49 results on '"Joseph B. Wick"'
Search Results
2. Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management
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Hai V, Le, Joseph B, Wick, Benjamin W, Van, and Eric O, Klineberg
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Spinal Fusion ,Treatment Outcome ,Osteogenesis ,Cervical Vertebrae ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Ossification of Posterior Longitudinal Ligament ,Decompression, Surgical ,Longitudinal Ligaments - Abstract
Ossification of the posterior longitudinal ligament (OPLL) occurs as heterotopic bone forms in the posterior longitudinal ligament, resulting in neural compression, myelopathy, and radiculopathy. OPLL is most commonly observed in East Asian populations, with prevalence rates of 1.9% to 4.3% reported in Japan. OPLL rates are lower in North American and European patients, with reported prevalence of 0.1% to 1.7%. Patients typically develop symptoms due to OPLL in their cervical spines. The etiology of OPLL is multifactorial, including genetic, metabolic, and anatomic factors. Asymptomatic or symptomatic patients with OPLL can be managed nonsurgically, whereas patients with neurologic symptoms may require surgical decompression from an anterior, posterior, or combined approach. Surgical treatment can provide notable improvement in neurologic function. Surgical decision making accounts for multiple factors, including patient comorbidities, neurologic status, disease morphology, radiographic findings, and procedure complication profiles. In this study, we review OPLL epidemiology and pathophysiology, clinical features, radiographic evaluation, management, and complications.
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- 2022
3. Assessment of Adult Spinal Deformity Complication Timing and Impact on 2-Year Outcomes Using a Comprehensive Adult Spinal Deformity Classification System
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Gregory M. Mundis, Hai Le, Eric O. Klineberg, Renaud Lafage, Peter G. Passias, Christopher I. Shaffrey, Munish C. Gupta, Themistocles S. Protopsaltis, Douglas C. Burton, Frank J. Schwab, Joseph B Wick, Virginie Lafage, Christopher P. Ames, Robert A. Hart, Shay Bess, and Justin S. Smith
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Adult ,Reoperation ,medicine.medical_specialty ,business.industry ,MEDLINE ,Postoperative complication ,Spine ,Surgery ,Postoperative Complications ,Cohort ,Propensity score matching ,Quality of Life ,Spinal deformity ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Prospective Studies ,Neurology (clinical) ,Complication ,business ,Adverse effect ,Survival analysis ,Retrospective Studies - Abstract
Study design Retrospective review of prospectively collected multicenter registry data. Objective To identify rates and timing of postoperative complications in adult spinal deformity (ASD) patients, the impact of complication type and timing on health related quality of life (HRQoL) outcomes, and the impact of complication timing on readmission and reoperation rates. Better understanding of complication timing and impact on HRQoL may improve patient selection, preoperative counseling, and postoperative complication surveillance. Summary of background data ASD is common and associated with significant disability. Surgical correction is often pursued, but is associated with high complication rates. The International Spine Study Group, AO Spinal Deformity Forum, and European Spine Study Group have developed a new complication classification system for ASD (ISSG-AO spine complications classification system). Methods The ISSG-AO spine complications classification system was utilized to assess complications occurring over the 2-year postoperative time period amongst a multicenter, prospectively enrolled cohort of patients who underwent surgery for ASD. Kaplan-Meier survival curves were established for each complication type. Propensity score matching was performed to adjust for baseline disability and comorbidities. Associations between each complication type and HRQoL, and reoperation/readmission and complication timing, were assessed. Results Of 584 patients meeting inclusion criteria, cardiopulmonary, gastrointestinal, infection, early adverse events, and operative complications contributed to a rapid initial decrease in complication-free survival. Implant-related, radiographic, and neurologic complications substantially decreased long-term complication-free survival. Only radiographic and implant-related complications were significantly associated with worse 2-year HRQoL outcomes. Need for readmission and/or reoperation was most frequent among those experiencing complications after postoperative day 90. Conclusion Surgeons should recognize that long-term complications have a substantial negative impact on HRQoL, and should carefully monitor for implant-related and radiographic complications over long-term follow-up.Level of Evidence: 4.
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- 2021
4. Diffuse Idiopathic Skeletal Hyperostosis of the Spine: Pathophysiology, Diagnosis, and Management
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Joseph B. Wick, Eric O. Klineberg, Benjamin W. Van, and Hai Le
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medicine.medical_specialty ,Hyperostosis, Diffuse Idiopathic Skeletal ,business.industry ,medicine.disease ,Dysphagia ,Asymptomatic ,Spine ,Pathophysiology ,Back Pain ,Osteogenesis ,Epidemiology ,Back pain ,Ankylosis ,Etiology ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,Radiology ,medicine.symptom ,Deglutition Disorders ,business ,Diffuse Idiopathic Skeletal Hyperostosis - Abstract
Diffuse idiopathic skeletal hyperostosis (DISH) is an ankylosing condition affecting up to 32.5% of the general cohort. Although often asymptomatic, affected individuals may present with back pain, stiffness, dysphagia, functional decline, and neurologic deficits. Radiographically, DISH is characterized by flowing ossifications along the anterior spine spanning ≥4 vertebral bodies. Although the etiology of DISH remains unknown, diabetes mellitus and other metabolic derangements are strongly associated with DISH. Importantly, spinal ankylosis in DISH predisposes patients to unstable spine fractures from low-energy trauma, and careful consideration must be taken in managing these patients. This article reviews the epidemiology and pathophysiology of DISH, and its clinical findings, diagnostic criteria, and management.
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- 2021
5. Ligament Augmentation With Mersilene Tape Reduces the Rates of Proximal Junctional Kyphosis and Failure in Adult Spinal Deformity
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Luke Hiatt, Joseph B. Wick, Hai Le, Eric O. Klineberg, Rolando Figueroa Roberto, Yashar Javidan, Pope Rodnoi, and Joshua Barber
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Pediatric Research Initiative ,medicine.medical_specialty ,Radiography ,Proximal junctional kyphosis ,Kyphosis ,Adult spinal deformity ,Proximal junctional angle ,Clinical Research ,Slow progression ,Adjacent segment disease ,Medicine ,RC346-429 ,Pelvis ,Proximal junctional failure ,Proximal junction disease ,business.industry ,medicine.disease ,Sagittal plane ,Surgery ,Rate of increase ,medicine.anatomical_structure ,Ligament ,Spinal deformity ,Original Article ,Neurology (clinical) ,Neurology. Diseases of the nervous system ,business - Abstract
Author(s): Rodnoi, Pope; Le, Hai; Hiatt, Luke; Wick, Joseph; Barber, Joshua; Javidan, Yashar; Roberto, Rolando; Klineberg, Eric O | Abstract: ObjectiveTo investigate prevention of proximal junctional kyphosis (PJK) and failure (PJF) following adult spinal deformity (ASD) surgery utilizing a novel technique of posterior ligament augmentation with polyester fiber tether.MethodsThis study evaluated ASD adult patients who underwent posterior decompression and instrumented fusion from the thoracolumbar junction (T9-L1) to the pelvis from 2011-2017. Basic demographic data were obtained. Radiographic outcomes included proximal junctional angle (PJA), sagittal vertical axis, PJK, and PJF. The study population was divided into patients who had ASD surgery with and without ligamentous augmentation.ResultsA total of 43 subjects were evaluated, including 20 without and 23 with ligamentous augmentation. PJA increased over time for both groups. PJA was smaller for the augmented group, and rate of increase in PJA was slower in the augmented group (p l 0.0001). The rate of PJK was significantly higher in the nonaugmented group (p = 0.01). PJF was significantly less common in the augmented group (p = 0.003). Time to revision surgery was lower in the nonaugmented group (p = 0.003).ConclusionOur novel ligament augmentation technique utilizing polyethylene tape is an effective technique to slow progression of the PJA and lower the risk for proximal junctional disease in ASD surgery.
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- 2021
6. Patient Characteristics, Injury Types, and Costs Associated with Secondary Over-Triage of Isolated Cervical Spine Fractures
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Eric O. Klineberg, Kranti Peddada, Steven Swinford, Adam Bacon, Allan R. Martin, Kee D. Kim, Trevor Carroll, Joseph B. Wick, Rolando Figueroa Roberto, Yashar Javidan, Gloria Han, Hai Le, Katherine D. Wick, and Julius O. Ebinu
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medicine.medical_specialty ,Nerve root ,business.industry ,Trauma center ,Retrospective cohort study ,Spinal cord ,Logistic regression ,Triage ,Cervical spine ,Surgery ,Neck Injuries ,medicine.anatomical_structure ,Injury types ,Cervical Vertebrae ,medicine ,Humans ,Spinal Fractures ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,Retrospective Studies - Abstract
STUDY DESIGN Retrospective Cohort. OBJECTIVE Identify patient variables, injury characteristics, and costs associated with operative and non-operative treatment following inter-facility transfer of patients with isolated cervical spine fractures. SUMMARY OF BACKGROUND DATA Patients with isolated cervical spine fractures are subject to inter-facility transfer for surgical assessment, yet are often treated non-operatively. The American College of Surgeons' benchmark rate of "secondary over-triage" is < 50%. Identifying patient and injury characteristics as well as costs associated with treatment following transfer of patients with isolated cervical spine fractures may help reduce rates of secondary over-triage and healthcare expenditures. METHODS Patients transferred to a Level-1 trauma center with isolated cervical spine fractures between January 2015 and September 2020 were identified. Patient demographics, comorbidities, insurance data, injury characteristics, imaging workup, treatment, and financial data were collected for all patients. Multivariable logistic regression models were constructed to identify patient and injury characteristics associated with surgical treatment. RESULTS Nearly 75% of patients were treated non-operatively. Over 97% of transfers were accepted by the general surgery trauma service. Multivariable modeling found that higher BMI, presence of any neurologic deficit including spinal cord or isolated spinal nerve root injuries, current smoking status, or cervical spine MRI obtained post-transfer, were associated with surgical treatment for isolated cervical spine fractures. Among patients with type II dens fractures, increased fracture displacement was associated with surgical treatment. Median charges to patients treated operatively and non-operatively were $380,890 and $90,734, respectively. Median hospital expenditures for patients treated operatively and non-operatively were $55,115 and $12,131, respectively. CONCLUSION A large proportion of patients with isolated cervical spine fractures are subject to over-triage. Injury characteristics are important for determining need for surgical treatment, and therefore inter-facility transfer. Improving communication with spine surgeons when deciding to transfer patients may significantly reduce healthcare costs and resource use.Level of Evidence: 4.
