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This article aims to study double-diffusive magneto-convective flow of electrically conducting and Newtonian fluid in the presence of throughflow and concentration modulation. Here, two infinite horizontal plates have been considered with heated from below and cooled and salted from above. The flow is also influenced by the induced magnetic field for which a constant magnetic field is applied in the perpendicular direction to the plates and vertically upward direction. A weakly nonlinear analysis is used to obtain the expression of heat and mass transport rate using Ginzburg–Landau equation. The influence of various physical parameters on Nusselt and Sherwood numbers is presented by graphs. From the numerical outcome, it is found that Péclet, Chandrasekhar, and magnetic Prandtl numbers enhance the mass and heat transport rate, while Lewis number increases only the rate of mass transport. The major result of this study is that the onset of convection postpones in the presence of throughflow and magnetic field.

Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Although the roles of metabolites have been extensively studied with regard to cellular signaling pathways, their effects on protein aggregation remain relatively unexplored. By computationally analysing the Human Metabolome Database, we identified two endogenous metabolites, carnosine and kynurenic acid, that inhibit the aggregation of the amyloid beta peptide (Aβ) and rescue a C. elegans model of Alzheimer's disease. We found that these metabolites act by triggering a cytosolic unfolded protein response through the transcription factor HSF-1 and downstream chaperones HSP40/J-proteins DNJ-12 and DNJ-19. These results help rationalise previous observations regarding the possible anti-ageing benefits of these metabolites by providing a mechanism for their action. Taken together, our findings provide a link between metabolite homeostasis and protein homeostasis, which could inspire preventative interventions against neurodegenerative disorders.

The stability and maintenance of the renewable energy penetrated multi-area power system (REPMAPS) are so complex. To ensure the optimal functioning of the complex interconnected power system (IPS), an automatic controller is necessary for the proper load frequency control (LFC) actions. For this, a three-degree-of-freedom proportional-integral-derivative (3DOFPID) controller is suggested in this work for simultaneous frequency regulation. However, the parameters of the 3DOFPID controller are to be ascertained using soft computing algorithms to obtain better performance. The fruit fly algorithm (FFA) is implemented in this paper for the fine-tuning of the 3DOFPID controller, and the efficacy of the FFA is demonstrated with other algorithms in the literature. Besides, the analysis of REPMAPS is deliberated with communication time delays (CTDs) as the practical constraint, and their effect on the system’s dynamic performance is showcased. Further, the REPMAPS is operated with the territory strategy of capacitive energy storage (CES) and the static synchronous series compensator (SSSC) to improve the system performance. The simulation study confirmed the enhancement in REPMAPS performance with the CES-SSSC strategy.