1. Preoperative hydronephrosis is an independent protective factor of renal function decline after nephroureterectomy for upper tract urothelial carcinoma
- Author
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Pai-Yu Cheng, Hsiang-Ying Lee, Wei-Ming Li, Steven K. Huang, Chien-Liang Liu, I-Hsuan Alan Chen, Jen-Tai Lin, Chi-Wen Lo, Chih-Chin Yu, Shian-Shiang Wang, Chuan-Shu Chen, Jen-Shu Tseng, Wun-Rong Lin, Jou Yeong-Chin, Ian-Seng Cheong, Yuan-Hong Jiang, Yu Khun Lee, Yung-Tai Chen, Shin-Hong Chen, Bing-Juin Chiang, Thomas Y. Hsueh, Chao-Yuan Huang, Chia-Chang Wu, Wei Yu Lin, Yao-Chou Tsai, Kai-Jie Yu, Chi-Ping Huang, Yi-You Huang, and Chung-You Tsai
- Subjects
hydronephrosis ,nephroureterectomy ,renal function ,upper tract urothelial carcinoma ,chronic kidney disease ,adjuvant therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectivesTo evaluate the predictive role of pre-nephroureterectomy (NU) hydronephrosis on post-NU renal function (RF) change and preserved eligibility rate for adjuvant therapy in patients with upper tract urothelial carcinoma (UTUC).Patients and methodsThis retrospective study collected data of 1018 patients from the Taiwan UTUC Collaboration Group registry of 26 institutions. The patients were divided into two groups based on the absence or presence of pre-NU hydronephrosis. Estimated glomerular filtration rate (eGFR) was calculated pre- and post-NU respectively. The one month post-NU RF change, chronic kidney disease (CKD) progression, and the preserved eligibility rate for adjuvant therapy were compared for each CKD stage.Results404 (39.2%) patients without and 614 (60.8%) patients with pre-NU hydronephrosis were enrolled. The median post-NU change in the eGFR was significantly lower in the hydronephrosis group (-3.84 versus -12.88, p
- Published
- 2023
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