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364 results on '"Josephs, Debra"'

1. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

Author

Spicer, James, Basu, Bristi, Montes, Ana, Banerji, Udai, Kristeleit, Rebecca, Miller, Rowan, Veal, Gareth J., Corrigan, Christopher J., Till, Stephen J., Figini, Mariangela, Canevari, Silvana, Barton, Claire, Jones, Paul, Mellor, Sarah, Carroll, Simon, Selkirk, Chris, Nintos, George, Kwatra, Vineet, Funingana, Ionut-Gabriel, Doherty, Gary, Gould, Hannah J., Pellizzari, Giulia, Nakamura, Mano, Ilieva, Kristina M., Khiabany, Atousa, Stavraka, Chara, Chauhan, Jitesh, Gillett, Cheryl, Pinder, Sarah, Bax, Heather J., Josephs, Debra H., and Karagiannis, Sophia N.

Published
2023
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2. Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

Author

Chauhan, Jitesh, Grandits, Melanie, Palhares, Lais C. G. F., Mele, Silvia, Nakamura, Mano, López-Abente, Jacobo, Crescioli, Silvia, Laddach, Roman, Romero-Clavijo, Pablo, Cheung, Anthony, Stavraka, Chara, Chenoweth, Alicia M., Sow, Heng Sheng, Chiaruttini, Giulia, Gilbert, Amy E., Dodev, Tihomir, Koers, Alexander, Pellizzari, Giulia, Ilieva, Kristina M., Man, Francis, Ali, Niwa, Hobbs, Carl, Lombardi, Sara, Lionarons, Daniël A., Gould, Hannah J., Beavil, Andrew J., Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Calonje, Eduardo, Downward, Julian, Nestle, Frank O., Tsoka, Sophia, Josephs, Debra H., Blower, Philip J., Karagiannis, Panagiotis, Lacy, Katie E., Spicer, James, Karagiannis, Sophia N., and Bax, Heather J.

Published
2023
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3. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Author

Bax, Heather J., Chauhan, Jitesh, Stavraka, Chara, Santaolalla, Aida, Osborn, Gabriel, Khiabany, Atousa, Grandits, Melanie, López-Abente, Jacobo, Palhares, Lais C. G. F., Chan Wah Hak, Charleen, Robinson, Alexandra, Pope, Amy, Woodman, Natalie, Naceur-Lombardelli, Cristina, Malas, Sadek, Coumbe, Jack E. M., Nakamura, Mano, Laddach, Roman, Mele, Silvia, Crescioli, Silvia, Black, Anna M., Lombardi, Sara, Canevari, Silvana, Figini, Mariangela, Sayasneh, Ahmad, Tsoka, Sophia, FitzGerald, Kevin, Gillett, Cheryl, Pinder, Sarah, Van Hemelrijck, Mieke, Kristeleit, Rebecca, Ghosh, Sharmistha, Montes, Ana, Spicer, James, Karagiannis, Sophia N., and Josephs, Debra H.

Published
2023
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4. Radical cancer treatment is safe during COVID-19: the real-world experience of a large London-based Comprehensive Cancer Centre during the first wave

Author

Russell, Beth, Moss, Charlotte, Monroy-Iglesias, Maria, Roberts, Graham, Dickinson, Harvey, Haire, Kate, Innes, Kathryn, Mulji-Shah, Bansi, Castell, Fiona, Al-Salihi, Omar, Lei, Mary, Francis, Angela, Dann, Bill, Jogia, Vikash, Hamid, Hisham, Challacombe, Ben, Simo, Ricard, Fraser, Stephanie, Gousis, Charalampos, Sawyer, Elinor, Tsotra, Eirini, Roca, Jose, Khan, Muhammad, Josephs, Debra, Enting, Deborah, Van Hemelrijck, Mieke, Harris, Victoria, and Dolly, Saoirse

Published
2022
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5. Update on the prognostic value of a novel immune-related toxicity grading system (OST score) in patients with advanced solid tumours treated with immune checkpoint inhibitors (ICI).

Author

Kapiris, Matthaios, primary, Santaolalla, Aida, additional, Bratsos, Sosipatros, additional, Guhnam, Sundeep, additional, McDonald, Louisa, additional, Fitzpatrick-Greening, Mary, additional, Muhith, Moe, additional, Wu, Yin, additional, Georgiou, Alexandros, additional, Josephs, Debra Hannah, additional, Sarker, Debashis, additional, and Cope, Andrew, additional

Published
2024
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6. Nivolumab and ipilimumab for metastatic prostate cancer with an immunogenic signature: The NEPTUNES multi-centre two-cohort, biomarker-selected phase 2 trial.

