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1. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

Author

Spicer, James, Basu, Bristi, Montes, Ana, Banerji, Udai, Kristeleit, Rebecca, Miller, Rowan, Veal, Gareth J., Corrigan, Christopher J., Till, Stephen J., Figini, Mariangela, Canevari, Silvana, Barton, Claire, Jones, Paul, Mellor, Sarah, Carroll, Simon, Selkirk, Chris, Nintos, George, Kwatra, Vineet, Funingana, Ionut-Gabriel, Doherty, Gary, Gould, Hannah J., Pellizzari, Giulia, Nakamura, Mano, Ilieva, Kristina M., Khiabany, Atousa, Stavraka, Chara, Chauhan, Jitesh, Gillett, Cheryl, Pinder, Sarah, Bax, Heather J., Josephs, Debra H., and Karagiannis, Sophia N.

Published
2023
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2. Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

Author

Chauhan, Jitesh, Grandits, Melanie, Palhares, Lais C. G. F., Mele, Silvia, Nakamura, Mano, López-Abente, Jacobo, Crescioli, Silvia, Laddach, Roman, Romero-Clavijo, Pablo, Cheung, Anthony, Stavraka, Chara, Chenoweth, Alicia M., Sow, Heng Sheng, Chiaruttini, Giulia, Gilbert, Amy E., Dodev, Tihomir, Koers, Alexander, Pellizzari, Giulia, Ilieva, Kristina M., Man, Francis, Ali, Niwa, Hobbs, Carl, Lombardi, Sara, Lionarons, Daniël A., Gould, Hannah J., Beavil, Andrew J., Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Calonje, Eduardo, Downward, Julian, Nestle, Frank O., Tsoka, Sophia, Josephs, Debra H., Blower, Philip J., Karagiannis, Panagiotis, Lacy, Katie E., Spicer, James, Karagiannis, Sophia N., and Bax, Heather J.

Published
2023
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3. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Author

Bax, Heather J., Chauhan, Jitesh, Stavraka, Chara, Santaolalla, Aida, Osborn, Gabriel, Khiabany, Atousa, Grandits, Melanie, López-Abente, Jacobo, Palhares, Lais C. G. F., Chan Wah Hak, Charleen, Robinson, Alexandra, Pope, Amy, Woodman, Natalie, Naceur-Lombardelli, Cristina, Malas, Sadek, Coumbe, Jack E. M., Nakamura, Mano, Laddach, Roman, Mele, Silvia, Crescioli, Silvia, Black, Anna M., Lombardi, Sara, Canevari, Silvana, Figini, Mariangela, Sayasneh, Ahmad, Tsoka, Sophia, FitzGerald, Kevin, Gillett, Cheryl, Pinder, Sarah, Van Hemelrijck, Mieke, Kristeleit, Rebecca, Ghosh, Sharmistha, Montes, Ana, Spicer, James, Karagiannis, Sophia N., and Josephs, Debra H.

Published
2023
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8. Supplementary figures from Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

Author

Cheung, Anthony, primary, Opzoomer, James, primary, Ilieva, Kristina M., primary, Gazinska, Patrycja, primary, Hoffmann, Ricarda M., primary, Mirza, Hasan, primary, Marlow, Rebecca, primary, Francesch-Domenech, Erika, primary, Fittall, Matthew, primary, Dominguez Rodriguez, Diana, primary, Clifford, Angela, primary, Badder, Luned, primary, Patel, Nirmesh, primary, Mele, Silvia, primary, Pellizzari, Giulia, primary, Bax, Heather J., primary, Crescioli, Silvia, primary, Petranyi, Gyula, primary, Larcombe-Young, Daniel, primary, Josephs, Debra H., primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Pinder, Sarah, primary, Nestle, Frank O., primary, Gillett, Cheryl, primary, Spicer, James F., primary, Grigoriadis, Anita, primary, Tutt, Andrew N.J., primary, and Karagiannis, Sophia N., primary

Published
2023
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9. Supplementary Table S1 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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10. Data from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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11. Supplementary Materials and Methods from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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12. Supplementary Figure Legends from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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13. Supplementary Figure S1 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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16. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Author

