly more positively (P < 0.001) on all questions regarding gender congruency. The greatest difference was observed in how subjects’ physical bodies represented their gender identity, where the surgery group rated higher on the five-point Likert scale by 2.0 points (P < 0.001). Surgical patients also reported less violence, verbal abuse, and discrimination (P < 0.003). Within the hormone arm, 87.1% stated desire for surgery and 62.5% declared barriers to surgery, with cost and insurance coverage representing the most common barriers. Finally, surgical subjects reported high satisfaction on the BREAST-Q, scoring more than 3.0 in all categories of breast augmentation and more than 2.6 for breast reduction on a four-point Likert scale. Conclusions:. Top surgery, in addition to HRT, significantly improves gender congruency and decreases discrimination and abuse, compared with HRT alone. Unfortunately, barriers including cost and lack of insurance continue to be obstacles for care.

Published
2024
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26. Monolithically integrated, broadband, high-efficiency silicon nitride-on-silicon waveguide photodetectors in a visible-light integrated photonics platform

Author

Lin, Yiding, Yong, Zheng, Luo, Xianshu, Azadeh, Saeed Sharif, Mikkelsen, Jared, Sharma, Ankita, Chen, Hong, Mak, Jason C. C., Lo, Patrick G. -Q., Sacher, Wesley D., and Poon, Joyce K. S.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Visible and near-infrared spectrum photonic integrated circuits are quickly becoming a key technology to address the scaling challenges in quantum information and biosensing. Thus far, integrated photonic platforms in this spectral range have lacked integrated photodetectors. Here, we report the first silicon nitride-on-silicon waveguide photodetectors that are monolithically integrated in a visible light photonic platform on silicon. Owing to a leaky-wave silicon nitride-on-silicon design, the devices achieved a high external quantum efficiency of > 60% across a record wavelength span from $\lambda$ ~400 nm to ~640 nm, an opto-electronic bandwidth up to 9 GHz, and an avalanche gain-bandwidth product up to 173 $\pm$ 30 GHz. As an example, a photodetector was integrated with a wavelength-tunable microring in a single chip for on-chip power monitoring., Comment: 20 pages, 21 figures

Published
2022
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29. Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study

