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2. Supplementary Data from Blood-Based Gene Expression Signatures in Non–Small Cell Lung Cancer

Author

Zander, Thomas, primary, Hofmann, Andrea, primary, Staratschek-Jox, Andrea, primary, Classen, Sabine, primary, Debey-Pascher, Svenja, primary, Maisel, Daniela, primary, Ansén, Sascha, primary, Hahn, Moritz, primary, Beyer, Marc, primary, Thomas, Roman K., primary, Gathof, Birgit, primary, Mauch, Cornelia, primary, Delank, Karl-Stefan, primary, Engel-Riedel, Walburga, primary, Wichmann, H.-Erich, primary, Stoelben, Erich, primary, Schultze, Joachim L., primary, and Wolf, Jürgen, primary

Published
2023
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3. Morbus Hodgkin

Author

Küppers, Ralf, Rajewsky, Klaus, Staratschek-Jox, Andrea, Wolf, Jürgen, Diehl, Volker, Ganten, Detlev, editor, Ruckpaul, Klaus, editor, Schlegelberger, Brigitte, editor, and Fonatsch, Christa, editor

Published
2003
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4. Hodgkin’s Disease

Author

Staratschek-Jox, Andrea, Wolf, Jürgen, Diehl, Volker, Masters, John R. W., editor, and Palsson, Bernhard O., editor

Published
2002
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7. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Author

Schwandt, Timo, Schumak, Beatrix, Gielen, Gerrit H, Jüngerkes, Frank, Schmidbauer, Patricia, Klocke, Katrin, Staratschek‐Jox, Andrea, van Rooijen, Niko, Kraal, Georg, Ludwig‐Portugall, Isis, Franken, Lars, Wehner, Sven, Kalff, Jörg C, Weber, Olaf, Kirschning, Carsten, Coch, Christoph, Kalinke, Ulrich, Wenzel, Jörg, Kurts, Christian, Zawatzky, Rainer, Holzmann, Bernhard, Layland, Laura, Schultze, Joachim L, Burgdorf, Sven, den Haan, Joke MM, Knolle, Percy A, and Limmer, Andreas

Published
2012
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14. Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium

Author

Truong, Therese, Hung, Rayjean J., Amos, Christopher I., Wu, Xifeng, Bickeböller, Heike, Rosenberger, Albert, Sauter, Wiebke, Illig, Thomas, Wichmann, H.-Erich, Risch, Angela, Dienemann, Hendrik, Kaaks, Rudolph, Yang, Ping, Jiang, Ruoxiang, Wiencke, John K., Wrensch, Margaret, Hansen, Helen, Kelsey, Karl T., Matsuo, Keitaro, Tajima, Kazuo, Schwartz, Ann G., Wenzlaff, Angie, Seow, Adeline, Ying, Chen, Staratschek-Jox, Andrea, Nürnberg, Peter, Stoelben, Erich, Wolf, Jürgen, Lazarus, Philip, Muscat, Joshua E., Gallagher, Carla J., Zienolddiny, Shanbeh, Haugen, Aage, van der Heijden, Henricus F., Kiemeney, Lambertus A., Isla, Dolores, Mayordomo, Jose Ignacio, Rafnar, Thorunn, Stefansson, Kari, Zhang, Zuo-Feng, Chang, Shen-Chih, Kim, Jin Hee, Hong, Yun-Chul, Duell, Eric J., Andrew, Angeline S., Lejbkowicz, Flavio, Rennert, Gad, Müller, Heiko, Brenner, Hermann, Le Marchand, Loïc, Benhamou, Simone, Bouchardy, Christine, Teare, M. Dawn, Xue, Xiaoyan, McLaughlin, John, Liu, Geoffrey, McKay, James D., Brennan, Paul, and Spitz, Margaret R.

