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1. Spatial distribution and characterization of non-apical progenitors in the zebrafish embryo central nervous system

Author

Rebecca McIntosh, Joseph Norris, Jon D. Clarke, and Paula Alexandre

Subjects
zebrafish, neurogenesis, basal progenitors, vsx1, live imaging, intermediate progenitors, Biology (General), QH301-705.5
Abstract

Studies of non-apical progenitors (NAPs) have been largely limited to the developing mammalian cortex. They are postulated to generate the increase in neuron numbers that underlie mammalian brain expansion. Recently, NAPs have also been reported in the retina and central nervous system of non-mammalian species; in the latter, however, they remain poorly characterized. Here, we characterize NAP location along the zebrafish central nervous system during embryonic development, and determine their cellular and molecular characteristics and renewal capacity. We identified a small population of NAPs in the spinal cord, hindbrain and telencephalon of zebrafish embryos. Live-imaging analysis revealed at least two types of mitotic behaviour in the telencephalon: one NAP subtype retains the apical attachment during division, while another divides in a subapical position disconnected from the apical surface. All NAPs observed in spinal cord lost apical contact prior to mitoses. These NAPs express HuC and produce two neurons from a single division. Manipulation of Notch activity reveals that neurons and NAPs in the spinal cord use similar regulatory mechanisms. This work suggests that the majority of spinal NAPs in zebrafish share characteristics with basal progenitors in mammalian brains.

Published
2017
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2. Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study

