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1. Assurance Case Arguments in the Large: The CERN LHC Machine Protection System

Author

Millet, Laure, Diemert, Simon, Rees, Chris, Viger, Torin, Chechik, Marsha, Menghi, Claudio, Joyce, Jeffrey, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Guiochet, Jérémie, editor, Tonetta, Stefano, editor, and Bitsch, Friedemann, editor

Published
2023
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2. Developing a Sustainable Research Culture in an Independent Academic Medical Center

Author

Joyce, Jeffrey N.

Abstract

Independent academic medical centers (IAMC) are challenged to develop and support a research enterprise and maintain primary goals of healthcare delivery and financial solvency. Strategies for promoting translational research have been shown to be effective at institutions in the top level of federal funding, but not for smaller IAMCs. The research program developed at Maricopa Integrated Health System (MIHS), an IAMC, focused on identifying research enterprise drivers which have an impact on core missions for MIHS and encompassed three domains: (1) Commercial ventures; (2) Clinical practice; and (3) Civic and Community relationships. Specific mechanisms were implemented to promote research, which had an impact on each enterprise driver. Case examples in 2 clinical arenas are described in detail, Pediatrics and Obstetrics/Gynecology, to demonstrate how the strategies were applied to increase translational research and influence the research enterprise drivers. These strategies included: reducing barriers within MIHS and with partner institutions, increasing revenue generated from grants and contracts, providing grant development support, and developing sustainable collaborations with partner institutions. The value in identifying and utilizing external resources is reciprocal as ongoing research collaborations have resulted in more contract and grant awards for both MIHS and partner institutions. (Contains 1 table and 1 figure.)