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- 2021
7. What is the Trend in Representation of Women and Under-represented Minorities in Orthopaedic Surgery Residency?
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Max R. Haffner, Benjamin W. Van, Joseph B. Wick, and Hai Le
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Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Clinical Sciences ,Ethnic group ,Specialty ,Graduate medical education ,Education ,Specialties, Surgical ,Databases ,Physicians, Women ,03 medical and health sciences ,0302 clinical medicine ,Mentorship ,Clinical Research ,Surgical ,Medical ,Physicians ,medicine ,Humans ,Women ,Orthopedics and Sports Medicine ,Longitudinal Studies ,030212 general & internal medicine ,Graduate ,Factual ,Minority Groups ,Retrospective Studies ,030222 orthopedics ,business.industry ,Internship and Residency ,General Medicine ,United States Medical Licensing Examination ,United States ,Quality Education ,Orthopedics ,Otorhinolaryngology ,Education, Medical, Graduate ,Family medicine ,Orthopedic surgery ,Female ,Surgery ,Patient Safety ,business ,Specialties ,Surgical Specialty - Abstract
BACKGROUND Orthopaedic surgery training programs have lagged behind other surgical specialties in increasing their representation of women and people from under-represented minority (URM) groups. Comparative data between orthopaedic surgery and other specialties are needed to help identify solutions to closing the diversity gap. QUESTIONS/PURPOSES (1) Which surgical specialties have the greatest representation of women residents and residents from URM groups? (2) How have the proportions of women residents and residents from URM groups changed across the surgical specialties during the past decade? METHODS This was a retrospective evaluation of a large, longitudinally maintained survey database. Resident data by gender and ethnicity were retrieved from the Accreditation Council for Graduate Medical Education Data Resource Books for the 2011 to 2012 through 2019 to 2020 academic years. The Accreditation Council for Graduate Medical Education database is updated annually; thus, it is the most up-to-date and complete database available for gender and ethnicity data for all surgical residents. Data were obtained and analyzed for seven different surgical specialties: orthopaedic surgery, neurosurgery, ophthalmology, otolaryngology, plastic surgery, general surgery, and urology. No sampling was necessary, and thus descriptive statistics of the data were completed. Because the entire population of residents was included for the period of time in question, no statistical comparisons were made, and the reported differences represent absolute differences between the groups for these periods. Linear regression analyses were performed to estimate the annual growth rates of women residents and residents from URM groups in each specialty. RESULTS Among the seven surgical specialties, representation of women residents increased from 28% (4640 of 16,854) of residents in 2012 to 33% (6879 of 20,788) in 2020. Orthopaedic surgery had the lowest representation of women residents every year, with women residents comprising 16% of residents (700 of 4342) in 2020. Among the seven surgical specialties, representation of residents from URM groups increased from 8.1% (1362 of 16,854) in 2012 to 9.7% (2013 of 20,788) in 2020. In 2020, the representation of residents from URM groups in orthopaedic surgery was 7.7% (333 of 4342). In 2020, general surgery had the highest representation of women residents (42%; 3696 of 8809) as well as residents from URM groups (12%; 1065 of 8809). Plastic surgery (1.46% per year) and general surgery (0.95% per year) had larger annual growth rates of women residents than the other specialties did. In each surgical specialty, the annual growth rate of residents from URM groups was insignificant. CONCLUSION During the past decade, there was only a small increase in the representation of women in orthopaedic surgery, while the representation of people from URM groups did not change. In contrast, by 2020, general surgery had become the most diverse among the seven surgical specialties. To increase diversity in our field, we need to evaluate and implement some of the effective interventions that have helped general surgery become the diverse surgical specialty that it is today. CLINICAL RELEVANCE General surgery has substantially reduced gender and ethnic disparities that existed in the past, while those in orthopaedic surgery still persist. General surgery residencies have implemented a holistic review of resident applications and longitudinal mentoring programs to successfully address these disparities. Orthopaedic surgery programs should consider placing less emphasis on United States Medical Licensing Examination score thresholds and more weight on applicants' non-academic attributes, and put more efforts into targeted longitudinal mentorship programs, some of which should be led by non-minority faculty.
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- 2021
8. Osteoporosis Is Undertreated After Low-energy Vertebral Compression Fractures
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Eric O. Klineberg, Connor Delman, Joseph B. Wick, Max R. Haffner, Rolando Figueroa Roberto, Yashar Javidan, Gloria Han, and Hai Le
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Adult ,Pediatrics ,medicine.medical_specialty ,Osteoporosis ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Quality of life ,Fractures, Compression ,Health care ,medicine ,Humans ,Orthopedics and Sports Medicine ,Retrospective Studies ,Aged, 80 and over ,030222 orthopedics ,business.industry ,Mortality rate ,Public health ,Trauma center ,030229 sport sciences ,Evidence-based medicine ,Middle Aged ,medicine.disease ,Quality of Life ,Spinal Fractures ,Surgery ,business ,Osteoporotic Fractures - Abstract
Introduction Despite guidelines recommending postfracture bone health workup, multiple studies have shown that evaluation and treatment of osteoporosis has not been consistently implemented after fragility fractures. The primary aim of this study was to evaluate rates of osteoporosis evaluation and treatment in adult patients after low-energy thoracolumbar vertebral compression fractures (VCFs). Methods We retrospectively reviewed all patients ≥60 years old presenting to a single academic trauma center with acute thoracolumbar VCFs after a ground-level fall from 2016 to 2020 . Rates of osteoporosis screening with dual-energy x-ray absorptiometry and initiation of pharmaceutical treatment were recorded at four time points: before the date of injury, during index hospitalization, at first primary care provider follow-up, and at final primary care provider follow-up. Rates of subsequent falls and secondary fragility fractures were recorded. One-year mortality and overall mortality were also calculated. Results Fifty-two patients with a mean age of 83 years presenting with thoracic and/or lumbar fractures after a ground-level fall were included. At a mean final follow-up of 502 days, only 10 patients (19.2%) received pharmacologic therapy for osteoporosis and only 6 (11.5%) underwent postinjury dual-energy x-ray absorptiometry evaluation. Twenty-five patients (48%) had at least one subsequent fall at a mean of 164 days from the initial date of injury. Eleven patients with subsequent falls sustained an additional fragility fracture because of the fall, including six operative injuries. One-year mortality among the 52 patients was 26.9%, and the overall mortality rate was 44.2% at the final follow-up. Discussion Osteoporosis remains a major public health issue that markedly affects quality of life and healthcare costs. Our study demonstrates the additional need for improved osteoporosis workup and intervention among patients who have sustained VCFs. We hope that our study helps raise awareness for improved osteoporosis evaluation and treatment among spine surgeons and all medical professionals treating patients with fragility fractures. Level of evidence Retrospective Case Series, Level IV Evidence.
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- 2021
9. Orthopaedic In-Training Examination: History, Perspective, and Tips for Residents
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Joseph B. Wick, George S.M. Dyer, Brian M. Haus, and Hai Le
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medicine.medical_specialty ,Sports medicine ,business.industry ,Perspective (graphical) ,MEDLINE ,Internship and Residency ,Orthopedic Surgeons ,Burnout ,Hand ,United States ,Memorization ,Test (assessment) ,Comprehension ,Orthopedics ,Education, Medical, Graduate ,Family medicine ,Orthopedic surgery ,medicine ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Clinical Competence ,Educational Measurement ,Child ,business - Abstract
Introduced in 1963, the orthopaedic in-training examination (OITE) is a standardized, national test administered annually to orthopaedic residents by the American Academy of Orthopaedic Surgeons. The examination consists of 275 multiple-choice questions that cover 11 domains of orthopaedic knowledge, including basic science, foot and ankle, hand, hip and knee, oncology, pediatrics, shoulder and elbow, spine, sports medicine, trauma, and practice management. The OITE has been validated and is considered predictive of success in both orthopaedic surgery residency and on the American Board of Orthopaedic Surgery part I examination. This article provides a historical overview of the OITE, details its current structure and scoring system, and reviews currently available study materials. For examination preparation, the residents are encouraged to (1) start the examination preparation early, (2) practice on old OITE or self-assessment examination questions, (3) focus on the questions answered incorrectly, (4) focus on comprehension over memorization, and (5) recognize and avoid burnout. Finally, the residents should have a systemic way of approaching each multiple-choice question, both during practice and on the actual examination.
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- 2021
10. Surgical Factors and Treatment Severity for Perioperative Complications Predict Hospital Length of Stay in Adult Spinal Deformity Surgery
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Hai V. Le, Joseph B. Wick, Renaud Lafage, Michael P. Kelly, Han Jo Kim, Munish C. Gupta, Shay Bess, Douglas C. Burton, Christopher P. Ames, Justin S. Smith, Christopher I. Shaffrey, Frank J. Schwab, Peter G. Passias, Themistocles S. Protopsaltis, Virginie Lafage, and Eric O. Klineberg
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Adult ,Postoperative Complications ,Quality of Life ,Humans ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Length of Stay ,Hospitals ,Retrospective Studies - Abstract
Retrospective review of prospectively collected multicenter registry data.The aim of this study was to determine whether surgical variables and complications as graded by treatment severity impact postoperative hospital length of stay (LOS).Surgical treatment can substantially improve quality of life for patients with adult spinal deformity (ASD). However, surgical treatment is associated with high complication rates, which may impact hospital LOS. Classifying complications by severity of subsequent treatment may allow surgeons to better understand complications and predict their impact on important outcome metrics, including LOS.Patients enrolled in a multicenter, prospectively enrolled database for ASD were assessed for study inclusion. Complications were graded based on intervention severity. Associations between LOS, complication intervention severity, and surgical variables (fusion length, use of interbody fusion, use of major osteotomy, primary versus revision surgery, same day vs. staged surgery, and surgical approach), were assessed. Two multivariate regression models were constructed to assess for independent associations with LOS.Of 1183 patients meeting inclusion criteria, 708 did not and 475 did experience a perioperative complication during their index hospitalization, with 660 and 436 included in the final cohorts, respectively. Among those with complications, intervention severities included 14.9% with no intervention, 68.6% with minor, 8.9% with moderate, and 7.6% with severe interventions. Multivariate regression modeling demonstrated that length of posterior fusion, use of major osteotomy, staged surgery, and severity of intervention for complications were significantly associated with LOS.Careful selection of surgical factors may help reduce hospital LOS following surgery for ASD. Classification of complications by treatment severity can help surgeons better understand and predict the implications of complications, in turn assisting with surgical planning and patient counseling.Level of Evidence: 4.
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- 2021
11. Gender, Racial, and Ethnic Differences in the Utilization of Cervical Disk Replacement for Cervical Radiculopathy
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Joseph B. Wick, Thomas Shen, Katherine D. Wick, Max R. Haffner, Eric O. Klineberg, Yashar Javidan, Rolando F. Roberto, Shaina A. Lipa, and Hai V. Le
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Spinal Fusion ,Treatment Outcome ,Adolescent ,Cervical Vertebrae ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Radiculopathy ,Neck ,Diskectomy ,Retrospective Studies - Abstract
Cervical radiculopathy (CR) is commonly treated by spine surgeons, with surgical options including anterior cervical diskectomy and fusion (ACDF) and cervical disk replacement (CDR). CDR is a motion-sparing alternative to ACDF and was approved by the US FDA in 2007. CDR utilization has increased because evidence has emerged demonstrating its long-term efficacy. Despite CDR's efficacy, studies have suggested that socioeconomic factors may influence which patients undergo CDR versus ACDF. Our objective was to determine whether gender, racial, and ethnic disparities exist in the utilization of CDR versus ACDF for CR.Patients age ≥18 years undergoing elective CDR or ACDF for CR between 2017 and 2020 were identified in the Vizient Clinical Database. Proportions of patients undergoing CDR and ACDF, as well as their comorbidities, complications, and outcomes, were compared by sex, race, and ethnicity. Bonferroni correction was done for multiple comparisons.A total of 7,384 patients, including 1,427 undergoing CDR and 5,957 undergoing ACDF, were reviewed. Black patients undergoing surgical treatment of CR were less likely to undergo CDR than ACDF, had a longer length of stay, and had higher readmission rates, while Hispanic patients had higher complication rates than non-Hispanic patients.Important racial and ethnic disparities exist in CR treatment. Interventions are necessary to ensure equal access to spine care by reducing barriers, such as underinsurance and implicit bias.IV (Case Series).