Author

Sinan Khadhouri, Kevin M. Gallagher, Kenneth R. MacKenzie, Taimur T. Shah, Chuanyu Gao, Sacha Moore, Eleanor F. Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Thineskrishna Anbarasan, Miles P. Mannas, Taeweon Lee, Giancarlo Marra, Juan Gómez Rivas, Gautier Marcq, Mark A. Assmus, Taha Uçar, Francesco Claps, Matteo Boltri, Giuseppe La Montagna, Tara Burnhope, Nkwam Nkwam, Tomas Austin, Nicholas E. Boxall, Alison P. Downey, Troy A. Sukhu, Marta Antón-Juanilla, Sonpreet Rai, Yew-Fung Chin, Madeline Moore, Tamsin Drake, James S.A. Green, Beatriz Goulao, Graeme MacLennan, Matthew Nielsen, John S. McGrath, Veeru Kasivisvanathan, Aasem Chaudry, Abhishek Sharma, Adam Bennett, Adnan Ahmad, Ahmed Abroaf, Ahmed Musa Suliman, Aimee Lloyd, Alastair McKay, Albert Wong, Alberto Silva, Alexandre Schneider, Alison MacKay, Allen Knight, Alkiviadis Grigorakis, Amar Bdesha, Amy Nagle, Ana Cebola, Ananda Kumar Dhanasekaran, Andraž Kondža, André Barcelos, Andrea Benedetto Galosi, Andrea Ebur, Andrea Minervini, Andrew Russell, Andrew Webb, Ángel García de Jalón, Ankit Desai, Anna Katarzyna Czech, Anna Mainwaring, Anthony Adimonye, Arighno Das, Arnaldo Figueiredo, Arnauld Villers, Artur Leminski, Arvinda Chippagiri, Asim Ahmed Lal, Asıf Yıldırım, Athanasios Marios Voulgaris, Audrey Uzan, Aye Moh Moh Oo, Ayman Younis, Bachar Zelhof, Bashir Mukhtar, Ben Ayres, Ben Challacombe, Benedict Sherwood, Benjamin Ristau, Billy Lai, Brechtje Nellensteijn, Brielle Schreiter, Carlo Trombetta, Catherine Dowling, Catherine Hobbs, Cayo Augusto Estigarribia Benitez, Cédric Lebacle, Cherrie Wing Yin Ho, Chi-Fai Ng, Chloe Mount, Chon Meng Lam, Chris Blick, Christian Brown, Christopher Gallegos, Claire Higgs, Clíodhna Browne, Conor McCann, Cristina Plaza Alonso, Daniel Beder, Daniel Cohen, Daniel Gordon, Daniel Wilby, Danny Gordon, David Hrouda, David Hua Wu Lau, Dávid Karsza, David Mak, David Martin-Way, Denula Suthaharan, Dhruv Patel, Diego M Carrion, Donald Nyanhongo, Edward Bass, Edward Mains, Edwin Chau, Elba Canelon Castillo, Elizabeth Day, Elsayed Desouky, Emily Gaines, Emma Papworth, Emrah Yuruk, Enes Kilic, Eoin Dinneen, Erika Palagonia, Evanguelos Xylinas, Faizan Khawaja, Fernando Cimarra, Florian Bardet, Francesca Kum, Francesca Peters, Gábor Kovács, Geroge Tanasescu, Giles Hellawell, Giovanni Tasso, Gitte Lam, Giuseppe Pizzuto, Gordan Lenart, Günal Özgür, Hai Bi, Hannah Lyons, Hannah Warren, Hashim Ahmed, Helen Simpson, Helena Burden, Helena Gresty, Hernado Rios Pita, Holly Clarke, Hosam Serag, Howard Kynaston, Hugh Crawford-Smith, Hugh Mostafid, Hugo Otaola-Arca, Hui Fen Koo, Ibrahim Ibrahim, Idir Ouzaid, Ignacio Puche-Sanz, Igor Tomašković, Ilker Tinay, Iqbal Sahibzada, Isaac Thangasamy, Iván Revelo Cadena, Jacques Irani, Jakub Udzik, James Brittain, James Catto, James Green, James Tweedle, Jamie Borrego Hernando, Jamie Leask, Jas Kalsi, Jason Frankel, Jason Toniolo, Jay D. Raman, Jean Courcier, Jeevan Kumaradeevan, Jennifer Clark, Jennifer Jones, Jeremy Yuen-Chun Teoh, John Iacovou, John Kelly, John P. Selph, Jonathan Aning, Jon Deeks, Jonathan Cobley, Jonathan Olivier, Jonny Maw, José Antonio Herranz-Yagüe, Jose Ignacio Nolazco, Jose Manuel Cózar-Olmo, Joseph Bagley, Joseph Jelski, Joseph Norris, Joseph Testa, Joshua Meeks, Juan Hernandez, Juan Luis Vásquez, Karen Randhawa, Karishma Dhera, Katarzyna Gronostaj, Kathleen Houlton, Kathleen Lehman, Kathryn Gillams, Kelvin Adasonla, Kevin Brown, Kevin Murtagh, Kiki Mistry, Kim Davenport, Kosuke Kitamura, Laura Derbyshire, Laurence Clarke, Lawrie Morton, Levin Martinez, Louise Goldsmith, Louise Paramore, Luc Cormier, Lucio Dell'Atti, Lucy Simmons, Luis Martinez-Piñeiro, Luis Rico, Luke Chan, Luke Forster, Lulin Ma, Maria Camacho Gallego, Maria José Freire, Mark Emberton, Mark Feneley, Marta Viridiana Muñoz Rivero, Matea Pirša, Matteo Tallè, Matthew Crockett, Matthew Liew, Matthew Trail, Max Peters, Meghan Cooper, Meghana Kulkarni, Michael Ager, Ming He, Mo Li, Mohamed Omran Breish, Mohamed Tarin, Mohammed Aldiwani, Mudit Matanhelia, Muhammad Pasha, Mustafa Kaan Akalın, Nasreen Abdullah, Nathan Hale, Neha Gadiyar, Neil