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158 results on '"Joseph, Jean-Marc"'

7. Supplementary Data Legends 1-3 from EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

Author

Riggi, Nicolò, primary, Suvà, Mario-Luca, primary, Suvà, Domizio, primary, Cironi, Luisa, primary, Provero, Paolo, primary, Tercier, Stéphane, primary, Joseph, Jean-Marc, primary, Stehle, Jean-Christophe, primary, Baumer, Karine, primary, Kindler, Vincent, primary, and Stamenkovic, Ivan, primary

Published
2023
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13. TWIST1 expression is associated with high-risk Neuroblastoma and promotes Primary and Metastatic Tumor Growth

Author

Sepporta, Maria-Vittoria, primary, Praz, Viviane, additional, Bourloud, Katia Balmas, additional, Joseph, Jean-Marc, additional, Jauquier, Nicolas, additional, Riggi, Nicolo’, additional, Nardou-Auderset, Katya, additional, Petit, Audrey, additional, Scoazec, Jean-Yves, additional, Sartelet, Hervé, additional, Renella, Raffaele, additional, and Mühlethaler-Mottet, Annick, additional

Published
2021
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21. Incidents and complications of totally implanted vascular access devices in children: a prospective study

Author

Lemay Katy, Clément Chantal, Diezi Manuel, Gapany Christophe, Tercier Stéphane, and Joseph Jean-Marc

Subjects
Surgery, RD1-811
Abstract

Abstract Background Totally implanted vascular access devices are frequently used in children for repeated blood samples or intravenous treatments. This prospective study aims at identifying the risk factors associated with infections, obstructions and surgical complications of these devices in pediatric patients. Methods From January 2006 to January 2008, all children older than one year of age with a diagnosis of solid or blood cell malignancy were included in the study. Insertion was performed by the surgeon according to a standardized protocol after landmark-guided puncture of the subclavian or internal jugular vein by a senior anesthesiologist. Dressing and post-operative care were standardized. Every manipulation was prospectively recorded by specialized dedicated nurses, and all patients were screened for complications one month post-surgery. Results 45 consecutive patients 1 to 16 years old were enrolled in the study. Mean age at the time of procedure was 8.5 years (range 1.3–15.6; SD ± 4.88). There were 12 peroperative adverse events in 45 procedures (27%), detailed as follows: 3 pneumothoraces (7%), 3 hematomas (7%), 6 arterial punctures (13%). Among these events, intervention was necessary for two pneumothorax and one arterial puncture. There was no air embolism. At one month, we recorded 5 post-operative complications (11%): 2 thrombotic obstructions, one unsightly scar, and one scapular pain of unknown etiology. One patient needed repositioning of the catheter. There was no catheter-related infection. Conclusion Prospective recording of TIVA insertion in children reveals a significant number of early incidents and complications, mainly associated with the percutaneous puncture technique. We found no infection in this series. Results of a longer follow-up in the same population are pending.

Published
2008
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22. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

Author

Nardou Katya, Bourloud Katia, Flahaut Marjorie, Meier Roland, Mühlethaler-Mottet Annick, Joseph Jean-Marc, and Gross Nicole

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Histone deacetylase inhibitors (HDACi) are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. Neuroblastoma (NB) is the second most common solid tumour in children still associated with poor outcome in higher stages and, thus NB strongly requires novel treatment modalities. Results We show here that the HDACi Sodium Butyrate (NaB), suberoylanilide hydroxamic acid (SAHA) and Trichostatin A (TSA) strongly reduce NB cells viability. The anti-tumour activity of these HDACi involved the induction of cell cycle arrest in the G2/M phase, followed by the activation of the intrinsic apoptotic pathway, via the activation of the caspases cascade. Moreover, HDACi mediated the activation of the pro-apoptotic proteins Bid and BimEL and the inactivation of the anti-apoptotic proteins XIAP, Bcl-xL, RIP and survivin, that further enhanced the apoptotic signal. Interestingly, the activity of these apoptosis regulators was modulated by several different mechanisms, either by caspases dependent proteolytic cleavage or by degradation via the proteasome pathway. In addition, HDACi strongly impaired the hypoxia-induced secretion of VEGF by NB cells. Conclusion HDACi are therefore interesting new anti-tumour agents for targeting highly malignant tumours such as NB, as these agents display a strong toxicity toward aggressive NB cells and they may possibly reduce angiogenesis by decreasing VEGF production by NB cells.

