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5. Exploring attitudes towards health preparedness in the Middle East and North Africa against chemical, biological, radiological, and nuclear threats: A qualitative study

Author

Farhat, Hassan, primary, Alinier, Guillaume, additional, Helou, Mariana, additional, Galatas, Ioannis, additional, Josse, Denis, additional, Campbell, Craig, additional, Olim, Nelson, additional, Handan Dökmeci, Ayşe, additional, Heriza, Mohammed, additional, Chebbi, Henda, additional, El‐Aifa, Kawther, additional, Jaafar, Amira, additional, Souissi, Sami, additional, Amor, Asma Ben, additional, Castle, Nicholas, additional, Al‐Shaikh, Loua, additional, Abougalala, Walid, additional, Dhiab, Mohamed Ben, additional, and Laughton, James, additional

Published
2023
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9. Exploring attitudes towards health preparedness in the Middle East and North Africa against chemical, biological, radiological, and nuclear threats: A qualitative study.

Author

Farhat, Hassan, Alinier, Guillaume, Helou, Mariana, Galatas, Ioannis, Josse, Denis, Campbell, Craig, Olim, Nelson, Dökmeci, Ayşe Handan, Heriza, Mohammed, Chebbi, Henda, El-Aifa, Kawther, Jaafar, Amira, Souissi, Sami, Amor, Asma Ben, Castle, Nicholas, Al-Shaikh, Loua, Abougalala, Walid, Dhiab, Mohamed Ben, and Laughton, James

Subjects
HEALTH attitudes, INTERNATIONAL cooperation, PREPAREDNESS, EMERGENCY management, SEMI-structured interviews
Abstract

Since 1970, Middle East and North African (MENA) countries have witnessed evolutionary industrial development and long-running terrorist and inter-country conflicts. Additionally, the risk of accidental, deliberate or natural chemical, biological, radiological, and nuclear (CBRN) threats has also increased, requiring a collaborative review of the health sectors' preparedness for potential CBRN risks within the region. This study aimed to explore the opinion of multidisciplinary experts interested in disaster management research in MENA about perspectives and challenges on readiness for potential CBRN incidents. A modified interview online link was sent to the participants. A qualitative thematic analysis was performed on the responses using Nvivo®12 software, following semistructured modified interviews using the Phonic® application. A total of 29 participants were sufficient to reach the data saturation. Through an inductive coding approach, five themes were identified: 'CBRN-Related Incidents are a Threat', 'Inadequate National Practice and Policy', 'Need for International Cooperation', 'Importance of Better Mass Gathering Management', and 'Ineffective Hospital Preparedness'. With the assistance of the World Health Organization, there is a consensus on the need for cooperation between the MENA countries to ensure adequate healthcare preparedness for CBRN threats. Suggested measures should be considered, such as creating a unified database and liaison officer designation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. PON1 Structure

Author

Josse, Denis, Masson, Patrick, Bartels, Cynthia, Lockridge, Oksana, Costa, Lucio G., editor, and Furlong, Clement E., editor

Published
2002
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17. Comparative analysis of the perception of nuclear risk in two populations (expert/non expert) in France

Author

Den Auwer, Christophe, Michel, Hervé, Greff, Gaëlle, Beccia, Maria Rosa, Josse, Denis, Provitolo, Damienne, Perez, Sandra, Carle, Georges, Pourcher, Thierry, Russo, Sandra, Steichen, Pascale, Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Côte d'Azur, CNRS, UMR 7272, Institut de Chimie de Nice, Nice, Bioénergétique et Ingénierie des Protéines (BIP ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Service Départemental d’Incendie et de Secours des Alpes-Maritimes, Service de Santé et de Secours Médical, Nice, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Génétique, physiopathologie et ingénierie du tissu osseux (GéPITOS), Transporteurs en Imagerie et Radiothérapie en Oncologie (TIRO - UMR E4320), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-UMR E4320 (TIRO-MATOs), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Groupe de Recherche en Droit, Economie et Gestion (GREDEG), and CoDiRem