Kocher, Nicholas Bullock, Nicholas Campain, Nicola Pavan, Nihad Al-Ibraheem, Nikita Bhatt, Nishant Bedi, Nitin Shrotri, Niyati Lobo, Olga Balderas, Omar Kouli, Otakar Capoun, Pablo Oteo Manjavacas, Paolo Gontero, Paramananthan Mariappan, Patricio Garcia Marchiñena, Paul Erotocritou, Paul Sweeney, Paula Planelles, Peter Acher, Peter C. Black, Peter K Osei-Bonsu, Peter Østergren, Peter Smith, Peter-Paul Michiel Willemse, Piotr L. Chlosta, Qurrat Ul Ain, Rachel Barratt, Rachel Esler, Raihan Khalid, Ray Hsu, Remigiusz Stamirowski, Reshma Mangat, Ricardo Cruz, Ricky Ellis, Robert Adams, Robert Hessell, Robert J.A. Oomen, Robert McConkey, Robert Ritchie, Roberto Jarimba, Rohit Chahal, Rosado Mario Andres, Rosalyn Hawkins, Rotimi David, Rustom P. Manecksha, Sachin Agrawal, Syed Sami Hamid, Samuel Deem, Sanchia Goonewardene, Satchi Kuchibhotla Swami, Satoshi Hori, Shahid Khan, Shakeel Mohammud Inder, Shanthi Sangaralingam, Shekhar Marathe, Sheliyan Raveenthiran, Shigeo Horie, Shomik Sengupta, Sian Parson, Sidney Parker, Simon Hawlina, Simon Williams, Simone Mazzoli, Slawomir Grzegorz Kata, Sofia Pinheiro Lopes, Sónia Ramos, Sophie Rintoul-Hoad, Sorcha O'Meara, Steve Morris, Stacey Turner, Stefano Venturini, Stephanos Almpanis, Steven Joniau, Sunjay Jain, Susan Mallett, Sven Nikles, null Shahzad, Sylvia Yan, Tarq Toma, Teresa Cabañuz Plo, Thierry Bonnin, Tim Muilwijk, Tim Wollin, Timothy Shun Man Chu, Timson Appanna, Tom Brophy, Tom Ellul, Tomaž Smrkolj, Tracey Rowe, Troy Sukhu, Trushar Patel, Tullika Garg, Turhan Çaşkurlu, Uros Bele, Usman Haroon, Víctor Crespo-Atín, Victor Parejo Cortes, Victoria Capapé Poves, Vincent Gnanapragasam, Vineet Gauhar, Vinnie During, Vivek Kumar, Vojtech Fiala, Wasim Mahmalji, Wayne Lam, Yew Fung Chin, Yigit Filtekin, Yih Chyn Phan, Youssed Ibrahim, Zachary A Glaser, Zainal Adwin Abiddin, Zijian Qin, Zsuzsanna Zotter, Zulkifli Zainuddin, Khadhouri, Sinan, Gallagher, Kevin M., Mackenzie, Kenneth R., Shah, Taimur T., Gao, Chuanyu, Moore, Sacha, Zimmermann, Eleanor F., Edison, Eric, Jefferies, Matthew, Nambiar, Arjun, Anbarasan, Thineskrishna, Mannas, Miles P., Lee, Taeweon, Marra, Giancarlo, Gómez Rivas, Juan, Marcq, Gautier, Assmus, Mark A., Uçar, Taha, Claps, Francesco, Boltri, Matteo, La Montagna, Giuseppe, Burnhope, Tara, Nkwam, Nkwam, Austin, Toma, Boxall, Nicholas E., Downey, Alison P., Sukhu, Troy A., Antón-Juanilla, Marta, Rai, Sonpreet, Chin, Yew-Fung, Moore, Madeline, Drake, Tamsin, Green, James S. A., Goulao, Beatriz, Maclennan, Graeme, Nielsen, Matthew, Mcgrath, John S., Kasivisvanathan, Veeru, Chaudry, Aasem, Sharma, Abhishek, Bennett, Adam, Ahmad, Adnan, Abroaf, Ahmed, Suliman, Ahmed Musa, Lloyd, Aimee, Mckay, Alastair, Wong, Albert, Silva, Alberto, Schneider, Alexandre, Mackay, Alison, Knight, Allen, Grigorakis, Alkiviadi, Bdesha, Amar, Nagle, Amy, Cebola, Ana, Dhanasekaran, Ananda Kumar, Kondža, Andraž, Barcelos, André, Galosi, Andrea Benedetto, Ebur, Andrea, Minervini, Andrea, Russell, Andrew, Webb, Andrew, de Jalón, Ángel García, Desai, Ankit, Czech, Anna Katarzyna, Mainwaring, Anna, Adimonye, Anthony, Das, Arighno, Figueiredo, Arnaldo, Villers, Arnauld, Leminski, Artur, Chippagiri, Arvinda, Lal, Asim Ahmed, Yıldırım, Asıf, Voulgaris, Athanasios Mario, Uzan, Audrey, Oo, Aye Moh Moh, Younis, Ayman, Zelhof, Bachar, Mukhtar, Bashir, Ayres, Ben, Challacombe, Ben, Sherwood, Benedict, Ristau, Benjamin, Lai, Billy, Nellensteijn, Brechtje, Schreiter, Brielle, Trombetta, Carlo, Dowling, Catherine, Hobbs, Catherine, Benitez, Cayo Augusto Estigarribia, Lebacle, Cédric, Ho, Cherrie Wing Yin, Ng, Chi-Fai, Mount, Chloe, Lam, Chon Meng, Blick, Chri, Brown, Christian, Gallegos, Christopher, Higgs, Claire, Browne, Clíodhna, Mccann, Conor, Plaza Alonso, Cristina, Beder, Daniel, Cohen, Daniel, Gordon, Daniel, Wilby, Daniel, Gordon, Danny, Hrouda, David, Lau, David Hua Wu, Karsza, Dávid, Mak, David, Martin-Way, David, Suthaharan, Denula, Patel, Dhruv, Carrion, Diego M, Nyanhongo, Donald, Bass, Edward, Mains, Edward, Chau, Edwin, Canelon