Author

Abraham, Rachael, Ager, Arijan, Aguilar, Franchesca A., Ahmadi-Izad, Ghazal, Ahmed, Dilshad R., Alvarez, Alicarmen, Anderson, Blake, Asencios, Walter D., Atha, Mary, Beaty, Casey L., Bedi, Brahmchetna, Berry, Jasmine A., Boone, Donchel, Bower, Mary, Bremner, James D., Brent, Corbin, Brown-Smith, Ke'Ara, Bull, Rachel, Bush, Patricia A., Capo, Gustavo, Carl-Igwe, Kelechi, Chitadze, Calista, Chukwumerije, Nachi, Clyburn, Erna, Collins, Shelby, Costello, Julie, Couture, Grace, Craft, Angel, Cribbs, Sushma K., Cui, Xiangqin, Dandy, Annette, Rio, Carlos del, Jasarevic, Rijalda, Detelich, Joshua F., Dixon, Cartia, Dow, Jeanne, Doyle, D'Andrea, Elchommali, Jannah, Ibeawuchi, Carmel, Elsey, Imani, Fineman, Rebecca, Francis, Anyssa G., Franks, Nicole, Gallini, Julia, Gander, Jennifer C., Gray, Natalie, Grimes, Ash, Gutter, Evan, Han, Jenny E., Hang, Tina P., Harding, Jess, Hernandez, Liliana, Hewitt, Lauren N., Holloway, Carla, Hudgins, Alex F., Huerta, Christopher, Ifejika, Cynthia, Ingram, Ketteria D., Javia, Vidhi N., Jeter, Mykayla, Johnson, Brandi, Joseph, Yasha, Juarez, Monica, Kajan, Dana, Khalil, Lana, Kirkpatrick, Caitlin M., Kleinhenz, Dean, Kolailat, Imanii, Koumanelis, Athena, Koumanelis, Alexandra, Kozoman, Rebecca, Krishnan, Shilpa, Lainez, Jordi, Lawrence, Brianna, Lee, Matthew A., Leon, Jose D., Lew, Valerie, Lewis, Kennedy C., Litvack, Matthew, Maroney, Mara, Maier, Cheryl L., Makkaoui, Nour, Marconi, Vincent C., Martin, Christopher F., Martinez, Monica, Mbogo, Loice, McCaslin, Atuarra, McIntyre, Jerrod, Moanna, Abeer, Montoya, Miranda, Morales, Elena, Moran, Caitlin A., Morgan-Billingslea, Jan, Murray, Calista, Nelson, Roslin, Neuman, Robert B., Nguyen, Tran, Ofotokun, Ighovwerha, Ojemakinde, Elizabeth I., Ojoawo, Bukkie, Osinski, Eileen, Oviedo, Sofia, Panganiban, Bernadine, Paredes-Gaitan, Yolanda, Patzer, Rachel E., Pemu, Priscilla, Prude, Michael, Rahman, Kazi, Ramakrishnan, Grace, Rebolledo, Paulina A., Roberts, Marjorie, Robinson, Keysha, Rogers, Chantrice, Rouphael, Nadine G., Searles, Charles, Shah, Anand, Segall, Marni, Shaw, Renata M., Silva, Ruvina, Simpson, Cheryl, Simpson-Derrell, Krystal, Sirajud-Deen, Talib, Smith, Veronica E., Stringer, Andre, Stroud, Jacob, Suthar, Mehul S., Sylber, Cory, Sylvera, Ashley, Tanner, Tehquin, Teunis, Larissa J., Tolbert, Maliya, Thomas, Kodasha M., Thompson, Sierra G., Titanji, Kehmia, Toy, Christopher, Traenkner, Jessica, Truong, Alex, Unterberger, Kristen, Vaccarino, Viola, Varney, Kris, Vyas, Kartavya, Vyas, Kurt, Walker, Tiffany A., Walkow, Max, Wang, Dongli, Wesley, Tamara, Wiley, Zanthia, Wimberly, Erika, Winston, Juton R., Winter, Terra J., Wongtrakool, Cherry, Aikawa, Masanori, Alba, George A., Aung, Taing N., Baden, Lindsey, Baslet, Gaston, Bassett, Ingrid V., Bennett, Lindsey, Bhattacharyya, Shamik, Blazey-Martin, Deborah, Buring, Julie, Cagnina, Rebecca E., Chen, Li Qing, Clark, Cheryl R., Cohen, Pieter, Collier, Ai-Ris, Czeisler, Charles, Duffy, Elizabeth, Estill, Peter, Fong, Tamara, Gay, Elizabeth, Ghamloush, Maher, Ginns, Leo C., Haack, Monika, Haas, Jennifer, Hamburg, Naomi, Hauser, Kristine