Published
2008
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23. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio

Author

Meier Roland, Auderset Katya, Bourloud Katia, Flahaut Marjorie, Mühlethaler-Mottet Annick, Joseph Jean-Marc, and Gross Nicole

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Neuroblastoma (NB) is the second most common solid childhood tumour, an aggressive disease for which new therapeutic strategies are strongly needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in most tumour cells, but not in normal tissues and therefore represents a valuable candidate in apoptosis-inducing therapies. Caspase-8 is silenced in a subset of highly malignant NB cells, which results in full TRAIL resistance. In addition, despite constitutive caspase-8 expression, or its possible restoration by different strategies, NB cells remain weakly sensitive to TRAIL indicating a need to develop strategies to sensitise NB cells to TRAIL. Histone deacetylase inhibitors (HDACIs) are a new class of anti-cancer agent inducing apoptosis or cell cycle arrest in tumour cells with very low toxicity toward normal cells. Although HDACIs were recently shown to increase death induced by TRAIL in weakly TRAIL-sensitive tumour cells, the precise involved sensitisation mechanisms have not been fully identified. Methods NB cell lines were treated with various doses of HDACIs and TRAIL, then cytotoxicity was analysed by MTS/PMS proliferation assays, apoptosis was measured by the Propidium staining method, caspases activity by colorimetric protease assays, and (in)activation of apoptotic proteins by immunoblotting. Results Sub-toxic doses of HDACIs strongly sensitised caspase-8 positive NB cell lines to TRAIL induced apoptosis in a caspases dependent manner. Combined treatments increased the activation of caspases and Bid, and the inactivation of the anti-apoptotic proteins XIAP, Bcl-x, RIP, and survivin, thereby increasing the pro- to anti-apoptotic protein ratio. It also enhanced the activation of the mitochondrial pathway. Interestingly, the kinetics of caspases activation and inactivation of anti-apoptotic proteins is accelerated by combined treatment with TRAIL and HDACIs compared to TRAIL alone. In contrast, cell surface expression of TRAIL-receptors or TRAIL is not affected by sub-toxic doses of HDACIs. Conclusion HDACIs were shown to activate the mitochondrial pathway and to sensitise NB cells to TRAIL by enhancing the amplitude of the apoptotic cascade and by restoring an apoptosis-prone ratio of pro- to anti-apoptotic proteins. Combining HDACIs and TRAIL could therefore represent a weakly toxic and promising strategy to target TRAIL-resistant tumours such as neuroblastomas.

Published
2006
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24. Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.

Author

Holmes, Keith, Pötschger, Ulrike, Pearson, Andrew D. J., Sarnacki, Sabine, Cecchetto, Giovanni, Gomez-Chacon, Javier, Squire, Roly, Freud, Enrique, Bysiek, Adam, Matthyssens, Lucas E., Metzelder, Martin, Monclair, Tom, Stenman, Jakob, Rygl, Michal, Rasmussen, Lars, Joseph, Jean-Marc, Irtan, Sabine, Avanzini, Stefano, Godzinski, Jan, and Björnland, Kristin

Published
2020
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25. The influence of surgical excision on survival in high-risk neuroblastoma revisited after introduction of ch14.18/CHO immunotherapy in the HR-NBL1/SIOPEN trial.