Castillo, Elba, Day, Elizabeth, Desouky, Elsayed, Gaines, Emily, Papworth, Emma, Yuruk, Emrah, Kilic, Ene, Dinneen, Eoin, Palagonia, Erika, Xylinas, Evanguelo, Khawaja, Faizan, Cimarra, Fernando, Bardet, Florian, Kum, Francesca, Peters, Francesca, Kovács, Gábor, Tanasescu, Geroge, Hellawell, Gile, Tasso, Giovanni, Lam, Gitte, Pizzuto, Giuseppe, Lenart, Gordan, Özgür, Günal, Bi, Hai, Lyons, Hannah, Warren, Hannah, Ahmed, Hashim, Simpson, Helen, Burden, Helena, Gresty, Helena, Rios Pita, Hernado, Clarke, Holly, Serag, Hosam, Kynaston, Howard, Crawford-Smith, Hugh, Mostafid, Hugh, Otaola-Arca, Hugo, Koo, Hui Fen, Ibrahim, Ibrahim, Ouzaid, Idir, Puche-Sanz, Ignacio, Tomašković, Igor, Tinay, Ilker, Sahibzada, Iqbal, Thangasamy, Isaac, Cadena, Iván Revelo, Irani, Jacque, Udzik, Jakub, Brittain, Jame, Catto, Jame, Green, Jame, Tweedle, Jame, Hernando, Jamie Borrego, Leask, Jamie, Kalsi, Ja, Frankel, Jason, Toniolo, Jason, Raman, Jay D., Courcier, Jean, Kumaradeevan, Jeevan, Clark, Jennifer, Jones, Jennifer, Teoh, Jeremy Yuen-Chun, Iacovou, John, Kelly, John, Selph, John P., Aning, Jonathan, Deeks, Jon, Cobley, Jonathan, Olivier, Jonathan, Maw, Jonny, Herranz-Yagüe, José Antonio, Nolazco, Jose Ignacio, Cózar-Olmo, Jose Manuel, Bagley, Joseph, Jelski, Joseph, Norris, Joseph, Testa, Joseph, Meeks, Joshua, Hernandez, Juan, Vásquez, Juan Lui, Randhawa, Karen, Dhera, Karishma, Gronostaj, Katarzyna, Houlton, Kathleen, Lehman, Kathleen, Gillams, Kathryn, Adasonla, Kelvin, Brown, Kevin, Murtagh, Kevin, Mistry, Kiki, Davenport, Kim, Kitamura, Kosuke, Derbyshire, Laura, Clarke, Laurence, Morton, Lawrie, Martinez, Levin, Goldsmith, Louise, Paramore, Louise, Cormier, Luc, Dell'Atti, Lucio, Simmons, Lucy, Martinez-Piñeiro, Lui, Rico, Lui, Chan, Luke, Forster, Luke, Ma, Lulin, Gallego, Maria Camacho, Freire, Maria José, Emberton, Mark, Feneley, Mark, Rivero, Marta Viridiana Muñoz, Pirša, Matea, Tallè, Matteo, Crockett, Matthew, Liew, Matthew, Trail, Matthew, Peters, Max, Cooper, Meghan, Kulkarni, Meghana, Ager, Michael, He, Ming, Li, Mo, Omran Breish, Mohamed, Tarin, Mohamed, Aldiwani, Mohammed, Matanhelia, Mudit, Pasha, Muhammad, Akalın, Mustafa Kaan, Abdullah, Nasreen, Hale, Nathan, Gadiyar, Neha, Kocher, Neil, Bullock, Nichola, Campain, Nichola, Pavan, Nicola, Al-Ibraheem, Nihad, Bhatt, Nikita, Bedi, Nishant, Shrotri, Nitin, Lobo, Niyati, Balderas, Olga, Kouli, Omar, Capoun, Otakar, Oteo Manjavacas, Pablo, Gontero, Paolo, Mariappan, Paramananthan, Marchiñena, Patricio Garcia, Erotocritou, Paul, Sweeney, Paul, Planelles, Paula, Acher, Peter, Black, Peter C., Osei-Bonsu, Peter K, Østergren, Peter, Smith, Peter, Willemse, Peter-Paul Michiel, Chlosta, Piotr L., Ul Ain, Qurrat, Barratt, Rachel, Esler, Rachel, Khalid, Raihan, Hsu, Ray, Stamirowski, Remigiusz, Mangat, Reshma, Cruz, Ricardo, Ellis, Ricky, Adams, Robert, Hessell, Robert, Oomen, Robert J. A., Mcconkey, Robert, Ritchie, Robert, Jarimba, Roberto, Chahal, Rohit, Andres, Rosado Mario, Hawkins, Rosalyn, David, Rotimi, Manecksha, Rustom P., Agrawal, Sachin, Hamid, Syed Sami, Deem, Samuel, Goonewardene, Sanchia, Swami, Satchi Kuchibhotla, Hori, Satoshi, Khan, Shahid, Mohammud Inder, Shakeel, Sangaralingam, Shanthi, Marathe, Shekhar, Raveenthiran, Sheliyan, Horie, Shigeo, Sengupta, Shomik, Parson, Sian, Parker, Sidney, Hawlina, Simon, Williams, Simon, Mazzoli, Simone, Grzegorz Kata, Slawomir, Pinheiro Lopes, Sofia, Ramos, Sónia, Rintoul-Hoad, Sophie, O'Meara, Sorcha, Morris, Steve, Turner, Stacey, Venturini, Stefano, Almpanis, Stephano, Joniau, Steven, Jain, Sunjay, Mallett, Susan, Nikles, Sven, Shahzad, Null, Yan, Sylvia, Toma, Tarq, Cabañuz Plo, Teresa, Bonnin, Thierry, Muilwijk, Tim, Wollin, Tim, Chu, Timothy Shun Man, Appanna, Timson, Brophy, Tom, Ellul, Tom, Smrkolj, Tomaž, Rowe, Tracey, Sukhu, Troy, Patel, Trushar, Garg, Tullika, Çaşkurlu, Turhan, Bele, Uro, Haroon, Usman, Crespo-Atín, Víctor, Parejo Cortes, Victor, Capapé Poves, Victoria, Gnanapragasam, Vincent, Gauhar, Vineet, During, Vinnie, Kumar, Vivek, Fiala, Vojtech, Mahmalji, Wasim, Lam, Wayne, Fung Chin, Yew, Filtekin, Yigit, Chyn Phan, Yih, Ibrahim, Youssed, Glaser, Zachary A, Abiddin, Zainal Adwin, Qin, Zijian, Zotter, Zsuzsanna, and Zainuddin, Zulkifli