Subjects
ecological transition, nuclear energy, nuclearrisk, [CHIM]Chemical Sciences, perception, [SDE.ES]Environmental Sciences/Environmental and Society, [CHIM.RADIO]Chemical Sciences/Radiochemistry, risk, [SHS]Humanities and Social Sciences
Abstract

International audience; In an effort to reduce CO2, emissions, manty countries throughout the word are initiating plans to transition to mor sustainable form of ernergy. Nuclear energy would appear to be a powerful contender to replace fossil fuels, ar at least be an unavaoidable option, from an energy-mix perspective.

Published
2020

18. Comparative analysis of the perception of nuclear risk among two populations (expert/non-expert) in France

Author

Perez, Sandra, den Auwer, Christophe, Pourcher, Thierry, Russo, Sandra, Drouot, Cyril, Beccia, Maria Rosa, Greff, Gaëlle, Fiorelli, Franck, Leriche, Audrey, Castagnola, Fréderic, Steichen, Pascale, Carle, Georges, Glaichenhaus, N., Michel, Hervé, Josse, Denis, Pottier, Nicolas, Provitolo, Damienne, Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Côte d'Azur (UCA)-Avignon Université (AU)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Transporteurs et Imagerie, Radiothérapie en Oncologie et Mécanismes biologiques des Altérations du Tissu Osseux (TIRO-MATOs - UMR E4320), UMR E4320 (TIRO-MATOs), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service Départemental d’Incendie et de Secours des Alpes-Maritimes, Service de Santé et de Secours Médical, Nice, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Génétique, physiopathologie et ingénierie du tissu osseux (GéPITOS), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institut de pharmacologie moléculaire et cellulaire (IPMC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), CODIREM, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-UMR E4320 (TIRO-MATOs), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA), and Perez, Sandra

Subjects
[SHS.GEO] Humanities and Social Sciences/Geography, [SDE.ES] Environmental Sciences/Environmental and Society, [SHS.GEO]Humanities and Social Sciences/Geography, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract

As part of the UCA JEDI IDEX program, the NR2P2* project brought together a multidisciplinary team to interview 2315 people via an online survey to assess their perception of nuclear risk via 33 questions; International audience; In the context of ecological change and the fight to reduce CO2 emissions, nuclear energy can appear to be an efficient energy source, or at least essential from the perspective of energy diversification. However, it suffers from a poor image and a lack of knowledge among the population, and among young people in particular, who favor the development of renewable energy. We wanted to know exactly what was happening in one of the most nuclearized countries in the world, France. To do this, we interviewed a young, student, "non-expert" population about their knowledge and perceptions of nuclear risk and compared the results with a so-called "expert" population: firefighters, most of whom had received training in radiation protection. Thus, in response to the question "Are you afraid of the nuclear sector?" 68% of students answered yes compared to 49% of firefighters. The reasons for fear are sometimes similar (radioactive waste, contamination over long periods, ageing of power plants), and sometimes divergent due to the better knowledge of the firefighters who had undergone radiological training (out of control, fear of the effects of radioactivity). Science students differed from other students by being more in favor of a partial exit from nuclear power (50%, compared to 12% for students from other disciplines), and by indicating that they were more open than others to the possibility of changing their minds if they had more knowledge on the subject (43%). In terms of behavior, the gaps are, as expected, wide between the 2 populations (students/firefighters): less than half (44%) of students adopt the right reflexes (seeking a confined space, sealing ventilation), 55% would prepare for an evacuation and 84% would keep themselves informed, not through social networks as we might think, but through a state organization in charge of managing the nuclear sector. If an alert were to occur, students report that they would be anxious (42%), frightened (12%) or even panicked (25%), unlike firefighters who would of course behave as expected, be more reasoned, and much less panicked (difference of 21%), although half of them admit that they would still be anxious. The results reveal differentiated profiles between the 2 populations (expert/non-expert) in terms of the association between exposure to radioactivity and the occurrence of cancers, and in the level of confidence in nuclear energy in France.