Author

Holmes, Keith, primary, Poetschger, Ulrike, additional, Sarnacki, Sabine, additional, Monclair, Tom, additional, Cecchetto, Giovanni, additional, Gomez Chacon, Javier, additional, Stenman, Jacob, additional, Joseph, Jean-Marc, additional, Luksch, Roberto, additional, Castel, Victoria, additional, Ash, Shifra, additional, Papadakis, Vassilios, additional, Malis, Josef, additional, Balwierz, Walentyna, additional, Owens, Cormac, additional, Lode, Holger N., additional, Boterberg, Tom, additional, Valteau Couanet, Dominique, additional, Pearson, Andrew DJ, additional, and Ladenstein, Ruth Lydia, additional

Published
2018
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26. EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

Author

Riggi, Nicolo, Suva, Mario-Luca, Vito, Claudio De, Provero, Paolo, Stehle, Jean-Christophe, Baumer, Karine, Cironi, Luisa, Janiszewska, Michalina, Petricevic, Tanja, Suva, Domizio, Tercier, Stephane, Joseph, Jean-Marc, Guillou, Louis, and Stamenkovic, Ivan

Subjects
Embryonic stem cells -- Research, Ewing's sarcoma -- Genetic aspects, Gene expression -- Analysis, Biological sciences
Published
2010

31. Huge mediastinal abscess in a 12-month-old child: case report and review of the literature

Author

Tercier, Stephane, Meier, Roland, Vasseur-Maurer, Sabine, Matoso, Vasco, and Joseph, Jean-Marc

Subjects
Abscess -- Risk factors, Abscess -- Diagnosis, Abscess -- Care and treatment, Abscess -- Patient outcomes, Abscess -- Case studies, Mediastinum -- Injuries, Mediastinum -- Medical examination, Mediastinum -- Research, Health
Abstract

Table of Contents Abstract Introduction Case Report Discussion References Abstract A 12-month-old highly feverish boy showed progressive dyspnea with a necrotic adenopathy in the axillla upon an extensive anterior mediastinal [...]

Published
2006

32. Huge mediastinal abscess in a 12-month-old child: case report and review of the literature

Author

Tercier, Stephane, Meier, Roland, Vasseur-Maurer, Sabine, Matoso, Vasco, and Joseph, Jean-Marc

Subjects
Shortness of breath -- Case studies, Shortness of breath -- Care and treatment, Clindamycin -- Usage, Health
Abstract

Abstract A 12-month-old highly feverish boy showed progressive dyspnea with a necrotic adenopathy in the axillla upon an extensive anterior mediastinal abscess. The abscess was drained with a suprasternal incision [...]

Published
2005

36. Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

Author

Montavon, Gisèle, Jauquier, Nicolas, Coulon, Aurélie, Peuchmaur, Michel, Flahaut, Marjorie, Bourloud, Katia Balmas, Yan, Pu, Delattre, Olivier; https://orcid.org/0000-0002-8730-2276, Sommer, Lukas; https://orcid.org/0000-0002-1143-7908, Joseph, Jean-Marc, Janoueix-Lerosey, Isabelle, Gross, Nicole, Mühlethaler-Mottet, Annick, Montavon, Gisèle, Jauquier, Nicolas, Coulon, Aurélie, Peuchmaur, Michel, Flahaut, Marjorie, Bourloud, Katia Balmas, Yan, Pu, Delattre, Olivier; https://orcid.org/0000-0002-8730-2276, Sommer, Lukas; https://orcid.org/0000-0002-1143-7908, Joseph, Jean-Marc, Janoueix-Lerosey, Isabelle, Gross, Nicole, and Mühlethaler-Mottet, Annick