Author

Linch, Mark David, primary, Leone, Gianmarco, additional, Wong, Yien Ning Sophia, additional, Jones, Robert J., additional, Sankey, Peter, additional, Josephs, Debra Hannah, additional, Crabb, Simon J., additional, Harris, Louise, additional, Tasnim, Aniqa, additional, Rashid, Memuna, additional, Quezada, Sergio A., additional, Ensell, Leah, additional, Jayaram, Anuradha, additional, Kayani, Mahaz, additional, Pritchard, Colin C., additional, Freeman, Alex, additional, Haider, Aiman, additional, Attard, Gerhardt, additional, Swanton, Charles, additional, and Marafioti, Teresa, additional

Published
2024
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9. A cohort profile of the Graham Roberts study cohort

Author

Russell, Beth, primary, Leech, Poppy, additional, Wylie, Harriet, additional, Moss, Charlotte Louise, additional, Haire, Anna, additional, Enting, Deborah, additional, Amery, Suzanne, additional, Chatterton, Kathryn, additional, Khan, Muhammad Shamim, additional, Thurairaja, Ramesh, additional, Nair, Rajesh, additional, Malde, Sachin, additional, Smith, Kate, additional, Gillett, Cheryl, additional, Josephs, Debra, additional, Pintus, Elias, additional, Rudman, Sarah, additional, Hughes, Simon, additional, Relton, Clare, additional, and Van Hemelrijck, Mieke, additional

Published
2024
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14. Cohort profile: King’s Health Partners bladder cancer biobank

Author

Kotecha, Pinky, Moss, Charlotte L., Enting, Deborah, Gillett, Cheryl, Joseph, Magdalene, Josephs, Debra, Rudman, Sarah, Hughes, Simon, Cahill, Fidelma, Wylie, Harriet, Haire, Anna, Rosekilly, James, Khan, Muhammad Shamin, Nair, Rajesh, Thurairaja, Ramesh, Malde, Sachin, and Van Hemelrijck, Mieke

Published
2020
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15. Supplementary figures from Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

Author

Cheung, Anthony, primary, Opzoomer, James, primary, Ilieva, Kristina M., primary, Gazinska, Patrycja, primary, Hoffmann, Ricarda M., primary, Mirza, Hasan, primary, Marlow, Rebecca, primary, Francesch-Domenech, Erika, primary, Fittall, Matthew, primary, Dominguez Rodriguez, Diana, primary, Clifford, Angela, primary, Badder, Luned, primary, Patel, Nirmesh, primary, Mele, Silvia, primary, Pellizzari, Giulia, primary, Bax, Heather J., primary, Crescioli, Silvia, primary, Petranyi, Gyula, primary, Larcombe-Young, Daniel, primary, Josephs, Debra H., primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Pinder, Sarah, primary, Nestle, Frank O., primary, Gillett, Cheryl, primary, Spicer, James F., primary, Grigoriadis, Anita, primary, Tutt, Andrew N.J., primary, and Karagiannis, Sophia N., primary

Published
2023
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16. Supplementary Table S1 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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17. Data from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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18. Supplementary Materials and Methods from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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19. Supplementary Figure Legends from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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20. Supplementary Figure S1 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Author

Josephs, Debra H., primary, Bax, Heather J., primary, Dodev, Tihomir, primary, Georgouli, Mirella, primary, Nakamura, Mano, primary, Pellizzari, Giulia, primary, Saul, Louise, primary, Karagiannis, Panagiotis, primary, Cheung, Anthony, primary, Herraiz, Cecilia, primary, Ilieva, Kristina M., primary, Correa, Isabel, primary, Fittall, Matthew, primary, Crescioli, Silvia, primary, Gazinska, Patrycja, primary, Woodman, Natalie, primary, Mele, Silvia, primary, Chiaruttini, Giulia, primary, Gilbert, Amy E., primary, Koers, Alexander, primary, Bracher, Marguerite, primary, Selkirk, Christopher, primary, Lentfer, Heike, primary, Barton, Claire, primary, Lever, Elliott, primary, Muirhead, Gareth, primary, Tsoka, Sophia, primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Montes, Ana, primary, Downes, Noel, primary, Dombrowicz, David, primary, Corrigan, Christopher J., primary, Beavil, Andrew J., primary, Nestle, Frank O., primary, Jones, Paul S., primary, Gould, Hannah J., primary, Sanz-Moreno, Victoria, primary, Blower, Philip J., primary, Spicer, James F., primary, and Karagiannis, Sophia N., primary

Published
2023
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25. Non-Small Cell Lung Cancer (NSCLC) in Young Adults, Age < 50, Is Associated with Late Stage at Presentation and a Very Poor Prognosis in Patients That Do Not Have a Targeted Therapy Option: A Real-World Study