Subjects
Renal cancer, Prostate cancer, Risk factors, Urology, Bladder cancer, Urothelial cancer, Risk factor, Urinary tract cancer, Haematuria, Risk Calculator
Abstract

Background: Patient factors associated with urinary tract cancer can be used to risk stratify patients referred with haematuria, prioritising those with a higher risk of cancer for prompt investigation. Objective: To develop a prediction model for urinary tract cancer in patients referred with haematuria. Design, setting, and participants: A prospective observational study was conducted in 10 282 patients from 110 hospitals across 26 countries, aged ≥16 yr and referred to secondary care with haematuria. Patients with a known or previous urological malignancy were excluded. Outcome measurements and statistical analysis: The primary outcomes were the presence or absence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC], and renal cancer). Mixed-effect multivariable logistic regression was performed with site and country as random effects and clinically important patient-level candidate predictors, chosen a priori, as fixed effects. Predictors were selected primarily using clinical reasoning, in addition to backward stepwise selection. Calibration and discrimination were calculated, and bootstrap validation was performed to calculate optimism. Results and limitations: The unadjusted prevalence was 17.2% (n = 1763) for bladder cancer, 1.20% (n = 123) for UTUC, and 1.00% (n = 103) for renal cancer. The final model included predictors of increased risk (visible haematuria, age, smoking history, male sex, and family history) and reduced risk (previous haematuria investigations, urinary tract infection, dysuria/suprapubic pain, anticoagulation, catheter use, and previous pelvic radiotherapy). The area under the receiver operating characteristic curve of the final model was 0.86 (95% confidence interval 0.85-0.87). The model is limited to patients without previous urological malignancy. Conclusions: This cancer prediction model is the first to consider established and novel urinary tract cancer diagnostic markers. It can be used in secondary care for risk stratifying patients and aid the clinician's decision-making process in prioritising patients for investigation. Patient summary: We have developed a tool that uses a person's characteristics to determine the risk of cancer if that person develops blood in the urine (haematuria). This can be used to help prioritise patients for further investigation.

Published
2022

3. Duoethnography: A Polytheoretical Approach to (Re)Storing, (Re)Storying the Meanings That One Gives

Author

Richard D. Sawyer and John Joseph Norris

Subjects
media_common.quotation_subject, Representation (systemics), Queer theory, Sociology, Liminality, Linguistics, media_common, Storytelling
Abstract

This chapter summarizes the advancement of duoethnography throughout its fifteen-year history, employing examples from a variety of topics in education and social justice to provide a wide range of approaches that one may take when conducting a duoethnography. A checklist articulates what its cofounders consider the core elements of duoethnographies, additional features that may or may not be employed and how some studies purporting to be duoethnographies may not be so. The chapter indicates connections between duoethnography and a number of methodological concepts including the third space, the problematics of representation, feminist inquiry, and critical theory using published examples by several duoethnographers.

Published
2020
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4. MP81-19 WHICH PROSTATE CANCERS ARE OVERLOOKED BY MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING? AN ANALYSIS FROM PROMIS

Author

Joseph Norris, Lina Carmona Echeverria, Simon Bott, Louise Brown, Nicholas Burns-Cox, Timothy Dudderidge, Ahmed El-Shater Bosaily, Elena Frangou, Alex Freeman, Maneesh Ghei, Alastair Henderson, Richard Hindley, Richard Kaplan, Alex Kirkham, Robert Oldroyd, Christopher Parker, Raj Persad, Shonit Punwani, Derek Rosario, Iqbal Shergill, Vasilis Stavrinides, Mathias Winkler, Hayley Whitaker, Hashim Ahmed, and Mark Emberton

Subjects
medicine.medical_specialty, Mri imaging, business.industry, Urology, food and beverages, Cancer, medicine.disease, medicine.anatomical_structure, Prostate, Risk stratification, Medicine, Radiology, business, Multiparametric Magnetic Resonance Imaging
Abstract

INTRODUCTION AND OBJECTIVE:All risk stratification strategies in cancer overlook a spectrum of disease. The Prostate MRI Imaging Study (PROMIS) provides a unique opportunity to explore prostate can...

Published
2020
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5. Making the Most of Your Medical Career : Maximising Your Chances of Success

Author

David McGowan, Helen Sims, Joseph Norris, Natalie Smith, Charles Zammit, David McGowan, Helen Sims, Joseph Norris, Natalie Smith, and Charles Zammit

Subjects
Career development--Great Britain, Medicine--Vocational guidance--Great Britain, Medicine--Study and teaching--Great Britain
Abstract

This book provides an excellent and easy-to-read path to making the most of your medical career starting as a student...and a ready source of really useful hints and tips that will help anyone reading this book maximise their personal and professional development.'From the Foreword by Dr Inam Haq Want to optimise your chances of success? Take a fresh look at the clinical world. Medical careers have changed and learning how to play the game is as important as being the best in your field. This inspirational new guide considers your medical career from a wide-ranging perspective, encouraging a positive, early outlook. On a highly practical note, it acts as a comprehensive information source, covering all aspects of job applications and medical careers. On a personal note the book fosters a complete reassessment of the way you view your working life. It offers fresh ideas to help identify important opportunities to improve your CV - taking opportunities when you can whilst making the most of what you have. Easy to read and conversational in tone, it details invaluable ideas on developing your portfolio and innovative methods to successfully market yourself, alongside sound approaches to the challenges and intricacies of the modern medical career.