Published
2019

20. Une approche de la perception publique de l'énergie nucléaire

Author

Den Auwer, Christophe, Michel, Hervé, Greff, Gaëlle, Beccia, Maria Rosa, Josse, Denis, Provitolo, Damienne, Perez, Sandra, Carle, Georges, Pourcher, Thierry, Russo, Sandra, Steichen, Pascale, Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, CNRS, UMR 7272, Institut de Chimie de Nice, Nice, Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service Départemental d’Incendie et de Secours des Alpes-Maritimes, Service de Santé et de Secours Médical, Nice, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Génétique, physiopathologie et ingénierie du tissu osseux (GéPITOS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Transporteurs en Imagerie et Radiothérapie en Oncologie (TIRO - UMR E4320), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-UMR E4320 (TIRO-MATOs), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA), and Groupe de Recherche en Droit, Economie et Gestion (GREDEG)

Subjects
[CHIM]Chemical Sciences, [SDE.ES]Environmental Sciences/Environmental and Society, [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

24. Novel active topical skin protectant against the penetration of organophosphates

Author

Bignon, Cécile, Zenerino, Arnaud, Boutard, Tifenn, Amigoni, Sonia, Josse, Denis, Devers, Thierry, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), Centre de Recherche sur la Matière Divisée (CRMD), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), IUT de Chartres, Université d'Orléans (UO), and Darmanin, Thierry

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

25. New smart nanoparticles-based formulations for skin protection

Author

Bignon, Cécile, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2014

26. Use of reconstructed human epidermis as alternative models for efficiency studies against the penetration of organophosphates

Author

Bignon, Cécile, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

27. Nanoparticular network-based formulations for skin protection

Author

Bignon, Cécile, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2014

28. Hair analysis as a useful procedure for detection of vapour exposure to chemical warfare agents: simulation of sulphur mustard with methyl salicylate

Author

Spiandore, Marie, Piram, Anne, Lacoste, Alexandre, Josse, Denis, Doumenq, Pierre, Laboratoire Chimie de l'environnement (LCE), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), BMPM-Bataillon des Marins Pompiers de Marseille, and SDIS06-Service Départemental d'Incendies et de Secours des Alpes Maritimes

Subjects
integumentary system, [CHIM]Chemical Sciences, [CHIM.OTHE]Chemical Sciences/Other, ComputingMilieux_MISCELLANEOUS
Abstract

18th Ccongress of the Society of Hair Testing (SoHT), Geneva, SWITZERLAND, AUG 28-30, 2013; International audience; Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited according to international convention, populations' exposure still recently occurred. Development of markers of exposure to CWA is necessary to distinguish exposed victims from unexposed ones. We present the first study of hair usage as passive sampler to assess contamination by chemicals in vapour form. This work presents more particularly the hair adsorption capacity for methyl salicylate used as a surrogate of the vesicant sulphur mustard. Chemical vapours toxicity through the respiratory route has historically been defined through Haber's law's concentration-time (Ct) product, and vapour exposure of hair to methyl salicylate was conducted with various times or doses of exposure in the range of incapacitating and lethal Ct products corresponding to sulphur mustard. Following exposure, extraction of methyl salicylate from hair was conducted by simple soaking in dichloromethane. Methyl salicylate could be detected on hair for vapour concentration corresponding to about one fifth of the sulphur mustard concentration that would kill 50% of exposed individuals (LCt50). The amount of methyl salicylate recovered from hair increased with time or dose of exposure. It showed a good correlation with the concentration-time product, suggesting that hair could be used like a passive sampler to assess vapour exposure to chemical compounds. It introduces great perspectives concerning the use of hair as a marker of exposure to CWA. Copyright (c) 2014 John Wiley & Sons, Ltd.