Bax, Heather J., primary, Chauhan, Jitesh, additional, Stavraka, Chara, additional, Santaolalla, Aida, additional, Osborn, Gabriel, additional, Khiabany, Atousa, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Palhares, Lais C. G. F., additional, Chan Wah Hak, Charleen, additional, Robinson, Alexandra, additional, Pope, Amy, additional, Woodman, Natalie, additional, Naceur-Lombardelli, Cristina, additional, Malas, Sadek, additional, Coumbe, Jack E. M., additional, Nakamura, Mano, additional, Laddach, Roman, additional, Mele, Silvia, additional, Crescioli, Silvia, additional, Black, Anna M., additional, Lombardi, Sara, additional, Canevari, Silvana, additional, Figini, Mariangela, additional, Sayasneh, Ahmad, additional, Tsoka, Sophia, additional, FitzGerald, Kevin, additional, Gillett, Cheryl, additional, Pinder, Sarah, additional, Van Hemelrijck, Mieke, additional, Kristeleit, Rebecca, additional, Ghosh, Sharmistha, additional, Montes, Ana, additional, Spicer, James, additional, Karagiannis, Sophia N., additional, and Josephs, Debra H., additional

Published
2022
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18. AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper

Author

Bergmann, Christoph, primary, Poli, Aurélie, additional, Agache, Ioana, additional, Bianchini, Rodolfo, additional, Bax, Heather J., additional, Castells, Mariana, additional, Crescioli, Silvia, additional, Dombrowicz, David, additional, Ferastraoaru, Denisa, additional, Fiebiger, Edda, additional, Gould, Hannah J., additional, Hartmann, Karin, additional, Izquierdo, Elena, additional, Jordakieva, Galateja, additional, Josephs, Debra H., additional, Jutel, Marek, additional, Levi‐Schaffer, Francesca, additional, de las Vecillas, Leticia, additional, Lotze, Michael T., additional, Osborn, Gabriel, additional, Pascal, Mariona, additional, Redegeld, Frank, additional, Rosenstreich, David, additional, Roth‐Walter, Franziska, additional, Schmidt‐Weber, Carsten, additional, Shamji, Mohamed, additional, Steveling, Esther H., additional, Turner, Michelle C., additional, Untersmayr, Eva, additional, Jensen‐Jarolim, Erika, additional, and Karagiannis, Sophia N., additional

Published
2022
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22. Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments

Author

McCraw, Alex J., primary, Chauhan, Jitesh, additional, Bax, Heather J., additional, Stavraka, Chara, additional, Osborn, Gabriel, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Josephs, Debra H., additional, Spicer, James, additional, Wagner, Gerd K., additional, Karagiannis, Sophia N., additional, Chenoweth, Alicia, additional, and Crescioli, Silvia, additional

Published
2021
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23. Abstract LB004: Nivolumab (NIVO) and ipilimumab (IPI) treatment in prostate cancer with an immunogenic signature: cohort 1 of the NEPTUNES multi-centre, two-stage biomarker-selected Phase II trial

Author

Linch, Mark D., primary, Wong, Yien Ning Sophia, additional, Jones, Robert, additional, Sankey, Peter, additional, Josephs, Debra H., additional, Crabb, Simon J., additional, Staffurth, John, additional, Zarkar, Anjali, additional, White, Laura, additional, Duggan, Marian, additional, Pellizzari, Giulia, additional, Wheeler, Graham, additional, Beare, Sandy, additional, Cartwright, Hayley, additional, Linares, Josep, additional, Akarca, Ayse, additional, Quezada, Sergio A., additional, Ensell, Leah, additional, Hartley, John, additional, Attard, Gerhardt, additional, Burr, Joanna, additional, Jayaram, Anuradha, additional, Kularatne, Bihani, additional, Kayani, Mahaz, additional, Chung, Moon, additional, Pritchard, Colin C., additional, Freeman, Alex, additional, Haider, Aiman, additional, and Marafioti, Teresa, additional

Published
2021
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25. IgG4 subclass antibodies impair antitumor immunity in melanoma

Author

Karagiannis, Panagiotis, Gilbert, Amy E., Josephs, Debra H., Ali, Niwa, Dodev, Tihomir, Saul, Louise, Correa, Isabel, Roberts, Luke, Beddowes, Emma, Koers, Alexander, Hobbs, Carl, Ferreira, Silvia, Geh, Jenny L.C., Healy, Ciaran, Harries, Mark, Acland, Katharine M., Blower, Philip J., Mitchell, Tracey, Fear, David J., Spicer, James F., Lacy, Katie E., Nestle, Frank O., and Karagiannis, Sophia N.