S., John, Janice, Jordan, Michael, Juelg, Boris D., Kanjilal, Diane G., Kim, Arthur Y., Klerman, Elizabeth B., Kobayashi, Misaki ., Kogelman, Laura, Lamas, Daniela, Levy, Bruce D., Levy-Carrick, Nomi, Lewis, Gregory, Maley, Jason H., Manson, JoAnn, Marathe, Jai G., Mullington, Janet M., O'Connor, George T., Ojikutu, Bisola, Perlis, Roy, Quintana, Yuri, Redline, Susan, Remis, Elijah J., Rosand, Jonathan, Sesso, Howard D., Shaughnessy, Lynn, Shepherd, Fitzgerald M., Solomon, Scott, Sparks, Jeffrey A., Spencer, Lia L., Stephenson, Kathryn, Systrom, David, Thomas, Robert J., Min Thu, Phyo Phyo, Ticotsky, Amberly, Torres, Robert, Wallace, Zachary S., Walt, David, Ward, Honorine D., Washko, George, Whittelsey, Maureen, Wiener, Rebecca, Williams, Charles T., Xerras, Dean, Zhang, Haihua, Zionts, Danielle, Armstrong, Donna, Binkley, Susan E., Blackwell, Kenneth, Brown, 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Tananshi, Chu, Helen Y., Del Alcazar, James, Duven, Alexandria M., Edmark, Rick, Emerson, Sarah, Goldman, Jason D., Gutierrez, Vanessa, Hadlock, Jennifer, Harteloo, Alex, Heath, James R., Hood, Susan, Jackman, Susan, Kaneko, John, Kemp, Megan, Kim, Christina, Kuykendall, Kelli, Li, Sarah, Logue, Jennifer K., Magis, Andrew T., Manner, Paula, Mason, Carly, McCaffrey, Kathryn, McDonald, Connor, McDonald, Dylan, Murray, Kim M., Nackviseth, Callista, Nguyen, Helen, Parimon, Tanyalak, Poussier, Rachel, Rowen, Lee, Satira, Richard, Torbati, Sam, Tuttle, Katherine R., Wallick, Julie A., Yuan, Dan, Watanabe, Kino, Wilcox, Lauren E., Contreras, Fatima, Dahlke, Lea, Gudipudi, Lasya, Modes, Matthew, Muttera, Nicole, Salinas, Nancy, Tadeo, Josie, White, Shane, Alvarado, Stephanie, Anderson, Reed, Arellanes, Azaneth, Barajas, Rose A., Chauhan, Suneet P., Clarke, Geoffrey D., Farner, Cheryl E., Fischer, Melinda S., Goldberg, Mark P., Hasbani, Keren, Hastings, Gabrielyd, Heard, Patricia, Herrera, Italia, Infante, Edgar, Johnson, Hillary, Jones, Johnnie, Kellogg, Dean L., Kraig, Ellen, Longoria, Lisa, Nambiar, Anoop M., Okafor, Emeka, Paredes, Claudia C., Patterson, Thomas F., Patterson, Jan E., Pinones, Alexis, Potter, Jennifer S., Reeves, W.B., Saade, George R., Salehi, Marzieh, Scholler, Irma, Seshadri, Sudha, Shah, Dimpy P., Shah, Pankil, Sharma, Kumar, Sharma, Kavita, Soileau, Bridgette, Solis, Pamela, Stoebner, Carmen, Sullivan, Michael, Taylor, Barbara S., Tragus, Robin, Tsevat, Joel, Verduzco-Gutierrez, Monica, Ahuja, Neera, Blish, Catherine A., Blomkalns, Andra L., Bonilla, Hector, Brotherton, Richard, Clinton, Kimberly, Dingankar, Vaidehi, Geng, Linda N., Go, Minjoung, Haddad, Francois, Jagannathan, Prasanna, Jamero, Christopher, Jee, Kathryn, Jia, Xiaolin K., Khurana, Naresh, Kumar, Andre, Maldonado, Yvonne, Miglis, Mitchell G., O'Conor, Ellen, Olszewski, Kelly, Pathak, Divya, Quintero, Orlando, Scott, Jake, Singh, Upinder, Urdaneta, Alfredo E., Utz, Paul J., Varkey, Mary R., Saperia, Corey, Autry, Lynn, Bime, Christian, Borwege, Sabine, Copeland, Jacquelynn, DiLise-Russo, Marjorie, Ernst, Kacey C., Esquivel, Denise