Author

Hughes, Daniel Johnathan, primary, Kapiris, Matthaios, additional, Podvez Nevajda, Andreja, additional, McGrath, Harriet, additional, Stavraka, Chara, additional, Ahmad, Shahreen, additional, Taylor, Benjamin, additional, Cook, Gary J. R., additional, Ghosh, Sharmistha, additional, Josephs, Debra, additional, Pintus, Elias, additional, Gennatas, Spyridon, additional, Bille, Andrea, additional, Ryanna, Kimuli, additional, Santis, George, additional, Montes, Ana, additional, Van Hemelrijck, Mieke, additional, Karapanagiotou, Eleni, additional, Smith, Daniel, additional, Spicer, James, additional, and Georgiou, Alexandros, additional

Published
2022
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26. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Author

Bax, Heather J., primary, Chauhan, Jitesh, additional, Stavraka, Chara, additional, Santaolalla, Aida, additional, Osborn, Gabriel, additional, Khiabany, Atousa, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Palhares, Lais C. G. F., additional, Chan Wah Hak, Charleen, additional, Robinson, Alexandra, additional, Pope, Amy, additional, Woodman, Natalie, additional, Naceur-Lombardelli, Cristina, additional, Malas, Sadek, additional, Coumbe, Jack E. M., additional, Nakamura, Mano, additional, Laddach, Roman, additional, Mele, Silvia, additional, Crescioli, Silvia, additional, Black, Anna M., additional, Lombardi, Sara, additional, Canevari, Silvana, additional, Figini, Mariangela, additional, Sayasneh, Ahmad, additional, Tsoka, Sophia, additional, FitzGerald, Kevin, additional, Gillett, Cheryl, additional, Pinder, Sarah, additional, Van Hemelrijck, Mieke, additional, Kristeleit, Rebecca, additional, Ghosh, Sharmistha, additional, Montes, Ana, additional, Spicer, James, additional, Karagiannis, Sophia N., additional, and Josephs, Debra H., additional

Published
2022
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29. [99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression.

Author

Nazir, Muhummad Sohaib, Hughes, Daniel Johnathan, Chand, Gitasha, Adamson, Kathryn, Johnson, Jessica, Bailey, Damion, Gibson, Victoria, Ting, Hong Hoi, Lyon, Alexander R., Cook, Gary J. R., PECan study group, Edmonds, Scott, Georgiou, Alexandros, Karapanagiotou, Eleni, Josephs, Debra, McLean, Emma, Spicer, James, and Goh, Vicky

Subjects
MYOCARDIAL perfusion imaging, IMMUNOGLOBULINS, MYOCARDIUM, COMPUTED tomography, PROGRAMMED death-ligand 1, MAJOR adverse cardiovascular events, SINGLE-photon emission computed tomography, BIOMARKERS
Abstract

Background: Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechanistic and predictive biomarker. The aim of this study was to determine non-invasive assessment of myocardial PD-L1 expression using [99mTc]-labelled anti-PD-L1 single-domain antibody (NM-01) SPECT/CT. Methods: Thoracic [99mTc]NM-01 SPECT/CT was performed in lung cancer patients (n = 10) at baseline and 9-weeks following anti-programmed cell death protein 1 (PD-1) therapy. Baseline and 9-week left ventricular and right ventricular to blood pool ratios (LVmax:BP) and (RVmax:BP) were measured. LVmax was compared to background skeletal muscle (musclemax). Intra-rater reliability was determined by intraclass correlation coefficient (ICC) and Bland–Altman analysis. Results: Mean LVmax:BP values were 2.76 ± 0.67 at baseline vs 2.55 ± 0.77 at 9 weeks (p = 0.42). Mean RVmax:BP was 1.82 ± 0.32 at baseline vs 1.76 ± 0.45 at 9 weeks (p = 0.67). Myocardial PD-L1 expression was at least threefold greater than skeletal muscle at baseline for the LV (LVmax to musclemax 3.71 ± 0.77 vs 0.98 ± 0.20 (p < 0.001)) and at least twofold for the RV (LVmax to musclemax 2.49 ± 0.63 vs 0.98 ± 0.20 (p < 0.001)). There was excellent intra-rater reliability for LVmax:BP with ICC 0.99 (95% confidence interval 0.94–0.99, p < 0.001), mean bias -0.05 ± 0.14 (95% limits of agreement -0.32 to 0.21). There were no major adverse cardiovascular events or myocarditis during follow-up. Conclusion: This study is the first to report PD-L1 expression of the heart that can be quantified non-invasively without invasive myocardial biopsy, with high reliability and specificity. This technique can be applied to investigate myocardial PD-L1 expression in ICI-associated myocarditis and cardiomyopathies. Clinical trial registration PD-L1 Expression in Cancer (PECan) study (NCT04436406). https://clinicaltrials.gov/ct2/show/NCT04436406 June 18th, 2020. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay

Author

Orlando, Francesco, Romanel, Alessandro, Trujillo, Blanca, Sigouros, Michael, Wetterskog, Daniel, Quaini, Orsetta, Leone, Gianmarco, Xiang, Jenny Z, Wingate, Anna, Tagawa, Scott, Jayaram, Anuradha, Linch, Mark, Swanton, Charles, Jamal-Hanjani, Mariam, Abbosh, Chris, Zaccaria, Simone, Hessey, Sonya, Shiu, Kai-Keen, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Lee, Siow-Ming, Ahmad, Tanya, Papadatos-Pastos, Dionysis, Janes, Sam, Van Loo, Peter, Enfield, Katey, McGranahan, Nicholas, Huebner, Ariana, Quezada, Sergio, Beck, Stephan, Parker, Peter, Enver, Tariq, Hynds, Robert E, Dijkstra, Krijn, Pearce, David R, Falzon, Mary, Proctor, Ian, Sinclair, Ron, Lok, Chi-wah, Rhodes, Zoe, Moore, David, Marafioti, Teresa, Mitchison, Miriam, Ellery, Peter, Sivakumar, Monica, Brandner, Sebastian, Rowan, Andrew, Hiley, Crispin, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Prymas, Paulina, Watkins, Tom, Bailey, Chris, Ruiz, Carlos Martinez, Litchfield, Kevin, Al-Bakir, Maise, Kanu, Nnenna, Ward, Sophie, Lim, Emilia, Reading, James, Chain, Benny, Alba, Blanca Trujillo, Akay, Melek, Flanagan, Adrienne, Biswas, Dhruva, Pich, Oriol, Dietzen, Michelle, Puttick, Clare, Colliver, Emma, Magness, Alistair, Angelova, Mihaela, Black, James, Lucas, Olivia, Hill, William, Liu, Wing-Kin, Frankell, Alexander, Magno, Neil, Athanasopoulou, Foteini, Wilson, Gareth, Rosenthal, Rachel, Salgado, Roberto, Lee, Claudia, Grigoriadis, Kristiana, Al-Sawaf, Othman, Karasaki, Takahiro, Bunkum, Abigail, Noorani, Imran, Benafif, Sarah, Barbe, Vittorio, Bola, Supreet, Vainauskas, Osvaldas, Hasan, Mahedi, Lise, Stefano, Leone, GianMarco, Alifrangis, Constantine, McGovern, Ursula, Thol, Kerstin, Gamble, Samuel, Ung, Seng Kuong, Sahwangarrom, Teerapon, Marin, Claudia Peinador, Wong, Sophia, Pawlik, Piotr, Gishen, Faye, Tookman, Adrian, Stone, Paddy, Stirling, Caroline, Turajlic, Samra, Larkin, James, Pickering, Lisa, Furness, Andrew, Young, Kate, Drake, Will, Edmonds, Kim, Hunter, Nikki, Mangwende, Mary, Pearce, Karla, Grostate, Lauren, Au, Lewis, Spain, Lavinia, Shepherd, Scott, Yan, Haixi, Shum, Ben, Tippu, Zayd, Hanley, Brian, Spencer, Charlotte, Emmerich, Max, Gerard, Camille, Schmitt, Andreas Michael, Del Rosario, Lyra, Carlyle, Eleanor, Lewis, Charlotte, Holt, Lucy, Lucanas, Analyn, O'Flaherty, Molly, Hazell, Steve, Mudhar, Hardeep, Messiou, Christina, Latifoltojar, Arash, Fendler, Annika, Byrne, Fiona, Pallinkonda, Husayn, Lobon, Irene, Coulton, Alex, Cattin, Anne Laure, Deng, Daqi, Feng, Geoffrey Hugang, Rowan, Andew, Yousaf, Nadia, Popat, Sanjay, Curtis, Olivia, Milner-Watts, Charlotte, Stamp, Gordon, Nye, Emma, Murra, Aida, Korteweg, Justine, Kelly, Denise, Terry, Lauren, Biano, Jennifer, Peat, Kema, Kelly, Kayleigh, Hill, Peter, Josephs, Debra, Irshad, Sheeba, Chandra, Ashish, Spicer, James, Mahadeva, Ula, Green, Anna, Stewart, Ruby, Iredale, Lara-Rose, Mackay, Tina, Deakin, Ben, Enting, Debra, Rudman, Sarah, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Brenton, James, Caldas, Carlos, Fitzgerald, Rebecca, Jimenez-Linan, Merche, Provenzano, Elena, Cluroe, Alison, Paterson, Anna, Aitken, Sarah, Allinson, Kieren, Stewart, Grant, McDermott, Ultan, Beddowes, Emma, Maughan, Tim, Ansorge, Olaf, Campbell, Peter, Roxburgh, Patricia, Fraser, Sioban, Kidd, Andrew, Blyth, Kevin, Le Quesne, John, Krebs, Matthew, Blackhall, Fiona, Summers, Yvonne, Oliveira, Pedro, Ortega-Franco, Ana, Dive, Caroline, Gomes, Fabio, Carter, Mat, Dransfield, Jo, Thomas, Anne, Fennell, Dean, Shaw, Jacqui, Naidu, Babu, Baijal, Shobhit, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Collard, Martin, Cockcroft, Peter, Ferris, Charlotte, Bancroft, Hollie, Kerr, Amy, Middleton, Gary, Webb, Joanne, Kadiri, Salma, Colloby, Peter, Olisemeke, Bernard, Wilson, Rodelaine, Tomlinson, Ian, McNeish, Iain, Jogai, Sanjay, Holden, Samantha, Fernandes, Tania, Hampton, Blanche, McKenzie, Mairead, Hackshaw, Allan, Sharp, Abby, Chan, Kitty, Farrelly, Laura, Bridger, Hayley, Leslie, Rachel, Consortium, PEACE, Rubin, Mark A, Wyatt, Alexander W, Beltran, Himisha, Attard, Gerhardt, and Demichelis, Francesca