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- 2021
12. Clinical and Radiographic Comparison Between Open Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion With Bilateral Facetectomies
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Rolando Figueroa Roberto, Yashar Javidan, Eric O. Klineberg, Eileen Phan, Joshua Barber, Ryan Anderson, Joseph B. Wick, and Hai Le
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medicine.medical_specialty ,Lordosis ,Radiography ,medicine.medical_treatment ,lordosis ,Lumbar interbody fusion ,Clinical Research ,lumbar interbody fusion ,medicine ,Orthopedics and Sports Medicine ,minimally invasive surgery ,spondylolisthesis ,business.industry ,Original Articles ,medicine.disease ,Facetectomies ,Spondylolisthesis ,Surgery ,spondylosis ,Spinal fusion ,Cohort ,spinal fusion ,Neurology (clinical) ,Patient Safety ,business - Abstract
Study Design: Age- and sex-matched cohort study. Objectives: To compare outcomes after open versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) with bilateral facetectomies. Methods: We retrospectively compared patients who underwent single- or 2-level MIS-TLIF with an age- and sex-matched open-TLIF cohort. Surgical data was collected for operative time, estimated blood loss (EBL), and drain use. Clinical outcomes included the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), length of stay (LOS), complications, and reoperations. Lumbar radiographs were measured for changes in global lumbar lordosis (LL) and segmental lordosis (SL). Results: Between 2016 and 2020, 38 MIS-TLIF patients were compared with 38 open-TLIF patients. No subfascial drain was used in the MIS-TLIF group ( P < .001). The MIS-TLIF group had longer operative time (310.8 vs 276.5 minutes; P = .046) but less EBL (282.4 vs 420.8 mL; P = .007). LOS ( P = .15), complication rates ( P = .50), and revision rates ( P = .17) were equivalent. VAS and ODI improved but did not differ between groups. In the open-TLIF group, LL and SL were restored or improved in 81.6% and 86.9% of cases, respectively. In the MIS-TLIF group, LL and SL were restored or improved in 86.8% and 97.4% of cases, respectively. There were no differences in changes in LL and SL between groups. Conclusions: Compared with the age- and sex-matched open-TLIF cohort, patients undergoing MIS-TLIF had reduced EBL and subfascial drain use but increased operative time. There were no differences in complications, reoperations, or LOS. Both groups demonstrated improvement in VAS and ODI. MIS-TLIF with bilateral facetectomies provided equivalent improvements in global and segmental LL.
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- 2021
13. Does L5-S1 Anterior Lumbar Interbody Fusion Improve Sagittal Alignment or Fusion Rates in Long Segment Fusion for Adult Spinal Deformity?
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Ahsan Khan, Eric O. Klineberg, Joseph B. Wick, Andrew J. Meyers, and Pope Rodnoi
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medicine.medical_specialty ,deformity ,Scoliosis ,Long segment ,Lumbar interbody fusion ,lumbar interbody fusion ,medicine ,Deformity ,Sagittal alignment ,degenerative ,Orthopedics and Sports Medicine ,sagittal balance ,Fusion ,sagittal alignment ,scoliosis ,business.industry ,pseudarthrosis ,Retrospective cohort study ,Original Articles ,medicine.disease ,Surgery ,Pseudarthrosis ,Neurology (clinical) ,medicine.symptom ,failed back surgery ,business - Abstract
Study Design: Retrospective cohort study. Objectives: To assess whether the addition of L5-S1 anterior lumbar interbody fusion (ALIF) improves global sagittal alignment and fusion rates in patients undergoing multilevel spinal deformity surgery. Methods: Two-year radiographic outcomes, including lumbar lordosis, pelvic incidence, pelvic tilt, and T1 pelvic angle; hardware complications; and nonunion/pseudarthrosis rates were compared between patients who underwent lumbosacral fusion at 4 or more vertebral levels with and without L5-S1 ALIF between November 2003 and September 2016. Results: A total of 51 patients who underwent fusion involving a mean of 11.1 levels with minimum 2-year postoperative radiographic follow-up data were included. Patients who underwent L5-S1 ALIF did not have significant improvement in global sagittal alignment parameters and demonstrated a trend toward a higher rate of nonunion and hardware failure. Conclusions: L5-S1 ALIF did not confer significant benefit in terms of global sagittal alignment and fusion rates in patients undergoing multilevel lumbosacral fusion. Given these results and that L5-S1 ALIF is associated with increased surgical morbidity, surgeons should be judicious in including L5-S1 ALIF in large multilevel constructs.
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- 2021
14. Preoperative Opioids and 1-year Patient-reported Outcomes After Spine Surgery
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Jeffrey M. Hills, Kristin R. Archer, Clinton J. Devin, Jacquelyn S. Pennings, Inamullah Khan, Joshua Daryoush, Richard Call, Joseph B. Wick, Marjorie Butler, and Ahilan Sivaganesan
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Male ,Pediatrics ,medicine.medical_specialty ,Time Factors ,MEDLINE ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Spine surgery ,Quality of life ,Preoperative Care ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Longitudinal Studies ,Patient Reported Outcome Measures ,Prospective Studies ,Registries ,Prospective cohort study ,Aged ,030222 orthopedics ,business.industry ,Middle Aged ,Opioid-Related Disorders ,Analgesics, Opioid ,Opioid ,Back Pain ,Elective Surgical Procedures ,Cohort ,Quality of Life ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug ,Cohort study - Abstract
Longitudinal Cohort Study.Determine 1-year patient-reported outcomes associated with preoperative chronic opioid therapy and high-preoperative opioid dosages in patients undergoing elective spine surgery.Back pain is the most disabling condition worldwide and over half of patients presenting for spine surgery report using opioids. Preoperative dosage has been correlated with poor outcomes, but published studies have not assessed the relationship of both preoperative chronic opioids and opioid dosage with patient-reported outcomes.For patients undergoing elective spine surgery between 2010 and 2017, our prospective institutional spine registry data was linked to opioid prescription data collected from our state's Prescription Drug Monitoring Program to analyze outcomes associated with preoperative chronic opioid therapy and high-preoperative opioid dosage, while adjusting for confounders through multivariable regression analyses. Outcomes included 1-year meaningful improvements in pain, function, and quality of life. Additional outcomes included 1-year satisfaction, return to work, 90-day complications, and postoperative chronic opioid use.Of 2128 patients included, preoperative chronic opioid therapy was identified in 21% and was associated with significantly higher odds (adjusted odds ratio [95% confidence interval]) of not achieving meaningful improvements at 1-year in extremity pain (aOR:1.5 [1.2-2]), axial pain (aOR:1.7 [1.4-2.2]), function (aOR:1.7 [1.4-2.2]), and quality of life (aOR:1.4 [1.2-1.9]); dissatisfaction (aOR:1.7 [1.3-2.2]); 90-day complications (aOR:2.9 [1.7-4.9]); and postoperative chronic opioid use (aOR:15 [11.4-19.7]). High-preoperative opioid dosage was only associated with postoperative chronic opioid use (aOR:4.9 [3-7.9]).Patients treated with chronic opioids prior to spine surgery are significantly less likely to achieve meaningful improvements at 1-year in pain, function, and quality of life; and less likely to be satisfied at 1-year with higher odds of 90-day complications, regardless of dosage. Both preoperative chronic opioid therapy and high-preoperative dosage are independently associated with postoperative chronic opioid use.2.
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- 2019
15. Perioperative Protocol for Elective Spine Surgery Is Associated With Reduced Length of Stay and Complications
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Joseph B. Wick, Ahilan Sivaganesan, Clinton J. Devin, Christy M. Cherkesky, Byron F. Stephens, and Silky Chotai
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Perioperative Care ,Cohort Studies ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Health care ,medicine ,Humans ,Orthopedic Procedures ,Orthopedics and Sports Medicine ,Young adult ,Elective surgery ,Aged ,Aged, 80 and over ,030222 orthopedics ,business.industry ,030229 sport sciences ,Perioperative ,Evidence-based medicine ,Length of Stay ,Middle Aged ,Spine ,Oswestry Disability Index ,Logistic Models ,Treatment Outcome ,Elective Surgical Procedures ,Emergency medicine ,Female ,Spinal Diseases ,Surgery ,Elective Surgical Procedure ,business ,Follow-Up Studies ,Cohort study - Abstract
Introduction Healthcare reform places emphasis on maximizing the value of care. Methods A prospective registry was used to analyze outcomes before (1,596 patients) and after (151 patients) implementation of standardized, evidence-based order sets for six high-impact dimensions of perioperative care for all patients who underwent elective surgery for degenerative spine disease after July 1, 2015. Results Apart from symptom duration, chronic obstructive pulmonary disease prevalence, estimated blood loss, and baseline Oswestry Disability Index, no significant differences existed between pre- and post-protocol cohorts. No differences in readmissions, discharge status, or 3-month patient-reported outcomes were seen. Multivariate regression analyses demonstrated reduced length of stay (P = 0.013) and odds of 90-day complications (P = 0.009) for postprotocol patients. Conclusion Length of stay and 90-day complications for elective spine surgery improved after implementation of an evidence-based perioperative protocol. Standardization efforts can improve quality and reduce costs, thereby improving the value of spine care. Level of evidence Level III (retrospective review of prospectively collected data).
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- 2019
16. Association of findings on preoperative extension lateral cervical radiography with osteotomy type, approach, and postoperative cervical alignment after cervical deformity surgery
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Hai V. Le, Joseph B. Wick, Renaud Lafage, Gregory M. Mundis, Robert K. Eastlack, Shay Bess, Douglas C. Burton, Christopher P. Ames, Justin S. Smith, Peter G. Passias, Munish C. Gupta, Virginie Lafage, and Eric O. Klineberg
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lordosis ,Databases, Factual ,medicine.medical_treatment ,Radiography ,Osteotomy ,Spinal Curvatures ,Thoracic Vertebrae ,Predictive Value of Tests ,Cervical deformity ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Patient Selection ,General Medicine ,Middle Aged ,medicine.disease ,Sagittal plane ,Cervical lordosis ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Lateral extension ,Cervical Vertebrae ,Female ,Anterior approach ,business - Abstract
OBJECTIVE The authors’ objective was to determine whether preoperative lateral extension cervical spine radiography can be used to predict osteotomy type and postoperative alignment parameters after cervical spine deformity surgery. METHODS A total of 106 patients with cervical spine deformity were reviewed. Radiographic parameters on preoperative cervical neutral and extension lateral radiography were compared with 3-month postoperative radiographic alignment parameters. The parameters included T1 slope, C2 slope, C2–7 cervical lordosis, cervical sagittal vertical axis, and T1 slope minus cervical lordosis. Associations of radiographic parameters with osteotomy type and surgical approach were also assessed. RESULTS On extension lateral radiography, patients who underwent lower grade osteotomy had significantly lower T1 slope, T1 slope minus cervical lordosis, cervical sagittal vertical axis, and C2 slope. Patients who achieved more normal parameters on extension lateral radiography were more likely to undergo surgery via an anterior approach. Although baseline parameters were significantly different between neutral lateral and extension lateral radiographs, 3-month postoperative lateral and preoperative extension lateral radiographs were statistically similar for T1 slope minus cervical lordosis and C2 slope. CONCLUSIONS Radiographic parameters on preoperative extension lateral radiography were significantly associated with surgical approach and osteotomy grade and were similar to those on 3-month postoperative lateral radiography. These results demonstrated that extension lateral radiography is useful for preoperative planning and predicting postoperative alignment.