R., Fadden, Susan, Gomez, Isaias, Grischo, Garrett, Hansen, Lillian, Harris, David T., Harris, Stefanie, Hartley, William, Hernandez, Michael, Hillier, Leah, Hsu, Harvey, Hughes, Trina, Ismail, Hira, Iusim, Stephanie, James, Michelle, Kala, Mrinalini, Karnafel, Maria, Kim, Daniel, Knox, Kenneth S., Koleski, Alison, LaFleur, Bonnie, Lambert, Brenda, LaRue, Sicily, Lee-Iannotti, Joyce K., Lieberman, David, Lutrick, Karen, Merchant, Nirav, Morton, Christopher, Mosier, Jarrod M., Murthy, Ganesh, Nikolich, Janko Z., Olorunnisola, Toluwanimi, Parthasarathy, Sairam, Peralta, Jeanette, Pilling, William, Pogreba-Brown, Kristen, Reiman, Eric M., Rischard, Franz P., Ryan, Lee T., Smith, Terry, Snyder, Manuel, Soto, Francisco, Subbian, Vignesh, Suhr, Kyle, Unzek, Samuel, Vadovicky, Sheila, Velarde, Deanna, Veres, Sharry, Wilson, Cathleen, Anderson, Grace, Anglin, Khamal, Argueta, Urania, Asare, Kofi, Buitrago, Melissa, Chang Song, Celina, Clark, Alexus, Conway, Emily, Deeks, Steven G., Del Castillo, Nicole, Deswal, Monika, Durstenfeld, Matthew S., Eilkhani, Elnaz, Eun, Avery, Fehrman, Emily, Figueroa, Tony, Flores, Diana, Grebe, Halle, Henrich, Timothy J., Hoh, Rebecca, Hsue, Priscilla, Huang, Beatrice, Ibrahim, Rania, Kelly, John D., Kerbleski, Marian, Kirtikar, Raushun, Lew, Megan T., Lombardo, James, Lopez, Monica, Luna, Michael, Marquez, Carina, Martin, Jeffrey N., Munter, Sadie, Ngo, Lynn, Peluso, Michael J., Pineda-Ramirez, Jesus, Rhoads, Kim, Rodriguez, Antonio, Romero, Justin, Ryder, Dylan, So, Matthew, Somsouk, Ma, Tai, Viva, Tran, Brandon, Uy, Julian, Valdivieso, Daisy, Verma, Deepshika, Williams, Meghann, Zamora, Andhy, Newman, Lisa T., Abella, Julie, Barnette, Quinn, Bevc, Christine, Beverly, Jennifer, Ceger, Patricia, Croxford, Julie, Enger, Mike, Fain, Katie, Farris, Tonya, Hanlon, Sean, Hines, David, Johnson-Lawrence, Vicki, Jordan, Kevin, Lefebvre, Craig, Linas, Beth, Luukinen, Bryan, Mandal, Meisha, McKoy, Nikki J., Nance, Susan, Pasquarelli, Demian, Quiner, Claire, Sembajwe, Rita, Shaw, Gwendolyn, Thornburg, Vanessa, Tosco, Kendall, Wright, Hannah, Gross, Rachel S., Hochman, Judith S., Horwitz, Leora I., Katz, Stuart D., Troxel, Andrea B., Adler, Lenard, Akinbo, Precious, Almenana, Ramona, Aschalew, Malate, Balick, Lara, Bello, Ola, Bhuiyan, Sultana, Blachman, Nina, Branski, Ryan, Briscoe, Jasmine, Brosnahan, Shari, Bueler, Elliott, Burgos, Yvette, Caplin, Nina, Chaplin, Domonique, Chen, Yu, Cheng, Shen, Choe, Peter, Choi, Jess, Chung, Alicia, Church, Richard, Cobos, Stanley, Croft, Nakia, Irving, Angelique Cruz, Del Boccio, Phoebe, Díaz, Iván, Divers, Jasmin, Doshi, Vishal, Dreyer, Benard, Ebel, Samantha, Esquenazi-Karonika, Shari, Faustin, Arline, Febres, Elias, Fine, Jeffrey, Fink, Sandra, Freeland, Catherine, Frontera, Jennifer, Gallagher, Richard, Gonzalez-Duarte, 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Manickas-Hill, Zachary, Yu, Xu G., Li, Jonathan Z., Alter, Galit, Kelly, J. Daniel, Goldberg, Sarah A., Talla, Aarthi, Li, Xiaojun, Skene, Peter, Bumol, Thomas F., Torgerson, Troy R., Czartoski, Julie L., McElrath, M. Juliana, and Walt, David R.