Abstract

The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the oncogenic process. However, the precise role of activating ALK mutations or ALK-wt overexpression in NB tumor initiation needs further clarification. Human ALK-wt, ALK-F1174L, or ALK-R1275Q were stably expressed in murine neural crest progenitor cells (NCPC), MONC-1 or JoMa1, immortalized with v-Myc or Tamoxifen-inducible Myc-ERT, respectively. While orthotopic implantations of MONC- 1 parental cells in nude mice generated various tumor types, such as NB, osteo/ chondrosarcoma, and undifferentiated tumors, due to v-Myc oncogenic activity, MONC-1-ALK-F1174L cells only produced undifferentiated tumors. Furthermore, our data represent the first demonstration of ALK-wt transforming capacity, as ALK-wt expression in JoMa1 cells, likewise ALK-F1174L, or ALK-R1275Q, in absence of exogenous Myc-ERT activity, was sufficient to induce the formation of aggressive and undifferentiated neural crest cell-derived tumors, but not to drive NB development. Interestingly, JoMa1-ALK tumors and their derived cell lines upregulated Myc endogenous expression, resulting from ALK activation, and both ALK and Myc activities were necessary to confer tumorigenic properties on tumor-derived JoMa1 cells in vitro.

Published
2014

37. Abstract B59: Wild-type ALK and both ALK-R1275Q and ALK-F1174L activating mutations display a strong oncogenic activity in vivo in murine neural crest progenitor cells via cooperation with c-myc

Author

Mühlethaler-Mottet, Annick, primary, Montavon, Gisèle, additional, Flahaut, Marjorie, additional, Jauquier, Nicolas, additional, Joseph, Jean-Marc, additional, Delattre, Olivier, additional, Sommer, Lukas, additional, Janoueix-Lerosey, Isabelle, additional, and Gross, Nicole, additional

Published
2014
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38. PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt high Metastatic Colon Cancer Cells

Author

Ragusa, Simone, primary, Cheng, Jianpin, additional, Ivanov, Konstantin I., additional, Zangger, Nadine, additional, Ceteci, Fatih, additional, Bernier-Latmani, Jeremiah, additional, Milatos, Stavros, additional, Joseph, Jean-Marc, additional, Tercier, Stephane, additional, Bouzourene, Hanifa, additional, Bosman, Fredrik T., additional, Letovanec, Igor, additional, Marra, Giancarlo, additional, Gonzalez, Michel, additional, Cammareri, Patrizia, additional, Sansom, Owen J., additional, Delorenzi, Mauro, additional, and Petrova, Tatiana V., additional

Published
2014
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40. Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

Author

Montavon, Gisèle, primary, Jauquier, Nicolas, additional, Coulon, Aurélie, additional, Peuchmaur, Michel, additional, Flahaut, Marjorie, additional, Bourloud, Katia Balmas, additional, Yan, Pu, additional, Delattre, Olivier, additional, Sommer, Lukas, additional, Joseph, Jean-Marc, additional, Janoueix-Lerosey, Isabelle, additional, Gross, Nicole, additional, and Mühlethaler-Mottet, Annick, additional

Published
2014
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44. Identification of Cancer Stem Cells in Ewing's Sarcoma

Author

Suvà, Mario-Luca, primary, Riggi, Nicolò, additional, Stehle, Jean-Christophe, additional, Baumer, Karine, additional, Tercier, Stéphane, additional, Joseph, Jean-Marc, additional, Suvà, Domizio, additional, Clément, Virginie, additional, Provero, Paolo, additional, Cironi, Luisa, additional, Osterheld, Maria-Chiara, additional, Guillou, Louis, additional, and Stamenkovic, Ivan, additional

Published
2009
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48. The Chemokine Receptor CXCR4 Strongly Promotes Neuroblastoma Primary Tumour and Metastatic Growth, but not Invasion

Author

Meier, Roland, primary, Mühlethaler-Mottet, Annick, additional, Flahaut, Marjorie, additional, Coulon, Aurélie, additional, Fusco, Carlo, additional, Louache, Fawzia, additional, Auderset, Katya, additional, Bourloud, Katia Balmas, additional, Daudigeos, Estelle, additional, Ruegg, Curzio, additional, Vassal, Gilles, additional, Gross, Nicole, additional, and Joseph, Jean-Marc, additional

Published
2007
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49. Tumeurs rénales de l’enfant

Author

Diezi, Manuel, primary, Tercier, Stéphane, additional, Joseph, Jean-Marc, additional, Osterheld, Maria-Chiara, additional, derWeid, N. X. von, additional, and Plan, P.-A., additional

Published
2007
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