- Published
- 2020
17. The Utility of Magnetic Resonance Imaging for Detecting Unstable Cervical Spine Injuries in the Neurologically Intact Traumatized Patient Following Negative Computed Tomography Imaging
- Author
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Rolando Figueroa Roberto, Fiona Scott, Eric O. Klineberg, Yashar Javidan, Joseph B. Wick, and Jacob H. Fennessy
- Subjects
medicine.medical_specialty ,Physical Injury - Accidents and Adverse Effects ,Cervical Spine ,unstable ,Computed tomography ,Bioengineering ,cervical spine ,Neurodegenerative ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,medicine ,magnetic resonance imaging ,Orthopedics and Sports Medicine ,Clinical significance ,Traumatic Head and Spine Injury ,ligamentous ,030222 orthopedics ,Neck pain ,screening and diagnosis ,medicine.diagnostic_test ,blunt trauma ,business.industry ,Trauma center ,Pain Research ,Neurosciences ,030208 emergency & critical care medicine ,Magnetic resonance imaging ,computed tomography ,Injuries and accidents ,posterior elements ,Occult ,Cervical spine ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,Good Health and Well Being ,Blunt trauma ,Biomedical Imaging ,Surgery ,Radiology ,Patient Safety ,medicine.symptom ,business ,occult injury ,4.2 Evaluation of markers and technologies - Abstract
Background: Neurologically intact blunt trauma patients with persistent neck pain and negative computed tomography (CT) imaging frequently undergo magnetic resonance imaging (MRI) for evaluation of occult cervical spine injury. There is a paucity of data to support or refute this practice. This study was therefore performed to evaluate the utility of cervical spine MRI in neurologically intact blunt trauma patients with negative CT imaging. Methods: A retrospective review was performed of all neurologically intact blunt trauma patients presenting to a level 1 trauma center from 2005 to 2015 with persistent neck pain and negative CT imaging. The proportion of patients with positive MRI findings, subsequent treatment, and time required to obtain MRI results was evaluated. Results: Of 223 patients meeting inclusion criteria, 11 had positive MRI findings; however, no patients were found to have unstable injuries requiring surgical treatment. The process for a complete evaluation of unstable cervical spine injury from the time of obtaining a CT scan was 19 hours and 43 minutes. Conclusions: Eleven patients had positive MRI findings, yet these findings did not alter treatment. In contrast, the time required to obtain MRI results may substantially delay patient care. Level of Evidence: IV (retrospective case series) Clinical Relevance: Our results demonstrate that MRI has limited utility in neurologically intact blunt trauma patients with negative CT imaging.
- Published
- 2020
18. Sarcopenia Is an Independent Risk Factor for Proximal Junctional Disease Following Adult Spinal Deformity Surgery
- Author
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Flynn Andrew Rowan, Daniel O’Connor, Ananth Eleswarapu, Hai Van Le, Joseph B. Wick, Yashar Javidan, Roberto Rolando, and Eric O. Klineberg
- Subjects
revision ,Aging ,medicine.medical_specialty ,proximal junctional kyphosis ,Disease ,sarcopenia ,Spine surgery ,Clinical Research ,medicine ,degenerative ,2.1 Biological and endogenous factors ,Orthopedics and Sports Medicine ,Aetiology ,Risk factor ,business.industry ,Prevention ,adult spinal deformity ,Retrospective cohort study ,medicine.disease ,proximal junctional failure ,Surgery ,Sarcopenia ,Spinal deformity ,Biomedical Imaging ,Neurology (clinical) ,business - Abstract
Study Design: Retrospective cohort study. Objectives: Sarcopenia is a risk factor for medical complications following spine surgery. However, the role of sarcopenia as a risk factor for proximal junctional disease (PJD) remains undefined. This study evaluates whether sarcopenia is an independent predictor of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) following adult spinal deformity (ASD) surgery. Methods: ASD patients who underwent thoracic spine to pelvis fusion with 2-year clinical and radiographic follow-up were reviewed for development of PJK and PJD. Average psoas cross-sectional area on preoperative axial computed tomography or magnetic resonance imaging at L4 was recorded. Previously described PJD risk factors were assessed for each patient, and multivariate linear regression was performed to identify independent risk factors for PJK and PJF. Disease-specific thresholds were calculated for sarcopenia based on psoas cross-sectional area. Results: Of 32 patients, PJK and PJF occurred in 20 (62.5%) and 12 (37.5%), respectively. Multivariate analysis demonstrated psoas cross-sectional area to be the most powerful independent predictor of PJK ( P = .02) and PJF ( P = .009). Setting ASD disease–specific psoas cross-sectional area thresholds of 2 in men and 2 in women resulted in a PJF rate of 69.2% for patients below these thresholds, relative to 15.8% for those above the thresholds. Conclusions: Sarcopenia is an independent, modifiable predictor of PJK and PJF, and is easily assessed on standard preoperative computed tomography or magnetic resonance imaging. Surgeons should include sarcopenia in preoperative risk assessment and consider added measures to avoid PJF in sarcopenic patients.
- Published
- 2020
19. Duration and Dosage of Opioids After Spine Surgery: Implications on Outcomes at 1 Year
- Author
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Joshua Daryoush, Joseph B. Wick, Richard Call, Clinton J. Devin, Kristin R. Archer, Jeffrey M. Hills, Inamullah Khan, Catherine Carlile, Marjorie Butler, and Jacquelyn S. Pennings
- Subjects
Adult ,Male ,Prescription drug ,Time Factors ,Drug Administration Schedule ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Orthopedics and Sports Medicine ,Longitudinal Studies ,Patient Reported Outcome Measures ,Prospective Studies ,Prospective cohort study ,Aged ,Retrospective Studies ,030222 orthopedics ,Pain, Postoperative ,Proportional hazards model ,business.industry ,Retrospective cohort study ,Odds ratio ,Middle Aged ,Opioid-Related Disorders ,Analgesics, Opioid ,Opioid ,Elective Surgical Procedures ,Anesthesia ,Female ,Spinal Diseases ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Cohort study ,medicine.drug - Abstract
Study design Longitudinal Cohort Study OBJECTIVE.: The aim of this study was to determine whether duration of postoperative opioids is associated with long-term outcomes, and if initial postoperative opioid dosage is associated with opioid cessation after spine surgery. Summary of background data Preoperative opioid use is associated with poor outcomes, but little evidence exists regarding the implications of opioid dosage and duration after spine surgery. Methods Data from our state's prescription drug database was linked to our prospective clinical spine registry to analyze opioid dispensing and outcomes in elective surgical spine patients between 2010 and 2017. Patients were stratified based on preoperative chronic opioid use and multivariable regression was used to assess associations between duration of postoperative opioids and outcomes at one year, including satisfaction, chronic opioid use, and meaningful improvements in pain, disability, and quality of life. In a secondary aim, a Cox proportional hazards model was used to determine whether initial postoperative opioid dosage was associated with time to opioid cessation. Results Of 2172 patients included, 35% had preoperative chronic opioid use. In patients without preoperative chronic opioid use, a postoperative opioid duration of 31 to 60 days was associated with chronic opioid use at 1 year (adjusted odds ratio [aOR]: 4.1 [1.7-9.8]) and no meaningful improvement in extremity pain (aOR: 1.8 [1.3-2.6]) or axial pain (aOR: 1.6 [1.1-2.2]); cessation between 61 and 90 days was associated with no meaningful improvement in disability (aOR: 2 [1.3-3]) and dissatisfaction (aOR:1.8 [1-3.1]). In patients with preoperative chronic opioid use, postoperative opioids for ≥90 days was associated with dissatisfaction. Cox regression analyses showed lower initial postoperative opioid dosages were associated with faster opioid cessation in both groups. Conclusion Our results suggest that a shorter duration of postoperative opioids may result in improved 1-year patient-reported outcomes, and that lower postoperative opioid dosages may lead to faster opioid cessation. Level of evidence 2.
- Published
- 2020
20. Patient-Reported Outcomes and Costs Associated With Revision Surgery for Degenerative Cervical Spine Diseases
- Author
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Ahilan Sivaganesan, Clinton J. Devin, Elliott J. Kim, David P. Stonko, Silky Chotai, and Joseph B. Wick
- Subjects
Adult ,Male ,Reoperation ,medicine.medical_specialty ,Revision procedure ,MEDLINE ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Recurrent disease ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Patient Reported Outcome Measures ,030212 general & internal medicine ,Neck Pain ,business.industry ,Evidence-based medicine ,Middle Aged ,Cervical spine ,Surgery ,Treatment Outcome ,Patient Satisfaction ,Cervical Vertebrae ,Etiology ,Female ,Spinal Diseases ,Neurology (clinical) ,business ,Complication ,030217 neurology & neurosurgery - Abstract
STUDY DESIGN A retrospective review of a prospective database. OBJECTIVE The aim of this study was to determine cost and outcomes of revision cervical spine surgery. SUMMARY OF BACKGROUND DATA Revision rates for cervical spine surgery are steadily increasing. It is important to counsel patients on expected results following a revision procedure. However, outcomes and cost of these procedures are poorly defined in the literature. METHODS Patients undergoing revision cervical spine surgery at a single institution were included between October 2010 and January 2016 in a prospective registry database. Patients were divided into three cohorts depending on their etiology for revision, including recurrent disease, pseudoarthrosis, or adjacent segment disease. Patient-reported outcomes (PROs), including Neck Disability Index (NDI), EuroQol-5D (EQ-5D), modified Japanese Orthopaedic Association (mJOA) score, numeric rating scale-neck pain (NRS-NP), and numeric rating scale-arm pain (NRS-AP), were measured at baseline and 12 months following revision surgery. Mean costs at 12 months following revision surgery were also calculated. Satisfaction was determined by the NASS patient satisfaction index. Variables were compared using Student t test. RESULTS A total of 115 patients underwent cervical revision surgery for recurrent disease (n = 21), pseudoarthrosis (n = 45), and adjacent segment disease (n = 49). There was significant improvement in all patient-reported outcomes at 12 months following surgery regardless of etiology (P
- Published
- 2018
21. Timing of Operative Intervention in Traumatic Spine Injuries Without Neurological Deficit
- Author
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Thomas H. Freeman, Joseph B. Wick, Silky Chotai, Elliott J. Kim, Diana G. Douleh, David P. Stonko, Akshitkumar M. Mistry, Clinton J. Devin, and Scott L. Parker
- Subjects
Adult ,Decompression ,Blood Loss, Surgical ,Neurosurgical Procedures ,Time-to-Treatment ,law.invention ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,law ,Intervention (counseling) ,Statistical significance ,Humans ,Medicine ,Retrospective Studies ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,Odds ratio ,Length of Stay ,Middle Aged ,Decompression, Surgical ,Intraoperative Hemorrhage ,Intensive care unit ,Confidence interval ,Anesthesia ,Spinal Fractures ,Female ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Numerous studies have demonstrated the benefits of early decompression and stabilization in unstable spine injuries with incomplete neurological deficits. However, a clear consensus on timing to operative intervention still does not exist in those with a normal neurological exam and unstable spine. Objective To determine the optimal timing of operative intervention in traumatic spine injuries without neurological deficit. Methods Retrospective chart review at a single institution was performed including patients with traumatic spine injuries without neurological deficit admitted from December 2001 to August 2012. Estimated intraoperative blood loss (EBL), in-hospital complications, postoperative hospital length of stay (HLOS), intensive care unit length of stay (ICULOS), and ventilator days were recorded. Delayed surgery was defined as surgery 72 h after admission. Results A total of 456 patients were included for analysis. There was a trend towards statistical significance between the time to operative intervention and EBL in bivariate analysis (P = .07). In the risk-adjusted multivariable analysis delayed vs early surgery was not associated with increased EBL or complications. Delayed surgery was associated with increased ICULOS (odds ratio [OR] = 2.19; 95% confidence interval [CI]: 1.38-3.51; P = .001), ventilator days (OR = 2.09; 95% CI: 1.28-3.43; P = .004), and increased postoperative HLOS (OR = 1.84; 95% CI: 1.22-2.76; P = .004). Conclusion Earlier operative intervention was associated with decreased ICULOS, ventilator days, and postoperative HLOS and did not show a statistically significant increase in EBL or complications. Earlier operative intervention for traumatic spine injuries without neurological deficit provides better outcomes compared to delayed surgery.