Published
2024
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31. Power-Efficient Silicon Nitride Thermo-Optic Phase Shifters for Visible Light

Author

Yong, Zheng, Chen, Hong, Luo, Xianshu, Govdeli, Alperen, Chua, Hongyao, Azadeh, Saeed S., Stalmashonak, Andrei, Lo, Guo-Qiang, Poon, Joyce K. S., and Sacher, Wesley D.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

We demonstrate power-efficient, thermo-optic, silicon nitride waveguide phase shifters for blue, green, and yellow wavelengths. The phase shifters operated with low power consumption due to a suspended structure and multi-pass waveguide design. The devices were fabricated on 200-mm silicon wafers using deep ultraviolet lithography as part of an active visible-light integrated photonics platform. The measured power consumption to achieve a $\pi$ phase shift (averaged over multiple devices) was 0.78, 0.93, 1.09, and 1.20 mW at wavelengths of 445, 488, 532, and 561 nm, respectively. The phase shifters were integrated into Mach-Zehnder interferometer switches, and $10- 90$\% rise(fall) times of about 570(590) $\mu$s were measured., Comment: Zheng Yong and Hong Chen contributed equally to this work

Published
2021
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33. Effects of donor smoking history on early post-transplant lung function measured by oscillometry

Author

Natalia Belousova, Albert Cheng, John Matelski, Anastasiia Vasileva, Joyce K. Y. Wu, Rasheed Ghany, Tereza Martinu, Clodagh M. Ryan, and Chung-Wai Chow

Subjects
lung transplant, oscillometry, donor smoking history, donor selection, lung function, Medicine (General), R5-920
Abstract

IntroductionPrior studies assessing outcomes of lung transplants from cigarette-smoking donors found mixed results. Oscillometry, a non-invasive test of respiratory impedance, detects changes in lung function of smokers prior to diagnosis of COPD, and identifies spirometrically silent episodes of rejection post-transplant. We hypothesise that oscillometry could identify abnormalities in recipients of smoking donor lungs and discriminate from non-smoking donors.MethodsThis prospective single-center cohort study analysed 233 double-lung recipients. Oscillometry was performed alongside routine conventional pulmonary function tests (PFT) post-transplant. Multivariable regression models were constructed to compare oscillometry and conventional PFT parameters between recipients of lungs from smoking vs non-smoking donors.ResultsThe analysis included 109 patients who received lungs from non-smokers and 124 from smokers. Multivariable analysis identified significant differences between recipients of smoking and non-smoking lungs in the oscillometric measurements R5-19, X5, AX, R5z and X5z, but no differences in %predicted FEV1, FEV1/FVC, %predicted TLC or %predicted DLCO. An analysis of the smoking group also demonstrated associations between increasing smoke exposure, quantified in pack years, and all the oscillometry parameters, but not the conventional PFT parameters.ConclusionAn interaction was identified between donor-recipient sex match and the effect of smoking. The association between donor smoking and oscillometry outcomes was significant predominantly in the female donor/female recipient group.

Published
2024
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34. Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Author

Joyce K. Anastasi, Bernadette Capili, Margaret Norton, Donald J. McMahon, and Karen Marder

Subjects
clinical trials, recruitment, retention, study participants, chronic pain, chronic conditions, Neurology. Diseases of the nervous system, RC346-429
Abstract

This paper aims to present and discuss the issues, challenges, and strategies related to recruitment and retention in clinical trials involving participants with chronic pain. The randomized controlled clinical trial (RCT) is widely regarded as the gold standard for evaluating clinical interventions. However, it is crucial to acknowledge and address the challenges associated with recruiting and retaining participants. To prioritize the experience of the study population, targeted outreach strategies and a patient-centric approach are necessary. Researchers should consider incorporating recruitment and retention strategies during the study design phase. Implementing multi-pronged recruitment methods, leveraging relationships with community providers, and involving representatives of the patient population are helpful approaches. Effective communication and maintaining a professional environment are vital for optimizing engagement and supporting the successful execution of clinical trials involving participants with chronic pain.