Subjects
Immunity -- Research, Immunoglobulin G -- Health aspects, Melanoma -- Research, Health care industry
Abstract

Host-induced antibodies and their contributions to cancer inflammation are largely unexplored. IgG4 sub-class antibodies are present in IL-10-driven Th2 immune responses in some inflammatory conditions. Since Th2-biased inflammation is a [...]

Published
2013
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26. Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2

Author

Pellizzari, Giulia, primary, Martinez, Olivier, additional, Crescioli, Silvia, additional, Page, Robert, additional, Di Meo, Ashley, additional, Mele, Silvia, additional, Chiaruttini, Giulia, additional, Hoinka, Jan, additional, Batruch, Ihor, additional, Prassas, Ioannis, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Bugallo-Blanco, Eva, additional, Ward, Malcolm, additional, Bax, Heather J, additional, French, Elise, additional, Cheung, Anthony, additional, Lombardi, Sara, additional, Figini, Mariangela, additional, Lacy, Katie E, additional, Diamandis, Eleftherios P, additional, Josephs, Debra H, additional, Spicer, James, additional, Papa, Sophie, additional, and Karagiannis, Sophia N, additional

Published
2021
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31. Combined anti‐PD‐1 and anti‐CTLA‐4 checkpoint blockade: Treatment of melanoma and immune mechanisms of action

Author

Willsmore, Zena N., primary, Coumbe, Ben G. T., additional, Crescioli, Silvia, additional, Reci, Sara, additional, Gupta, Ayushi, additional, Harris, Robert J., additional, Chenoweth, Alicia, additional, Chauhan, Jitesh, additional, Bax, Heather J., additional, McCraw, Alexa, additional, Cheung, Anthony, additional, Osborn, Gabriel, additional, Hoffmann, Ricarda M., additional, Nakamura, Mano, additional, Laddach, Roman, additional, Geh, Jenny L. C., additional, MacKenzie‐Ross, Alastair, additional, Healy, Ciaran, additional, Tsoka, Sophia, additional, Spicer, James F., additional, Josephs, Debra H., additional, Papa, Sophie, additional, Lacy, Katie E., additional, and Karagiannis, Sophia N., additional

Published
2021
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32. In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

Author

Man, Francis, primary, Koers, Alexander, additional, Karagiannis, Panagiotis, additional, Josephs, Debra H., additional, Bax, Heather J., additional, Gilbert, Amy E., additional, Dodev, Tihomir S., additional, Mele, Silvia, additional, Chiaruttini, Giulia, additional, Crescioli, Silvia, additional, Chauhan, Jitesh, additional, Blower, Julia E., additional, Cooper, Margaret S., additional, Spicer, James, additional, Karagiannis, Sophia N., additional, and Blower, Philip J., additional

Published
2021
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33. AllergoOncology:Expression platform development and functional profiling of an anti-HER2 IgE antibody

Author

Ilieva, Kristina M., Fazekas-Singer, Judit, Bax, Heather J., Crescioli, Silvia, Montero-Morales, Laura, Mele, Silvia, Sow, Heng Sheng, Stavraka, Chara, Josephs, Debra H., Spicer, James F., Steinkellner, Herta, Jensen-Jarolim, Erika, Tutt, Andrew N. J., and Karagiannis, Sophia N.

Subjects
Receptor, ErbB-2, Gene Expression Profiling, Neoplasms, Gene Expression, Humans, Transcriptome, Article
Published
2019

35. IgE Activates Monocytes from Cancer Patients to Acquire a Pro-Inflammatory Phenotype

Author

Nakamura, Mano, primary, Souri, Elmira Amiri, additional, Osborn, Gabriel, additional, Laddach, Roman, additional, Chauhan, Jitesh, additional, Stavraka, Chara, additional, Lombardi, Sara, additional, Black, Anna, additional, Khiabany, Atousa, additional, Khair, Duaa O., additional, Figini, Mariangela, additional, Winship, Anna, additional, Ghosh, Sharmistha, additional, Montes, Ana, additional, Spicer, James F., additional, Bax, Heather J., additional, Josephs, Debra H., additional, Lacy, Katie E., additional, Tsoka, Sophia, additional, and Karagiannis, Sophia N., additional

Published
2020
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36. Impact of age on the toxicity of immune checkpoint inhibition