Published
2010
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20. The association between active participation in a sports club, physical activity and social network on the development of lung cancer in smokers: a case-control study

Author

Schmidt Anna, Jung Julia, Ernstmann Nicole, Driller Elke, Neumann Melanie, Staratschek-Jox Andrea, Schneider Christian, Wolf Jürgen, and Pfaff Holger

Subjects
Social network, Sports club, Physical activity, Lung cancer, Smokers, Germany, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background This study analyses the effect of active participation in a sports club, physical activity and social networks on the development of lung cancer in patients who smoke. Our hypothesis is that study participants who lack social networks and do not actively participate in a sports club are at a greater risk for lung cancer than those who do. Methods Data for the study were taken from the Cologne Smoking Study (CoSmoS), a retrospective case-control study examining potential psychosocial risk factors for the development of lung cancer. Our sample consisted of n = 158 participants who had suffered lung cancer (diagnosis in the patient document) and n = 144 control group participants. Both groups had a history of smoking. Data on social networks were collected by asking participants whether they participated in a sports club and about the number of friends and relatives in their social environment. In addition, sociodemographic data (gender, age, education, marital status, residence and religion), physical activity and data on pack years (the cumulative number of cigarettes smoked by an individual, calculated by multiplying the number of cigarettes smoked per day by the number of years the person has smoked divided by 20) were collected to control for potential confounders. Logistic regression was used for the statistical analysis. Results The results reveal that participants who are physically active are at a lower risk of lung cancer than those who are not (adjusted OR = 0.53*; CI = 0.29-0.97). Older age and lower education seem also to be risk factors for the development of lung cancer. The extent of smoking, furthermore, measured by pack years is statistically significant. Active participation in a sports club, number of friends and relatives had no statistically significant influence on the development of the cancer. Conclusions The results of the study suggest that there is a lower risk for physically active participants to develop lung cancer. In the study sample, physical activity seemed to have a greater protective effect than participation in a sports club or social network of friends and relatives. Further studies have to investigate in more detail physical activity and other club participations.

Published
2012
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21. Identification of lung cancer with high sensitivity and specificity by blood testing

Author

Stephan Bernhard, Stoelben Erich, Wolf Jürgen, Staratschek-Jox Andrea, Andres Claudia, Klein Veronika, Rheinheimer Stefanie, Ludwig Nicole, Heisel Sabrina, Keller Andreas, Leidinger Petra, Stehle Ingo, Hamacher Jürg, Huwer Hanno, Lenhof Hans-Peter, and Meese Eckart

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Lung cancer is a very frequent and lethal tumor with an identifiable risk population. Cytological analysis and chest X-ray failed to reduce mortality, and CT screenings are still controversially discussed. Recent studies provided first evidence for the potential usefulness of autoantigens as markers for lung cancer. Methods We used extended panels of arrayed antigens and determined autoantibody signatures of sera from patients with different kinds of lung cancer, different common non-tumor lung pathologies, and controls without any lung disease by a newly developed computer aided image analysis procedure. The resulting signatures were classified using linear kernel Support Vector Machines and 10-fold cross-validation. Results The novel approach allowed for discriminating lung cancer patients from controls without any lung disease with a specificity of 97.0%, a sensitivity of 97.9%, and an accuracy of 97.6%. The classification of stage IA/IB tumors and controls yielded a specificity of 97.6%, a sensitivity of 75.9%, and an accuracy of 92.9%. The discrimination of lung cancer patients from patients with non-tumor lung pathologies reached an accuracy of 88.5%. Conclusion We were able to separate lung cancer patients from subjects without any lung disease with high accuracy. Furthermore, lung cancer patients could be seprated from patients with other non-tumor lung diseases. These results provide clear evidence that blood-based tests open new avenues for the early diagnosis of lung cancer.

Published
2010
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22. Validation of the 'SmoCess-GP' instrument - a short patient questionnaire for assessing the smoking cessation activities of general practitioners: a cross-sectional study

Author

Wolf Jürgen, Staratschek-Jox Andrea, Wirtz Markus, Ernstmann Nicole, Neumann Melanie, Jung Julia, and Pfaff Holger