Subjects
Chemical Biology & High Throughput, Signalling & Oncogenes, Human Biology & Physiology, Ecology,Evolution & Ethology, Genome Integrity & Repair, Tumour Biology, Genetics & Genomics, Computational & Systems Biology
Abstract

Sequencing of cell-free DNA (cfDNA) in cancer patients’ plasma offers a minimally-invasive solution to detect tumor cell genomic alterations to aid real-time clinical decision-making. The reliability of copy number detection decreases at lower cfDNA tumor fractions, limiting utility at earlier stages of the disease. To test a novel strategy for detection of allelic imbalance, we developed a prostate cancer bespoke assay, PCF_SELECT, that includes an innovative sequencing panel covering ∼25 000 high minor allele frequency SNPs and tailored analytical solutions to enable allele-informed evaluation. First, we assessed it on plasma samples from 50 advanced prostate cancer patients. We then confirmed improved detection of genomic alterations in samples with

Published
2022
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31. Additional file 1 of Safe provision of systemic anti-cancer treatment for urological cancer patients during COVID-19: a tertiary centre experience in the first wave of COVID-19

Author

So, Alfred Chung Pui, Karampera, Christina, Khan, Muhammad, Russell, Beth, Moss, Charlotte, Monroy-Iglesias, Maria J., Thillai, Kiruthikah, Josephs, Debra Hannah, Pintus, Elias, Rudman, Sarah, Van Hemelrijck, Mieke, Dolly, Saoirse, and Enting, Deborah

Subjects
endocrine system, endocrine system diseases, urogenital system, urologic and male genital diseases
Abstract

Additional file 1: Table S1. Patient demographics of prostate, renal, urothelial, and testicular cancer groups. Table S2. Oncological characteristics of prostate, renal, urothelial, and testicular cancer groups.

Published
2022
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32. AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper

Author

Bergmann, Christoph, primary, Poli, Aurélie, additional, Agache, Ioana, additional, Bianchini, Rodolfo, additional, Bax, Heather J., additional, Castells, Mariana, additional, Crescioli, Silvia, additional, Dombrowicz, David, additional, Ferastraoaru, Denisa, additional, Fiebiger, Edda, additional, Gould, Hannah J., additional, Hartmann, Karin, additional, Izquierdo, Elena, additional, Jordakieva, Galateja, additional, Josephs, Debra H., additional, Jutel, Marek, additional, Levi‐Schaffer, Francesca, additional, de las Vecillas, Leticia, additional, Lotze, Michael T., additional, Osborn, Gabriel, additional, Pascal, Mariona, additional, Redegeld, Frank, additional, Rosenstreich, David, additional, Roth‐Walter, Franziska, additional, Schmidt‐Weber, Carsten, additional, Shamji, Mohamed, additional, Steveling, Esther H., additional, Turner, Michelle C., additional, Untersmayr, Eva, additional, Jensen‐Jarolim, Erika, additional, and Karagiannis, Sophia N., additional

Published
2022
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33. Clinical predictors of long-term efficacy of first-line pembrolizumab monotherapy in non-small cell lung cancer (NSCLC): an interim analysis of real-world data