Published
2021

6. Surface tension of a Yukawa fluid according to mean-field theory

Author

Sylvio May, Joseph Norris, and Guilherme Volpe Bossa

Subjects
Physics, Equation of state, Phase boundary, 010304 chemical physics, Yukawa potential, General Physics and Astronomy, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Critical point (mathematics), Surface tension, Classical mechanics, Mean field theory, Lattice (order), 0103 physical sciences, Particle size, Physical and Theoretical Chemistry, 0210 nano-technology
Abstract

Yukawa fluids consist of particles that interact through a repulsive or attractive Yukawa potential. A surface tension arises at the walls of the container that encloses the fluid or at the interface between two coexisting phases. We calculate that surface tension on the level of mean-field theory, thereby either ignoring the particle size (ideal Yukawa fluid) or accounting for a non-vanishing particle size through a nonideal contribution to the free energy, exemplified either on the level of a lattice gas (lattice Yukawa fluid) or based on the Carnahan-Starling equation of state (Carnahan-Starling Yukawa fluid). Our mean-field results, which do not rely on assuming small gradients of the particle concentrations, become exact in the limit of large temperature and large screening length. They are calculated numerically in the general case and analytically in the two limits of small particle concentration and close to the critical point for a phase-separating system. For a sufficiently small particle concentration, our predicted surface tension is accurate whereas for a phase boundary, we expect good agreement with exact calculations in the limit of a large screening length and if the mean-field model employs the Carnahan-Starling equation of state.

Published
2017

7. Three-wave coupling in a transitioning hypersonic boundary layer

Author

Joseph Norris, Ndaona Chokani, Roger Kimmel, and Jonathan Poggie

Subjects
Quadratic growth, Physics, Hypersonic speed, business.industry, Perturbation (astronomy), Transfer function, Computational physics, Nonlinear system, Boundary layer, symbols.namesake, Mach number, symbols, business, Digital signal processing
Abstract

The digitized, two-point, hot-film probe measurements made in a transitioning Mach 8 boundary layer are analyzed. A digital signal processing technique that allows the local spectral dynamics to be characterized is applied. This technique is based on a nonlinear system that contains both linear and quadratically nonlinear system elements. The linear and nonlinear transfer functions and the local coherency are estimated from the uncalibrated hot-film measurements. The results show that for the probe spacing and test conditions that are examined, linear growth dominates the local interaction, and thus the three-wave coupling that is due to high frequency difference interactions, is a small perturbation. The use of this technique is, however, a first step towards quantitatively measuring the local nonlinear spectral dynamics of a transitioning hypersonic boundary layer.

Published
2001
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8. Mononuclear and binuclear copper(II) complexes of 3,5-diisopropylsalicylic acid

Author

John R. J. Sorenson, Frederick T. Greenaway, and L. Joseph Norris

Subjects
Denticity, Ligand, Dimer, Inorganic chemistry, chemistry.chemical_element, Copper, law.invention, Inorganic Chemistry, Solvent, chemistry.chemical_compound, chemistry, law, Polymer chemistry, Materials Chemistry, Molecule, Physical and Theoretical Chemistry, Electron paramagnetic resonance, Dichloromethane
Abstract

Several copper(II) complexes of 3,5-diisopropylsalicylic acid and a variety of ligating solvents have been prepared and studied by elemental analysis, and by infrared, electronic, and EPR spectroscopy. In the solid state, all of the compounds are binuclear, carboxylate-bridged Cu2(3,5-DIPS)4(L)2, where L may be a vacant site or a coordinating ligand. In non-coordinating solvents such as hexane and dichloromethane, the binuclear structure is retained in solution, but in polar coordinating solvents the dimer dissociates into monomers where the copper is coordinated to two solvent molecules and to two bidentate diisopropylsalicylate ligands through their carboxylic and phenolic oxygen atoms.

Published
1988
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9. Carl Sandburg remembered