Subjects
Medicine (General), R5-920
Abstract

Abstract Background We developed an instrument assessing the extent of smoking cessation activities by general practitioners (GPs) within the Cologne Smoking Study (CoSmoS). The objective of the present study was to examine further psychometric quality of the "SmoCess-GP" instrument (Smoking Cessation by General Practitioners). Methods 127 current smokers who had participated in the Cologne Smoking Study (CoSmoS) were included in our analyses. Confirmatory factor analysis (CFA) was conducted to examine the model fit and to retest the single-factor structure of the instrument using the Mplus software. Further construct validity was tested with bivariate analysis using an instrument which measures patients' trust in physicians. Results CFA supported the unidimensional structure of the instrument. The factor loadings exceed the threshold of ≥ 0.50. All indicator reliabilities were higher than 0.30. The composite reliability was 0.86 and the average variance extracted (AVE) resulted in a value of 0.50. The calculation of global fit indices identified a CFI value of 1.00 and for TLI a value of 1.02. The root mean square error of approximation (RMSEA) indicates that 0% of the information is not accounted for by the model. The chi-square value was χ2df = 6 = 4.63 (p = 0.59). Analysis of discriminant validity resulted in a non-significiant correlation of r = 0.092 (p = 0.350). Conclusions Results indicate preliminary evidence for the construct validity of the "SmoCess-GP" instrument which therefore appears to be a promising tool for analyzing the extent of smoking cessation advice offered by GPs from the patients' perspective. Future research should examine the psychometric properties in a population based sample, further improvements of the instrument and should apply other methods of validation.

Published
2010
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25. Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium

Author

Truong, Therese, Hung, Rayjean J., Amos, Christopher I., Wu, Xifeng, Bickeböller, Heike, Rosenberger, Albert, Sauter, Wiebke, Illig, Thomas, Wichmann, H.-Erich, Risch, Angela, Dienemann, Hendrik, Kaaks, Rudolph, Yang, Ping, Jiang, Ruoxiang, Wiencke, John K., Wrensch, Margaret, Hansen, Helen, Kelsey, Karl T., Matsuo, Keitaro, Tajima, Kazuo, Schwartz, Ann G., Wenzlaff, Angie, Seow, Adeline, Ying, Chen, Staratschek-Jox, Andrea, Nürnberg, Peter, Stoelben, Erich, Wolf, Jürgen, Lazarus, Philip, Muscat, Joshua E., Gallagher, Carla J., Zienolddiny, Shanbeh, Haugen, Aage, van der Heijden, Henricus F. M., Kiemeney, Lambertus A., Isla, Dolores, Mayordomo, Jose Ignacio, Rafnar, Thorunn, Stefansson, Kari, Zhang, Zuo-Feng, Chang, Shen-Chih, Kim, Jin Hee, Hong, Yun-Chul, Duell, Eric J., Andrew, Angeline S., Lejbkowicz, Flavio, Rennert, Gad, Müller, Heiko, Brenner, Hermann, Le Marchand, Loïc, Benhamou, Simone, Bouchardy, Christine, Teare, M. Dawn, Xue, Xiaoyan, McLaughlin, John, Liu, Geoffrey, McKay, James D., Brennan, Paul, Spitz, Margaret R., Truong, Therese, Hung, Rayjean J., Amos, Christopher I., Wu, Xifeng, Bickeböller, Heike, Rosenberger, Albert, Sauter, Wiebke, Illig, Thomas, Wichmann, H.-Erich, Risch, Angela, Dienemann, Hendrik, Kaaks, Rudolph, Yang, Ping, Jiang, Ruoxiang, Wiencke, John K., Wrensch, Margaret, Hansen, Helen, Kelsey, Karl T., Matsuo, Keitaro, Tajima, Kazuo, Schwartz, Ann G., Wenzlaff, Angie, Seow, Adeline, Ying, Chen, Staratschek-Jox, Andrea, Nürnberg, Peter, Stoelben, Erich, Wolf, Jürgen, Lazarus, Philip, Muscat, Joshua E., Gallagher, Carla J., Zienolddiny, Shanbeh, Haugen, Aage, van der Heijden, Henricus F. M., Kiemeney, Lambertus A., Isla, Dolores, Mayordomo, Jose Ignacio, Rafnar, Thorunn, Stefansson, Kari, Zhang, Zuo-Feng, Chang, Shen-Chih, Kim, Jin Hee, Hong, Yun-Chul, Duell, Eric J., Andrew, Angeline S., Lejbkowicz, Flavio, Rennert, Gad, Müller, Heiko, Brenner, Hermann, Le Marchand, Loïc, Benhamou, Simone, Bouchardy, Christine, Teare, M. Dawn, Xue, Xiaoyan, McLaughlin, John, Liu, Geoffrey, McKay, James D., Brennan, Paul, and Spitz, Margaret R.