Author

Younan, Helen-Cara, primary, Zhang, Shuai, additional, Monroy, Maria, additional, Almusarhed, Manar, additional, Julve, Max, additional, Roy, Debashree, additional, Toghey, Sopozme, additional, Ahmed, Zartaj, additional, Slater, Stephanie, additional, Altharwane, Shaymaa, additional, Giorgiou, Alex, additional, Ghosh, Sharmistha, additional, Gennatas, Spyridon, additional, Karapanagiotou, Eleni, additional, Montes, Ana, additional, Pintus, Elias, additional, Spicer, James, additional, Shah, Riyaz, additional, Ahmed, Samreen, additional, Newsom-Davis, Tom, additional, Mohammed, Waleed, additional, Power, Danielle, additional, Evans, Joanne, additional, Hatcher, Olivia, additional, Lakhani, Amish, additional, Samani, Amit, additional, and Josephs, Debra, additional

Published
2022
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35. Safe Provision of Systemic Anti-Cancer Treatment for Urological Cancer Patients During COVID-19: A Tertiary Centre Experience in the First Wave of COVID-19

Author

So, Alfred Chung Pui, primary, Karampera, Christina, additional, Khan, Muhammad, additional, Russell, Beth, additional, Moss, Charlotte, additional, Monroy-Iglesias, Maria J, additional, Thillai, Kiruthikah, additional, Josephs, Debra Hannah, additional, Pintus, Elias, additional, Rudman, Sarah, additional, Hemelrijck, Mieke, additional, Dolly, Saoirse, additional, and Enting, Deborah, additional

Published
2022
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36. The Impact of COVID-19 on the Delivery of Systemic Anti-Cancer Treatment at Guy’s Cancer Centre

Author

Russell, Beth, primary, Moss, Charlotte, additional, Tsotra, Eirini, additional, Gousis, Charalampos, additional, Josephs, Debra, additional, Enting, Deborah, additional, Karampera, Christina, additional, Khan, Muhammad, additional, Roca, Jose, additional, Sita-Lumsden, Ailsa, additional, Owczarczyk, Kasia, additional, Wylie, Harriet, additional, Haire, Anna, additional, Smith, Daniel, additional, Zaki, Kamarul, additional, Swampillai, Angela, additional, Lei, Mary, additional, Manik, Vishal, additional, Michalarea, Vasiliki, additional, Kristeleit, Rebecca, additional, Mera, Anca, additional, Sawyer, Elinor, additional, Flanders, Lucy, additional, De Francesco, Irene, additional, Papa, Sophie, additional, Ross, Paul, additional, Spicer, James, additional, Dann, Bill, additional, Jogia, Vikash, additional, Shaunak, Nisha, additional, Kristeleit, Hartmut, additional, Rigg, Anne, additional, Montes, Ana, additional, Van Hemelrijck, Mieke, additional, and Dolly, Saoirse, additional

Published
2022
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38. Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