Published
2013

3. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Jaffe, Glenn J., Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora (Nora) M., Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha (Shah), Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A., Scott, Adrienne Williams, See, Robert F., Shuler, Robert K., Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F., Srivastava, Sunil, Dunn, James P., Begum, Hosne, Boring, Jeff, Brotherson, Kristen L., Burkholder, Bryn, Butler, Nicholas J., Cain, Dennis, Cook, Mary A., Emmert, David, Graul, Janis R., Herring, Mark, Laing, Ashley, Leung, Theresa G., Mahon, Michael C., Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L., Reed, Terry, Arnold, Ellen, Barnabie, Patricia M., Belair, Marie-Lynn, Bolton, Stephen G., Brodine, Joseph B., Brown, Diane M., Brune, Lisa M., Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A., Livingston, Alison G., Morton, Yavette, Nolan, Kisten, Peters, George B., Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C. Stephen, Anesi, Stephen D., Bruner, Linda, Ceron, Olga, Hinkle, David M., Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q., Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S., Sprague, Janet, Yilmaz, Taygan, Sen, H. Nida, Bono, Michael, Cunningham, Denise, Hayes, Darryl, Koutsandreas, Dessie, Nussenblatt, Robert B., Sherry, Patti R., Short, Gregory L., Smith, Wendy, Temple, Alana, Bamji, Allison, Coleman, Hanna, Davuluri, Geetaniali, Faia, Lisa, Gottlieb, Chloe, Jirawuthiworavong, Guy V., Lew, Julie C., Mercer, Richard, Obiyor, Dominic, Perry, Cheryl H., Potapova, Natalia, Weichel, Eric, Wroblewski, Keith J., Latkany, Paul A., Coonan, Corinne, Honda, Andrea, Lorenzo-Latkany, Monica, Masini, Robert, Morell, Susan, Nguyen, Angela, Badamo, Jason, Boyd, Kenneth M., Enos, Matthew, Gallardo, Jenny, Jarczynski, Jacek, Lee, Ji Yun, McGrosky, Mirjana, Nour, Ann, Sanchez, Meredith, Steinberg, Kate, Stawell, Richard J., Breayley, Lisa, D'Sylva, Carly, Glatz, Elizabeth, Hodgson, Lauren, Lim, Lyndell, Ling, Cecilia, McIntosh, Rachel, Morrison (Ewing), Julie, Newton, Andrew, Sanmugasundram, Sutha, Smallwood, Richard, Zamir, Ehud, Hunt, Nicola, Jones, Lisa, Koukouras, Ignatios, Williams, Suzanne, Merrill, Pauline T., Carns, Danielle, Richine, Len, Voskuil-Marre, Denise L., Woo, Kisung, Gaynes, Bruce, Giannoulis, Christina, Hulvey, Pam, Kernbauer, Elaine, Khan, Heena S., Levine, Sarah J., Toennessen, Scott, Tonner, Eileen, Wang, Robert C., Aguado, Hank, Arceneaux, Sally, Duignan, Karen, Fish, Gary E., Hesse, Nick, Jaramillo, Diana, Mackens, Michael, Arnwine, Jean, Callanan, David, Cummings, Kimberly, Gray, Keith, Howden, Susie, Mutz, Karin, Sanchez, Brenda, Lightman, Susan, Ismetova, Filis, Prytherch, Ashley, Seguin-Greenstein, Sophie, Tomkins, Oren, Bar, Asat, Edwards, Kate, Joshi, Lavanish, Moraji, Jiten, Samy, Ahmed, Stubbs, Timothy, Taylor, Simon, Towler, Hamish, Tronnberg, Rebecca, Holland, Gary N., Almanzor, Robert D., Castellanos, Jose, Hubschman, Jean Pierre, Johiro, Ann K., Kukuyev, Alla, Levinson, Ralph D., McCannel, Colin A., Ransome, Susan S., Gonzales, Christine R., Gupta, Anurag, Kalyani, Partho S., Kapamajian, Michael A., Kappel, Peter J., Arcinue, Cheryl, Chuang, Janne, Barteselli, Giulio, Currie, Glenn, Mendoza, Veronica, Powell, Debbie, Clark, Tom, Cochran, Denine E., Freeman, William R., Hedaya, Joshua, Kemper, Tiara, Kozak, Igor, LeMoine, Jacqueline M., Loughran, Megan E., Magana, Luzandra, Mojana, Francesca, Morrison, Victoria, Nguyen, Vivian, Oster, Stephen F., Acharya, Nisha, Clay, David, Lee, Salena, Lew, Mary, Margolis, Todd P., Stewart, Jay, Wong, Ira G., Brown, Debra, Khouri, Claire M., Goldstein, Debra A., Birnbaum, Andrea, Degillio, Andrea, Rosa, Gemma De la, Ramirez, Carmen, Simjanowski, Evica, Skelly, Mariner, Castro-Malek, Anna L., Crooke, Catherine E., Huntley, Melody, Nash, Katrina, Niec, Marcia, Pyatetsky, Dimitry, Ramirez, Misel, Rozenbajgier, Zuzanna, Tessler, Howard H., Davis, Janet L., Albini, Thomas A., Chin, Marie, Castaño, Daniela, Elizondo, Ariana, Ho, Macy, Kovach, Jaclyn