Author

Samani, Amit, primary, Zhang, Shuai, additional, Spiers, Laura, additional, Mohamed, Ali Abdulnabi, additional, Merrick, Sophie, additional, Tippu, Zayd, additional, Payne, Miranda, additional, Faust, Guy, additional, Papa, Sophie, additional, Fields, Paul, additional, Van Hemelrijck, Mieke, additional, and Josephs, Debra H, additional

Published
2020
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37. Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome

Author

Bax, Heather J., primary, Chauhan, Jitesh, additional, Stavraka, Chara, additional, Khiabany, Atousa, additional, Nakamura, Mano, additional, Pellizzari, Giulia, additional, Ilieva, Kristina M., additional, Lombardi, Sara, additional, Gould, Hannah J., additional, Corrigan, Christopher J., additional, Till, Stephen J., additional, Katugampola, Sidath, additional, Jones, Paul S., additional, Barton, Claire, additional, Winship, Anna, additional, Ghosh, Sharmistha, additional, Montes, Ana, additional, Josephs, Debra H., additional, Spicer, James F., additional, and Karagiannis, Sophia N., additional

Published
2020
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38. Basophil activation test in cancer patient blood evaluating potential hypersensitivity to an anti‐tumor IgE therapeutic candidate

Author

Bax, Heather J., primary, Khiabany, Atousa, additional, Stavraka, Chara, additional, Pellizzari, Giulia, additional, Chan Wah Hak, Charleen, additional, Robinson, Alexandra, additional, Ilieva, Kristina M., additional, Woodman, Natalie, additional, Naceur‐Lombardelli, Cristina, additional, Gillett, Cheryl, additional, Pinder, Sarah, additional, Gould, Hannah J., additional, Corrigan, Christopher J., additional, Till, Stephen J., additional, Katugampola, Sidath, additional, Barton, Claire, additional, Winship, Anna, additional, Ghosh, Sharmistha, additional, Montes, Ana, additional, Josephs, Debra H., additional, Spicer, James F., additional, and Karagiannis, Sophia N., additional

Published
2020
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40. Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

Author

Sollie, Sam, primary, Santaolalla, Aida, additional, Michaud, Dominique S., additional, Sarker, Debashis, additional, Karagiannis, Sophia N., additional, Josephs, Debra H., additional, Hammar, Niklas, additional, Walldius, Goran, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2020
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41. In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model

Author

Williams, Iwan P., primary, Crescioli, Silvia, additional, Sow, Heng Sheng, additional, Bax, Heather J., additional, Hobbs, Carl, additional, Ilieva, Kristina M., additional, French, Elise, additional, Pellizzari, Giulia, additional, Cox, Vivienne, additional, Josephs, Debra H., additional, Spicer, James F., additional, Karagiannis, Sophia N., additional, and Mele, Silvia, additional

Published
2019
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42. Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma

Author

Nakamura, Mano, Bax, Heather J., Scotto, Daniele, Souri, Elmira Amiri, Sollie, Sam, Harris, Robert J., Hammar, Niklas, Walldius, Goran, Winship, Anna, Ghosh, Sharmistha, Montes, Ana, Spicer, James F., Van Hemelrijck, Mieke, Josephs, Debra H., Lacy, Katie E., Tsoka, Sophia, and Karagiannis, Sophia N.

Subjects
lcsh:Immunologic diseases. Allergy, Immune activation, ovarian cancer, immune mediators, inflammation, M1/M2, biomarkers, Th1/Th2/Th17, lcsh:RC581-607, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Original Research
Abstract

Immune and inflammatory cascades may play multiple roles in ovarian cancer. We aimed to identify relationships between expression of immune and inflammatory mediators and patient outcomes. We interrogated differential gene expression of 44 markers and marker combinations (n = 1,978) in 1,656 ovarian carcinoma patient tumors, alongside matched 5-year overall survival (OS) data in silico. Using machine learning methods, we investigated whether genomic expression of these 44 mediators can discriminate between malignant and non-malignant tissues in 839 ovarian cancer and 115 non-malignant ovary samples. We furthermore assessed inflammation markers in 289 ovarian cancer patients’ sera in the Swedish Apolipoprotein MOrtality-related RISk (AMORIS) cohort. Expression of the 44 mediators could discriminate between malignant and non-malignant tissues with at least 96% accuracy. Higher expression of classical Th1, Th2, Th17, anti-parasitic/infection and M1 macrophage mediator signatures were associated with better OS. Contrastingly, inflammatory and angiogenic mediators, CXCL-12, C-reactive protein (CRP) and platelet-derived growth factor subunit A (PDGFA) were negatively associated with OS. Of the serum inflammatory markers in the AMORIS cohort, women with ovarian cancer who had elevated levels of haptoglobin (≥1.4 g/L) had a higher risk of dying from ovarian cancer compared to those with haptoglobin levels