Author

Au, Lewis, primary, Hatipoglu, Emine, additional, Robert de Massy, Marc, additional, Litchfield, Kevin, additional, Beattie, Gordon, additional, Rowan, Andrew, additional, Schnidrig, Desiree, additional, Thompson, Rachael, additional, Byrne, Fiona, additional, Horswell, Stuart, additional, Fotiadis, Nicos, additional, Hazell, Steve, additional, Nicol, David, additional, Shepherd, Scott T.C., additional, Fendler, Annika, additional, Mason, Robert, additional, Del Rosario, Lyra, additional, Edmonds, Kim, additional, Lingard, Karla, additional, Sarker, Sarah, additional, Mangwende, Mary, additional, Carlyle, Eleanor, additional, Attig, Jan, additional, Joshi, Kroopa, additional, Uddin, Imran, additional, Becker, Pablo D., additional, Sunderland, Mariana Werner, additional, Akarca, Ayse, additional, Puccio, Ignazio, additional, Yang, William W., additional, Lund, Tom, additional, Dhillon, Kim, additional, Vasquez, Marcos Duran, additional, Ghorani, Ehsan, additional, Xu, Hang, additional, Spencer, Charlotte, additional, López, José I., additional, Green, Anna, additional, Mahadeva, Ula, additional, Borg, Elaine, additional, Mitchison, Miriam, additional, Moore, David A., additional, Proctor, Ian, additional, Falzon, Mary, additional, Pickering, Lisa, additional, Furness, Andrew J.S., additional, Reading, James L., additional, Salgado, Roberto, additional, Marafioti, Teresa, additional, Jamal-Hanjani, Mariam, additional, Kassiotis, George, additional, Chain, Benny, additional, Larkin, James, additional, Swanton, Charles, additional, Quezada, Sergio A., additional, Turajlic, Samra, additional, Abbosh, Chris, additional, Shiu, Kai-Keen, additional, Bridgewater, John, additional, Hochhauser, Daniel, additional, Forster, Martin, additional, Lee, Siow-Ming, additional, Ahmad, Tanya, additional, Papadatos-Pastos, Dionysis, additional, Janes, Sam, additional, Van Loo, Peter, additional, Enfield, Katey, additional, McGranahan, Nicholas, additional, Huebner, Ariana, additional, Beck, Stephan, additional, Parker, Peter, additional, Walczak, Henning, additional, Enver, Tariq, additional, Hynds, Rob, additional, Sinclair, Ron, additional, Lok, Chi-wah, additional, Rhodes, Zoe, additional, Moore, David, additional, Khiroya, Reena, additional, Trevisan, Giorgia, additional, Ellery, Peter, additional, Linch, Mark, additional, Brandner, Sebastian, additional, Hiley, Crispin, additional, Veeriah, Selvaraju, additional, Razaq, Maryam, additional, Shaw, Heather, additional, Attard, Gert, additional, Akther, Mita Afroza, additional, Naceur-Lombardelli, Cristina, additional, Manzano, Lizi, additional, Al-Bakir, Maise, additional, Summan, Simranpreet, additional, Kanu, Nnenna, additional, Ward, Sophie, additional, Asghar, Uzma, additional, Lim, Emilia, additional, Gishen, Faye, additional, Tookman, Adrian, additional, Stone, Paddy, additional, Stirling, Caroline, additional, Hunter, Nikki, additional, Vaughan, Sarah, additional, Spain, Lavinia, additional, Yan, Haixi, additional, Shum, Ben, additional, Yousaf, Nadia, additional, Popat, Sanjay, additional, Curtis, Olivia, additional, Stamp, Gordon, additional, Toncheva, Antonia, additional, Nye, Emma, additional, Murra, Aida, additional, Korteweg, Justine, additional, Josephs, Debra, additional, Chandra, Ashish, additional, Spicer, James, additional, Stewart, Ruby, additional, Iredale, Lara-Rose, additional, Mackay, Tina, additional, Deakin, Ben, additional, Enting, Debra, additional, Rudman, Sarah, additional, Ghosh, Sharmistha, additional, Karapagniotou, Lena, additional, Pintus, Elias, additional, Tutt, Andrew, additional, Howlett, Sarah, additional, Michalarea, Vasiliki, additional, Brenton, James, additional, Caldas, Carlos, additional, Fitzgerald, Rebecca, additional, Jimenez-Linan, Merche, additional, Provenzano, Elena, additional, Cluroe, Alison, additional, Stewart, Grant, additional, Watts, Colin, additional, Gilbertson, Richard, additional, McDermott, Ultan, additional, Tavare, Simon, additional, Beddowes, Emma, additional, Roxburgh, Patricia, additional, Biankin, Andrew, additional, Chalmers, Anthony, additional, Fraser, Sioban, additional, Oien, Karin, additional, Kidd, Andrew, additional, Blyth, Kevin, additional, Krebs, Matt, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Dive, Caroline, additional, Marais, Richard, additional, Gomes, Fabio, additional, Carter, Mat, additional, Dransfield, Jo, additional, Le Quesne, John, additional, Fennell, Dean, additional, Shaw, Jacqui, additional, Naidu, Babu, additional, Baijal, Shobhit, additional, Tanchel, Bruce, additional, Langman, Gerald, additional, Robinson, Andrew, additional, Collard, Martin, additional, Cockcroft, Peter, additional, Ferris, Charlotte, additional, Bancroft, Hollie, additional, Kerr, Amy, additional, Middleton, Gary, additional, Webb, Joanne, additional, Kadiri, Salma, additional, Colloby, Peter, additional, Olisemeke, Bernard, additional, Wilson, Rodelaine, additional, Tomlinson, Ian, additional, Jogai, Sanjay, additional, Ottensmeier, Christian, additional, Harrison, David, additional, Loda, Massimo, additional, Flanagan, Adrienne, additional, McKenzie, Mairead, additional, Hackshaw, Allan, additional, Ledermann, Jonathan, additional, Chan, Kitty, additional, Sharp, Abby, additional, Farrelly, Laura, additional, Bridger, Hayley, additional, Challacombe, Ben, additional, Chowdhury, Simon, additional, Drake, William, additional, Fernando, Archana, additional, Harrison-Phipps, Karen, additional, Hill, Peter, additional, Horsfield, Catherine, additional, O'Brien, Tim, additional, Olsburgh, Jonathon, additional, Polson, Alexander, additional, Varia, Mary, additional, and Verma, Hema, additional

Published
2021
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41. Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments

Author

McCraw, Alex J., primary, Chauhan, Jitesh, additional, Bax, Heather J., additional, Stavraka, Chara, additional, Osborn, Gabriel, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Josephs, Debra H., additional, Spicer, James, additional, Wagner, Gerd K., additional, Karagiannis, Sophia N., additional, Chenoweth, Alicia, additional, and Crescioli, Silvia, additional

Published
2021
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42. Abstract LB004: Nivolumab (NIVO) and ipilimumab (IPI) treatment in prostate cancer with an immunogenic signature: cohort 1 of the NEPTUNES multi-centre, two-stage biomarker-selected Phase II trial