Published
2024
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35. Insecticide resistant Anopheles gambiae have enhanced longevity but reduced reproductive fitness and a longer first gonotrophic cycle

Author

Osoro, Joyce K, Machani, Maxwell G, Ochomo, Eric, Wanjala, Christine, Omukunda, Elizabeth, Githeko, Andrew K, Yan, Guiyun, and Afrane, Yaw A

Subjects
Agricultural Biotechnology, Agricultural, Veterinary and Food Sciences, Medical Microbiology, Biomedical and Clinical Sciences, Infectious Diseases, Malaria, Vector-Borne Diseases, Rare Diseases, Prevention of disease and conditions, and promotion of well-being, 3.2 Interventions to alter physical and biological environmental risks, Infection, Good Health and Well Being, Animals, Anopheles, Female, Genetic Fitness, Insecticide Resistance, Insecticides, Longevity, Male, Mosquito Control, Mosquito Vectors, Pyrethrins
Abstract

Widespread insecticide resistance in African malaria vectors raises concerns over the potential to compromise malaria vector control interventions. Understanding the evolution of resistance mechanisms, and whether the selective disadvantages are large enough to be useful in resistance management or designing suitable control strategies is crucial. This study assessed whether insecticide resistance to pyrethroids has an effect on the gonotrophic cycle and reproductive potential of malaria vector Anopheles gambiae. Comparative tests were performed with pyrethroid-resistant and susceptible colonies of Anopheles gambiae colonized from the same geographical area, and the reference Kisumu strain was used as a control. Adult females aged 3 days old were given a blood meal and kept separately for individual egg-laying. The number of days taken to lay eggs post-blood-feeding was recorded to determine the length of the gonotrophic cycle. To measure adult longevity and reproduction potential, newly emerged males and females of equal numbers were aspirated into a cage and females allowed to blood feed daily. The number of eggs laid and the surviving mosquitoes were recorded daily to determine fecundity, net reproduction rate, intrinsic growth rate and adult longevity. Overall, the resistant females had a significantly longer (1.8 days) gonotrophic cycle than susceptible females (F2, 13 = 9. 836, P

Published
2022

36. Optical phased array neural probes for beam-steering in brain tissue

Author

Sacher, Wesley D., Chen, Fu-Der, Moradi-Chameh, Homeira, Liu, Xinyu, Almog, Ilan Felts, Lordello, Thomas, Chang, Michael, Naderian, Azadeh, Fowler, Trevor M., Segev, Eran, Xue, Tianyuan, Mahallati, Sara, Valiante, Taufik A., Moreaux, Laurent C., Poon, Joyce K. S., and Roukes, Michael L.

Subjects
Physics - Optics
Abstract

Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue was simulated and characterized. The probes were used for optogenetic stimulation and calcium imaging.

Published
2021
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40. Observation of photoelectric nonvolatile memory and oscillations in VO2 at room temperature

Author

Jung, Youngho, Jeong, Junho, Qu, Zhongnan, Cui, Bin, Khanda, Ankita, Parkin, Stuart S. P., and Poon, Joyce K. S.

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

Vanadium dioxide (VO2) is a phase change material that can reversibly change between high and low resistivity states through electronic and structural phase transitions. Thus far, VO2 memory devices have essentially been volatile at room temperature, and nonvolatile memory has required non-ambient surroundings (e.g., elevated temperatures, electrolytes) and long write times. Here, we report the first observation of optically addressable nonvolatile memory in VO2 at room temperature with a readout by voltage oscillations. The read and write times had to be kept shorter than about 150 {\mu}s. The writing of the memory and onset of the voltage oscillations had a minimum optical power threshold. This discovery demonstrates the potential of VO2 for new computing devices and architectures, such as artificial neurons and oscillatory neural networks., Comment: 31 pages