Published
2019

43. An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE

Author

Josephs, Debra H, Nakamura, Mano, Bax, Heather J, Dodev, Tihomir S, Muirhead, Gareth, Saul, Louise, Karagiannis, Panagiotis, Ilieva, Kristina M, Crescioli, Silvia, Gazinska, Patrycja, Woodman, Natalie, Lomardelli, Cristina, Kareemaghay, Sedigeh, Selkirk, Christopher, Lentfer, Heike, Barton, Claire, Canevari, Silvana, Figini, Mariangela, Downes, Noel, Dombrowicz, David, Corrigan, Christopher J, Nestle, Frank O, Jones, Paul S, Gould, Hannah J, Blower, Philip J, Tsoka, Sophia, Spicer, James F, and Karagiannis, Sophia N

Abstract

BACKGROUND: Designing biologically informative models for assessing the safety of novel agents, especially for cancer immunotherapy, carries substantial challenges. The choice of an in vivo system for studies on IgE antibodies represents a major impediment to their clinical translation, especially with respect to class-specific immunological functions and safety. Fcε receptor expression and structure are different in humans and mice, so that the murine system is not informative when studying human IgE biology. By contrast, FcεRI expression and cellular distribution in rats mirrors that of humans.METHODS: We are developing MOv18 IgE, a human chimeric antibody recognizing the tumour-associated antigen folate receptor alpha. We created an immunologically congruent surrogate rat model likely to recapitulate human IgE-FcεR interactions, and engineered a surrogate rat IgE equivalent to MOv18. Employing this model, we examined in vivo safety and efficacy of anti-tumour IgE antibodies.RESULTS: In immunocompetent rats, rodent IgE restricted growth of syngeneic tumours in the absence of clinical, histopathological or metabolic signs associated with obvious toxicity. No physiological or immunological evidence of a 'cytokine-storm' or allergic response was seen, even at 50 mg/kg weekly doses. IgE treatment was associated with elevated serum concentrations of TNFα, a mediator previously linked with IgE-mediated anti-tumour and anti-parasitic functions, alongside evidence of substantially elevated tumoural immune cell infiltration and immunological pathway activation in tumour-bearing lungs.CONCLUSION: Our findings indicate safety of MOv18 IgE, in conjunction with efficacy and immune activation, supporting the translation of this therapeutic approach to the clinical arena. This article is protected by copyright. All rights reserved.

Published
2018

44. Targeting folate receptor alpha for cancer treatment

Author

Cheung, Anthony, Bax, Heather J., Josephs, Debra H., Ilieva, Kristina M., Pellizzari, Giulia, Opzoomer, James, Bloomfield, Jacinta, Fittall, Matthew, Grigoriadis, Anita, Figini, Mariangela, Canevari, Silvana, Spicer, James F., Tutt, Andrew N., and Karagiannis, Sophia N.

Subjects
folate receptor alpha, Neoplasms, cancer, biomarker, Humans, Folate Receptor 1, Review, monoclonal antibodies, immunotherapy
Abstract

Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα). FRα is a glycosylphosphatidylinositol (GPI)-anchored membrane protein. Its overexpression in tumors such as ovarian, breast and lung cancers, low and restricted distribution in normal tissues, alongside emerging insights into tumor-promoting functions and association of expression with patient prognosis, together render FRα an attractive therapeutic target. In this review, we summarize the role of FRα in cancer development, we consider FRα as a potential diagnostic and prognostic tool, and we discuss different targeted treatment approaches with a specific focus on monoclonal antibodies. Renewed attention to FRα may point to novel individualized treatment approaches to improve the clinical management of patient groups that do not adequately benefit from current conventional therapies.