L., Lin, Richard C-S., Mandelcorn, Efrem, Nguyen, Jackie K-D., Pacini, Aura, Pineda, Susan, Pinto, David A., Rebimbas, Jose, Stepien, Kimberly E., Teran, Claudia, Elner, Susan G., Bernard, Hillary, Fournier, Linda, Godsey, Lindsay, Goings, Linda, Hackel, Richard, Hesselgrave, Moella, Jayasundera, K. Thiran, Prusak, Robert, Titus, Pamela, Bergeron, Melissa, Blosser, Reneé, Brown, Rebecca, Chrisman-McClure, Carrie, Gothrup, Julie R., Saxe, Stephen J., Sizemore, Deanna, Kempen, John H., Berger, James, Drossner, Sheri, DuPont, Joan C., Maguire, Albert M., Petner, Janice, Engelhard, Stephanie, Hopkins, Tim, Lo, Jonathan, McCall, Dawn, McRay, Monique, Salvo, Rebecca, Will, Daniel, Xu, Wei, Windsor, Elizabeth, Weeney, Laurel, Pavan, Peter R., Albritton, Ken, Leto, JoAnn, Madow, Brian, Mayor, Lori, Pautler, Scott E., Saxon, Wyatt, Soto, Judy, Goldstein, Burton, Klukoff, Amy, Lambright, Lucy, McDonald, Kim, Ortiz, Maria, Scymanky, Susan, Szalay, Dee Dee, Rao, Narsing, Davis, Tamara, Douglass, Jackie, Linton, Judith, Padilla, Margaret, Ramos, Sylvia, Rao, Narsing A., Aguirre, Alexia, Chong, Lawrence, Cisneros, Lupe, Corona, Elizabeth, Eliott, Dean, Fawzi, Amani, Garcia, Jesse, Khurana, Rahul, Lim, Jennifer, Mead, Rachel, Tsai, Julie H., Vitale, Albert, Bernstein, Paul S., Carlstrom, Bonnie, Gilman, James, Hanseen, Sandra, Morris, Paula, Ramirez, Diana, Wegner, Kimberley, Sheppard, John D., Anthony, Brianne, Casper, Amber, Felix-Kent, Lisa, Fernandez, Jeanette, Johnson, Tari, Scoper, Stephen V., Cole, R. Denise, Crawford, Nancy, Franklin, Lisa, Hamelin, Krista, Martin, Jen, Marx, Rebecca, Schultz, Gregory, Webb, Joseph, Yeager, Pamela, Kim, Rosa Y., Benz, Matthew S., Brown, David M., Chen, Eric, Fish, Richard H., Kegley, Eric, Shawver, Laura, Wong, Tien P., De La Garza, Rebecca, Friday (Hay), Shayla, Rao, P. Kumar, Adcock, Eve, Apte, Rajendra S., Baladenski, Amy, Curtis, Rhonda, Gould, Sarah, Hebden, Amanda, Kambarian, Jamie, Meyer, Charla, Pistorius, Sam, Quinn, Melanie, Rathert, Greg, Blinder, Kevin J., Hartz, Ashley, Light, Pam, Shah, Gaurav K., VanGelder, Russell, Jabs, Douglas A., Altaweel, Michael M., Holbrook, Janet T., Kurinij, Natalie, Brown, Diane, Prusakowski, Nancy, Thorne, Jennifer E., Hubbard, Larry, Wittes, Janet, Barlow, William E., Hochberg, Marc, Lyon, Alice T., Palestine, Alan G., Simon, Lee S., Rosenbaum, James T., Smith, Harmon, Davis, Janet, Thorne, Jennifer, Acharya, Nisha R., Vitale, Albert T., Boring, Jeffrey A., Alexander, Judith, Ng, Wai Ping, Friedman, David S., Adler, Anna, Burke, Alyce, Katz, Joanne, Reed, Susan, Ansari, Husam, Cohen, Nicholas, Modak, Sanjukta, Sugar, Elizabeth A., Burke, Alyce E., Drye, Lea T., Van Natta, Mark L., Frick, Kevin, Katz, JoAnn, Louis, Thomas A., Shade, David, Pascual, Karen, Slutsky-Sanon, Jill S., Allen, Amanda, Glomp, Colby, Hilal, Yasmin, Nieves, Melissa A., Stevens, Maria, Abreu, Francis, Casper, Anne Shanklin, Ewing, Cathleen, Hart, Adante, Lears, Andrea, Li, Shirley, Meinert, Jill, Morrison, Vinnette, Nowakowski, Deborah, Reyes, Girlie, Shade, Dave M., Smith, Jacqueline, Steuernagle, Karen, Van Natta, Mark, Venugopal, Vidya, Yu, Tsung, Chen, Paul, Collins, Karen, Dodge, John, Frick, Kevin D., Jackson, Rosetta, Jimenez, Christian, Landers, Ariel, Livingston, Hope, Meinert, Curtis L., Rayapudi, Sobharani, Shen, Weijiang, Shiflett, Charles, Smith, Rochelle, Tieman, Ada, Tonascia, James A., Zheng, Richard, Allan, James, Benz, Wendy K., Domalpally, Amitha, Johnson, Kristine A., Myers, Dawn J., Won Pak, Jeong, Reimers, James L., Chambers, Geoffrey, Christianson, Debra J., Fleischli, Margaret A., Freund, Jacquelyn, Gama, Vonnie, Gangaputra, Sapna, Glander, Kathleen E., Goulding, Anne, Hafford, Dennis, Harris, Susan E., Hubbard, Larry D., Joyce, Jeffrey M., Kruse, Christina N., Nagle, Lauren, Padden-Lechten, Gwyn E., Pohlman, Alyson, Remm, Amy, Shaw, Ruth A., Sivesind, Peggy, Thayer, Dennis, Treichel, Erika, Warren, Kelly J., Watson, Sheila M., Webster, Mary K., White, James K., Wilhelmson, Tara, Zhang, Grace, and Lightman, Susan L.