Abstract

Background Genome-wide association studies have identified three chromosomal regions at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these associations in independent studies and investigate heterogeneity of these associations within specific subgroups, we conducted a coordinated genotyping study within the International Lung Cancer Consortium based on independent studies that were not included in previous genome-wide association studies. Methods Genotype data for single-nucleotide polymorphisms at chromosomes 15q25 (rs16969968, rs8034191), 5p15 (rs2736100, rs402710), and 6p21 (rs2256543, rs4324798) from 21 case-control studies for 11 645 lung cancer case patients and 14 954 control subjects, of whom 85% were white and 15% were Asian, were pooled. Associations between the variants and the risk of lung cancer were estimated by logistic regression models. All statistical tests were two-sided. Results Associations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, Ptrend = 2 × 10−26), and this association was stronger for those diagnosed at younger ages. There was no association in never-smokers or in Asians between either of the 15q25 variants and the risk of lung cancer. For the chromosome 5p15 region, we confirmed statistically significant associations in whites for both rs2736100 (OR = 1.15, 95% CI = 1.10 to 1.20, Ptrend = 1 × 10−10) and rs402710 (OR = 1.14, 95% CI = 1.09 to 1.19, Ptrend = 5 × 10−8) and identified similar associations in Asians (rs2736100: OR = 1.23, 95% CI = 1.12 to 1.35, Ptrend = 2 × 10−5; rs402710: OR = 1.15, 95% CI = 1.04 to 1.27, Ptrend = .007). The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas. This pattern was observed in both ethni

Published
2017

26. Keratin 1 maintains skin integrity and participates in an inflammatory network in skin via interleukin-18

Author

Roth, Wera, Kumar, Vinod, Beer, Hans-Dietmar, Richter, Miriam, Wohlenberg, Claudia, Reuter, Ursula, Thiering, Sören, Staratschek-Jox, Andrea, Hofmann, Andrea, Kreusch, Fatima, Schultze, Joachim L, Vogl, Thomas, Roth, Johannes, Reichelt, Julia, Hausser, Ingrid, Magin, Thomas M, University of Zurich, and Magin, Thomas M

Subjects
1307 Cell Biology, 10177 Dermatology Clinic, 610 Medicine & health
Published
2012
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28. Intrahepatic IL-8 producing Foxp3+CD4+ regulatory T cells and fibrogenesis in chronic hepatitis C

Author

Langhans, Bettina, primary, Krämer, Benjamin, additional, Louis, Marcell, additional, Nischalke, Hans Dieter, additional, Hüneburg, Robert, additional, Staratschek-Jox, Andrea, additional, Odenthal, Margarethe, additional, Manekeller, Steffen, additional, Schepke, Michael, additional, Kalff, Jörg, additional, Fischer, Hans-Peter, additional, Schultze, Joachim L., additional, and Spengler, Ulrich, additional

Published
2013
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29. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

Author

Böttcher, Jan P., primary, Schanz, Oliver, additional, Wohlleber, Dirk, additional, Abdullah, Zeinab, additional, Debey-Pascher, Svenja, additional, Staratschek-Jox, Andrea, additional, Höchst, Bastian, additional, Hegenbarth, Silke, additional, Grell, Jessica, additional, Limmer, Andreas, additional, Atreya, Imke, additional, Neurath, Markus F., additional, Busch, Dirk H., additional, Schmitt, Edgar, additional, van Endert, Peter, additional, Kolanus, Waldemar, additional, Kurts, Christian, additional, Schultze, Joachim L., additional, Diehl, Linda, additional, and Knolle, Percy A., additional

Published
2013
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30. High-Resolution Transcriptome of Human Macrophages

Author

Beyer, Marc, primary, Mallmann, Michael R., additional, Xue, Jia, additional, Staratschek-Jox, Andrea, additional, Vorholt, Daniela, additional, Krebs, Wolfgang, additional, Sommer, Daniel, additional, Sander, Jil, additional, Mertens, Christina, additional, Nino-Castro, Andrea, additional, Schmidt, Susanne V., additional, and Schultze, Joachim L., additional

Published
2012
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32. Keratin 1 maintains skin integrity and participates in an inflammatory network in skin via interleukin-18