- Published
- 2018
22. Effect of Complications within 90 Days on Cost Per Quality-Adjusted Life Year Gained Following Elective Surgery for Degenerative Lumbar Spine Disease
- Author
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Silky Chotai, David P. Stonko, Clinton J. Devin, Joseph B. Wick, Ahilan Sivaganesan, Matthew J. McGirt, and Scott L. Parker
- Subjects
medicine.medical_specialty ,Lumbar spine disease ,business.industry ,MEDLINE ,Surgery ,Quality-adjusted life year ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030212 general & internal medicine ,Neurology (clinical) ,Elective surgery ,business ,030217 neurology & neurosurgery - Published
- 2017
23. Is There a Preoperative Morphine Equianalgesic Dose that Predicts Ability to Achieve a Clinically Meaningful Improvement Following Spine Surgery?
- Author
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Silky Chotai, Joel R Campbell, Samuel L. Posey, Joseph B. Wick, Clinton J. Devin, Parker T. Evans, Kristin R. Archer, and Ahilan Sivaganesan
- Subjects
Adult ,Male ,medicine.medical_specialty ,Minimal Clinically Important Difference ,Logistic regression ,Preoperative care ,Disability Evaluation ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,medicine ,Humans ,Patient Reported Outcome Measures ,Elective surgery ,Retrospective Studies ,030222 orthopedics ,Dose-Response Relationship, Drug ,business.industry ,Minimal clinically important difference ,food and beverages ,Bayes Theorem ,Retrospective cohort study ,Middle Aged ,Spine ,Equianalgesic ,Surgery ,Oswestry Disability Index ,Analgesics, Opioid ,Treatment Outcome ,Back Pain ,Anesthesia ,Preoperative Period ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Preoperative opioid use is widespread and associated with worse patient-reported outcomes following spine surgery. Objective To calculate a threshold preoperative morphine equianalgesic (MEA) dose beyond which patients are less likely to achieve the minimum clinically important difference (MCID) following elective surgery for degenerative spine disease. Methods The study included 543 cervical and 1293 lumbar patients. Neck Disability Index and Oswestry Disability Index scores were collected at baseline and 12 mo postoperatively. Preoperative MEA doses were calculated retrospectively. Multivariate logistic regression was then performed to determine the relationship between MEA dose and the odds of achieving MCID. As a part of this regression, Bayesian inference and Markov Chain Monte Carlo methods were used to estimate the values of inflection points (or "thresholds") in MEA. Results Overall, 1020 (55.5%) patients used preoperative opioids. A total of 50.3% of cervical and 61.9% of lumbar patients achieved MCID. The final logistic regression model demonstrated that MCID achievement decreased significantly when mean preoperative MEA dose exceeded 47.8 mg/d, with a 95% credible interval of 29.0 to 60.0 mg/d. Conclusion Minimum and maximum MEA doses exist, between which increasing opioid dose is associated with decreased ability to achieve clinically meaningful improvement following spine surgery. Patients with preoperative MEA dose exceeding 29 mg/d, the lower limit of the 95% credible interval for the mean MEA dose above which patients exhibit significantly decreased achievement of MCID, may be considered for preoperative opioid weaning.
- Published
- 2017
24. Healthcare Resource Utilization and Patient-Reported Outcomes Following Elective Surgery for Intradural Extramedullary Spinal Tumors
- Author
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Joseph B. Wick, Andrew T. Hale, Silky Chotai, Joseph S. Cheng, Scott L. Zuckerman, Matthew J. McGirt, Clinton J. Devin, Scott L. Parker, and David P. Stonko
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cost-Benefit Analysis ,Population ,Upper limb pain ,03 medical and health sciences ,Indirect costs ,0302 clinical medicine ,Quality of life ,Health care ,medicine ,Humans ,Longitudinal Studies ,Patient Reported Outcome Measures ,Prospective Studies ,Registries ,030212 general & internal medicine ,Elective surgery ,education ,health care economics and organizations ,Aged ,Neck pain ,education.field_of_study ,Lumbar Vertebrae ,Spinal Neoplasms ,business.industry ,Middle Aged ,Patient Acceptance of Health Care ,Health Surveys ,Mental health ,Treatment Outcome ,Elective Surgical Procedures ,Quality of Life ,Physical therapy ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
BACKGROUND Healthcare resource utilization and patient-reported outcomes (PROs) for intradural extramedullary (IDEM) spine tumors are not well reported. OBJECTIVE To analyze the PROs, costs, and resource utilization 1 year following surgical resection of IDEM tumors. METHODS Patients undergoing elective spine surgery for IDEM tumors and enrolled in a single-center, prospective, longitudinal registry were analyzed. Baseline and postoperative 1-year PROs were recorded. One-year spine-related direct and indirect healthcare resource utilization was assessed. One-year resource use was multiplied by unit costs based on Medicare national payment amounts (direct cost). Patient and caregiver workday losses were multiplied by the self-reported gross-of-tax wage rate (indirect cost). RESULTS A total of 38 IDEM tumor patients were included in this analysis. There was significant improvement in quality of life (EuroQol-5D), disability (Oswestry and Neck Disability Indices), pain (Numeric rating scale pain scores for back/neck pain and leg/arm pain), and general physical and mental health (Short-form-12 health survey, physical and mental component scores) in both groups 1 year after surgery (P < .0001). Eighty-seven percent (n = 33) of patients were satisfied with surgery. The 1-year postdischarge resource utilization including healthcare visits, medication, and diagnostic cost was $4111 ± $3596. The mean total direct cost was $23 717 ± $7412 and indirect cost was $5544 ± $4336, resulting in total 1-year cost $29 177 ± $9314. CONCLUSION Surgical resection of the IDEM provides improvement in patient-reported quality of life, disability, pain, general health, and satisfaction at 1 year following surgery. Furthermore, we report the granular costs of surgical resection and healthcare resource utilization in this population.
- Published
- 2017
25. Effect of obesity on cost per quality-adjusted life years gained following anterior cervical discectomy and fusion in elective degenerative pathology
- Author
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J. Alex Sielatycki, Harrison L. Kay, Ahilan Sivaganesan, Scott L. Parker, David P. Stonko, Joseph B. Wick, Clinton J. Devin, Silky Chotai, and Matthew J. McGirt
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Subgroup analysis ,Anterior cervical discectomy and fusion ,Intervertebral Disc Degeneration ,03 medical and health sciences ,Indirect costs ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Orthopedics and Sports Medicine ,health care economics and organizations ,Aged ,030222 orthopedics ,Neck pain ,Lumbar Vertebrae ,business.industry ,Middle Aged ,Obesity, Morbid ,Quality-adjusted life year ,Spinal Fusion ,Cervical Vertebrae ,Quality of Life ,Physical therapy ,Female ,Surgery ,Quality-Adjusted Life Years ,Neurology (clinical) ,medicine.symptom ,business ,Body mass index ,030217 neurology & neurosurgery ,Diskectomy - Abstract
Obese patients have greater comorbidities along with higher risk of complications and greater costs after spine surgery, which may result in increased cost and lower quality of life compared with their non-obese counterparts.The aim of the present study was to determine cost-utility following anterior cervical discectomy and fusion (ACDF) in obese patients.This study analyzed prospectively collected data.Patients undergoing elective ACDF for degenerative cervical pathology at a single academic institution were included in the study.Cost and quality-adjusted life years (QALYs) were the outcome measures.One- and two-year medical resource utilization, missed work, and health state values (QALYs) were assessed. Two-year resource use was multiplied by unit costs based on Medicare national payment amounts (direct cost). Patient and caregiver workday losses were multiplied by the self-reported gross-of-tax wage rate (indirect cost). Total cost (direct+indirect) was used to compute cost per QALY gained. Patients were defined as obese for body mass index (BMI) ≥35 based on the WHO definition of class II obesity. A subgroup analysis was conducted in morbidly obese patients (BMI≥40).There were significant improvements in pain (neck pain or arm pain), disability (Neck Disability Index), and quality of life (EuroQol-5D and Short Form-12) at 2 years after surgery (p.001). There was no significant difference in post-discharge health-care resource utilization, direct cost, indirect cost, and total cost between obese and non-obese patients at postoperative 1-year and 2-year follow-up. Mean 2-year direct cost for obese patients was $19,225±$8,065 and $17,635±$6,413 for non-obese patients (p=.14). There was no significant difference in the mean total 2-year cost between obese ($23,144±$9,216) and non-obese ($22,183±$10,564) patients (p=.48). Obese patients had a lower mean cumulative gain in QALYs versus non-obese patients at 2-years (0.34 vs. 0.42, p=.32). Two-year cost-utility in obese ($68,070/QALY) versus non-obese patients ($52,816/QALY) was not significantly different (p=.11). Morbidly obese patients had lower QALYs gained (0.17) and higher cost per QALYs gained ($138,094/QALY) at 2 years.Anterior cervical discectomy and fusion provided a significant gain in health state utility in obese patients, with a mean 2-year cost-utility of $68,070 per QALYs gained, which can be considered moderately cost-effective. Morbidly obese patients had lower cost-effectiveness; however, surgery does provide a significant improvement in outcomes. Obesity, and specifically morbid obesity, should to be taken into consideration as physician and hospital reimbursements move toward a bundled model.
- Published
- 2016
26. Factors Associated With Return-to-Work Following Cervical Spine Surgery in Non-Worker's Compensation Setting
- Author
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Elliott J. Kim, Mohamad Bydon, Joseph B. Wick, Kristin R. Archer, Inamullah Khan, Clinton J. Devin, Silky Chotai, and Ahilan Sivaganesan
- Subjects
Cervical spine surgery ,Adult ,Male ,medicine.medical_specialty ,MEDLINE ,Intervertebral Disc Degeneration ,Return to work ,03 medical and health sciences ,0302 clinical medicine ,Return to Work ,Spinal Stenosis ,Medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Prospective Studies ,Registries ,Prospective cohort study ,Aged ,Retrospective Studies ,030222 orthopedics ,Neck Pain ,business.industry ,Compensation (psychology) ,Follow up studies ,Retrospective cohort study ,Middle Aged ,Spinal Fusion ,Treatment Outcome ,Elective Surgical Procedures ,Physical therapy ,Cervical Vertebrae ,Quality of Life ,Workers' Compensation ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Intervertebral Disc Displacement ,Follow-Up Studies - Abstract
This study retrospectively analyzes prospectively collected data.Here in this study we aim to determine the factors which impact a patient's ability to return to work (RTW) in the setting of cervical spine surgery in patients without worker's compensation status.Surgical management of degenerative cervical disease has proven cost-effectiveness and shown significant improvement in quality of life. However, the ability to RTW is an important clinical outcome for preoperatively employed patients.All adult patients undergoing elective surgery for cervical degenerative disease at our institution are enrolled in a prospective, web-based registry. A multivariable Cox proportional hazards regression model was built for time to RTW. The variables included in the model were age, sex, smoking status, occupation type, number of levels operated on, ASA grade, body mass index, history of diabetes, history of coronary artery disease (CAD), history of chronic obstructive pulmonary disease (COPD), anxiety, depression, myelopathy at presentation, duration of symptoms more than 12 months, diagnosis, type of surgery performed, and preoperative Neck Disability Index, EuroQol Five Dimensions, and Numeric Rating Scale pain scores for neck pain and arm pain scores.Of the total 324 patients with complete 3-month follow-up data 83% (n = 269) returned to work following surgery. The median time to RTW was 35 days (range, 2-90 d). Patients with a labor-intensive occupation, higher ASA grade, history of CAD, and history of COPD were less likely to RTW. The likelihood of RTW was lower in patients with a diagnosis of disc herniation compared with cervical stenosis, patients undergoing cervical corpectomy compared laminectomy and fusion and patient with longer operative time.Our study identifies the various factors associated with a lower likelihood of RTW at 3 months after cervical spine surgery in the non-worker's compensation setting. This information provides expectations for the patient and employer when undergoing cervical spine surgery.3.