Published
2016

45. Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Author

Hoffmann, Ricarda M, Coumbe, Ben G T, Josephs, Debra H, Mele, Silvia, Ilieva, Kristina M, Cheung, Anthony, Tutt, Andrew N, Spicer, James F, Thurston, David E, Crescioli, Silvia, and Karagiannis, Sophia N

Subjects
lcsh:Immunologic diseases. Allergy, immunoglobulin fc, stability, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, effector functions, body regions, igg1, kinetics, antibody drug conjugate (adc), igg4, antibodies, lcsh:RC581-607, biodistribution
Abstract

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of "toxic warheads", chemically linked to antibodies, and from fine-tuning the intricate properties of chemical linkers. Here, we focus on the antibody moiety of ADCs, dissecting the impact of Fab, linkers, isotype and Fc structure on the anti-tumoral and immune-activating functions of ADCs. Novel design approaches informed by antibody structural attributes present opportunities that may contribute to the success of next generation ADCs.

Published
2018

46. Abstract CT179: ATLAS: A Phase II, open-label study of rucaparib in patients with locally advanced or metastatic urothelial carcinoma

Author

Grivas, Petros, primary, Teo, Min Yuen, additional, Vogelzang, Nicholas, additional, Alva, Ajjai, additional, Zakharia, Yousef, additional, Adra, Nabil, additional, Drakaki, Alexandra, additional, Hussain, Arif, additional, Morales-Barrera, Rafael, additional, Necchi, Andrea, additional, Rodriguez-Vida, Alejo, additional, Feyerabend, Susan, additional, Gupta, Sumati, additional, Josephs, Debra H., additional, Loriot, Yohann, additional, Srinivas, Sandy, additional, Wride, Kenton, additional, Thomas, Daleen, additional, Dusek, Rachel, additional, Simmons, Andrew D., additional, Nepert, Dale, additional, and Chowdhury, Simon, additional

Published
2019
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47. AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody

Author

Ilieva, Kristina M., primary, Fazekas‐Singer, Judit, additional, Bax, Heather J., additional, Crescioli, Silvia, additional, Montero‐Morales, Laura, additional, Mele, Silvia, additional, Sow, Heng Sheng, additional, Stavraka, Chara, additional, Josephs, Debra H., additional, Spicer, James F., additional, Steinkellner, Herta, additional, Jensen‐Jarolim, Erika, additional, Tutt, Andrew N. J., additional, and Karagiannis, Sophia N., additional

Published
2019
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48. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states

Author

Pellizzari, Giulia, primary, Hoskin, Coran, additional, Crescioli, Silvia, additional, Mele, Silvia, additional, Gotovina, Jelena, additional, Chiaruttini, Giulia, additional, Bianchini, Rodolfo, additional, Ilieva, Kristina, additional, Bax, Heather J., additional, Papa, Sophie, additional, Lacy, Katie E., additional, Jensen-Jarolim, Erika, additional, Tsoka, Sophia, additional, Josephs, Debra H., additional, Spicer, James F., additional, and Karagiannis, Sophia N., additional

Published
2019
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49. Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma

Author

Khair, Duaa O., primary, Bax, Heather J., additional, Mele, Silvia, additional, Crescioli, Silvia, additional, Pellizzari, Giulia, additional, Khiabany, Atousa, additional, Nakamura, Mano, additional, Harris, Robert J., additional, French, Elise, additional, Hoffmann, Ricarda M., additional, Williams, Iwan P., additional, Cheung, Anthony, additional, Thair, Benjamin, additional, Beales, Charlie T., additional, Touizer, Emma, additional, Signell, Adrian W., additional, Tasnova, Nahrin L., additional, Spicer, James F., additional, Josephs, Debra H., additional, Geh, Jenny L., additional, MacKenzie Ross, Alastair, additional, Healy, Ciaran, additional, Papa, Sophie, additional, Lacy, Katie E., additional, and Karagiannis, Sophia N., additional

Published
2019
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50. AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Author

Untersmayr, Eva, primary, Bax, Heather J., additional, Bergmann, Christoph, additional, Bianchini, Rodolfo, additional, Cozen, Wendy, additional, Gould, Hannah J., additional, Hartmann, Karin, additional, Josephs, Debra H., additional, Levi‐Schaffer, Francesca, additional, Penichet, Manuel L., additional, O'Mahony, Liam, additional, Poli, Aurelie, additional, Redegeld, Frank A., additional, Roth‐Walter, Franziska, additional, Turner, Michelle C., additional, Vangelista, Luca, additional, Karagiannis, Sophia N., additional, and Jensen‐Jarolim, Erika, additional

Published
2019
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