Author

Roth, Wera, primary, Kumar, Vinod, additional, Beer, Hans-Dietmar, additional, Richter, Miriam, additional, Wohlenberg, Claudia, additional, Reuter, Ursula, additional, Thiering, Sören, additional, Staratschek-Jox, Andrea, additional, Hofmann, Andrea, additional, Kreusch, Fatima, additional, Schultze, Joachim L, additional, Vogl, Thomas, additional, Roth, Johannes, additional, Hausser, Ingrid, additional, and Magin, Thomas M, additional

Published
2012
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33. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Author

Schwandt, Timo, primary, Schumak, Beatrix, additional, Gielen, Gerrit H, additional, Jüngerkes, Frank, additional, Schmidbauer, Patricia, additional, Klocke, Katrin, additional, Staratschek-Jox, Andrea, additional, van Rooijen, Niko, additional, Kraal, Georg, additional, Ludwig-Portugall, Isis, additional, Franken, Lars, additional, Wehner, Sven, additional, Kalff, Jörg C, additional, Weber, Olaf, additional, Kirschning, Carsten, additional, Coch, Christoph, additional, Kalinke, Ulrich, additional, Wenzel, Jörg, additional, Kurts, Christian, additional, Zawatzky, Rainer, additional, Holzmann, Bernhard, additional, Layland, Laura, additional, Schultze, Joachim L, additional, Burgdorf, Sven, additional, den Haan, Joke MM, additional, Knolle, Percy A, additional, and Limmer, Andreas, additional

Published
2011
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35. Blood-Based Gene Expression Signatures in Non–Small Cell Lung Cancer

Author

Zander, Thomas, primary, Hofmann, Andrea, additional, Staratschek-Jox, Andrea, additional, Classen, Sabine, additional, Debey-Pascher, Svenja, additional, Maisel, Daniela, additional, Ansén, Sascha, additional, Hahn, Moritz, additional, Beyer, Marc, additional, Thomas, Roman K., additional, Gathof, Birgit, additional, Mauch, Cornelia, additional, Delank, Karl-Stefan, additional, Engel-Riedel, Walburga, additional, Wichmann, H.-Erich, additional, Stoelben, Erich, additional, Schultze, Joachim L., additional, and Wolf, Jürgen, additional

Published
2011
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36. Application of T cell-based transcriptomics to identify three candidate biomarkers for monitoring anti-TGFβR therapy

Author

Classen, Sabine, primary, Muth, Christine, additional, Debey-Pascher, Svenja, additional, Eggle, Daniela, additional, Beyer, Marc, additional, Mallmann, Michael R., additional, Rudlowski, Christian, additional, Zander, Thomas, additional, Pölcher, Martin, additional, Kuhn, Walther, additional, Lahn, Michael, additional, Schultze, Joachim L., additional, and Staratschek-Jox, Andrea, additional

Published
2010
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38. Identification of lung cancer with high sensitivity and specificity by blood testing

Author

Leidinger, Petra, primary, Keller, Andreas, additional, Heisel, Sabrina, additional, Ludwig, Nicole, additional, Rheinheimer, Stefanie, additional, Klein, Veronika, additional, Andres, Claudia, additional, Staratschek-Jox, Andrea, additional, Wolf, Jürgen, additional, Stoelben, Erich, additional, Stephan, Bernhard, additional, Stehle, Ingo, additional, Hamacher, Jürg, additional, Huwer, Hanno, additional, Lenhof, Hans-Peter, additional, and Meese, Eckart, additional

Published
2010
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47. Suppression of the tumorigenic growth of Burkitt's lymphoma cells in immunodeficient mice by cytokine gene transfer using EBV-derived episomal expression vectors

Author

M�cke, Susanne, primary, Draube, Andreas, additional, Polack, Axel, additional, Pawlita, Michael, additional, Massoudi, Nadia, additional, Staratschek-Jox, Andrea, additional, Bohlen, Heribert, additional, Bornkamm, Georg, additional, Diehl, Volker, additional, and Wolf, J�rgen, additional

Published
2000
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50. Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: the progenitor cell of the malignant clone?

Author

Jansen, Maurice P. H. M., primary, Hopman, Anton H. N., additional, Bot, Fredrik J., additional, Haesevoets, Annick, additional, Stevens-Kroef, Marian J. P. L., additional, Arends, Jan Willem, additional, Jox, Andrea, additional, Wolf, J�rgen, additional, Ramaekers, Frans C. S., additional, and Schouten, Harry C., additional

Published
1999
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