Published
2015
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4. Placental Transfusion, Timing of Plastic Wrap or Bag Placement, and Preterm Neonates.

Author

Engle, William, Lien, Izlin, Benneyworth, Brian, Tully, Jennifer Stanton, Barbato, Alana, Kunkel, Melissa, Boon, Win, Waheed, Saira, Hoesli, Sandra, Chua, Rosario, Singhal, Abhay, Buchh, Basharat, Winchester, Paul, Guilfoy, Veronica, Proctor, Cathy, Sanchez, Mario, Joyce, Jeffrey, and He, Tian

Subjects
HOSPITALS, NEONATAL necrotizing enterocolitis, PLASTICS, TIME, HOSPITAL birthing centers, VERY low birth weight, RETROSPECTIVE studies, UMBILICAL cord clamping, TREATMENT duration, PREGNANCY outcomes, TREATMENT effectiveness, ARTIFICIAL respiration, INTRAUTERINE blood transfusion, MEDICAL practice, BODY temperature regulation, DEATH, PROBABILITY theory, DISEASE risk factors
Abstract

Objective Compare delivery room practices and outcomes of infants born at less than 32 weeks' gestation or less than 1,500 g who have plastic wrap/bag placement simultaneously during placental transfusion to those receiving plastic wrap/bag placement sequentially following placental transfusion. Study Design Retrospective analysis of data from a multisite quality improvement initiative to refine stabilization procedures pertaining to placental transfusion and thermoregulation using a plastic wrap/bag. Delivery room practices and outcome data in 590 total cases receiving placental transfusion were controlled for propensity score matching and hospital of birth. Results The simultaneous and sequential groups were similar in demographic and most outcome metrics. The simultaneous group had longer duration of delayed cord clamping compared with the sequential group (42.3 ± 14.8 vs. 34.1 ± 10.3 seconds, p < 0.001), and fewer number of times cord milking was performed (0.41 ± 1.26 vs. 0.86 ± 1.92 seconds, p < 0.001). The time to initiate respiratory support was also significantly shorter in the simultaneous group (97.2 ± 100.6 vs. 125.2 ± 177.6 seconds, p = 0.02). The combined outcome of death or necrotizing enterocolitis in the simultaneous group was more frequent than in the sequential group (15.3 vs. 9.3%, p = 0.038); all other outcomes measured were similar. Conclusion Timing of plastic wrap/bag placement during placental transfusion did affect duration of delayed cord clamping, number of times cord milking was performed, and time to initiate respiratory support in the delivery room but did not alter birth hospital outcomes or respiratory care practices other than the combined outcome of death or necrotizing enterocolitis. Key Points Plastic bag placement during placental transfusion is effective in stabilization of preterms. Plastic bag placement after placental transfusion is effective in stabilization of preterms. Plastic bag placement during placental transfusion and risk of death or necrotizing enterocolitis needs additional study. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Symbolic Functional Evaluation