Published
2020

41. Insecticide resistance exerts significant fitness costs in immature stages of Anopheles gambiae in western Kenya.

Author

Osoro, Joyce K, Machani, Maxwell G, Ochomo, Eric, Wanjala, Christine, Omukunda, Elizabeth, Munga, Stephen, Githeko, Andrew K, Yan, Guiyun, and Afrane, Yaw A

Subjects
Anopheles gambiae, Fitness, Insecticide resistance, Larval life-traits, Tropical Medicine, Microbiology, Medical Microbiology, Public Health and Health Services
Abstract

BackgroundDespite increasing documentation of insecticide resistance in malaria vectors against public health insecticides in sub-Saharan Africa, there is a paucity of information on the potential fitness costs of pyrethroid resistance in malaria vectors, which is important in improving the current resistant management strategies. This study aimed to assess the fitness cost effects of insecticide resistance on the development and survival of immature Anopheles gambiae from western Kenya.MethodsTwo-hour old, first instar larvae (L1) were introduced and raised in basins containing soil and rainwater in a semi-field set-up. Each day the number of surviving individuals per larval stage was counted and their stage of development were recorded until they emerged as adults. The larval life-history trait parameters measured include mean larval development time, daily survival and pupal emergence. Pyrethroid-resistant colony of An. gambiae sensu stricto and susceptible colony originating from the same site and with the same genetic background were used. Kisumu laboratory susceptible colony was used as a reference.ResultsThe resistant colony had a significantly longer larval development time through the developmental stages than the susceptible colony. The resistant colony took an average of 2 days longer to develop from first instar (L1) to fourth instar (L4) (8.8 ± 0.2 days) compared to the susceptible colony (6.6 ± 0.2 days). The development time from first instar to pupa formation was significantly longer by 3 days in the resistant colony (10.28 ± 0.3 days) than in susceptible colony (7.5 ± 0.2 days). The time from egg hatching to adult emergence was significantly longer for the resistant colony (12.1 ± 0.3 days) than the susceptible colony (9.6 ± 0.2 days). The pupation rate (80%; 95% (CI: 77.5-83.6) vs 83.5%; 95% (CI: 80.6-86.3)) and adult emergence rate (86.3% vs 92.8%) did not differ between the resistant and susceptible colonies, respectively. The sex ratio of the females to males for the resistant (1:1.2) and susceptible colonies (1:1.07) was significantly different.ConclusionThe study showed that pyrethroid resistance in An. gambiae had a fitness cost on their pre-imaginal development time and survival. Insecticide resistance delayed the development and reduced the survivorship of An. gambiae larvae. The study findings are important in understanding the fitness cost of insecticide resistance vectors that could contribute to shaping resistant management strategies.

Published
2021

43. Microcantilever-integrated photonic circuits for broadband laser beam scanning

Author

Saeed Sharif Azadeh, Jason C. C. Mak, Hong Chen, Xianshu Luo, Fu-Der Chen, Hongyao Chua, Frank Weiss, Christopher Alexiev, Andrei Stalmashonak, Youngho Jung, John N. Straguzzi, Guo-Qiang Lo, Wesley D. Sacher, and Joyce K. S. Poon

Subjects
Science
Abstract

Abstract Laser beam scanning is central to many applications, including displays, microscopy, three-dimensional mapping, and quantum information. Reducing the scanners to microchip form factors has spurred the development of very-large-scale photonic integrated circuits of optical phased arrays and focal plane switched arrays. An outstanding challenge remains to simultaneously achieve a compact footprint, broad wavelength operation, and low power consumption. Here, we introduce a laser beam scanner that meets these requirements. Using microcantilevers embedded with silicon nitride nanophotonic circuitry, we demonstrate broadband, one- and two-dimensional steering of light with wavelengths from 410 nm to 700 nm. The microcantilevers have ultracompact ~0.1 mm2 areas, consume ~31 to 46 mW of power, are simple to control, and emit a single light beam. The microcantilevers are monolithically integrated in an active photonic platform on 200-mm silicon wafers. The microcantilever-integrated photonic circuits miniaturize and simplify light projectors to enable versatile, power-efficient, and broadband laser scanner microchips.