- Published
- 2019
27. The Profile of a Smoker and Its Impact on Outcomes After Cervical Spine Surgery
- Author
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Joseph S. Cheng, Matthew J. McGirt, Raul A. Vasquez, David P. Stonko, Mohamad Bydon, Anthony L. Asher, Joseph B. Wick, Silky Chotai, and Clinton J. Devin
- Subjects
Male ,Cervical spine surgery ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Spinal Cord Diseases ,Preoperative care ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Longitudinal Studies ,Self report ,030222 orthopedics ,Neck pain ,Smokers ,business.industry ,Smoking ,Middle Aged ,Surgery ,Tissue Degeneration ,Treatment Outcome ,Cervical Vertebrae ,Smoking cessation ,Female ,Spinal Diseases ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Published
- 2016
28. Intersurgeon Cost Variability in Anterior Cervical Discectomy and Fusion
- Author
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Clinton J. Devin, Joseph B. Wick, J. Alex Sielatycki, Silky Chotai, and Ahilan Sivaganesan
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Anterior cervical discectomy and fusion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,health care economics and organizations ,Cost database ,Aged ,Retrospective Studies ,Surgeons ,business.industry ,Retrospective cohort study ,Evidence-based medicine ,Length of Stay ,Middle Aged ,Cost reduction ,Spinal Fusion ,Spinal fusion ,Physical therapy ,Costs and Cost Analysis ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Diskectomy ,Follow-Up Studies - Abstract
Study design Retrospective review of prospective patient outcomes and cost data. Objective To analyze the contribution of surgeon-specific variability in cost and patient-reported outcomes (PROs) to overall variability in anterior cervical discectomy and fusion (ACDF), whereas adjusting for patient comorbidities. Summary of background data Cost reduction in surgical care has received increased attention. Patient factors contributing to cost variability in ACDF have been described; however, intersurgeon cost and outcome variability has received less attention in the literature. Methods Adult patients undergoing elective primary ACDF by five different surgeons were analyzed from a prospective registry database. Direct and indirect 90-day costs were compared across each surgeon, along with PROs. Predicted costs were calculated based on patient co-morbidities, and an "observed versus expected" cost differential was measured for each surgeon; this O/E cost ratio was then compared with PROs. Results A total of 431 patients were included in the analysis. There were no differences in comorbidities, age, smoking status, or narcotic use. There was significant variation between surgeons in total 90-day costs, as well as variation between each surgeon's observed versus expected cost ratio. Despite these surgeon-specific cost variations, there were no differences in PROs across the participating surgeons. Conclusion Intersurgeon cost variation in elective ACDF persists even after adjusting for patient comorbidities. There was no apparent correlation between increased surgeon-specific costs and 90-day PROs. These findings show there is opportunity for improvement in inter-surgeon cost variation without compromise in PROs. Level of evidence 3.
- Published
- 2018
29. Causes and Timing of Unplanned 90-day Readmissions Following Spine Surgery
- Author
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Benjamin M. Weisenthal, Joshua Daryoush, Joseph B. Wick, Anthony L. Asher, Silky Chotai, Clinton J. Devin, Inamullah Khan, Thomas H. Freeman, Jeffrey M. Hills, Ahilan Sivaganesan, and Marjorie Butler
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Patient Readmission ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Spine surgery ,Postoperative Complications ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,health care economics and organizations ,Aged ,Retrospective Studies ,Pain, Postoperative ,business.industry ,General surgery ,Middle Aged ,Elective Surgical Procedures ,Cohort ,Female ,Spinal Diseases ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Retrospective cohort study.The aim of this study was to evaluate the causes, timing, and factors associated with unplanned 90-day readmissions following elective spine surgery.Unplanned readmissions after spine surgery are costly and an important determinant of the value of care. Several studies using database information have reported on rates and causes of readmission. However, these often lack the clinical detail and actionable data necessary to guide early postdischarge interventions.Patients undergoing elective spine surgery for degenerative disease at a major medical center were enrolled in a prospective longitudinal registry. Patient and surgery-specific characteristics, baseline, and 3-month patient-reported outcomes were prospectively recorded. Readmissions were reviewed retrospectively to establish the reason and time to readmission. A multivariable Cox proportional hazard model was created to analyze the independent effects of several factors on readmission.Of 2761 patients with complete 3-month follow-up, 156 had unplanned 90-day readmissions (5.6%). The most common reason was surgery-related (52%), followed by medical complications (38%) and pain (10%). Pain readmissions presented with a median time of 6 days. Medical readmissions presented at 12 days. Surgical complications presented at various times with wound complications at 6 days, cerebrospinal fluid leaks at 12 days, surgical site infections at 23 days, and surgical failure at 38 days. A history of myocardial infarction, osteoporosis, higher baseline leg and arm pain scores, longer operative duration, and lumbar surgery were associated with readmission.Nearly half of all unplanned 90-day readmissions were because of pain and medical complications and occurred with a median time of 6 and 12 days, respectively. The remaining 52% of readmissions were directly related to surgery and occurred at various times depending on the specific reason. This timeline for pain and medical readmissions represents an opportunity for targeted postdischarge interventions to prevent unplanned readmissions following spine surgery.3.
- Published
- 2017
30. Erratum to: Impact of old age on patient-report outcomes and cost utility for anterior cervical discectomy and fusion surgery for degenerative spine disease
- Author
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Matthew J. McGirt, J. Alex Sielatycki, Joseph B. Wick, Clinton J. Devin, Ahilan Sivaganesan, Silky Chotai, Harrison L. Kay, and Scott L. Parker
- Subjects
medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Anterior cervical discectomy and fusion ,Disease ,medicine.disease ,Surgery ,Older population ,03 medical and health sciences ,0302 clinical medicine ,Degenerative disease ,Cost utility ,Cohort ,medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Patient report ,education ,business ,health care economics and organizations ,030217 neurology & neurosurgery - Abstract
With growing older population and increasing rates of cervical spinal surgery, it is vital to understand the value of cervical surgery in this population. We set forth to determine the cost utility following anterior cervical decompression and fusion (ACDF) for degenerative disease in older patients. Patients undergoing ACDF for degenerative diseases were enrolled into prospective longitudinal registry. Patient-reported outcomes (PROs) were recorded at baseline, 1-year, and 2-year postoperatively. Two-year medical resource utilization, missed work, and health-state values [quality-adjusted life years (QALYs)] were assessed to compute cost per QALY gained. Patients were dichotomized based on age
- Published
- 2017
31. A retrospective review comparing two-year patient-reported outcomes, costs, and healthcare resource utilization for TLIF vs. PLF for single-level degenerative spondylolisthesis
- Author
-
Clinton J. Devin, Silky Chotai, Alex Sielatycki, Joseph B. Wick, Elliott Kim, and David P. Stonko
- Subjects
Adult ,Male ,Reoperation ,medicine.medical_specialty ,Total cost ,Medicare ,03 medical and health sciences ,Indirect costs ,0302 clinical medicine ,Postoperative Complications ,Quality of life ,Health care ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Patient Reported Outcome Measures ,health care economics and organizations ,Aged ,Retrospective Studies ,Aged, 80 and over ,Retrospective review ,Lumbar Vertebrae ,business.industry ,Middle Aged ,medicine.disease ,Degenerative spondylolisthesis ,Spondylolisthesis ,United States ,Spinal Fusion ,Patient Satisfaction ,Physical therapy ,Surgery ,Female ,Neurosurgery ,Quality-Adjusted Life Years ,business ,030217 neurology & neurosurgery - Abstract
The purpose of this study was to compare patient-reported outcomes (PROs), morbidity, and costs of TLIF vs PLF to determine whether one treatment was superior in the setting of single-level degenerative spondylolisthesis. Patients undergoing TLIF or PLF for single-level spondylolisthesis were included for retrospective analysis. EQ-5D, ODI, SF-12 MCS/PCS, NRS-BP/LP scores were collected at baseline and 24 months after surgery. 90-day post-operative complications, revision surgery rates, and satisfaction scores were also collected. Two-year resource use was multiplied by unit costs based on Medicare payment amounts (direct cost). Patient and caregiver workday losses were multiplied by the self-reported gross-of-tax wage rate (indirect cost). Total cost was used to assess mean total 2-year cost per QALYs gained after surgery. 62 and 37 patients underwent TLIF and PLF, respectively. Patients in the PLF group were older (p
- Published
- 2016
32. Patient-reported outcomes after lumbar epidural steroid injection for degenerative spine disease in depressed versus non-depressed patients
- Author
-
Matthew J. McGirt, Silky Chotai, David P. Stonko, Joseph B. Wick, Elliott J. Kim, Byron J Schneider, and Clint J. Devin
- Subjects
Anesthesia, Epidural ,Male ,medicine.medical_specialty ,Injections, Epidural ,Context (language use) ,Intervertebral Disc Degeneration ,Neurosurgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Numeric Rating Scale ,medicine ,Back pain ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Patient Reported Outcome Measures ,Depression (differential diagnoses) ,Aged ,Lumbar Vertebrae ,business.industry ,Depression ,Middle Aged ,medicine.disease ,humanities ,Oswestry Disability Index ,Radicular pain ,Concomitant ,Physical therapy ,Surgery ,Female ,Steroids ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Medical interventional modalities such as lumbar epidural steroid injections (LESIs) are often used in the setting of lumbar spine disorders where other conservative measures have failed. Concomitant depression can lead to worse outcomes in lumbar spine pathology. A number of studies have demonstrated an association between preoperative depression and poor outcomes following surgery, but the effect of depression on outcomes following medical interventional modalities is poorly understood.To evaluate the differences in patient-reported outcomes (PROs) between depressed and non-depressed patients undergoing LESI.This study is an analysis of a prospective longitudinal registry database at a single academic institution.All patients undergoing LESI from 2012 to 2014 were eligible for enrollment into a prospective, web-based registry. Eligible patients had radicular pain, correlative imaging findings of degenerative pathology, and failed 6 weeks of conservative care.The PROs measured included the (1) numeric rating scale for back pain (NRS-BP), (2) numeric rating scale for leg pain (NRS-LP), (3) disease-specific physical disability-Oswestry Disability Index (ODI), and (4) preference-based health status-EuroQol-5D (EQ-5D).Patients who met the inclusion criteria underwent LESI. Patient-reported outcomes were collected at baseline and at 12 months following treatment. Based on previously validated values for the Zung Depression Scale (ZDS) as a screening tool for depression, patients were dichotomized into non-depressed (ZDS score ≤33) and depressed (ZDS score33). The PRO change scores from baseline to 12 months were calculated. The mean absolute and change scores between the groups were compared using Student t test. Multivariable linear regression analysis for ODI, EQ-5D, NRS-LP, and NRS-BP was performed.A total of 161 patients with complete 12-month follow-up were included. Seventy-one patients (44%) were classified as depressed and 90 patients (56%) were classified as non-depressed. The mean baseline PRO scores were significantly worse in depressed patients compared with non-depressed patients: ODI (p.001), NRS-BP (p=.013), NRS-LP (p.001), and EQ-5D (p=.001). The mean absolute scores at 12 months were significantly lower in the depressed versus non-depressed patients: ODI (p.001), NRS-BP (p=.001), NRS-LP (p=.05), and EQ-5D (p=.003). However, there was no difference in mean change scores observed at 12 months between the depressed and non-depressed cohorts: ODI (p=.42), NRS-BP (p=.31), NRS-LP (p=.25), EQ-5D (p=.14). Adjusting for pre-procedure variables, the higher ZDS score was associated with higher disability (ODI) at 12 months.Depression led to worse absolute scores for PROs and is associated with higher disability following LESI. However, patients with depressive symptoms can expect similar improvement in PROs at 12 months.
