1. Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center
- Author
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Renaudier, M, Binois, Y, Dumas, F, Lamhaut, L, Beganton, F, Jost, D, Charpentier, J, Lesieur, O, Marijon, E, Jouven, X, Cariou, A, and Bougouin, W
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Clinical Research ,Neurosciences ,Cardiovascular ,Paris Sudden Death Expertise Center group ,Brain death ,Epidemiology ,Organ donation ,Out-of-hospital cardiac arrest ,Public Health and Health Services ,Clinical sciences - Abstract
BackgroundOrgan shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry covering a well-defined geographic area.MethodsWe prospectively analyzed consecutive adults with OHCA who were successfully resuscitated, but died in intensive care units in the Paris region in 2011-2018. The primary outcome was organ donation after brain death. Independent risk factors were identified using logistic regression analysis. One-year graft survival was assessed using Cox and log-rank tests.ResultsOf the 3061 included patients, 136 (4.4%) became organ donors after brain death, i.e., 28% of the patients with brain death. An interaction between admission pH and post-resuscitation shock was identified. By multivariate analysis, in patients with post-resuscitation shock, factors associated with organ donation were neurological cause of OHCA (odds ratio [OR], 14.5 [7.6-27.4], P
- Published
- 2022