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MIB/MS data

comparison of abemaciclib targets

Supplemental Figure Legends

Abemeciclib competitive MIB/MS TMT dose response

Expanded detail on MIB MS experiment

Structural reorganization and amelanotic intratumoral nests are evident in persistent melanoma on MEKi.

Kinome and transcriptome responses to combined BRAF and MEK inhibition in murine tumors, patient samples, and human cell lines

Graphical representation and model of results

mRNAseq pathway signature analysis reveals gene expression reprogramming on MEKi.

MEKi Experiment Overview

BRAFV600E and PTEN-loss are required for tumor growth, which is temporally controlled and reproducible at the cell level.

Sup Fig Legends

Achievement of reproducible spatial and temporal control of melanoma growth with

Background. Disproportionate increases in dementia morbidity in ethnic minorities challenge established screening methodologies because of language and culture barriers, varying access to health services, and a relative paucity of cross­ cultural data validating their use. Simple screening techniques adapted to a range of health and social service settings would ac­ celerate dementia detection and social and health services planning for demented minority elders. Methods. The effectiveness of the Clock Drawing Test (CDT) for dementia detection was compared with that of the Mini­ Mental State Examination (MMSE) and the Cognitive Abilities Screening Instrument (CASI) in community-dwelling elders of diverse linguistic, ethnic, and educational backgrounds. Subjects (N =295) were tested at home in their native languages (English, n =141; another language, n =154). An informant-based clinical dementia history and functional severity index de­ rived from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) protocols were used to classify subjects as probably demented (n =170), and probably not demented (n =125). Results. All tests were significantly affected by education ( p .05). Sensitivities and specificities for probable dementia were 82% and 92%, respectively, for the COT; 92% and 92% for the MMSE; and 93% and 97% for the CASI for subjects completing each test. However, in poorly educated non-English speakers, the COT detected demented subjects with higher sensitivity than the two longer instruments (sensitivity and specificity 85% and 94% for the COT, 46% and 100% for the MMSE, and 75% and 95% for the CASI). Moreover, less information was lost due to noncomple­ tion ofthe CDTthan the MMSE or CAS/ (severedementiaor CDT8%. MMSE/2%, and CAS/ 16%). Conclusions. Overall, the COT may be as effectiveas the MMSE or CASI as a first-level dementia screen for clinical use in multiethnic, multilingual samples of older adults. Its brevity (1-5 minutes), minimal language requirements, high acceptability, and lack of dependence on specialized testing materials are well adapted for screening of non-English-speaking elderly persons in settings where bilingual interpreters are not readily available and screening time is at a premium.