Author

Dodson, Kenneth M.; Allen, Carl; Asklund, Erik; Babcock, Frederic; Ballantine, Lesley Frost; Barry, John D.; Belot, Robert B.; Benjamin, Paul L.; Brenton, Mrs. W. Harold; Bromberger, F. S.; Brown, Vanessa; Butcher, Fanny; Chapman, Stella Weston; Doggett, Dorothy Emerson; Clemens, Cyril; Clough, William O.; Crawford, Nelson Antrim; Dahlstedt, Marden Armstrong; Davis, Elrick B.; Douglass, William O.; Frankenstein, Alfred; Gerschefski, Edwin; Golden, Harry; Grelling, Claude; Haefner, Esther M.; Herzog, William; Hoffman, Arthur; Hyer, Helen von Kolnitz; Jaffe, Dorothea; Keck, Mrs. Paul; Leiserson, William; Leiserson, Emily; Leiserson, Mark; Lerner, Leo A.; Liemohn, Mrs. Edwin; Lomax, Joseph F.; Looström, Lars; Marshall, F. Elmer; Mersand, Joseph; Norris, Jack; Noyes, Russell; Oliver, Albert I.; Orso, Leo; Parten, Ailese; Paulding, Litti; Pawson, Jessie Bond; Bond, George C.; Pinkham, Glenn; Price, Robert; Robb, Lynda Johnson; Root, E. Merrill; Rosengren, Herbert; Samuelsson, May; Samuelsson, Gunnar; Schacht, Paul L.; McKitrick, Ada J.; Schwengel, Fred; Sergeev, Andrey; Sharp, H. Jay; Shaw, Mrs. Dorothy Stott; Sizer, Lawrence B.; Starmont, Mrs. Leon; Sutherland, Arthur E.; Sutton, William Alfred, 1915-.; Taylor, Millicent; Truman, Harry S., 1884-1972; Tull, Clyde C.; Van Etten, Winifred M.; Vose, Caroline Elizabeth; Wheeler, Lois T.; Zimmerman, Mary T., Sutton, William Alfred, 1915, Dodson, Kenneth M.; Allen, Carl; Asklund, Erik; Babcock, Frederic; Ballantine, Lesley Frost; Barry, John D.; Belot, Robert B.; Benjamin, Paul L.; Brenton, Mrs. W. Harold; Bromberger, F. S.; Brown, Vanessa; Butcher, Fanny; Chapman, Stella Weston; Doggett, Dorothy Emerson; Clemens, Cyril; Clough, William O.; Crawford, Nelson Antrim; Dahlstedt, Marden Armstrong; Davis, Elrick B.; Douglass, William O.; Frankenstein, Alfred; Gerschefski, Edwin; Golden, Harry; Grelling, Claude; Haefner, Esther M.; Herzog, William; Hoffman, Arthur; Hyer, Helen von Kolnitz; Jaffe, Dorothea; Keck, Mrs. Paul; Leiserson, William; Leiserson, Emily; Leiserson, Mark; Lerner, Leo A.; Liemohn, Mrs. Edwin; Lomax, Joseph F.; Looström, Lars; Marshall, F. Elmer; Mersand, Joseph; Norris, Jack; Noyes, Russell; Oliver, Albert I.; Orso, Leo; Parten, Ailese; Paulding, Litti; Pawson, Jessie Bond; Bond, George C.; Pinkham, Glenn; Price, Robert; Robb, Lynda Johnson; Root, E. Merrill; Rosengren, Herbert; Samuelsson, May; Samuelsson, Gunnar; Schacht, Paul L.; McKitrick, Ada J.; Schwengel, Fred; Sergeev, Andrey; Sharp, H. Jay; Shaw, Mrs. Dorothy Stott; Sizer, Lawrence B.; Starmont, Mrs. Leon; Sutherland, Arthur E.; Sutton, William Alfred, 1915-.; Taylor, Millicent; Truman, Harry S., 1884-1972; Tull, Clyde C.; Van Etten, Winifred M.; Vose, Caroline Elizabeth; Wheeler, Lois T.; Zimmerman, Mary T., and Sutton, William Alfred, 1915

Abstract

Annotated, draft manuscript.; The letters, memoirs, and the recollections of friends and associates provide insight into the life, personality, and literary world of Carl Sandburg.; Draft manuscript with annotations., Includes a duplicate of page 372c., This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

Published
1979

10. Estelle Helen Fox Survey

Author

Fox, Estelle Helen, Fox, Estelle Helen, McPhail, Joseph Norris (Mrs.), Fox, Estelle Helen, Fox, Estelle Helen, and McPhail, Joseph Norris (Mrs.)

Abstract

4 continuous tone images, Responses to survey mailed by the University of Michigan Alumnae Council to women who had attended the University in the period 1870-1924. The survey included information on activities, memories of faculty and college life, descriptions of influence of University on their lives, occupations, public services, etc., (dlps) 8730.0915.001, (voicesdb) 916, https://www.lib.umich.edu/about-us/policies/copyright-policy

