1. Epidemiology of Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States and factors predictive of outcomeCapsule Summary
- Author
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Paul Wasuwanich, BSc, Joshua M. So, BA, Teja S. Chakrala, MD, Jinghua Chen, MD, PhD, and Kiran Motaparthi, MD
- Subjects
drug eruptions ,inpatient dermatology ,risk factors ,severe cutaneous adverse reactions ,Stevens-Johnson syndrome ,toxic epidermal necrolysis ,Dermatology ,RL1-803 - Abstract
Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap syndrome are rare severe cutaneous adverse reactions associated with high mortality. Objectives: To estimate incidence and describe trends of SJS/TEN hospitalizations in the United States and to describe the clinical, demographic, and geographic characteristics of affected patients and risk factors for mortality. Methods: We utilized hospitalization data from the 2010 to 2020 National Inpatient Sample. SJS, SJS-TEN overlap syndrome, and TEN were identified by International Classification of Diseases, 9th Revision and International Classification of Diseases, 10th Revision codes and analyzed by logistic regression. Results: We identified 51,040 hospitalizations involving SJS/TEN. Amog those, 37,283 (73.0%) were for SJS only, 7818 (15.3%) were for SJS-TEN overlap syndrome, and 7160 (14.0%) were for TEN only. Overall, SJS/TEN hospitalization rates declined over time, 2010 to 2020 (P
- Published
- 2023
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