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16 results on '"Joubert, Lloyd"'

6. Causes of infective endocarditis in the Western Cape, South Africa: a prospective cohort study using a set protocol for organism detection and central decision making by an endocarditis team

Author

Pecoraro, Alfonso Jan Kemp, primary, Pienaar, Colette, additional, Herbst, Philippus George, additional, Poerstamper, Simon, additional, Joubert, Lloyd, additional, Taljaard, Jantjie, additional, Prozesky, Hans, additional, Janson, Jacques, additional, Newton-Foot, Mae, additional, and Doubell, Anton Frans, additional

Published
2021
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10. PROVE-Pre-Eclampsia Obstetric Adverse Events : Establishment of a Biobank and Database for Pre-Eclampsia

Author

Bergman, Lina, Bergman, Karl, Langenegger, Eduard, Moodley, Ashley, Griffith-Richards, Stephanie, Wikström, Johan, Hall, David, Joubert, Lloyd, Herbst, Philip, Schell, Sonja, van Veen, Teelkien, Belfort, Michael, Tong, Stephen Y. C., Walker, Susan, Hastie, Roxanne, Cluver, Catherine, Bergman, Lina, Bergman, Karl, Langenegger, Eduard, Moodley, Ashley, Griffith-Richards, Stephanie, Wikström, Johan, Hall, David, Joubert, Lloyd, Herbst, Philip, Schell, Sonja, van Veen, Teelkien, Belfort, Michael, Tong, Stephen Y. C., Walker, Susan, Hastie, Roxanne, and Cluver, Catherine

Abstract

Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a focus on phenotyping severe disease.The approach of our biobank is to collect biological specimens, detailed clinical data, tests, and biophysical examinations, including magnetic resonance imaging (MRI) of the brain, MRI of the heart, transcranial Doppler, echocardiography, and cognitive function tests.Women diagnosed with pre-eclampsia and normotensive controls are enrolled in the biobank at admission to Tygerberg University Hospital (Cape Town, South Africa). Biological samples and clinical data are collected at inclusion/delivery and during the hospital stay. Special investigations as per above are performed in a subset of women. After two months, women are followed up by telephonic interviews. This project aims to establish a biobank and database for severe organ complications of pre-eclampsia in a low-middle income country where the incidence of pre-eclampsia with organ complications is high. The study integrates different methods to investigate pre-eclampsia, focusing on improved understanding of pathophysiology, prediction of organ complications, and potentially future drug evaluation and discovery.

Published
2021
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11. PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia

Author

Bergman, Lina, primary, Bergman, Karl, additional, Langenegger, Eduard, additional, Moodley, Ashley, additional, Griffith-Richards, Stephanie, additional, Wikström, Johan, additional, Hall, David, additional, Joubert, Lloyd, additional, Herbst, Philip, additional, Schell, Sonja, additional, van Veen, Teelkien, additional, Belfort, Michael, additional, Tong, Stephen Y. C., additional, Walker, Susan, additional, Hastie, Roxanne, additional, and Cluver, Catherine, additional

Published
2021
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12. Radial artery dilatation to improve access and lower complications during coronary angiography: the RADIAL trial

Author

Doubell, Jacques, primary, Kyriakakis, Charles, additional, Weich, Hellmuth, additional, Herbst, Philip, additional, Pecoraro, Alfonso, additional, Moses, Jane, additional, Griffiths, Bradley, additional, Snyman, H. W., additional, Kabwe, Lorrita, additional, Du Toit, Rudolf, additional, Joubert, Lloyd, additional, Hassan, Karim, additional, and Doubell, Anton, additional

Published
2021
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16. The de Winter's pattern revisited: a case series.

Author

John TJ, Pecoraro A, Weich H, Joubert L, Griffiths B, and Herbst P

Abstract

Background: The de Winter's electrocardiogram (ECG) pattern signifying proximal left anterior descending (LAD) artery occlusion was first described in 2008. The ECG changes were thought to be static and mechanisms for this were suggested. In addition, the optimal management of these patients was reported to be via a primary percutaneous coronary intervention (PCI) strategy., Case Summary: Case 1 : A 48-year-old gentleman presented with a 2-h history of ischaemic chest pain with initial de Winter's pattern on ECG. This progressed to anterior ST-elevation myocardial infarction (STEMI) complicated by ventricular fibrillation. Emergency angiography revealed a mid-vessel LAD occlusion which was successfully reperfused. Case 2 : A 34-year-old female presented with a 2-h history of ischaemic chest pain with initial ECG showing a de Winter's pattern. Due to concerns of performing PCI timeously, a pharmacoinvasive strategy of reperfusion was adopted with resolution of the de Winter's pattern. Urgent angiography revealed a proximal LAD lesion which was successfully stented., Discussion: The two cases highlight that the de Winter's pattern may in fact not be static, but rather lie along the continuum of ischaemia and may evolve into STEMI. In addition, we provide further evidence that if primary PCI cannot be offered in a timeous manner, thrombolytic therapy may be considered in such patients. The de Winter's pattern remains a high-risk ECG pattern that requires early recognition and intervention., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2020
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