Published
2023
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44. Baseline characteristics of the North American prodromal Synucleinopathy cohort

Author

Jonathan E. Elliott, Miranda M. Lim, Allison T. Keil, Ronald B. Postuma, Amelie Pelletier, Jean‐François Gagnon, Erik K. St. Louis, Leah K. Forsberg, Julie A. Fields, Daniel E. Huddleston, Donald L. Bliwise, Alon Y. Avidan, Michael J. Howell, Carlos H. Schenck, Jennifer McLeland, Susan R. Criswell, Aleksandar Videnovic, Emmanuel H. During, Mitchell G. Miglis, David R. Shprecher, Joyce K. Lee‐Iannotti, Bradley F. Boeve, Yo‐El S. Ju, and the North American Prodromal Synucleinopathy (NAPS) Consortium

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, RBD offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created a multisite RBD participant, primarily clinic‐based cohort to better understand characteristics at diagnosis, and in future work, identify predictors of phenoconversion, develop synucleinopathy biomarkers, and enable early stage clinical trial enrollment. Methods Participants ≥18 years of age with overnight polysomnogram‐confirmed RBD without Parkinson's disease, dementia, multiple system atrophy, or narcolepsy were enrolled from nine sites across North America (8/2018 to 4/2021). Data collection included family/personal history of RBD and standardized assessments of cognitive, motor, sensory, and autonomic function. Results Outcomes are primarily reported based on sex (361 total: n = 295 male, n = 66 female), and secondarily based on history of antidepressant use (n = 200 with, n = 154 without; with correction for sex differences) and based on extent of synucleinopathy burden (n = 56 defined as isolated RBD, n = 305 defined as RBD+ [i.e., exhibiting ≥1 abnormality]). Overall, these participants commonly demonstrated abnormalities in global cognition (MoCA; 38%), motor function (alternate tap test; 48%), sensory (BSIT; 57%), autonomic function (orthostatic hypotension, 38.8%), and anxiety/depression (BAI and PHQ‐9; 39.3% and 31%, respectively). Interpretation These RBD participants, assessed with extensive history, demographic, cognitive, motor, sensory, and autonomic function demonstrated a lack of sex differences and high frequency of concomitant neurological abnormalities. These participants will be valuable for future longitudinal study and neuroprotective clinical trials.

Published
2023
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48. Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers

Author

Daniel J. Levendowski, Thomas C. Neylan, Christine M. Walsh, Debby Tsuang, David Salat, Joanne M. Hamilton, Joyce K. Lee-Iannotti, Chris Berka, Gandis Mazeika, Bradley F. Boeve, and Erik K. St. Louis

Subjects
sleep spindles, non-REM hypertonia, neurodegenerative disease, sleep biomarkers, Alzheimer’s disease, parkinsonism, Neurology. Diseases of the nervous system, RC346-429
Abstract

Study objectiveThis proof-of-concept study aimed to determine whether the combined features of two non-rapid eye movement (NREM) sleep biomarkers acquired predominantly in-home could characterize different neurodegenerative disorders.MethodsSleep spindle duration and non-REM hypertonia (NRH) were evaluated in seven groups including a control group (CG = 61), and participants with isolated REM sleep behavior disorder (iRBD = 19), mild cognitive impairment (MCI = 41), Parkinson disease (PD = 16), Alzheimer disease dementia (ADem = 29), dementia with Lewy Bodies or Parkinson disease dementia (LBD = 19) and progressive supranuclear palsy (PSP = 13). One-way analysis of variance (ANOVA), Mann–Whitney U, intra-class (ICC) and Spearman ranked correlations, Bland–Altman plots and Kappa scores, Chi-square and Fisher exact probability test, and multiple-logistic regression were focused primarily on spindle duration and NRH and the frequencies assigned to the four normal/abnormal spindle duration/NRH combinations.ResultsANOVA identified group differences in age, sleep efficiency, REM, NRH (p

Published
2023
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