1. XRD, Thermal, Haemolysis and DNA Binding Studies of L-Arginine Functionalized Hydroxyapatite Nano-particles
- Author
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Thaker Vs, M J Joshi Mj, Jogiya Bv, and Chudasama Ks
- Subjects
Nanocomposite ,Materials science ,stomatognathic system ,Biophysics ,Surface modification ,Nanoparticle ,Thermal stability ,Particle size ,Fourier transform infrared spectroscopy ,Haemolysis ,Nanomaterials ,Nuclear chemistry - Abstract
Hydroxyapatite (HAP), an important bio-mineral, finds numerous applications in the clinical field. As amino acids exhibit synergetic effects on structure, morphology and several bio-logical properties of HAP, an attempt was made by the present authors to synthesize pure and different amount of L-arginine functionalized HAP nano-particles by the surfactant mediated approach. The samples were characterized by using different techniques, viz., powder X-Ray Diffraction (powder XRD), Fourier Transform Infrared (FT-IR) spectroscopy, Transmission Electron Microscopy (TEM) and Thermo-Gravimetry Analysis (TGA). The Williamson and Hall (W-H) analysis was performed on the powder XRD patterns, which indicated the particle size in nano-meter range and the strain associated with nano- particles changed with functionalization of HAP by L-arginine. FTIR study indicated the presence of various functional groups due to the functionalization of L-arginine with HAP. TGA results indicated slightly poor thermal stability of L-arginine functionalized HAP samples with comparison to pure HAP. The DNA binding studies indicated improved DNA binding on L-arginine functionalization of HAP. The haemolysis studies were also carried out.
- Published
- 2016
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