- Published
- 2016
33. Surgical Resection of Intradural Extramedullary Spinal Tumors: Patient Reported Outcomes and Minimum Clinically Important Difference
- Author
-
Matthew J. McGirt, Andrew T. Hale, Scott L. Parker, Scott L. Zuckerman, Joseph B. Wick, Clinton J. Devin, Joseph S. Cheng, David P. Stonko, and Silky Chotai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Minimal Clinically Important Difference ,03 medical and health sciences ,Disability Evaluation ,0302 clinical medicine ,Quality of life ,Surveys and Questionnaires ,Numeric Rating Scale ,Medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Patient Reported Outcome Measures ,Prospective Studies ,Prospective cohort study ,Aged ,Pain Measurement ,Neck pain ,Spinal Neoplasms ,business.industry ,Minimal clinically important difference ,Middle Aged ,humanities ,Oswestry Disability Index ,Quality-adjusted life year ,Treatment Outcome ,Patient Satisfaction ,Physical therapy ,Quality of Life ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Relative validity - Abstract
Study design Analysis of prospectively collected longitudinal web-based registry data. Objective To determine relative validity, responsiveness, and minimum clinically important difference (MCID) thresholds in patients undergoing surgery for intradural extramedullary (IDEM) spinal tumors. Summary of background data Patient-reported outcomes (PROs) are vital in establishing the value of care in spinal pathology. There is limited availability of prospective, quality studies reporting PROs for IDEM spine tumors. Methods . A total of 40 patients were analyzed. Baseline, postoperative 3-month, and 12-month PROs were recorded: Oswestry Disability Index or Neck disability Index (ODI/NDI), Quality of life EuroQol-5D (EQ-5D), Short Form-12 (SF-12), Numeric Rating Scale (NRS)-pain scores. Responders were defined as those who achieved a level of improvement one or two, after surgery, on health transition index (HTI) of SF-36. Receiver-operating characteristic curves were generated to assess the validity of PROs, and the difference between standardized response means (SRMs) in responders versus nonresponders was utilized to determine the relative responsiveness of each PRO measure. MCID thresholds were derived using previously reported minimal detectable change approach. Results A significant improvement across all PROs at 3-months and 12-months follow up was noted. The derived MCID thresholds were 13.9 points: ODI/NDI, 0.14 quality adjusted life years: EQ-5D, 2.8 points: SF-12PCS and 10.7 points: SF-12MCS, 1.9 points: NRS-back/neck pain, and 1.8 points: NRS-leg/arm pain. SF-12PCS was most accurate discriminator of meaningful improvement (area under the curve, AUC-0.83) and most responsive (SRM-1.36) to postoperative improvement. EQ-5D, ODI/NDI, NRS-pain scores were all accurate discriminator (AUC-0.7-0.8) and responsive measures (0.97-0.67) of meaningful postoperative improvement. SF-12MCS was neither a valid discriminator (AUC-0.48) nor a responsive measure (SRM: -1.5) of outcome. Conclusion Surgical resection of IDEM spinal tumors provides significant and sustained improvement in quality of life, general health, disability, and pain at 12-month after surgery. The surgically resected IDEM-specific clinically meaningful thresholds are reported. All the PROs reported in this study can accurately discriminate responders and nonresponder based on SF-36 HTI index except for SF-12 MCS. Level of evidence 3.
- Published
- 2016
34. Impact of old age on patient-report outcomes and cost utility for anterior cervical discectomy and fusion surgery for degenerative spine disease
- Author
-
Silky Chotai, Scott L. Parker, J. Alex Sielatycki, Ahilan Sivaganesan, Harrison L. Kay, Joseph B. Wick, Matthew J. McGirt, and Clinton J. Devin
- Subjects
Male ,030222 orthopedics ,Cost-Benefit Analysis ,Age Factors ,United States ,03 medical and health sciences ,Disability Evaluation ,0302 clinical medicine ,Spinal Fusion ,Spinal Stenosis ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Female ,Longitudinal Studies ,Patient Reported Outcome Measures ,Prospective Studies ,Quality-Adjusted Life Years ,Registries ,Spondylosis ,030217 neurology & neurosurgery ,Intervertebral Disc Displacement ,Aged ,Diskectomy - Abstract
With growing older population and increasing rates of cervical spinal surgery, it is vital to understand the value of cervical surgery in this population. We set forth to determine the cost utility following anterior cervical decompression and fusion (ACDF) for degenerative disease in older patients.Patients undergoing ACDF for degenerative diseases were enrolled into prospective longitudinal registry. Patient-reported outcomes (PROs) were recorded at baseline, 1-year, and 2-year postoperatively. Two-year medical resource utilization, missed work, and health-state values [quality-adjusted life years (QALYs)] were assessed to compute cost per QALY gained. Patients were dichotomized based on age: 65 years (younger) and ≥65 years (older) to compare the cost utility in these age groups.Total 218 (87%) younger patients and 33 (13%) older patients who underwent ACDF were analyzed. Both the groups demonstrated a significant improvement in PROs 2-year following surgery. The older patients had a lower mean cumulative gain in QALYs compared to younger patients at 1 year (0.141 vs. 0.28, P = 0.05) and 2 years (0.211 vs. 0.424, P = 0.04). There was no significant difference in the mean total 2-year cost between older [$21,041 (95% CI $18,466-$23,616)] and younger [$22,669 (95% CI $$21,259-$24,079)] patients (P = 0.27). Two-year cost per QALY gained in older vs. younger patients was ($99,720/QALYs gained vs. ($53,464/QALYs gained, P = 0.68).ACDF surgery provided a significant gain in health-state utility in older patients with degenerative cervical pathology, with a mean cumulative 2-year cost per QALY gained of $99,720/QALY. While older patients have a slightly higher cost utility compared to their younger counterparts, surgery in the older cohort does provide a significant improvement in pain, disability, and quality-of-life outcomes.
- Published
- 2016
35. A Population-Based Study of Prevalence and Adherence Trends in Average Risk Colorectal Cancer Screening, 1997 to 2008
- Author
-
L. Joseph Melton, Paul A. Decker, Noralane M. Lindor, Timothy J. Beebe, Christina M. Smith, Sally W. Vernon, Joseph B. Wick, Pamela S. Sinicrope, Paul J. Limburg, Tabetha A. Brockman, Gloria M. Petersen, Andrew C. Hanson, Ellen L. Goode, Christi A. Patten, and Frank A. Sinicrope
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Epidemiology ,Minnesota ,Population ,Article ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,medicine ,Humans ,Mass Screening ,Mammography ,education ,neoplasms ,Early Detection of Cancer ,Mass screening ,Aged ,Gynecology ,Average risk ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Medical record ,Cancer ,Middle Aged ,medicine.disease ,digestive system diseases ,Population based study ,Oncology ,Colorectal cancer screening ,Patient Compliance ,Female ,Colorectal Neoplasms ,business - Abstract
Background: Increasing colorectal cancer screening (CRCS) is important for attaining the Healthy People 2020 goal of reducing CRC-related morbidity and mortality. Evaluating CRCS trends can help identify shifts in CRCS, and specific groups that might be targeted for CRCS. Methods: We utilized medical records to describe population-based adherence to average-risk CRCS guidelines from 1997 to 2008 in Olmsted County, MN. CRCS trends were analyzed overall and by gender, age, and adherence to screening mammography (women only). We also carried out an analysis to examine whether CRCS is being initiated at the recommended age of 50. Results: From 1997 to 2008, the size of the total eligible sample ranged from 20,585 to 21,468 people. CRCS increased from 22% to 65% for women and from 17% to 59% for men (P < 0.001 for both) between 1997 and 2008. CRCS among women current with mammography screening increased from 26% to 74%, and this group was more likely to be adherent to CRCS than all other subgroups analyzed (P < 0.001).The mean ages of screening initiation were stable throughout the study period, with a mean age of 55 years among both men and women in 2008. Conclusion: Although overall CRCS tripled during the study period, there is still room for improvement. Impact: Working to decrease the age at first screening, exploration of gender differences in screening behavior, and targeting women adherent to mammography but not to CRCS seem warranted. Cancer Epidemiol Biomarkers Prev; 21(2); 347–50. ©2011 AACR.
- Published
- 2012
36. Predicting the Odds of Returning to Work for Patients Undergoing Elective Cervical Spine Surgery
- Author
-
Elliott Kim, David P. Stonko, Clinton J. Devin, Ahilan Sivaganesan, Silky Chotai, and Joseph B. Wick
- Subjects
Cervical spine surgery ,medicine.medical_specialty ,Work (electrical) ,business.industry ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,Odds - Published
- 2017
37. Is obesity associated with worse patient-reported outcomes following lumbar surgery for degenerative conditions?
- Author
-
J. Alex Sielatycki, David P. Stonko, Matthew J. McGirt, Clinton J. Devin, Harrison F. Kay, Silky Chotai, and Joseph B. Wick
- Subjects
Male ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Body Mass Index ,03 medical and health sciences ,Disability Evaluation ,0302 clinical medicine ,Patient satisfaction ,Lumbar ,Spinal Stenosis ,Internal medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Obesity ,Patient Reported Outcome Measures ,Registries ,Depression (differential diagnoses) ,Lumbar Vertebrae ,business.industry ,Laminectomy ,humanities ,United States ,Surgery ,Oswestry Disability Index ,Spinal Fusion ,Patient Satisfaction ,Anxiety ,Female ,medicine.symptom ,Spondylolisthesis ,business ,Body mass index ,030217 neurology & neurosurgery ,Intervertebral Disc Displacement - Abstract
To investigate whether obesity is associated with worse patient-reported outcomes following surgery for degenerative lumbar conditions. We evaluated consecutive patients undergoing elective lumbar laminectomy or laminectomy with fusion for degenerative lumbar conditions. The Oswestry Disability Index (ODI), EuroQol-5D (EQ-5D), Short-Form 12 (SF-12), and NASS patient satisfaction were utilized. Chi-square tests and student t test assessed the association of obesity with PROs. Multivariate regression controlled for age, sex, smoking status, anxiety, depression, revision, preoperative narcotic use, payer status, and diabetes. A total of 602 patients were included. All PROs improved significantly in both groups. BMI ≥35 was associated with increased ODI at baseline (50.6 vs. 47.2 %, p = 0.012) and 12 months (30.5 vs. 25.7 %, p = 0.005). There was no difference in ODI change scores (21.2 vs. 19.4 %, p = 0.32). With multivariate analysis, BMI ≥35 was not predictive of worse ODI at 12 months (correlation coefficient 1.23, 95 % CI −0.225 to 2.676.) There was no significant difference between groups in percentage of patients achieving the minimum clinically important difference for ODI (59.6 vs. 64 %, p = 0.46) or patient satisfaction (80.5 vs. 78.9 %, p = 0.63). Body mass index ≥35 is associated with worse baseline and 12-month PROs, however, there was no difference in change scores across BMI groups. Controlling for important co-variables, BMI greater than 35 was not an independent predictor of worse PROs at 12 months.