Author

Day, Nancy A., Joyce, Jeffrey J., Bertot, Yves, editor, Dowek, Gilles, editor, Théry, Laurent, editor, Hirschowitz, André, editor, and Paulin, Christine, editor

Published
1999
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19. Totally verified systems: Linking verified software to verified hardware

Author

Joyce, Jeffrey J., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, Leeser, Miriam, editor, and Brown, Geoffrey, editor

Published
1990
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20. Placental Transfusion, Timing of Plastic Wrap or Bag Placement, and Preterm Neonates

Author

Engle, William, additional, Lien, Izlin, additional, Benneyworth, Brian, additional, Tully, Jennifer Stanton, additional, Barbato, Alana, additional, Kunkel, Melissa, additional, Boon, Win, additional, Waheed, Saira, additional, Hoesli, Sandra, additional, Chua, Rosario, additional, Singhal, Abhay, additional, Buchh, Basharat, additional, Winchester, Paul, additional, Guilfoy, Veronica, additional, Proctor, Cathy, additional, Sanchez, Mario, additional, Joyce, Jeffrey, additional, and He, Tian, additional

Published
2021
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24. Developing a sustainable research culture in an independent academic medical center

Author

Joyce, Jeffrey N.

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Medical centers -- Research -- Environmental aspects, Business, general, Business
Abstract

Independent academic medical centers (IAMC) are challenged to develop and support a research enterprise and maintain primary goals of healthcare delivery and financial solvency. Strategies for promoting translational research have been shown to be effective at institutions in the top level of Federal funding, but not for smaller IAMCs. The research program developed at Maricopa Integrated Health System (MIHS), an IAMC, focused on identifying research enterprise drivers which have an impact on core missions for MIHS and encompassed three domains: (1) Commercial ventures; (2) Clinical practice; and (3) Civic and Community relationships. Specific mechanisms were implemented to promote research, which had an impact on each enterprise driver. Case examples in 2 clinical arenas are described in detail, Pediatrics and Obstetrics/Gynecology, to demonstrate how the strategies were applied to increase translational research and influence the research enterprise drivers. These strategies included: reducing barriers within MIHS and with partner institutions, increasing revenue generated from grants and contracts, providing grant development support, and developing sustainable collaborations with partner institutions. The value in identifying and utilizing external resources is reciprocal as ongoing research collaborations have resulted in more contract and grant awards for both MIHS and partner institutions. Keywords: translational, clinical, administration, health care, medical center, university, Introduction Traditional academic medical centers (AMCs), with a teaching hospital associated with a medical school, have been the home for clinical and translational research for several decades. However, independent academic [...]

Published
2013

26. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Author

Massa, Stephen M., Yang, Tao, Xie, Youmei, Shi, Jian, Bilgen, Mehmet, Joyce, Jeffrey N., Nehama, Dean, Rajadas, Jayakumar, and Longo, Frank M.

Subjects
Neurons -- Genetic aspects, Alzheimer's disease -- Genetic aspects, Cellular signal transduction -- Genetic aspects, Brain-derived neurotrophic factor -- Properties -- Genetic aspects, Health care industry
Abstract

Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations between altered BDNF expression and/or function and mechanism(s) underlying numerous neurodegenerative conditions, including Alzheimer disease and traumatic brain injury, suggest that TrkB agonists might have therapeutic potential. Using in silico screening with a BDNF loop-domain pharmacophore, followed by low-throughput in vitro screening in mouse fetal hippocampal neurons, we have efficiently identified small molecules with nanomolar neurotrophic activity specific to TrkB versus other Trk family members. Neurotrophic activity was dependent on TrkB and its downstream targets, although compound-induced signaling activation kinetics differed from those triggered by BDNF. A selected prototype compound demonstrated binding specificity to the extracellular domain of TrkB. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with efficacy equal to that of BDNF, and when administered in vivo, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats. These studies demonstrate the utility of loop modeling in drug discovery and reveal what we believe to be the first reported small molecules derived from a targeted BDNF domain that specifically activate TrkB. We propose that these compounds constitute a novel group of tools for the study of TrkB signaling and may provide leads for developing new therapeutic agents for neurodegenerative diseases., Introduction Nerve growth factor (NGF), brain-derived neurotrophin factor (BDNF), and neurotrophin-3 (NT-3) are members of the neurotrophin protein family and act through their cognate tropomyosin-related kinase (Trk) receptors (NGF/TrkA, BDNF/TrkB, [...]