Published
2014
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29. In vitro permeation of organophosphates trough reconstructed human epidermis and artificial membranes

Author

Bignon, Cécile, Josse, Denis, Pelletier, Jocelyne, Briançon, Stéphanie, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

30. Nanoparticules de cérine polymérisées en réseau actif ou bioactif, topiques protecteurs, leurs procédés de préparation et leurs utilisations

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Devers, Thierry, Josse, Denis, Guittard, Frédéric, Bignon, Cécile, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), IUT de Chartres, and Université d'Orléans (UO)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2013

31. Stabilisation of nanoparticles in polymer networks

Author

Amigoni, Sonia, Zenerino, Arnaud, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2013

32. Nanoparticules polymérisées en réseau actif ou bioactif, topiques protecteurs, leurs procédés de préparation et leurs utilisations

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2013

33. Silica nanoparticles dispersion into fluorocarbon or hydrocarbon polymers: study in fluid matrices and on a support

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

34. Nano-hybrides organiques/inorganiques contre la bio-contamination

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2012

35. Influence of fluorocarbon or hydrocarbon polymers in nano-hybrid organic/inorganic network

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

36. New hybrid organic/inorganic pH responsive polymeric network

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

37. Hybrid organic/inorganic pH responsive polymeric network

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

38. New hybrid organic/inorganic pH responsive polymeric network for skin protection

Author

Zenerino, Arnaud, Darmanin, Thierry, Amigoni, Sonia, Taffin De Givenchy, Elisabeth, Josse, Denis, Guittard, Frédéric, Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry
Published
2012

43. Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities

Author

Josse, Denis, Xie, Weihua, Renault, Frederique, Rochu, Daniel, Schopfer, Lawrence M., Masson, Patrick, and Lockridge, Oksana

Subjects
Organophosphorus compounds -- Analysis, Serum -- Research, Mutagenesis -- Research, Biological sciences, Chemistry
Abstract

Identification of residues that are essential for human serum paraoxonase (PON1) activity was done via adoption of complementary approaches based on chemical modification and site-directed mutagenesis. The results supported the importance of aromatic/hydrophobic character of the residue 280. 12 animo acids were identified essential for PON1 arylesterase and organophosphatase activities: E194, E52, D278, D276, D182, D168, D53, H284, H242, H154, H133 and H144.

Published
1999

45. In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions - evidence for a wash-in effect.

Author

Misik, Jan, Pavlikova, Ruzena, Josse, Denis, Cabal, Jiri, and Kuca, Kamil

Subjects
SKIN disease treatment, PARAOXON, DECONTAMINATION (From gases, chemicals, etc.), ORGANOPHOSPHORUS pesticides, CHEMICAL warfare agents, CHEMICAL industry, LABORATORY swine
Abstract

Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques are needed. In this study, in vitro permeation and decontamination of a potentially hazardous compound paraoxon, an active metabolite of organophosphorus pesticide parathion, was investigated. Skin permeation and decontamination experiments were carried out in modified Franz diffusion cells. Pig skin was used as a human skin model. Commercially produced detergent-based washing solutions FloraFree™ and ArgosTM were used as decontamination means. The experiments were done under 'warm', 'cold', 'dry' and 'wet' skin conditions in order to determine an effect of various physical conditions on skin permeation of paraoxon and on a subsequent decontamination process. There was no significant difference in skin permeation of paraoxon under warm, cold and dry conditions, whereas wet conditions provided significantly higher permeation rates. In the selected conditions, decontamination treatments performed 1 h after a skin exposure did not decrease the agent volume that permeated through the skin. An exception were wet skin conditions with non-significant decontamination efficacy 18 and 28% for the FloraFree™ and Argos™ treatment, respectively. In contrast, the skin permeation of paraoxon under warm, cold and dry conditions increased up to 60-290% following decontamination compared to non-decontaminated controls. This has previously been described as a skin wash-in effect. [ABSTRACT FROM AUTHOR]

Published
2012
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46. Les cheveux aussi peuvent parler.