- Published
- 2015
38. Preoperative and surgical factors associated with postoperative intensive care unit admission following operative treatment for degenerative lumbar spine disease
- Author
-
Clinton J. Devin, Matthew J. McGirt, Silky Chotai, Harrison F. Kay, Joseph B. Wick, and David P. Stonko
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lumbar spine disease ,Arthrodesis ,medicine.medical_treatment ,Operative Time ,Blood Loss, Surgical ,Comorbidity ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Patient Admission ,Sex Factors ,law ,Medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,Registries ,Depression (differential diagnoses) ,Aged ,Postoperative Care ,030222 orthopedics ,Lumbar Vertebrae ,business.industry ,Age Factors ,Laminectomy ,Middle Aged ,Intensive care unit ,United States ,Surgery ,Intensive Care Units ,Spinal Fusion ,Cardiovascular Diseases ,Anxiety ,Female ,Spinal Diseases ,Neurosurgery ,medicine.symptom ,business - Abstract
Evaluate the factors associated with postoperative ICU admission in patients undergoing surgical management of degenerative lumbar spine disease. Patients undergoing surgery for degenerative lumbar spine disease were enrolled into a prospective registry over a 2-year period. Preoperative variables (age, gender, ASA grade, ODI %, CAD, HTN, MI, CHF, DM, BMI, depression, anxiety) and surgical variables (instrumentation, arthrodesis, estimated blood loss, length of surgery) were collected prospectively. Postoperative ICU admission details were retrospectively determined from the electronic medical record. Student’s t test (continuous variables) and Chi-square test (categorical variables) were used to determine the association of each preoperative and surgical variable with ICU admission. 808 Patients (273 laminectomy, 535 laminectomy and fusion) were evaluated. Forty-one (5.1 %) patients were found to have postoperative ICU admissions. Reasons for admission included blood loss (12.2 %), cardiac (29.3 %), respiratory (19.5 %), neurologic (31.7 %), and other (7.3 %). For preoperative variables, female gender (P
- Published
- 2015
39. Effect of Complications within 90 Days on Cost-Utility following Lumbar Decompression with and without Fusion for Degenerative Spine Disease
- Author
-
Clinton J. Devin, Matthew J. McGirt, John A. Sielatycki, Ahilan Sivaganesan, Joseph B. Wick, David P. Stonko, Silky Chotai, and Scott L. Parker
- Subjects
Spine (zoology) ,medicine.medical_specialty ,Lumbar ,business.industry ,Decompression ,Cost utility ,Medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Disease ,business - Published
- 2016
40. Surgical Resection of Intradural Extramedullary Spinal Tumors: Patient-Reported Outcomes and Minimum Clinically Important Difference
- Author
-
Joseph S. Cheng, Scott L. Zuckerman, David P. Stonko, Matthew J. McGirt, Scott L. Parker, Clinton J. Devin, Silky Chotai, Joseph B. Wick, and Andrew T. Hale
- Subjects
medicine.medical_specialty ,Neck pain ,business.industry ,Minimal clinically important difference ,Area under the curve ,humanities ,Quality-adjusted life year ,Oswestry Disability Index ,Quality of life ,medicine ,Numeric Rating Scale ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Radiology ,medicine.symptom ,business ,Relative validity - Abstract
Study design Analysis of prospectively collected longitudinal web-based registry data. Objective To determine relative validity, responsiveness, and minimum clinically important difference (MCID) thresholds in patients undergoing surgery for intradural extramedullary (IDEM) spinal tumors. Summary of background data Patient-reported outcomes (PROs) are vital in establishing the value of care in spinal pathology. There is limited availability of prospective, quality studies reporting PROs for IDEM spine tumors. Methods . A total of 40 patients were analyzed. Baseline, postoperative 3-month, and 12-month PROs were recorded: Oswestry Disability Index or Neck disability Index (ODI/NDI), Quality of life EuroQol-5D (EQ-5D), Short Form-12 (SF-12), Numeric Rating Scale (NRS)-pain scores. Responders were defined as those who achieved a level of improvement one or two, after surgery, on health transition index (HTI) of SF-36. Receiver-operating characteristic curves were generated to assess the validity of PROs, and the difference between standardized response means (SRMs) in responders versus nonresponders was utilized to determine the relative responsiveness of each PRO measure. MCID thresholds were derived using previously reported minimal detectable change approach. Results A significant improvement across all PROs at 3-months and 12-months follow up was noted. The derived MCID thresholds were 13.9 points: ODI/NDI, 0.14 quality adjusted life years: EQ-5D, 2.8 points: SF-12PCS and 10.7 points: SF-12MCS, 1.9 points: NRS-back/neck pain, and 1.8 points: NRS-leg/arm pain. SF-12PCS was most accurate discriminator of meaningful improvement (area under the curve, AUC-0.83) and most responsive (SRM-1.36) to postoperative improvement. EQ-5D, ODI/NDI, NRS-pain scores were all accurate discriminator (AUC-0.7-0.8) and responsive measures (0.97-0.67) of meaningful postoperative improvement. SF-12MCS was neither a valid discriminator (AUC-0.48) nor a responsive measure (SRM: -1.5) of outcome. Conclusion Surgical resection of IDEM spinal tumors provides significant and sustained improvement in quality of life, general health, disability, and pain at 12-month after surgery. The surgically resected IDEM-specific clinically meaningful thresholds are reported. All the PROs reported in this study can accurately discriminate responders and nonresponder based on SF-36 HTI index except for SF-12 MCS. Level of evidence 3.
- Published
- 2016
41. What, If Any, Preoperative Morphine Equianalgesic Dose Predicts Ability to Achieve a Clinically Meaningful Improvement following Spine Surgery?
- Author
-
Silky Chotai, Clinton J. Devin, Samuel L. Posey, Parker T. Evans, Ahilan Sivaganesan, Joseph B. Wick, and Kristin R. Archer
- Subjects
medicine.medical_specialty ,Spine surgery ,business.industry ,Anesthesia ,Morphine ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,Equianalgesic ,medicine.drug - Published
- 2017
42. Does Depression or Anxiety Affect Patient-Reported Outcomes and Satisfaction Following Operative Treatment for Cervical Myelopathy?
- Author
-
Ahilan Sivaganesan, Joseph B. Wick, Harrison F. Kay, Silky Chotai, Matthew J. McGirt, David P. Stonko, and Clinton J. Devin
- Subjects
medicine.medical_specialty ,business.industry ,Affect (psychology) ,Cervical radiculopathy ,Anesthesia ,medicine ,Physical therapy ,Anxiety ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,medicine.symptom ,business ,Depression (differential diagnoses) - Published
- 2015
43. Does Obesity Predict Poor Patient-Reported Outcomes following Lumbar Surgery for Degenerative Conditions?
- Author
-
John A. Sielatycki, Clinton J. Devin, Matthew J. McGirt, Silky Chotai, Joseph B. Wick, Harrison F. Kay, and David P. Stonko
- Subjects
medicine.medical_specialty ,business.industry ,Lumbar surgery ,Anesthesia ,Medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,medicine.disease ,Obesity - Published
- 2015
44. Does Obesity Correlate with Poor Patient-Reported Outcomes following Cervical Surgery for Degenerative Conditions?
- Author
-
David P. Stonko, Kevin R. O'Neill, Harrison F. Kay, Joseph B. Wick, Clinton J. Devin, John A. Sielatycki, and Silky Chotai
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,medicine.disease ,Obesity ,Cervical surgery - Published
- 2015
45. Health Care Resource Utilization and Patient-Reported Outcomes following Elective Surgery for Intradural Extramedullary Spinal Tumors
- Author
-
Joseph S. Cheng, Matthew J. McGirt, Scott L. Parker, Andrew T. Hale, Scott L. Zuckerman, Joseph B. Wick, Silky Chotai, Clinton J. Devin, and David P. Stonko
- Subjects
medicine.medical_specialty ,Intradural Extramedullary Spinal Tumors ,business.industry ,Health care ,Emergency medicine ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Elective surgery ,business ,Resource utilization - Published
- 2016
46. Timing of Operative Intervention in Traumatic Spine Injuries without Neurologic Deficit
- Author
-
Clinton J. Devin, Silky Chotai, Akshitkumar M. Mistry, Elliott Kim, Joseph B. Wick, David P. Stonko, Thomas H. Freeman, Scott L. Parker, and Diana G. Douleh
- Subjects
Spine (zoology) ,medicine.medical_specialty ,business.industry ,Intervention (counseling) ,Physical therapy ,Medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business - Published
- 2016
47. Two-Year Patient-Reported Outcomes Costs and Health Care Resource Utilization for TLIF versus PLF for Single-Level Degenerative Spondylolisthesis
- Author
-
Clinton J. Devin, David P. Stonko, John A. Sielatycki, Elliott Kim, Joseph B. Wick, and Silky Chotai
- Subjects
medicine.medical_specialty ,business.industry ,Health care ,Physical therapy ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Single level ,business ,Degenerative spondylolisthesis ,Resource utilization - Published
- 2016
48. 106 Effect of Complications Within 90 Days on Cost-Utility Following Elective Surgery for Degenerative Lumbar Spine Disease
- Author
-
David P. Stonko, Matthew J. McGirt, Joseph B. Wick, Ahilan Sivaganesan, Scott L. Parker, Clinton J. Devin, and Silky Chotai
- Subjects
030222 orthopedics ,medicine.medical_specialty ,Lumbar spine disease ,business.industry ,Area under the curve ,Oswestry Disability Index ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Cost utility ,Health care ,Medicine ,Lumbar spine ,Neurology (clinical) ,Elective surgery ,business ,030217 neurology & neurosurgery - Abstract
Current health care systems are rapidly transitioning from the "fee-for service" to the "pay-for performance" model. With this paradigm shift, the providers and payers are constantly striving to determine tools to provide cost-effective and high-quality patient care. Therefore, it is vital to account for the complications and their effects on the cost and quality of life. We set forth to determine the cost-utility associated with complications after lumbar spine surgery.Total 407 patients undergoing elective surgery for degenerative lumbar pathology enrolled in the prospective longitudinal registry were included in the study. PROs: Oswestry Disability Index (ODI), numeric rating scale-Back and leg pain (BP, LP), general health (SF-12), and quality-of-life scores EQ-5D were recorded at baseline and 2 years after surgery. Two-year back-related medical resource utilization, missed work, and health state values (quality-adjusted life-years [QALYs], calculated from the EQ-5D with US valuation using the time-weighted area under the curve approach) were assessed. Mean 2-year cost per QALY gained after surgery was assessed. The patients were divided into groups with and without complications to compare the QALYs gained and the cost-utility in these groups.Fourteen percent (n = 58) of patients developed complications within 90 days after surgery. Most frequent surgical complication was surgical site infection (4.2%, n = 17), 1.5% (n = 6) had deep surgical site infections. There was a significant improvement in pain (BP, LP), disability (ODI), and general health scores (EQ-5D and SF-12) in both groups at postoperative 2 years (P < .0001). Patients with complications had lower mean cumulative 2-year QALY gained compared with those without complications (0.49 vs 0.57, P = .36). Cost-per-QALYs gained in patients with and without complications was $70 822 vs $45 831 (P = .03).Lumbar surgery provided a significant improvement in outcomes and gain in health state utility regardless of the occurrence of complications within the 90-day global period. The cost-utility, which was higher in patients with complications, was $70 822, which is within the range of commonly accepted threshold of willingness to pay. Clearly, measures focused on prevention of complications to reduce the cost and increase cost-utility.
- Published
- 2016
49. Does Number of Reported Drug Allergies Affect Patient-Reported Outcomes and Satisfaction following Operative Treatment for Degenerative Lumbar Spine Disease?
- Author
-
Joseph B. Wick, David P. Stonko, Matthew J. McGirt, Silky Chotai, Clinton J. Devin, Harrison F. Kay, and Anthony L. Asher
- Subjects
Drug ,Allergy ,medicine.medical_specialty ,Lumbar spine disease ,business.industry ,media_common.quotation_subject ,medicine.disease ,Affect (psychology) ,Anesthesia ,Internal medicine ,medicine ,Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) ,business ,media_common - Published
- 2015
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