Author

Linch, Mark D., primary, Wong, Yien Ning Sophia, additional, Jones, Robert, additional, Sankey, Peter, additional, Josephs, Debra H., additional, Crabb, Simon J., additional, Staffurth, John, additional, Zarkar, Anjali, additional, White, Laura, additional, Duggan, Marian, additional, Pellizzari, Giulia, additional, Wheeler, Graham, additional, Beare, Sandy, additional, Cartwright, Hayley, additional, Linares, Josep, additional, Akarca, Ayse, additional, Quezada, Sergio A., additional, Ensell, Leah, additional, Hartley, John, additional, Attard, Gerhardt, additional, Burr, Joanna, additional, Jayaram, Anuradha, additional, Kularatne, Bihani, additional, Kayani, Mahaz, additional, Chung, Moon, additional, Pritchard, Colin C., additional, Freeman, Alex, additional, Haider, Aiman, additional, and Marafioti, Teresa, additional

Published
2021
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44. IgG4 subclass antibodies impair antitumor immunity in melanoma

Author

Karagiannis, Panagiotis, Gilbert, Amy E., Josephs, Debra H., Ali, Niwa, Dodev, Tihomir, Saul, Louise, Correa, Isabel, Roberts, Luke, Beddowes, Emma, Koers, Alexander, Hobbs, Carl, Ferreira, Silvia, Geh, Jenny L.C., Healy, Ciaran, Harries, Mark, Acland, Katharine M., Blower, Philip J., Mitchell, Tracey, Fear, David J., Spicer, James F., Lacy, Katie E., Nestle, Frank O., and Karagiannis, Sophia N.

Subjects
Immunity -- Research, Immunoglobulin G -- Health aspects, Melanoma -- Research, Health care industry
Abstract

Host-induced antibodies and their contributions to cancer inflammation are largely unexplored. IgG4 sub-class antibodies are present in IL-10-driven Th2 immune responses in some inflammatory conditions. Since Th2-biased inflammation is a [...]

Published
2013
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45. Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2

Author

Pellizzari, Giulia, primary, Martinez, Olivier, additional, Crescioli, Silvia, additional, Page, Robert, additional, Di Meo, Ashley, additional, Mele, Silvia, additional, Chiaruttini, Giulia, additional, Hoinka, Jan, additional, Batruch, Ihor, additional, Prassas, Ioannis, additional, Grandits, Melanie, additional, López-Abente, Jacobo, additional, Bugallo-Blanco, Eva, additional, Ward, Malcolm, additional, Bax, Heather J, additional, French, Elise, additional, Cheung, Anthony, additional, Lombardi, Sara, additional, Figini, Mariangela, additional, Lacy, Katie E, additional, Diamandis, Eleftherios P, additional, Josephs, Debra H, additional, Spicer, James, additional, Papa, Sophie, additional, and Karagiannis, Sophia N, additional

Published
2021
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46. The impact of COVID-19 on delivery of systemic anti-cancer treatment in urological cancer patients: A comparison with 2019 data from Guy’s Cancer Center.

Author

Karampera, Christina, primary, Khan, Muhammad, additional, Russell, Beth, additional, Moss, Charlotte, additional, Monroy-Iglesias, Maria J, additional, Dolly, Saoirse, additional, Thillai, Kiruthikah, additional, Josephs, Debra Hannah, additional, Pintus, Elias, additional, Rudman, Sarah, additional, Van Hemelrijck, Mieke, additional, and Enting, Deborah, additional

Published
2021
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47. COVID-19 Risk Factors for Cancer Patients: A First Report with Comparator Data from COVID-19 Negative Cancer Patients

Author

Russell, Beth, primary, Moss, Charlotte L., additional, Palmer, Kieran, additional, Sylva, Rushan, additional, D’Souza, Andrea, additional, Wylie, Harriet, additional, Haire, Anna, additional, Cahill, Fidelma, additional, Steel, Renee, additional, Hoyes, Angela, additional, Wilson, Isabelle, additional, Macneil, Alyson, additional, Shifa, Belul, additional, Monroy-Iglesias, Maria J, additional, Papa, Sophie, additional, Irshad, Sheeba, additional, Ross, Paul, additional, Spicer, James, additional, Kordasti, Shahram, additional, Crawley, Danielle, additional, Zaki, Kamarul, additional, Sita-Lumsden, Ailsa, additional, Josephs, Debra, additional, Enting, Deborah, additional, Swampillai, Angela, additional, Sawyer, Elinor, additional, Fields, Paul, additional, Wrench, David, additional, Rigg, Anne, additional, Sullivan, Richard, additional, Van Hemelrijck, Mieke, additional, and Dolly, Saoirse, additional

Published
2021
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