Published
2010
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29. eNOS gradients in cycling and pregnant ewes

Author

Joyce, Jeffrey M., Phernetton, Terrance M., Shaw, Cynthia E., Modrick, Mary L., and Magness, Ronald R.

Subjects
Physiology -- Research, Ewes -- Physiological aspects, Blood vessels -- Dilatation, Uterus -- Physiological aspects, Shear flow -- Physiological aspects, Biological sciences
Abstract

Endothelial vasodilator production by uterine and systemic arteries. IX. eNOS gradients in cycling and pregnant ewes. Am J Physiol Heart Circ Physiol 282: H342-H348, 2002; 10.1152/ajpheart.00438.2001.--The follicular phase (FOL) and pregnancy exhibit increases in uterine blood flow (UBF), estrogen levels, and uterine artery (UA) endothelial nitric oxide synthase (eNOS) expression. UA branching within the mesometrium increases the total vascular cross-sectional area, which reduces the vascular perfusion pressure gradient, thus locally decreasing the blood flow velocity. Shear stress (SS) activates eNOS and may be associated with UBF elevations during FOL and pregnancy. We hypothesized that regional differences in eNOS responses are observed with both decreases in vessel diameter and during the ovarian cycle and pregnancy. Endothelial isolated proteins were collected from renal (RA) and internal iliac arteries (II) as well as from primary (UA 1 [degrees]), secondary (UA 2 [degrees]), and tertiary (UA 3 [degrees]) UA branches of nonpregnant luteal phase (LUT; n = 6) and FOL (n = 6) as well as midpregnant (MP; 82 [+ or -] 1 days gestation, n = 6) and late pregnant (LP; 127 [+ or -] 3 days gestation, n = 6) ewes (term = 145 [+ or -] 3 days gestation) for Western blot analysis. LUT RA, II, and UA 1 [degrees] eNOS levels were similar. There was a (30.7 [+ or -] 9.8% reduction in eNOS expression in UA 2 [degrees] and UA 3 [degrees]. A similar decreasing eNOS regional expression gradient was observed in LP ewes. No eNOS regional expression gradient was observed in FOL or MP ewes because eNOS increased in UA 2 [degrees] and UA 3 [degrees]. In UA 2 [degrees] and UA 3 [degrees], MP > LP = FOL > LUT. Thus, with increasing UBF, FOL and pregnancy rises in SS may regulate eNOS protein expression in smaller diameter UAs. A decrease in LUT and LP UA 2 [degrees] and UA 3 [degrees] endothelial eNOS suggest a possible negative feedback mechanism due to downregulation of eNOS if SS is normalized. uterus; shear stress; endothelial nitric oxide synthase; ovarian; estrogen; progesterone