Author

Spiandore, Marie, Piram, Anne, and Josse, Denis

Abstract

Dans le domaine judiciaire, les cheveux sont progressivement devenus un outil très utile pour contribuer à résoudre certaines enquêtes. Dans ce cadre, leur capacité de stockage des composés chimiques absorbés par l'organisme est mise à profit. Ils peuvent aussi capter certains produits toxiques présents dans l'air. Mais une fois contaminés, les cheveux deviennent à leur tour une source potentielle d'intoxication. Peuvent-ils être décontaminés ? [ABSTRACT FROM AUTHOR]

Published
2017

47. Homogeneous dispersion of SiO2 nanoparticles in an hydrosoluble polymeric network.

Author

Zenerino, Arnaud, Amigoni, Sonia, Taffin de Givenchy, Elisabeth, Josse, Denis, and Guittard, Frédéric

Subjects
*SILICON oxide, *NANOPARTICLES, *POLYMERS, *DISPERSION (Chemistry), *NANOCOMPOSITE materials, *AQUEOUS solutions
Abstract

Abstract: The main difficulty still encountered in the elaboration of polymer/silica nanocomposites is the control of the nanoparticles dispersion homogeneity and the stability of the nanoparticle dispersion in the surrounding substance. The innovative point of this work is the elaboration of hybrid networks in aqueous solution performed with ASE (alkali swellable emulsion) thickeners grafted with silica nanoparticles. The thickening ability of the polymer should favour silica nanoparticles dispersion in fluid matrices. Two ASE copolymers were realised by copolymerisation in emulsion of MA (methacrylic acid) and EA (ethyl acrylate) and/or TFEM (trifluoroethyl methacrylate). The substitution of a part of EA by TFEM gave fluorinated ASE copolymers. Their free acid functions were then coupled with different ratio of amine functionalized silica nanoparticles to afford nanocomposites. The amounts of silica nanoparticles in the copolymers were determined by thermogravimetric experiments. Depending on the silica nanoparticles/copolymer ratio in basic aqueous solutions we achieved stable translucent gel like aqueous suspensions of silica nanoparticles containing 1wt.% of the polymer/SiO2 nanocomposite. [Copyright &y& Elsevier]

Published
2013
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48. Hair analysis as a useful procedure for detection of vapour exposure to chemical warfare agents: simulation of sulphur mustard with methyl salicylate.

Author

Spiandore M, Piram A, Lacoste A, Josse D, and Doumenq P

Subjects
Humans, Time Factors, Chemical Warfare Agents analysis, Environmental Exposure analysis, Gases analysis, Hair chemistry, Mustard Gas analysis, Salicylates analysis
Abstract

Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited according to international convention, populations' exposure still recently occurred. Development of markers of exposure to CWA is necessary to distinguish exposed victims from unexposed ones. We present the first study of hair usage as passive sampler to assess contamination by chemicals in vapour form. This work presents more particularly the hair adsorption capacity for methyl salicylate used as a surrogate of the vesicant sulphur mustard. Chemical vapours toxicity through the respiratory route has historically been defined through Haber's law's concentration-time (Ct) product, and vapour exposure of hair to methyl salicylate was conducted with various times or doses of exposure in the range of incapacitating and lethal Ct products corresponding to sulphur mustard. Following exposure, extraction of methyl salicylate from hair was conducted by simple soaking in dichloromethane. Methyl salicylate could be detected on hair for vapour concentration corresponding to about one fifth of the sulphur mustard concentration that would kill 50% of exposed individuals (LCt50). The amount of methyl salicylate recovered from hair increased with time or dose of exposure. It showed a good correlation with the concentration-time product, suggesting that hair could be used like a passive sampler to assess vapour exposure to chemical compounds. It introduces great perspectives concerning the use of hair as a marker of exposure to CWA., (Copyright © 2014 John Wiley & Sons, Ltd.)

Published
2014
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