4 results on '"Jose R.A. Miranda"'
Search Results
2. CARACTERIZAÇÃO E COMPARAÇÃO DE MÉTODOS MAGNÉTICOS PARA FUTURAS APLICAÇÕES BIOMÉDICAS
- Author
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Guilherme A. Soares, Erick G. Stoppa, Leonardo A. Pinto, and Jose R.A. Miranda
- Published
- 2022
3. AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats
- Author
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Daniela Carvalho dos Santos, André G. Próspero, Milena F Miranda, Andris F. Bakuzis, Guilherme Augusto Soares, Patrícia Fidelis-de-Oliveira, Nicholas Zufelato, Jose R.A. Miranda, Leonardo Antonio Pinto, Vanessa dos Santos Silva, Universidade Estadual Paulista (Unesp), and Universidade Federal de Goiás (UFG)
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Nephrology ,magnetic nanoparticles ,medicine.medical_specialty ,Biodistribution ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,02 engineering and technology ,Development ,Pharmacology ,Kidney ,doxorubicin ,biomagnetism ,03 medical and health sciences ,In vivo ,Internal medicine ,polycyclic compounds ,medicine ,Animals ,General Materials Science ,Doxorubicin ,Tissue Distribution ,Magnetite Nanoparticles ,030304 developmental biology ,0303 health sciences ,business.industry ,021001 nanoscience & nanotechnology ,medicine.disease ,nanomedicine ,Rats ,renal perfusion ,Magnetic nanoparticles ,Nanomedicine ,0210 nano-technology ,business ,Perfusion ,chronic kidney disease ,Kidney disease ,medicine.drug - Abstract
Made available in DSpace on 2020-12-10T19:59:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Aim: This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. Materials & methods: We used the ACB to detect the MNP kidney perfusion in vivo. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution. Results: We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved. Conclusion: This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine. Graphical abstract Univ Estadual Paulista, Dept Fis & Biofis, IBB, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Fisiol, IBB, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Patol, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Clin Med, BR-18618689 Botucatu, SP, Brazil Univ Fed Goias, Inst Fis, Alameda Palmeiras St, BR-74690900 Goiania, Go, Brazil Univ Estadual Paulista, Dept Fis & Biofis, IBB, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Fisiol, IBB, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Patol, BR-18618689 Botucatu, SP, Brazil Univ Estadual Paulista, Dept Clin Med, BR-18618689 Botucatu, SP, Brazil FAPESP: 2015/14923-9 CAPES: 1491705
- Published
- 2020
4. Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry
- Author
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Sunil Krishnan, Gustavo M. Moretto, Andris F. Bakuzis, Nicholas Zufelato, Ricardo Brandt de Oliveira, Marcos F.F. Calabresi, Oswaldo Baffa, André G. Próspero, Jose R.A. Miranda, Caio C. Quini, Diana Rodrigues de Pina, Universidade Estadual Paulista (Unesp), Universidade Federal de Goiás (UFG), Univ Texas MD Anderson Canc Ctr, and Universidade de São Paulo (USP)
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0301 basic medicine ,Male ,Biodistribution ,Materials science ,Biomedical Engineering ,Analytical chemistry ,Pharmaceutical Science ,Medicine (miscellaneous) ,Bioengineering ,NANOPARTÍCULAS ,02 engineering and technology ,03 medical and health sciences ,Magnetics ,In vivo ,Distribution (pharmacology) ,Animals ,General Materials Science ,Tissue Distribution ,Nanoparticle uptake ,Rats, Wistar ,Correlation index ,Magnetite Nanoparticles ,Biomedical instruments ,Electron Spin Resonance Spectroscopy ,021001 nanoscience & nanotechnology ,Extravasation ,030104 developmental biology ,AC biosusceptometry ,Liver ,Real time monitoring ,Magnetic nanoparticles ,Molecular Medicine ,0210 nano-technology ,Quantification methods ,Quantitative analysis (chemistry) ,Ex vivo ,Biomedical engineering - Abstract
Made available in DSpace on 2018-11-26T17:34:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-05-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR). The ACB had viable temporal resolution and accuracy to differentiate temporal parameters of liver accumulation, caused by vasculature extravasation and macrophages action. The biodistribution experiment showed different uptake profiles for different doses and injection protocols. Comparisons with the ESR system indicated a correlation index of 0.993. We present the ACB system as an accessible and versatile tool to monitor magnetic nanoparticles, allowing in vivo and real-time evaluations of distribution and quantitative assessments of particle concentrations. (C) 2017 Elsevier Inc. All rights reserved. Univ Estadual Paulista, Dept Fis & Biofis, Lab Biomagnetismo, IBB, Botucatu, SP, Brazil Univ Fed Goias, Inst Fis, Goiania, Go, Brazil Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, Botucatu, SP, Brazil Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Fis, Ribeirao Preto, SP, Brazil Univ Estadual Paulista, Dept Fis & Biofis, Lab Biomagnetismo, IBB, Botucatu, SP, Brazil Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, Botucatu, SP, Brazil FAPESP: 2010/07639-9 FAPESP: 2011/18696-6 FAPESP: 2013/20842-6 FAPESP: 2015/14914-0
- Published
- 2016
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