12. The leading conceptions of property in American social Christianity

Author

Loper, Joseph Norris

Abstract

The purpose of this dissertation is to present in organized form and show the significance of the basic ideas regarding property as conceived by the leading men of that movement in America, which has come to be known as "social Christianity." The problem requires a careful selection of the prominent men on the basis of their contributions to the movement itself, to Protestantism in America, and to the development of the nation's social thought. Social Christianity is a movement in American Protestantism which began to take form during the late 1870's and which reached the zenith of its influence during the period of approximately ten years preceding the First World War. The climactic stage of its development came during the first decade of the present century when it began to receive official recognition by the major Protestant denominations of America. Its major religious achievement was the impetus it gave to the formation of the Federal Council of the Churches of Christ in America in 1908. Since that time its social principles have been promoted both from within the framework of the activities of the Federal Council and by a number of spokesmen within the tradition of social Christianity who are representative of some of the more radical ideas which were prominent in the earlier days of the movement. This movement historically has emphasized the social implications of the Christian gospel and attempted to apply a practical social doctrine, as distinguished from a speculative theological doctrine, to the social and economic problems of society. As a movement it had its beginnings about the time when the machinery of the Industrial Revolution was undergoing tremendous expansion, following the Civil War, and when the American "gospel of wealth," proclaimed by Andrew Carnegie and others, began a steady climb to the peak of its popularity which was reached during the last decade of the nineteenth century. Its doctrine of social ethics is often called the "social gospel," and its extreme form is referred to as "Christian socialism," although both terms are sometimes used as if they were synonomous with "social Christianity." By 1900 this movement had already reached a stage of maturity in which its social claims were generally acceptable in the main stre·am of American Protestantism. By the time of the First World War, social Christianity had developed into a forceful movement within American Protestantism, and dared to call seriously for social changes in the nation's economy and policies by which the secularism of capitalism would be supplanted by social conditions based on Christian ethical considerations. The subject matter of this study is of particular interest and importance at this time because of the growing tensions throughout the world today. The various conflicting theories and the ideological incompatibilities leading toward disintegration among nations have to do largely with the role which property must play in the world society of today and in the future. The method of approach in this study has been to consider the prominent ideas of the most representative personalities of social Christianity from the standpoint of the principal issues involved in the subject of property. The issues and sub-issues are used as chapter headings and sub-topics. The choice of significant primary source material was governed largely by the selection of the leading men of the movement. This selection was not arbitrary but was made inductively from a survey of the literature of the outstanding personalities, and also from insights gained by studying the secondary source material such as that found in several historical studies of the Christian social movement. Choices were based upon two factors: (1) whether the man was fairly representative of social Christianity, and (2) the extent to which his work had dealt with the subject of property from an ethical point of view. These criteria led to the selection of several men who were not clergymen, and one (Henry D. Lloyd) who was not a church member. The men whose works were examined most carefully were: Washington Gladden, Henry George, Henry D. Lloyd, Richard T. Ely, Josiah Strong, W.D.P. Bliss, Edward Bellamy, Francis G. Peabody, Shailer Mathews, George D. Herron, Walter Rauschenbusch, and Harry F. Ward. Other men who, because of necessary limitations of space, received less careful attention were: A.J.F. Behrends, Kirby Page, and E. Stanley Jones. Occasional references were of course made to various other men connected with the movement who have made important statements on particular issues considered in the investigation. The first chapter is introductory and deals with definitions, methods, historical background, and a review of the work previously done in this field. Chapter II deals definitively with the leading issues in the problem of property, gives some indication of their magnitude, and anticipates the main argument by listing the Christian standards upon which the conceptions of property in American social Christianity are based. Chapters III and IV portray the conceptions of social Christianity, as expressed by its leading spokesmen, on what are considered the most important factors involved in the relationship of property to the individual and in the role of property in society. Chapter V deals with the solution to the problem of property, as offered by social Christianity, and represents the main argument. The solution offered is two-fold. It calls for the socialization of property and demands that property shall be "Christianized." What these two terms mean, within the framework of the movement generally and in the conceptions of the leading spokesmen of the movement in particular, is made clear in this chapter. Socialization is defined in terms of Christian ethics. It usually means that material things should be collectively owned and democratically managed by the community. This is not the same as mere government ownership, but involves economic democracy with control in the hands of the people, whose equal rights in determining how property shall be used are not to be abrogated. It means that property is to be managed by the people for the people so as to contribute to their welfare, and not by a few individuals for building up their economic and political power over others. This power aspect of accumulated property controlled py individuals is strongly condemned; because of its tendency toward economic injustice, and because both its acquisition and its use tend to divide the people into classes. From the standpoint of Christian ethics this is not considered the true role of property. Thus the socialization of property means basically that property is in reality to be Christianized, but some of the men studied believe that collective ownership and control, under democratic management from the grass roots, is one of the requisites for achieving the goal of Christianization. "Christianizing property" is a phrase made use of, principally by Walter Rauschenbusch but occasionally by most of the others studied, to mean that property should be considered for use to express and fulfill the merits and claims of Christian love as taught in the New Testament. This conception concerns desires and attitudes based on Christian motives, rather than on programs and policies, except of course that programs and policies require proper motives in their administration. An example of property that was Christianized would be found in the spirit and attitudes of the members of a well-adjusted Christian family toward the property which is used to provide the material comforts of the home. The primary emphasis here is upon collective property rights, with accompanying but secondary prescriptions for de~irable ownership arrangements. Coercion is prescribed only to prevent the disruption of the fraternal community by those who would attack it for predatory purposes. This meaning of Christianization is based upon right use and not upon a particular system of ownership. It expresses the principle: "property for use and not for power." In chapter VI the writer analyzes briefly the impact which the social gospel movement has had upon American thinking about property. It deals with the leading conceptions in their influence upon American Protestantism, upon the developing labor movement, and upon American economic policy. Several conclusions are drawn from the study of these conceptions of property: (1) that valid moral demands are made for collective property rights, but that there is no general agreement among the men studied with respect to the economic system most favorable to a proper administration of property; (2) that their views are validated by Christian ethics when they contend that the particular economic system to be put into effect is of secondary importance to considerations of the primary purpose of property in society--that of serving human values; (3) that moral considerations sustain them in claiming that the right to private property is sacred only to the extent that the use of it contributes to public welfare, human brotherhood, and social solidarity; (4) that, as they have insisted, the true or ideal purpose of property is to serve in the enhancement of personality values, in the role of an instrumental social value rather than as a power weapon; (5) that the leaders of the movement have both ethical and sociological grounds for assuming that there is no way of solving the problem of property without making property secondary in relation to the total needs of persons in their social relationships; and finally, (6) that they have historical grounds for insisting that high and seemingly impossible ideals tend sooner or later to pass over into the realm of reality.

Published
1952

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