Published
2002

39. Contributors

Author

Abel, Ty W., primary, Aisen, Paul S., additional, Alexander, Gene E., additional, Allman, John M., additional, Anderson, Nicole D., additional, Armstrong, David M., additional, Avis, Nancy E., additional, Baxter, Mark G., additional, Beal, M. Flint, additional, Bouras, Constantin, additional, Browne, Susan E., additional, Buée, Luc, additional, Burkard, Robert, additional, Bussière, Thierry, additional, Cassel, Christine K., additional, Conley, Kevin E., additional, Copinschi, Georges, additional, Cotman, Carl W., additional, Cowen, Tim, additional, Cronin-Golomb, Alice, additional, De Kloet, E. Ron, additional, Delacourte, André, additional, Dhenain, Marc, additional, Dickson, Dennis W., additional, Ding, Dalian, additional, Doty, Richard L., additional, Duan, Huiling, additional, Eddins, Ann Clock, additional, Ek, Kirsten, additional, Erwin, Joseph M., additional, Eshuis, S.A., additional, Frisina, D. Robert, additional, Frisina, Robert D., additional, Furey, Maura L., additional, Gabaldón, A.M., additional, Gannon, Patrick J., additional, Gerhardt, Greg A., additional, Giannakopoulos, Panteleimon, additional, Gilissen, Emmanuel P., additional, Godschalk, Michael, additional, Gold, Gabriel, additional, Grady, Cheryl L., additional, Gruenewald, David A., additional, Guazzelli, Mario, additional, Hansen, Lawrence, additional, Harvey, Philip D., additional, Hays, Nicholas P., additional, Head, Elizabeth, additional, Hebert, Meleik A., additional, Henderson, Donald, additional, Hernandez, M. Rosario, additional, Herrmann, François R., additional, Hof, Patrick R., additional, Horwitz, B.A., additional, Ikonomovic, Milos, additional, Ingram, Donald K., additional, Ison, James R., additional, Joray, Sabine, additional, Joyce, Jeffrey N., additional, Jubrias, Sharon A., additional, Keck, B. Jane, additional, Kolker, Daniel E., additional, Kordower, Jeffrey H., additional, Kövari, Enikö, additional, Kuchel, George A., additional, Kuljis, Rodrigo O., additional, Kuno, Helen, additional, Lakoski, Joan M., additional, LaPolt, Philip S., additional, Leenders, K.L., additional, Leproult, Rachel, additional, Lu, John K.H., additional, Lucassen, Paul J., additional, Magistretti, Pierre J., additional, Marin, Deborah B., additional, Masliah, Eliezer, additional, Matsumoto, Alvin M., additional, Mattson, Mark P., additional, McCoy, Norma L., additional, McDonald, R.B., additional, McFadden, Sandra L., additional, McKeon-O'Malley, Catherine, additional, Michel, Jean-Pierre, additional, Milgram, Norton William, additional, Mishizen, Amanda, additional, Mobbs, Charles V., additional, Mohs, Richard C., additional, Mufson, Elliott J., additional, Mulligan, Thomas, additional, Neufeld, Arthur H., additional, Nimchinsky, Esther A., additional, Pasinetti, Giulio Maria, additional, Pellerin, Luc, additional, Perl, Daniel P., additional, Pietrini, Pietro, additional, Rance, Naomi E., additional, Riggs, Jack E., additional, Roberts, Susan B., additional, Rowe, John W., additional, Salvi, Richard J., additional, Sims, Donald G., additional, Smith, Matthew J., additional, Snell, Karen B., additional, Sonntag, William E., additional, Stanford, John A., additional, Tanzi, Rudolph, additional, Thornton, Phillip L., additional, Tsopelas, Nicholas D., additional, Turek, Fred W., additional, Vallet, Philippe G., additional, Van Cauter, Eve, additional, Vickers, James C., additional, Vogt, Brent A., additional, Vogt, Leslie J., additional, Walton, Joseph P., additional, Willott, James F., additional, and Wise, Phyllis M., additional

Published
2001
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46. Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain

Author

Murray, Angela M., Ryoo, Han L., Gurevich, Eugenia, and Joyce, Jeffrey N.

Subjects
Brain -- Localization of functions, Dopamine receptors -- Analysis, Binding sites (Biochemistry) -- Analysis, Science and technology
Abstract

Experimental studies using selective substitution of (125I)epidepride in D3 receptors by 7-hydroxy-N,N-di(1-propyl)-2-aminotetralin and partial replacement of (125I)epidepride from D2 receptors with domperidone help estimate the localization of (125I)epidepride-bound D2-like and D3-like receptors in the basal ganglia and limbic regions of human brain. Islands of dense binding in the nucleus accumbens and ventral putamen exhibit significant binding of (125I)epidepride to D3-like receptors. Cortex and hippocampus exhibit the binding of (125I)epidepride to D2 receptors but not to D3 receptors.

Published
1994

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