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Introduction: Hyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti‐pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2‐mercaptonicotinoyl glycine (2‐MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in vitro and in vivo. Objectives: A Bayesian network meta‐analysis (BNMA) was conducted to map and rank the anti‐pigmenting and depigmenting efficacy of 2‐MNG 0.5% on UV daylight (UVDL)‐induced pigmentation together with 13 other reference molecules. A comparison in the kinetics of 2‐MNG 0.5% was also performed. Methodology: Fourteen studies were conducted, for each, on 15–30 women of skin phototype III in Shanghai, China and Paris, France. The products were applied on mini zone, in randomized and blinded protocol, on the back, 5 days a week during 6 weeks, at a dose of 4 mg/cm2. During the second week, volunteers were exposed under to varying minimum erythemal dose of UVDL during 4 consecutive days—adapted to obtain a similar induction of skin pigmentation regardless of the population. Assessments were performed instrumentally using Chromameter®. Ascorbic acid 7% was used as a positive control for all experiments. A Bayesian network meta‐analysis was then established to map and follow the kinetics of 2‐MNG 0.5% performance with 13 reference molecules (glutathione 2%, kojic acid 1%, hydroquinone 4%, ascorbyl glucoside 2%, niacinamide 4%, etc.). Results: 2‐MNG 0.5% dominated the ranking at all time points with a significant high probability of strong efficacy against UVDL‐induced pigmentation. Ascorbic acid 7% ranks second after 4 days of irradiations (D12) whereas hydroquinone 4% ranks second 1 month after irradiations (D40). In the kinetics, 2‐MNG at 0.5% was effective as from the end of irradiations (D12) to the study endpoint (D40). This suggested an immediate and persistent efficacy across all timepoints evaluated. Conclusion: The BNMA revealed a rapid and lasting efficacy of 2‐MNG 0.5% on the anti‐pigmenting and depigmenting phases of the clinical protocol. 2‐MNG 0.5% ranked first, with immediate and lasting effect compared to 13 other references. This study is the first allowing comparison between reference anti‐pigmenting and depigmenting agents and will help clinicians for proposing the most effective approach for their patients. [ABSTRACT FROM AUTHOR]

Introduction: Acne vulgaris (acne) is characterized by both inflammatory and non‐inflammatory lesions. Benzoyl peroxide (BPO) 5% is approved to treat acne but may cause skin irritation and/or contact allergy. Objectives: To compare the benefit in acne of a multitargeted dermocosmetic cream containing salicylic acid, lipohydroxy acid, niacinamide, 2‐oleamido‐1,3‐octadecanediol, piroctone olamine, zinc, Aqua posae filiformis, and thermal spring water (DC‐Eff) to BPO 5% gel. Materials and Methods: 150 Caucasian subjects (50% female) aged between 18 and 40 years, with mild to moderate acne according to the GEA (Global Evaluation of Acne) grading system were randomized into two parallel groups (DC‐Eff or BPO to be applied twice daily for 56 days). IGA (investigator global assessment), GEA, lesion count, clinical signs and symptoms, and subject assessment were evaluated at baseline, and after 28 and 56 days (D28 and D56) of treatment. Results: The responder analyses of the IGA and GEA scores showed that 62.2% and 47.3%, respectively, in the DC‐Eff, compared with 50.0% and 36.5%, respectively, in the BPO, had improved by at least one point at D56. Inflammatory, non‐inflammatory, and total lesion counts significantly (p < 0.0001) decreased with both products from baseline, with no between‐group difference. Subjects considered that their skin was smoother and that DC‐Eff was easy to apply. DC‐Eff was better tolerated than BPO. Conclusions: DC‐Eff applied twice daily is as beneficial as BPO in improving mild‐to‐moderate acne. DC‐Eff was better tolerated than BPO and highly appreciated. [ABSTRACT FROM AUTHOR]